陈国强
发布人: 发布时间: 2008-12-04 作者: 访问次数: 1920

陈国强  特聘讲座教授


--------------------------------------------------------------------------------
      陈国强教授,男,研究员。1988年和1996年分获上海第二医科大学硕士和 内科血液学博士学位,并先后在法国和美国从事高访。现任国家重点基础研究计划首席科学家,上海第二医科大学病理生理学教研室主任,中国科学院上海生命科学研究院/上海第二医科大学健康科学中心肿瘤功能基因组学研究室主任,上海第二医科大学附属瑞金医院上海血液学研究所副所长。《癌症》杂志副主编、《中华医学杂志》和《肿瘤防治杂志》等编委。 
 
 

研究方向
--------------------------------------------------------------------------------
      陈国强教授领导的课题组强调从事科学假说和兴趣驱动的原创性研究,强调学科前沿和国家需求,主要开展治疗肿瘤的药物靶基因的基础性探索性工作,具体研究内容主要包括:识别白血病相关的AML1、ETO和AML1-ETO的相互作用蛋白并探讨它们在AML1-ETO信号中的作用;M2b白血病蛋白的AML1-ETO调控基因,并研究其功能;白血病蛋白质组学研究; 应用蛋白质芯片技术分析肿瘤血清标志物和 肿瘤细胞分化和凋亡机制研究。他要求他的研究生在答辩之前,学位论文必须由影响因子3以上的国际权威杂志所接受发表。
 

获奖成果
--------------------------------------------------------------------------------
      多年来,一直致力于白血病分子发病学和治疗学机制研究,尤其是他所从事的三氧化二砷治疗急性早幼粒细胞性白血病(APL)的基础和临床研究工作在国际血液学界开拓了一种全新的研究领域。最近,他领导的课题组在低氧诱导因子(HIF-1)和磷脂爬行酶(PLSCR1)介导白血病分化中的作用及其表达调控机制研究方面取得系列原创发现,在利用蛋白质组学技术研究白血病相关蛋白的功能方面也取得重要进展。近几年来,他在国际权威刊物《BLOOD》、《JNCI》、《PNAS》、《LEUKEMIA》以及国内核心期刊共发表了70余篇学术论文。自97年以来,在全国单篇论文引用数统计排名中始终处于前八位,共达1400余次。他先后获得杰出青年科学基金、国家自然科学基金、国家973计划、中科院百人计划、国家科技部国际合作重大项目、霍英东高校青年教师基金、卫生部优秀青年科技人才专项基金、上海青年启明星计划和上海科技发展重大项目的资助,并获得国家自然科学二等奖、上海市科技进步一等奖、杜邦科技创新奖、中国青年科技奖等学术奖励和新世纪首批百千万人才工程国家级人选、上海“十大杰出青年”、上海科技英才、上海市劳动模范、上海市优秀学科带头人、上海优秀青年教师、市卫生系统杰出青年人才 “银蛇奖”等荣誉称号,并享受国务院特殊津贴。

 

