黄青春
发布人: 黄青春   作者:   发布时间: 2014-03-26   访问次数: 8777

黄青春  博士,教授    

Tel:  021-64253724;   E-mail:  qchuang@ecust.edu.cn

 

 个人简介 
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        黄青春1969年生。博士,教授。上海市昆虫学会会员,中国生物化学与分子生物学会会员1993年获学士学位,1998年获硕士学位;2001年获博士学位。20019月至今任华东理工大学讲师、副教授、教授。20116-20126月美国Purdue大学访问学者。主要研究领域为:药物的生理毒理与应用。研究生招生专业为(1)农药学和(2)生物化学与分子生物学。

 

    Chemosphere, Environ Toxic Pharmacol, J Agri Food Chem, Environ Toxic Chem, Pestic Biochem Physiol, J Insect Sci, Pest Manag Sci, Arch Phytopathol Plant Prot, J Asia-Pacific Entomol, Monatsh Chem, Carbohydrate Res, Chemistry and Biodiversity, J Environ Sci Health等国际同领域重要学术期刊发表SCI论文70余篇,申请并公开发明专利近20项。2004年获得教育部自然科学一等奖1项。作为课题负责人,先后完成了国家自然科学基金项目(30400295)、国家科技支撑计划项目(2006BAE01A03-9)、上海市科委重点和基础研究项目(034319245, 073919107, 15431906800)等课题;作为研究成员,参与了国家973项目(2003CB114402, 2010CB126101)、863项目(2001AA235011, 2005AA235050)等国家和省部级研究课题。

 

研究方向 
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方向一:开展生物农药或化学农药的高效筛选、作用机制、代谢与转化、及环境行为等研究,主要研究天然源生物农药的毒理与应用技术。


方向二:针对生物或化学源农药与医药的新机制,开展细胞发育与凋亡、DNA损伤修复、信号转导和调控等研究主要开展EGFR靶向的抗癌药物研究。 

 

发表的部分研究论文
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[1] Zhang L, Rao W, Muhayimana S, Zhang X, Xu J, Xiao C, Huang Q*. Purification and biochemical characterization of a novel transglutaminase from Mythimna separata larvae (Noctuidae, Lepidoptera). J. Biotech. 2017, Online.

[2] Xiao C, Luan S, Xu Z, Lang J, Rao W, Huang Q*. Tolerance potential of Chilo suppressalis larvae to fipronil exposure via the modulation of detoxification and GABA responses. J. Asia Pac. Entomol. 2017, 20: 1287-1293.

[3] Yun X, Huang Q*, Rao W, Xiao C, Zang T, Mao Z, Wan Z. A comparative assessment of cytotoxicity of commonly used agricultural insecticides to human and insect cells. Ecotox. Environ. Safe. 2017, 137: 179-185.

[4] Luan S,Rao W, Yun X, Xiao C, Xu Z,Lang J, Huang Q*. Emamectin benzoate induces ROS-mediated DNA damage and apoptosis in Trichoplusia Tn5B1-4 cells. Chem. Biol. Interact. 2017, 273: 90-98.

[5] Huang Q*,Yun X, Rao W, Xiao C. Antioxidative cellular response of lepidopteranovariancells to photoactivated alpha-terthienyl. Pestic. Biochem. Physiol. 2017, 137: 1-7.

[6] Yun X, Rao W, Xiao C, Huang Q*. Apoptosis of leukemia K562 and Molt-4 cells induced by emamectin benzoate involving mitochondrial membrane potential loss and intracellular Ca2+ modulation. Environ. Toxicol. Pharm. 2017, 52: 280-287.

[6] Huang Q*, Zhang L, Yang C, Yun X, He Y. The competence of hemocyte immunity in the armyworm Mythimna separata larvae to sublethal hexaflumuron exposure. Pestic. Biochem.Physiol. 2016, 130: 31-38.

[7]  Wu X, Zhang L, Yang C, Zong M, HuangQ*, et al. Detection on emamectin benzoate-induced apoptosis and DNA damage in Spodoptera frugiperda Sf9 cell line. Pestic Biochem  Physiol 2016, 126: 6-12. 

[8] Liu P, Shu C, Liu L, Huang Q, Peng Y. Design and synthesis of thiourea derivatives with sulfur-containing heterocyclic scaffolds as potential tyrosinase inhibitors. Bioorg Med Chem 2016, 24: 1866-1871.

[9] Huang Q*,  Wu X, Yu X, et al. Suppression of carbendazim-susceptible and -resistant Sclerotinia sclerotiorum with Macleya alkaloids. Arch Phytopathol Plant Prot 2015, 48(6): 485-494.

[10] Li D, Huang Q*,  Lu M, Zhang L, et al. The organophosphate insecticide chlorpyrifos confers its genotoxic effects by inducing DNA damage and cell apoptosis. Chemosphere 2015, 135: 387-393. 

