须志平
发布人: 须志平   作者:   发布时间: 2008-12-04   访问次数: 2802



  

须志平  博士  副教授



电话:021-64253979

办公室:实验十八楼1310A

E-mailzhipingxu@ecust.edu.cn



个人简介:

1998.09-2002.06     农学学士   南京农业大学 植物保护系

2002.09-2008.06     理学博士   南京农业大学 植物保护学院 农药系

2008.07-至今          华东理工大学 药学院 药物化工研究所

2015.09-2016.10    访问学者    美国 Kansas State University 昆虫系



主要研究方向:

ø 农药的生物评价及生理毒理研究:

1.  针对绿色化学农药的创制需求,建立多个靶标昆虫的活体和离体筛选模型,进行生物活性评价和作用机制研究;

2.  借助细胞技术,利用昆虫细胞系和急性解离昆虫神经细胞,对新杀虫化合物和重要杀虫剂品种进行细胞毒理学研究;

ø 杀虫剂毒理学和害虫抗药性研究:

1.  构建烟粉虱(CYP6CM1)和果蝇(CYP6G1)的细胞色素P450s体外表达系统,用于新型杀虫化合物和重要杀虫剂品种的代谢机理和交互抗性研究;



目前在领域内相关学术期刊参与发表22SCI学术论文,其中以第一作者或通讯作者发表学术论文10篇。主持国家自然科学基金青年基金1项 (31501674),完成中央高校基本科研业务费专项基金和上海市优秀青年教师基金各1项,参与多项国家级研究项目。参与申请发明中国专利8项,PCT专利3项,中国专利授权3项,美国授权专利1项,加拿大授权专利1项。



发表部分论文:

[1] Zhiping Xu, Miaoqing Lu, Mingjun Yang, Wenping Xu, Jufang Gao, Yang Zhang,Yun Yang, Liming Tao*. Pyrethrum-extract induced autophagy in insect cells: A new target?Pestic Biochem Physiol. 2017,137: 21-26.

[2]  吴勇超, 须志平*, 邵旭升, 程家高*, 李忠. 环氧虫啶对苜蓿蚜的毒力及对其体内解毒酶活性的影响[J]. 农药学学报 2016, 18(6): 710-716.

[3] Ziqian Zhang, Jiayao Wu, Zhihao Shang, Chao Wang, Jiagao Cheng,Xuhong Qian, Yi Xiao,*Zhiping Xu,* and Youjun Yang*. Photocalibrated NO Release from NNitrosated Napthalimides upon One-Photon or Two-Photon Irradiation. Anal. Chem., 2016, 88, 7274-7280.

[4] Zhiping Xu, Lina Shi, Danping Jiang, Jiagao Cheng, Xusheng Shao*, Zhong Li. Azobenzene Modified Imidacloprid Derivatives as Photoswitchable Insecticides: Steering Molecular Activity in a Controllable Manner. Scientific Reports, 2015, 5, 13962.

[5] Baoyan Zhang, Zhiping Xu*, Yixi Zhang, Xusheng Shao, Xiaoyong Xu, Jiagao Cheng, Li Zhong. Fipronil induces apoptosis through caspase-dependent mitochondrial pathways in Drosophila S2 cells. Pestic Biochem Physiol. 2015, 119, 81-89.

[6] Xin Fang, Ying Tong Di, Yu Zhang, Zhi Ping Xu, Yang Lu, Qian Qian Chen, Qi Tai Zheng, and Xiao Jiang Hao*. Unprecedented Quassinoids with Promising Biological Activity from Harrisonia perforate. Angew. Chem. Int. Ed.2015, 54, 5592 –5595

[7] Ziqian Zhang, Baoyan Zhang, Xuhong Qian, Zhong Li, Zhiping Xu*, Youjun Yang*. Simultaneous Quantification of Hg2+ and MeHg+ in Aqueous Media with a Single Fluorescent Probe by Multiplexing in the Time Domain. Anal. Chem., 2014, 86, 11919-11924.

[8] Linlin Song, Zuhai Lei, Baoyan Zhang, Zhiping Xu*, Zhong Li* and Youjun Yang*. A Zero-Background Fluorescent Probe for Hg2+ Designed via the “Covalent-Assembly” Principle. Anal. Methods, 2014, 6, 7597–7600

[9] Siyuan Lu, Xusheng Shao, Zhong Li, Zhiping Xu*, Shishuai Zhao, Yinli Wu, and Xiaoyong Xu*. Design, Synthesis and Particular Biological Behaviors of Chain-opening Nitromethylene Neonicotinoids with cis-Configuration. J. Agric. Food Chem. 2012, 60(1), 322-330.

[10] Fengyi Liu, Zhiping Xu, Yu Cheng Zhu, Fangneng Huang, Yanhua Wang, Huiling Li, Hua Li, Congfen Gao, Weijun Zhou and Jinliang Shen*. Evidence of field-evolved resistance to Cry1Ac-expressing Bt cotton in Helicoverpa armigera (Lepidoptera: Noctuidae) in northern China. Pest Management Science, 2010, 66(2):155–161.共一

[11] Zhiping Xu, Fengyi Liu, Jin ChenFangneng Huang, David A Andow, Yanhua Wang, Yu Cheng Zhu and Jinliang Shen* . Using F2 screen to monitor frequency of resistance alleles to Bt cotton in field populations of Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae). Pest Management Science, 2009, 65:391-397.

[12] Fengyi Liu, Zhiping Xu, Juhua Chang, Jin Chen, Fenxia Meng, Yu Cheng Zhu, Jinliang Shen*. Resistance allele frequency to Bt cotton in field populations of Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae) in China. Journal of Economic Entomology,2008, 101(3): 933-943.(共一)

[13] Wang Yanhua, Gao Congfen, Xu Zhiping, Zhu Yu Chen, Lin Youwei, Dai Dejiang, Zhou Weijun, Shen Jinliang*. Buprofezin susceptibility survey, resistance selection and preliminary determination of resistance mechanism in Nilaparvata lugens (Homopetra: Delphacidae). Pest Management Science, 2008, 64(10):1050-1056.

[14] Yu Cheng Zhu, Fengyi Liu, Zhiping Xu, Juhua Chang, Jinliang Shen. F1 Screening for Resistance Gene Alleles to Bt Cotton in Helicoverpa armigera: How to Differentiate S and R Genotypes. J. Entomol. Sci. 2008. 43(3): 311-319.