王 卫
发布人: 发布时间: 2008-12-04 作者: 访问次数: 11239

王 卫  特聘讲座教授
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电话: +1-5052770756
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传真: +1-5052772609
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E-mail: wwang@unm.edu
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个人简介
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  受教育情况

1984-1988:理学学士    南京师范大学化学系(中国南京)
1990-1993:理学硕士    中国科学院上海药物研究所(导师:顾坤健教授、嵇汝运院士)
1996-2000:化学博士    北卡州立大学化学系(美国罗利,导师:王炳和教授)
2000-2001:博士后        亚利桑那大学化学系(美国图桑,导师:Victor J. Hruby教授)

工作和受聘情况

1993/07-1994/09:     助理研究员    华东理工大学康拜化学研究所(中国上海)
1994/10-1996/07:     助理研究员    俄克拉何马大学药学院(美国俄克拉何马市)
2001/12-2003/08:     研究员            若华(Novartis)基因研究所(美国圣地亚哥)
2003/08-:               助理教授        新墨西哥大学化学系(美国埃尔伯格基)
2005/06-:       讲座教授    华东理工大学(中国上海)
 

研究方向
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  有机化学:

1)  有机合成新方法学:不对称催化和绿色化学有机反应
2)  具有生物活性的复杂天然产物的全合成

化学生物学(Chemical Biology)和系统生物学 (System Biology):

1)  细胞凋亡(Apoptosis):小分子为探针去理解生物过程中蛋白-蛋白之间的相互作用,开发和研制新型的抗癌,抗HIV和抗炎新药
2)  分子成像(Molecular Imaging):化学小分子为探针进行体内氧自由基、糖、激酶生物作用和机理的研究和癌症的诊断
3)  组合化学(Combinatorial Chemistry):设计、合成和高通量筛选化学库,快速寻找先导化学物
4)  新药的开发(Drug Discovery):以计算机辅助设计、先导化学物为起点,有目的得设计和合成化学集中库,进行生物活性的测定和构效关系的研究
5)  药剂化学(Pharmaceutical Chemistry):利用生物手段进行药物的控制释放,改进药物的理化性能和生物利用率,降低药物的毒性,和提高药物的靶向性和耐药性

材料化学(Material Chemistry):

1)  分子的印刷(Molecular Imprinting): 设计和合成具有识别和记忆功能的人造纳米材料,模仿酶催化反应和药物的控制释放
2)  生物材料(Biomaterials): 设计和合成具有生物功能的骨材料
 

获奖成果
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  2001:美国多肽学会Bruce W. Erickson杰出青年学者奖
2001:美国名人录
1999:北卡州立大学杰出研究奖
1998:格兰素研究生奖学金
 

代表性论著
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  1) Zu, L.-S.; Wang, J.; Li, H.; Yu, X.-H.; Wang, W.* “A Recyclable Fluorous (S)-Pyrrolidine Sulfonamide Promoted Direct, Highly Enantioselective Michael Addition of Ketones and Aldehydes to Nitroolefins in Water” Org. Lett., 2006, in press.

2) Wang, W.;* Li, H.; Wang, J.; Zu, L.-S.; “Enantioselective Organocatalytic Tandem Michael-Aldol Reactions: One-Pot Synthesis of Chiral Thiochromenes” J. Am. Chem. Soc., 2006, in press.

3) Wang, J.; Li, H.; Zu, L.-S.; Wang, W.* “Enantioselective Organocatalytic Michael Addition Reactions between N-Heterocycles and Nitroolefins” Org. Lett., 2006, 8, 1391-1394.

4) Wang, J.; Li, H.; Zu, L.-S.; Wang, W.* “Highly Enantioselective Organocatalytic Michael Addition Reactions of Ketones with Chalcones” Adv. Synth. Catal., 2006, 348, 425-428.

5) Zu, L.-S.; Wang, J.; Li, H.; Yu, X.-H.;* Wang, W.* “Highly Enantioselective Aldehyde-Nitroolefin Michael Addition Reactions Catalyzed by Recyclable Fluorous (S) Diphenylpyrrolinol Silyl Ether” Tetrahedron Lett., 2006, 47, 5131-5134.

6) Zhang, S.-L.; Duan, W.-H.;* Wang, W.* “Efficient, Enantioselective Organocatalytic Synthesis of Trichostatin A” Adv. Synth. Catal., 2006, in press.

7) Li, H.; Wang, J.; Zu, L.-S.; Wang, W.* “Organocatalytic Asymmetric Conjugate Addition of Thioacetic Acid to beta-Nitrostyrenes” Tetrahedron Lett., 2006, 47, 2585-2589.