代表性论著
--------------------------------------------------------------------------------
  1. Ke-Wen Zhao, Xi Li, Qian Zhao, Ying Huang, Zhen-Gang Peng, Wu-Zhong Shen, Ji Zhao, Quansheng Zhou, Zhu Chen, Peter J. Sims, Therese Wiedmer, and Chen GQ. Protein Kinase C Mediates Retinoic Acid and Phorbol Myristate Acetate-induced Phospholipid Scramblase 1 Gene Expression: Its Role in Leukemic Cell Differentiation. BLOOD,2004,  in press.
2. Yin T, Wu YL, Sun HP, Sun GL, Du YZ, Wang KK, Zhang J, Chen GQ, Chen SJ, Chen Z. Combined effects of As4S4 and imatinib on chronic myeloid leukemia cells and BCR-ABL oncoprotein. Blood. 2004,in press
3. Yi JIANG, Wu-Zhong SHEN, Zhi-Hong XUE, Hua YAN, Zhen-Gang PENG, Jian-Hua TONG, Zhu CHEN, Ying HUANG, Micheal LÜBBERT and Chen GQ. Desferrioxamine Induces Leukemic Cell Differentiation By Hypoxia Inducible Factor-1a And CCAAT/enhancer-binding Protein- -Dependent Mechanisms. Leukemia, in revision
4. Yun Yu, Sheng Chen, Li-Shun Wang, Wen-Li Chen, Wei-Jian Guo, Hua Yan, Wei-Hua Zhang, Cheng-Hong Peng, Sheng-Dao Zhang, Hong-Wei Li, Chen GQ. Prediction of Serum Biomarkers For Pancreatic Cancer By Surface Enhanced Laser Desorption/ionization-based Decision Tree Classification. ONCOLOGY, 2004, in press
5. Huang Y, Du KM, Xue ZH, Yan H, Li D, Liu W, Chen Z, Zhao Q, Tong JH, Zhu YS, Chen GQ. Cobalt chloride and low oxygen tension trigger differentiation of acute myeloid leukemic cells: possible mediation of hypoxia-inducible factor-1alpha. Leukemia. 2003 Nov;17(11):2065-73.
6. Cai X, Yu Y, Huang Y, Zhang L, Jia PM, Zhao Q, Chen Z, Tong JH, Dai W, Chen GQ. Arsenic trioxide-induced mitotic arrest and apoptosis in acute promyelocytic leukemia cells. Leukemia. 2003 Jul;17(7):1333-7.
7. Chen GQ, Zhou L, Styblo M, Walton F, Jing Y, Weinberg R, Chen Z, Waxman S. Methylated metabolites of arsenic trioxide are more potent than arsenic trioxide as apoptotic but not differentiation inducers in leukemia and lymphoma cells. Cancer Res. 2003 Apr 15;63(8):1853-9.
8. Zhao Q, Tao J, Zhu Q, Jia PM, Dou AX, Li X, Cheng F, Waxman S, Chen GQ, Chen SJ, Lanotte M, Chen Z, Tong JH. Rapid induction of cAMP/PKA pathway during retinoic acid-induced acute promyelocytic leukemia cell differentiation. Leukemia. 2003;18(20):285
9. Gu BW, Xiong H, Zhou Y, Chen B, Wang L, Dong S, Yu ZY, Lu LF, Zhong M, Yin HF, Zhu GF, Huang W, Ren SX, Gallagher RE, Waxman S, Chen GQ, Wang ZG, Chen Z, Fu G, Chen SJ.Variant-type PML-RAR(alpha) fusion transcript in acute promyelocytic leukemia: use of a cryptic coding sequence from intron 2 of the RAR(alpha) gene and identification of a new clinical subtype resistant to retinoic acid therapy. Proc Natl Acad Sci U S A. 2002 May 28;99(11):7640-5.
10. Jing YK,Wang L,Guo-Qiang Chen , Waxman S.Combined effects of all-trans retinoic acid and arsenic trioxide in APL cells in vitro and in vivo. Blood, 2001, 97(1):264-9
11. Chen Z, Chen GQ, Shen ZX, Sun GL, Tong JH, Wang ZY, Chen SJ.Expanding the use of arsenic trioxide: leukemias and beyond. Semin Hematol 2002 Apr;39(2 Suppl 1):22-6
12. Zhao WL, Chen SJ, Shen Y, Xu L, Cai X, Chen GQ, Shen ZX, Chen Z, Wang ZY. Treatment of acute promyelocytic leukemia with arsenic trioxide: clinical and basic studies. Leuk Lymphoma 2001 Nov-Dec;42(6):1265-73
13. Zhang TD, Chen GQ, Wang ZG, Wang ZY, Chen SJ, Chen Z.Arsenic trioxide, a therapeutic agent for APL. Oncogene 2001 Oct 29;20(49):7146-53
14. Chen Z, Chen GQ, Shen ZX, Chen SJ, Wang ZY.Treatment of acute promyelocytic leukemia with arsenic compounds: in vitro and in vivo studies. Semin Hematol 2001 Jan;38(1):26-36
