张井岩
发布人: 发布时间: 2008-12-03 作者: 访问次数: 11490

 

 

张井岩  教授,博士生导师

 
 
实验十八楼727室
电话/传真: 021-64253846

E-mail: jyzhang@ecust.edu.cn

个人简介

   
张井岩,女,20003月毕业于以色列魏兹曼科学研究院(Weizmann Institute of Science Israel),获理学博士学位。  20003月至20033月先后在美国明尼苏达大学(University of Minnesota)化学系和生物化学系做博士后研究。20034月至200510 月在美国明尼苏达大学生物化学系做研究员(Research Associate)200511月起任华东理工大学药学院教授。 已在J. Am. Chem. Soc., ACS Nano, Chem. Commun., Small, J. Phys. Chem. B, J. Biology.Chem., Langumir, Biochemistry 等国外专业期刊发表研究论文,单篇被同行引用上百次。现完成和主持三项国家自然基金、国家重点实验室重点项目、浦江人才计划项目以及政府间科技合作项目等科研项目。先后获得 Robert Jenness Award (明尼苏达大学生物化学系,2006),浦江人才计划(2006),天鼎东岳讲教金(2007),上海化学工业区理工创新奖(2011) 华东理工大学育英奖(2012)等奖励。

研究方向

化学生物学:研究化学小分子以及材料等对生物大分子如核酸,蛋白的结构和性质的影响,以及它们在抗癌药物发现中的应用。

无机药物化学:具有潜在药物活性的金属配合物的合成、药物活性以及作用机理研究。

生物化学:含金属蛋白质的结构、活性、机理以及他们在药物合成中的应用。

 

代表性论著

 

1)        Wanjun Lan, Satoshi Yamaguchi, Teruyasu Yamamoto, Shinya Yamahira, Modong Tan, Naoka Murakami, Jingyan Zhang, Motonao Nakamura, and Teruyuki Nagamune, Visualization of the pH-dependent dynamic distribution of G2A in living cells FASEB J 2014, 28, 3965-3974.

 

2)        Jie Feng, Xin Du, Hui Liu, Xin Sui, Chen Zhang, Yun Tang and Jingyan Zhang Manganese-mefenamic acid complexes exhibit high lipoxygenase inhibitory activity Dalton Trans., 2014, 43, 10930–10939

 

3)        Bin Zheng, Chong Wang, Xiaozhen Xin, Fei Liu, Xuejiao Zhou, jingyan Zhang, and Shouwu Guo, Electron Transfer from Graphene Quantum Dots to the Copper Complex Enhances Its Nuclease Activity J. Phys. Chem. C 2014, 118, 7637−7642

 

4)        Bin Zheng, Hui Liu, Jie Feng and Jingyan Zhang, Effect of coordination sphere of the copper center and Cu―Cu distance on catechol oxidase and nuclease activities of the copper complexes Appl. Organometal. Chem. 2014, 28, 372–378

 

5)        Xiaochen Wu, Yan Zhang, Ting Han, Haixia Wu, Shouwu Guo and Jingyan Zhang, Composite of Graphene Quantum Dots and Fe3O4 Nanoparticles: Excellent Peroxidase Activity and Application in Phenolic Compound Removal, RSC Advances, 2014, 4, 3299–3305

 

6)        Chong Wang, Congyu Wu, Xuejiao Zhou, Ting Han, Xiaozhen Xin, Jiaying Wu, Jingyan Zhang, Shouwu Guo, Enhancing Cell Nucleus Accumulation and DNA Cleavage Activity of Anti-Cancer Drug via Graphene Quantum Dots, Scientific Reports 2013, 3, 2852.

 

7)        Congyu Wu , Chong Wang , Ting Han , Xuejiao Zhou , Shouwu Guo  and Jingyan Zhang Insight into the Cellular Internalization and Cytotoxicity of Graphene Quantum Dots, Adv. Healthcare Mater. 2013, 2, 1613–1619

 

8)        Xuejiao Zhou, Shouwu Guo, and Jingyan Zhang Solution-Processable Graphene Quantum Dots, ChemPhysChem 2013, 14, 2627.

