程家高
发布人:   作者:   发布时间: 2016-09-30   访问次数: 7852

 

 

 

 

程家高  博士、教授

 

 

电话: 64251348   E-mail: jgcheng@ecust.edu.cn

 

 

  

 

个人简介

 

 

 

程家高:博士,教授。20007月毕业于山东曲阜师范大学化学系获学士学位;20057月获有机化学药物设计方向博士学位,导师:陈凯先院士、蒋华良研究员;20079月华东理工大学药学院博士后出站后留校工作,2009年晋升副教授、硕导,2016年晋升教授。主要研究领域包括:主要研究方向包括:1)作用于乙酰胆碱受体、GABA受体等重要医药、农药靶标的活性分子设计、合成、构效关系及活性研究;2)重磅杀虫剂品种的作用机制、生态毒理学、抗性机制研究。
 

JAFC; Chem. Biol. Drug. Des.; QSAR Comb. Sci.; J. Org. Chem.; Chem. Phys. Lett.; Bioorg. Med. Chem. Lett.; J. Phys. Org. ChemJACS等国际重要学术期刊上发表外文SCI论文五十余篇。作为课题负责人,共主持国家自然科学基金3项、教育部博士点基金等省部级科研基金3项、中央高校基本科研业务费2项;作为骨干研究人员,承担国家973863及科技支撑课题多项。

   

 

发表的部分论文

 

[1]     Xiaoqing Meng, Chengchun Zhu, Yue Feng, Weihua Li, Xusheng Shao, Zhiping Xu, Jiagao Cheng*, and Zhong Li, Computational Insights into the Different Resistance Mechanism of Imidacloprid versus Dinotefuran in Bemisia tabaci. J. Agric. Food Chem., 2016, 64(6), 1231–1238

 

[2]     Dan-Ping Jiang, Cheng-Chun Zhu, Xu-Sheng Shao, Jia-Gao Cheng*, Zhong Li. Bioactive conformation analysis of anthranilic diamide insecticides: DFT-based potential energy surface scanning and 3D-QSAR investigations. Chin. Chem. Lett., 2015, 26, 662-666

 

[3]     Nan Zheng, Jiagao Cheng*, Wei Zhang, Weihua Li, Xusheng Shao, Zhiping Xu, Xiaoyong Xu, Zhong Li*, The binding difference of fipronil with GABAARs in fruitfly and zebrafish: Insights from homology modeling, docking and molecular dynamics simulation studiesJ. Agric. Food. Chem. 2014, 62, 10646-10653

 

[4]     Zheng Wang, Jinjin Ye, Rui Wu, Yang-Zi Liu, John S Fossey, Jiagao Cheng*, Wei-Ping Deng*. Bi-Aryl Rotation in Phenyl-dihydroimidazoquinoline Catalysts for Kinetic Resolution of Arylalkyl Carbinols. Catal. Sci. Technol., 2014, 4(7), 1909-1913(封面文章)

 

[5]     Shuang Xia, Yue Feng, Jiagao Cheng*, Haibin Luo, Zhong Li*, Zhengming Li. QAAR exploring on pesticides with high solubility: an investigation on sulfonylurea herbicide dimers based on π-π stacking interaction. Chin. Chem. Lett., 2014, 25, 973-977

 

[6]     Shuang Xia, Jiagao Cheng*, Yue Feng, Xusheng Shao, Haibin Luo, Zhiping Xu, Xiaoyong Xu and Zhong Li*. Computational Investigations about the Effects of Hetero-molecular Aggregation on Bioactivities: a Case of Neonicotinoids and Water. Chin. J. Chem., 2014, 32(4), 324–334

 

[7]     Ying Yang, Wei Zhang, Jiagao Cheng*, Yun Tang, Yanqing Peng, Zhong Li*, Pharmacophore, 3D-QSAR and Bayesian Model Analysis for Ligands Binding at the Benzodiazepine Site of GABAA Receptors: the Key Roles of Amino Group and Hydrophobic Sites. Chem. Biol. Drug. Des.2013, 81, 583-590(封面文章)

 

[8]     Wei Zhang, Shuang Xia, Jinjin Ye, Yun Tang, Zhong Li*, Weiping Zhu, Jiagao Cheng*, Structural Features of GABAA Receptor Antagonists: Pharmacophore Modeling and 3D-QSAR Studies, Med. Chem. Res., 2013, 22, 5961–5972

 

[9]     Hou-ling Dai, Li-xin Gao, Ying Yang, Jing-ya Li, Jia-gao Cheng*, Jia Li*, Ren Wen,Yan-qing Peng, Jian-bin Zheng*. Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors. Bioorgan. Med. Chem. Lett. 2012, 22(24), 7440–7443.