[11] Li D, Wu X, Yu X, Huang Q*, et al. Synergistic effect of nonionic surfactants Tween 80 and PEG6000 on cytotoxicity of insecticides. Environ Toxicol Pharmacol 2015, 39: 677–682. 

[12] Huang Q*, Wu X, Yu X, Zhang L, et al. Comparison of the cytotoxic impact of chlorfluazuron on selected insect and human cell lines. Environ Toxicol Chem 2015, 34: 1675-1682. 

[13] Xu W, Huang Q*, Wu X, Yu X, et al. Property of midgut a-amylase from Mythimna separata (Lepidoptera: Noctuidae) larvae and its responses to potential inhibitors in vitro. J Insect Sci 2014, 14(282). 

[14] Xiao C, Huang Q*. Inhibitory effects of two 1,3,4-oxadiazoles on larval growth and α-amylase in the midguts of Mythimna separata larvae. J Asia-Pacific Entomol 2014, 17: 251-256. 

[15] Guo P, Huang J, Huang Q, Qian X. Synthesis of novel 1,3-oxazole derivatives with insect growth-inhibiting activities. Chin Chem Let 2013, 24: 957-961. 

[16] Qian Q, Zhu Y, Zhang M, Lu D, Cao W, Song L, Huang Q*. Efficient synthesis and insecticidal activity of novel pyridin-3-yl-[1,2,4]triazolo [3,4-b][1,3,4]thiadiazoles. Monatshefte für Chemie 2013, 144: 231-236.

[17] Wu M, Zhao W, Jin G, Huang Q, Cao S. Synthesis and insecticidal activities of novel analogues of flubendiamide containing a hexafluoroisopropanol moiety. Chin J Chem 2012, 30: 1310-1314. 

[18] Zhu Q, He Y, Yao J, Liu Y, Tao L, Huang Q*. Effects of sublethal concentrations of the chitin synthesis inhibitor, hexaflumuron, on the development and hemolymph physiology of the cutworm, Spodoptera litura. J Insect Sci 2012, 12 (27).

[19] Huang Q*, Y Liu, T Zhan, Y Deng, Y He. Comparable Susceptibility of Human 293 Cells and  Insect Tn-5B1-4 Cells to Photoactivated α-Terthienyl. J. Agric. Food Chem.2010, 58(5): 2637-2642.

[20] Li B, H Yuan, J Fang, L Tao, Huang Q*, X Qian*, Z Fan. Recent progress of highly efficient in vivo  biological  screening for novel agrochemicals in China. Pest Manag. Sci.2010, 66: 107-112.

[21] Huang Q*,  Deng Y,  Zhan T,  He Y. Differential synergism of fipronil by piperonyl butoxide in the susceptible and resistant Chilo suppressalis. Journal of Insect Science 2010, 10/162. 

[22] Deng Y, He Y, Zhan T, Huang Q*. Novel 2′-hydroxylfurylchalcones: Synthesis and biological activity. Carbohydrate Research 2010, 5: 1844-1855.

[23] Cai M, Z Li, F Fan, Q Huang, X Shao, G Song. Design and synthesis of novel insecticides based on serotonergic ligand PAPP. J. Agric. Food Chem. 2010, 58, 2624-2629.

 

授权和申请发明专利
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喹唑啉基羧酸酯类化合物及其用途.   201710809500.3

亚氨基噻唑烷类化合物的新用途.    201710140803.0

分离纯化昆虫谷氨酰胺转氨酶的方法.  201610458931.5

一种新型昆虫细胞免疫抑制剂的用途201610301431.0

用于制备昆虫神经元细胞的生理缓冲液、消解液及方法    201410025109.0

阿维菌素B1a荧光标记物及其应用    201410025107.1

用于检测油菜菌核病菌的方法和培养基    201310564218.5

含七氟异丙基苯甲酰脲类化合物及其用途    101538227B

2’-羟基六氟异丙基的邻苯二甲酰胺类化合物及其用途    102320998

新型3-硒代吲哚的合成对植物生长促进和富硒作用    101117329B 

含二氟(亚)甲基邻甲酰胺基苯甲酰胺类化合物    102617551A

具有杀虫活性的含氮杂环化合物、其制备及用途    PCT/CN2008/071115

一类具有高杀虫活性化合物的制备方法及用途    PCT/CN 2006/000360

硝基亚甲基衍生物及其用途    PCT/CN2005/000617,WO05745204.7,US11/751,836,EP1826209A1,JP2007-541642

含硒三唑酰胺类化合物及其制备和应用    200310108478.8

一类新型3-硒代吲哚的合成对植物生长促进和富硒作用    200610029737. 1

一种噁唑哒嗪及其衍生物的剂型与应用    200410017164.1

哌嗪衍生物及其用途    200710045661.6

腺苷衍生物及其用途    201510022902.X

美国专利 Nitrogenous heterocyclic compounds with insecticidal activity, and the preparation and use thereof.    US 12/864,410

PCT专利 Benzoylurea compounds bearing heptafluoroisopropyl and uses thereof. WO/2009/115040 A1