 

9)        Yan Zhang , Congyu Wu , Shouwu Guo  and Jingyan Zhang  Interactions of graphene and graphene oxide with proteins and peptides, Nanotechnol Rev 2013; 2(1): 27–45

 

10)     Yan Zhang, Congyu Wu, Xuejiao Zhou, Xiaochen Wu, Yongqiang Yang, Haixia Wu, Shouwu Guo and Jingyan Zhang  Graphene quantum dots/gold electrode and its application in living cell H2O2 detection Nanoscale, 2013, 5, 1816

 

11)     Xin Chen, Xuejiao Zhou, Ting Han, Jiaying Wu, Jingyan Zhang, and Shouwu Guo, Stabilization and Induction of Oligonucleotide i-Motif Structure via Graphene Quantum Dots ACS Nano 2013, 7, 531–537.

 

12)     Xuejiao Zhou, Yan Zhang, Chong Wang, Xiaochen. Wu,Yang, Bin Zheng, Wu, Shouwu Guo, Jingyan Zhang, Photo-Fenton Reaction of Graphene Oxide: A New Strategy to Prepare Graphene Quantum Dots for DNA Cleavage, ACS Nano 2012, 6, 6592-6599.

 

13)     Bin Zheng, Chong Wang, Congyu Wu, Xuejiao Zhou, Min Lin, Xiaochen Wu,  Xioazhen Xin, Xin Chen, Jing Zheng, Hui, Liu, Jingyan Zhang, Shouwu Guo; Nuclease Activity and Cytotoxicity Enhancement of the DNA Intercalators via Graphene Oxide J. Phys. Chem. C  2012, 116, 15839-15846.

 

14)     Wanjun Lan, Hongliu Ren, Yu Pang, Chuseng Huang, Yufang Xu, Robert J. Brooker and Jingyan Zhang, A facile transport assay for H+ coupled membrane transport using fluorescence probes, Analytical Methods2012, 4, 44-46.

 

15)     Yan Zhang , Jingyan Zhang, Xuelei Huang , Xuejiao Zhou , Haixia Wu ,and  Shouwu Guo, Assembly of Graphene Oxide–Enzyme Conjugates through Hydrophobic Interaction, Small2012, 8, 154–159.

 

16)     Lijun Lu, Yanying Song, Hui Liu, Jingyan Zhang, Synthesis, characterization, and polyphenol oxidase activity of CuII, MnII, and FeIII complexes with a N2O2 Ligand. J. Coord. Chem. 2012, 65, 1278–1288.

 

17)     Y. Zhang, J.Zhang, H. Wu, S. Guo, J. Zhang, Glass carbon electrode modified with horseradish peroxidase immobilized on partially reduced graphene oxide for detecting phenolic compounds  J. Electroanal. Chem. 2012, 681, 49–55.

 

18)     Rong Li, Jinlei Tian, Hui Liu, Shiping Yan, Shouwu Guo, Jingyan Zhang Direct evidence for the role of imidazole in disproportionation of hydrogen peroxide by a mononuclear manganese salen complex, Transition Met Chem  2011, 36, 811–817.

 

19)     Yan Zhang, Haixia Wu, Xuelei Huang, Jingyan Zhang and Shouwu Guo, Effect of substrate (ZnO) morphology on enzyme immobilization and its catalytic activity Nanoscale Res. Let.  2011, 6, 450-456.

 

20)     Xuejiao Zhou, Jiali Zhang, Haixia Wu, Haijun Yang, Jingyan Zhang, and Shouwu  Guo , Reducing Graphene Oxide via Hydroxylamine: A Simple and Efficient Route to Graphene J. Phys. Chem. C 2011, 115, 11957–11961

 

21)     Ren, Hongliu; Wang, Chong; Zhang, Jiali; Zhou, Xuejiao; Xu, Dafeng; Zheng, Jing; Guo, Shouwu; Zhang, Jingyan. DNA Cleavage System of Nanosized Graphene Oxide Sheets and Copper Ions. ACS Nano 2010, 4(12), 7169-7174.

 

22)     Feng Zhang, Bin Zheng, Jiali Zhang, Xuelei Huang, Hui Liu, Shouwu Guo, Jingyan Zhang Horseradish Peroxidase Immobilized on Graphene Oxide: Physical Properties and Applications in Phenolic Compound Removal. J. Phys. Chem. C, 2010, 114, 8469-8473.

 

23)     Jiali Zhang, Feng Zhang, Haijun Yang, Xuelei Huang, Hui Liu, Jingyan Zhang Shouwu Guo, Graphene Oxide as a Matrix for Enzyme Immobilization. Langmuir 2010, 26(9), 6083-6085.

 

24)     Rong Li, Fuqiang Huang, Xiaojun Jiang, Minyuan Liu, Yanying Song, Hui Liu, Jingyan Zhang Catalase-like Catalytic Reaction of the Dinuclear Manganese-salen Complex J. Coord. Chem. 2010, 63(9), 1611-1618.