 

[10] Wenwen Zhang, Yefeng Fan, Tao Yu, Zhiping Xu, Xiaoyong Xu*, Jiagao Cheng*, Zhong Li, Synthesis, Insecticidal Assay and Molecular Docking Study of Novel Neonicotinoids N-Oxide Analogues. Chin. J. Chem., 2012, 30(2)说明: http://webmanage.ecust.edu.cn/control/FCKeditor/editor/images/spacer.gif, 357-361.

 

[11] Feng Fan, Jiagao Cheng, Zhong Li*, Xiaoyong Xu, Xuhong Qian*. “Novel dimer based descriptors with solvational computation for QSAR study of oxadiazoylbenzoyl-ureas as novel isect-growth regulators”. Journal of Computational Chemistry. 2010, 31(3), 586-591

 

[12] Qing Shen, Hui-fang Liu, Wei Li, Ying Li, Jia-gao Cheng*, Jing-gen Liu, Wei Fu*, “Modulated interaction of m/d opioid receptors and the drug discovery and design strategy”, Chinese Pharmacological Bulletin, 2010, 26(1), 4-8

 

[13] Tingting Cao, Yipei Ma, Xiuhua Yan, Jiagao Cheng*, Youhua Luo, Liming He,  Weiliang Zhu*. “Is Free Cyclooctatetraene Dianion an Aromatic System? A Quantum Chemistry Study”, Chin. J. Chem. 2009, 27, 1914-1918

 

[14] Feng Fan, Jin Zhu, Shuaishuai Ni, Jiagao Cheng*, Yun Tang, Congmin Kang, Jian Li, Hualiang Jiang. “Pharmacophore Refinement and 3D-QSAR Studies of Inhibitors of Cyclophilin A Containing Amide Linker” QSAR Comb. Sci., 2009, 28(2), 183-193

 

[15] Lingyan He§, Jiagao Cheng§, Tao Wang, Caimei Li, Zhen Gong, Hong Liu, Bu-Bing Zeng, Hualiang Jiang, Weiliang Zhu, "Cation-π complexes formed between cyclooctantetraene and alkaline earth metals: predicted and recorded NMR features", Chem. Phys. Lett. 2008, 462, 45-58. (§并列一作)

 

[16] Jiagao Cheng, WeiLiang Zhu, YanLi Wang, XiuHua Yan, Zhong Li, Yun Tang, HuaLiang Jiang*, "The Open-Close Mechanism of M2 Channel Protein in Influenza A Virus: A Computational Study on the Hydrogen Bonds and Cation-pi interactions among His37 and Trp41", Sci. China Ser.B-Chem, 2008, 51(8), 768-775.

 

[17] Jiagao Cheng, XiaoMin Luo, XiuHua Yan, Zhong Li, Yun Tang, HuaLiang JiangWeiLiang Zhu, "Research Progress in Cation-pi interactions", Sci. China Ser.B-Chem, 2008, 51(8), 709-717.

 

[18] Jiagao Cheng, Zhen Gong, Weiliang Zhu, Yun Tang, Weihua Li, Zhong Li, Hualiang Jiang. “Cation sitting in aromatic cages: ab initio computational studies on tetramethylammonium–(benzene)n (n=3–4) complexes” J. Phys. Org. Chem., 2007, 20, 48-457.

 

[19] Jiagao Cheng, Weiliang Zhu, Yun Tang, Yufang Xu, Zhong Li, Kaixian Chen, Hualiang Jiang. “Effect of cation-π interaction on NMR: A theoretical investigation on complexes of Li+, Na+, Be2+, and Mg2+ with aromatics.” Chem. Phys. Lett. 2006, 422, 455-460.

 

[20] Jiagao Cheng, Congmin Kang, Weiliang Zhu, Xiaomin Luo, Chum Mok Puah, Kaixian Chen, Jianhua Shen, Hualiang Jiang. “N-Methylformamide-Benzene Complex as a Prototypical Peptide N-H∙∙∙π Hydrogen-Bonded System: Density Functional Theory and MP2 Studies.” J. Org. Chem. 2003, 68(2), 7490-7495.