8) Li, H.; Zu, L.-S.; Wang, J.; Wang, W.* “Organocatalytic Asymmetric Conjugate Addition of Thioacetic Acid to Enones” Tetrahedron Lett., 2006, 47, 3145-3148.

9) Mei, Y.; Bentley, P. A.; Wang, W. “A Selective and Sensitive Chemosensor for Cu2+ Based on 8-Hydroxyquinoline” Tetrahedron Lett., 2006, 47, 2447-2449.

10) Wang, J.; Li, H.; Lou, B.; Zu, L.-S.; Guo, H.; Wang, W.* "Enantio- and Diastereoselective Michael Addition Reactions of Unmodified Aldehydes and Ketones with Nitroolefins Catalyzed by a Pyrrolidine Sulfonamide" Eur. J. Chem., 2006, 12, 4321-4332.

11) Wang, J.; Li, H.; Yu, X.-H.; Zu, L-S.; Wang, W.* “Chiral Binaphthyl-Derived Amine-Thiourea Organocatalyst Promoted Asymmetric Morita-Baylis-Hillman Reaction” Org. Lett., 2005, 7, 4293-4296.

12) Wang, J.; Li, H.; Duan, W.-H.; Zu, L-S.; Wang, W.* “Organocatalytic Asymmetric Michael Addition of 2,4-Pentandione to Nitroolefins” Org. Lett., 2005, 7, 4713-4716.

13) Wang, J.; Li, H.; Mei, Y.; Lou, B.; Xu, D.; Xie, D.; Guo, H.; and Wang, W.* “Direct, Facile Aldehyde and Ketone alpha-Selenenylation Reactions Promoted by L-Prolinamide and Pyrrolidine Sulfonamide Organocatalysts” J. Org. Chem. 2005, 70, 5678-5687.

14) Wang, W.;* Li, H.; Wang, J. “Pyrrolidine Sulfonamide Promoted Direct, Enantioselective Aldol Reactions of alpha,alpha-Dialkyl Aldehydes: Synthesis of Quaternary Carbon-Containing beta-Hydroxy Carbonyl Compounds” Tetrahedron Lett., 2005, 46, 5077-5079.

15) Wang, W.;* Li, H.; Wang, J. “Enantioselective, Organocatalytic Mukaiyama-Michael Addition of Silyl Ethers to alpha,beta-Unsaturated Aldehydes” Org. Lett., 2005, 7, 1637-1639.

16) Wang, W.;* Mei, J.; Li, H.; Wang, J. “A Novel Pyrrolidine Imide Catalyzed Direct Formation of alpha,beta-Unsaturated Ketones from Unmodified Ketones and Aldehydes” Org. Lett., 2005, 7, 601-604.

17) Wang, W.;* Wang, J.; and Li, H. “Direct, Highly Enantioselective Pyrrolidine Sulfonamide Catalyzed Michael Addition Reactions of Aldehydes to Nitrostyrenes” Angew. Chem. Int. Ed., 2005, 44, 1369-1371.

18) Wang, W.;* Wang, J.; Li, H. “A Simple and Efficient L-Prolinamide-Catalyzed alpha-Selenenylation Reactions of Aldehydes,” Org. Lett., 2004, 6, 2817-2820.

19) Wang, W.;* Li, H. “An Efficient Synthesis of the Intrinsic Fluorescent Peptide Labels, (S) and (R) (6,7-Dimethoxyl-4-coumaryl)alanines via Asymmetric Hydrogenations” Tetrahedron Lett., 2004, 45, 8479-8481.

20) Wang, W.;* Li, H.; Wang, J., Liao, L.-X. “Direct, Organocatalytic alpha-Sulfenylation of Aldehydes and Ketones” Tetrahedron Lett., 2004, 45, 8229-8231.

21) Wang, W.;* Wang, J.; Li, H., Liao, L.-X. “A Novel Amine Sulfonamide Organocatalyst for Promoting Direct, Highly Enantioselective alpha-Aminoxylation Reactions of Aldehydes and Ketones”, Tetrahedron Lett., 2004, 45, 7235-7238.

22) Wang, W.;* Wang, J.; Li, H. “Catalysis of Highly Stereoselective Mannich-Type Reactions of Ketones with alpha-Imino Esters by a Pyrrolidine Sulfonamide. Synthesis of Unnatural alpha-Amino Acids,” Tetrahedron Lett., 2004, 45, 7243-7246.