 

25)     Guanke Zuo, Xiaojun Jiang, Hui Liu,Jingyan Zhang A Novel Urinary Oxalate Determination Method via a Catalase Model Compound with Oxalate Oxidase  Analytical Methods  2010, 2, 254-258.

 

26)     Jiali Zhang, Haijun Yang, Guangxia Shen, Ping Cheng, Jingyan Zhang Shouwu Guo, Reduction of graphene oxide via L-ascorbic acid  Chem. Commun., 2010, 46, 1112–1114.

 

27)     Hui Liu, Jinlei Tian, Yingying Kou, Jingyan Zhang, Li Feng, Dongdong Li, Wen Gu, Xin Liu, Daizheng Liao, Peng Cheng, Joan Ribas and Shiping Yan, Synthesis, structures and magnetic properties of polynuclear mixed-valence MnIIMnIII complexes containing 3-(2-phenol)-5-(pyridin-2-yl)-1,2,4-triazole ligand  Dalton Trans., 2009, 10511–10517

 

28)     Xiaojun Jiang, Hui Liu, Bing Zheng and Jingyan Zhang, Coordination modes of bridge carboxylates in dinuclear manganese compounds determine their catalase-like activities Dalton Trans., 2009, 8714–8723.

 

29)     Jing Hou, Guanke Zuo, Guangxia Shen, He Guo, Hui Liu, Ping Cheng, Jingyan Zhang, Shouwu Guo Hollow Sodium Tungsten Bronze (Na0.15WO3) Nanospheres: Preparation, Characterization, and Their Adsorption Properties  Nanoscale Res Lett. 2009, 4, 1241–1246.

 

30)     Jingyan Zhang, John Lipscomb. Mapping the binding conformation of B component to hydroxylase in soluble methane monooxygenase using Spin Labeling EPR spectroscopy  Biochemistry  2006452913-2926.

 

31)     Jingyan Zhang, John Lipscomb.Role of the C-terminal Region of the B Component of Methylosinus trichosporium OB3b Methane Monooxygenase in the Regulation of Oxygen Activation  Biochemistry 2006, 45, 1459-1469.

 

32)     Jingyan Zhang, Hui Zheng, Stecphen Groce, John LipscombBasis for specificity in methane monooxygenase and related non-heme iron-containing biological oxidation catalysts J. Mol.Cat. A: Chemical  2006251,  54-65.

 

33)     Aimin Liu, Yi Jin, Jingyan Zhang, Brain Brazeau, John Lipscomb Substrate radical intermidiates in soluable methane monooxygenase BBRC  2005, 338, 254-261

 

34)     Patzlaff, J. S.; Jingyan Zhang, Brooker, R. J.; Barry, B. A. An Isotope-edited FT-IR Study of a Symporter, the Lactose Permease. Biochemistry 2002, 41, 7366-7372

 

35)     Jingyan Zhang,  Patzlaff, J; Brooker, RJ, et al. FT-IR study of the isotope labelled lactose permease of E-coli Biophysical Journal  2002, 82, 532A.

 

36)     DiDonato, M.; Jingyan Zhang,  Larry, Que, Jr., and Sarkar, B. Zinc Binding to the N-Terminal Domain of the Wilson Disease Copper-Transporting ATPase: Implications for in vivo Metal Ion Mediated Regulation of ATPase Activity. J. Biol. Chem. 2002, 277, 13409.

 

37)     Jingyan Zhang, Carl, P. J.; Zimmerman, H.; Goldfarb, D. Investigation of the formation of MCM-41 by Electron Spin Echo Envelope Modulation spectroscopy.  J. Phys. Chem. B. 2002, 106, 5382

 

38)     Jingyan Zhang, Daniella Goldfarb,In-situ investigation of the Formation mechanism of mesoporous materials via the dynamics and ordering of spin-probes-pH and Si/surfactant effect.  Microporous Mesoporous Mater. 2001, 48, 143.

 

39)     Jingyan Zhang, Daniella Goldfarb, Manganese incorporation into the MCM-41 under acidic conditions and studies by high field EPR and ENDOR techniques  J. Am. Chem. Soc. 2000, 122, 7034.

 

40)     Jingyan Zhang, Zeev Luz, Daniella Goldfarb, Evolution of the rotational diffusion rates and order parameters during the formation of MCM-41 J. Phys. Chem. B  2000,104, 279.