中文 | English
 
张辰

张辰 博士

E-mail: czhang@ecust.edu.cn

地址:华东理工大学 徐汇校区实验十八楼1513


教育经历

2015/10-2018/09   图卢兹大学,化学专业,理学博士,导师:Heinz Gornitzka

2011/09-2014/06   华东理工大学,药学专业,医学硕士,导师:徐玉芳

2007/09-2011/06   华东理工大学,制药工程,工学学士


科研与学术工作经历

2019/01-至今,华东理工大学,药物科学系,博士后,合作导师:李洪林

2014/07-2015/09,中科院上海有机化学研究所,生命有机国家重点实验室马大为课题组,研究助理


代表性研究成果

期刊论文

(1) Chen Zhang(#); Marie-Lise Maddelein; Raymond Wai-Yin Sun; Heinz Gornitzka(*); Olivier Cuvillier(*); Catherine Hemmert (*),Pharmacomodulation on Gold-NHC complexes for anticancer applications is lipophilicity the key point?,European Journal of Medicinal Chemistry, 2018, 157: 320~332

(2) Chen Zhang(#); Sandra Bourgeade Delmas; Alvaro Fernandez Alvarez; Alexis Valentin; Catherine Hemmert(*); Heinz Gornitzka(*),Synthesis, characterization,and antileishmanial activity of neutral N-heterocyclic carbenes gold(I)complexes, European Journal of Medicinal Chemistry, 2017, 143: 1635~1643

(3) Chen Zhang(#); Catherine Hemmert(*); Heinz Gornitzka(*); Olivier Cuvillier(*); Ming Zhang; Raymond Wai-Yin Sun(*),Cationic and Neutral N-HeterocyclicCarbene Gold(I) Complexes: Cytotoxicity, NCI-60 Screening, Cellular Uptake, Inhibition of Mammalian Thioredoxin Reductase, and Reactive Oxygen SpeciesFormation, ChemMedChem, 2018, 13: 1~13

(4) Rui Gao(#); Sha Liao(#); Chen Zhang; Weilong Zhu; Liyan Wang; Jin Huang; Zhenjiang Zhao(*); Honglin Li; Xuhong Qian; Yufang Xu(*),Optimization ofheterocyclic substituted benzenesulfonamides as novel carbonic anhydrase IXinhibitors and their structure activity relationship, European Journal ofMedicinal Chemistry, 2013, 62: 597~604

(5) Changlong Wang(#); Jimena Tuninetti; Zhao Wang; Chen Zhang; Roberto Ciganda; Lionel Salmon; Sergio Moya; Jaime Ruiz; Didier Astruc(*),Hydrolysis ofAmmonia-Borane over Ni/ZIF 8 Nanocatalyst: High Efficiency, Mechanism, andControlled Hydrogen Release, Journal of the American Chemical Society, 2017, 139 (33): 11610~11615

授权发明专利

1)马大为,俞强; 袁钧瑛; 夏宏光; 蔡东坡; 王开亮; 张辰; 夏尚华, EGFR激酶抑制剂及其制备方法和应用, 2017.3.30-2037.3.29, WIPO, WO 2017/049992 Al

2)李洪林; 徐玉芳; 赵振江; 黄瑾; 高瑞; 王立言; 张辰; 朱伟龙; 杨春梅, 苯磺酰胺类化合物及其用途, 2012.10.3-2032.10.2, 中国, CN102702109A

3徐玉芳; 赵振江; 黄瑾; 朱维平; 刘莉; 王立言; 杨春梅; 朱伟龙; 张辰李洪林, 磺酰胺类化合物及其用途, 2012.10.3-2032.10.2, 中国, CN102702057A


网页发布时间: 2019-03-11