15. Xun Cai, Yu-Lei Shen, Qi Zhu, Pei-Min Jia, Yun Yu, Li Zhou, Ying Huang, Ji-Wang Zhang, Shu-Min Xiong, Sai-Juan Chen, Zhen-Yi Wang, Zhu Chen, and Chen GQ. As2O3–induced APL cell Apoptosis and Differentiation Are Associated Respectively with Mitochondrial Transmembrane Potential Collapse /Caspase Activation and RA Signaling. Leukemia. 2000;14:262
16. Xin-Hua Zhu, Yu-Lei Shen, Yong-kui Jing, Xun Cai, Pei-Ming Jia, Ying Huang, Wei Tang, Gui-Ying Shi, Yue-Ping Sun, Jie Dai, Zhen-Yi Wang, Sai-Juan Chen, Ting-Dong Zhang, Samuel Waxman, Zhu Chen, Chen GQ. Apoptosis and Growth Inhibition in Malignant Lymphocytes after treatment with Arsenic Trioxide at Clinically achievable Concentrations. J Natl Cancer Inst. 1999; 91(9):772-8
17. G-X Cheng, XH Zhu, X-Q Men, L Wang, QH Huang, X-L Jin, SM Xiong, J Zhu, WM Guo, JQ Chen, SF Xu, E So, LC Chan, S Waxman, A Zelent, Guo-Qiang Chen, S Dong, JX Liu, S-J Chen. Distinct leukemia Phenotypes in Trabsgenic Mice and Different Corepressor Interactions Generated by Promyelocytic Leukemia Variant Fusion Genes PLZF-RAR and NPM-RARa. Proc Natl Acad Sci USA.1999; 96:6318-6323
18. Niu C, Yan H, Liu JX, Yu T, Sun HP, Li XS, Wu W, Zhang FQ, Chen Y, Zhou L, Li JM, Zeng XY, Ou Yang RR, Yuan MM, Ren MY, Gu FY, Gu BW, Cao Q, Su XY, Guo-Qiang Chen, Xiong SM, Zhang TD, Waxman S, Wang ZY, Chen Z, Hu J, Shen ZX, and Chen SJ. Studies on treatment of APL with arsenic trioxide: remission induction, follow-up and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients. Blood, 1999;94:3315-3324
19. Zhu J, Guo WM, Yao YY, Zhao WL, Pan L, Cai X, Ju B, Sun GL, Wang HL, Chen SJ, Guo-Qiang Chen, Caen J, Chen Z, Wang ZY Tissue factors on acute promyelocytic leukemia and endothelial cells are differently regulated by retinoic acid, arsenic trioxide and chemotherapeutic agents. Leukemia 1999 Jul;13(7):1062-70
20. Guo-Qiang Chen, Xue-Geng Shi,Wei Tang,Shu-Min Xiong, Jun Zhu, Xun Cai, Ze-Guang Han, Jian-Hua Ni, Gui-Ying Shi, Pei-Ming Jia, Meng-MIn Liu, Kai-Li He, Chao Niu, Jun Ma,Peng Zhang,Ting-Dong Zhang, Pascale Paul, Samuel Waxman, Zhen-Yi Wang,Sai-Juan Chen, Zhu Chen. Use of arsenic trioxide(As2O3) in the treatment of acute promyelocytic leukemia (APL):I.As2O3 exerts dose-dependent dual effects on APL Cells.  Blood 1997, 89:3345-3353.
21. Zhi-Xiang Shen, Guo-Qiang Chen, Jian-Hua Ni, Xiu-Shong Li, Shu-Min Xiong, Qian-Yao Qiu, Jun Zhu, Wei Tang, Kan-Qi Yang, Yu Chen, Li Zhou, Zhi-Wen Fang, Yan-Ting Wang, Jun Ma, Peng Zhang, Ting-Dong Zhang, Sai-Juan Chen,  Zu Chen, Zhen-Yi Wang.  Use of arsenic trioxide(As2O3) in the treatment of acute promyelocytic leukemia(APL):    II. Clinical efficacy and pharmacokinetics in  relapsed patients. Blood 1997, 89:3354-3360
22. Guo-Qiang Chen, Zhixiang Shen, Fang Wu, Jieyin Han, Jinming Miao, Haojie Zhong, Xiusong Li, Jingqiu Zhao,Jun Zhu, Zhiwen Fang, Saijuan Chen, Zhu Chen, Zhenyi Wang. Pharmacokinetics and efficacy of low-dose all-trans retinoic acid in the treatment of acute promyelocytic leukmia. Leukemia 1996;10:825
23. Guo-Qiang Chen, Jun Zhu, Xue-Geng Shi, Jian-Hua Ni, Hao-Jie Zhong, Gui-Ying Shi,Xiao-Long Jin, Wei Tang, Xiu-Shong Li,   Shu-Ming Xong,Zhi-Xiang Shen,Jun Ma, Peng Zhang, Ting-Dong Zhang, Claude Gazin, Tomoki Naoe, Sai-Juan Chen, Zhen-Yi Wang, Zhu Chen.  In vitro studies on cellular and molecular mechanisms of arsenic trioxide(As2O3) in  the treatment of APL:As2O3 induces NB4 cell apoptosis  with down-regulation of Bcl-2 expression and modulation of PML-RARA/PML Protein. Blood 1996;88:1052
24. Su-Yin Zhang,Jun Zhu, Guo-Qiang Chen, Xin-Xu Du, Li-Juan Lu, Zhou Zhang, Hao-Jie Zhong, Zhen-Yi Wang,Roland Berger , Michel Lanotte, Samuel Waxman, Zhu Chen, Sai-Juan Chen. Establishment of a human acute promyelocytic leukemia- ascites model in SCID mice.  Blood 1996; 87:3404
25. 陈国强、冉丕鑫主编.《基础病理生理学》.上海科学技术出版社
26. 曾益新主编,陈国强等副主编.《肿瘤学》.人民卫生出版社