徐玉芳
发布人：佚名 　 作者： 　 发布时间：2010-04-28 　 访问次数：

 

徐玉芳 教授

Tel: 021-64251399;  Fax: 021-64252603 
E-mail: yfxu@ecust.edu.cn

 

个人简介
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        徐玉芳，博士，教授，博士生导师。上海市优秀学科带头人。1994年博士毕业于华东理工大学精细化工专业；1999.10-2001.09日本东京医科齿科大学博士后；2004.9至今华东理工大学教授。2006.11～2006.12 日本京都大学日本学术振兴会（JSPS）访问学者。近年来主要从事化学生物技术方面的研究，主要包括荧光传感技术及细胞激活与调控技术。主持完成了国家自然基金、国家科技支撑计划、上海市光科技重点项目、上海市科委基础研究重点项目，共同主持完成了国家973子课题。目前承担着上海市优秀学科带头人计划、共同承担着863专项。作为研究骨干参与研究团队学术带头人钱旭红教授领衔的国家自然科学基金重点项目。迄今为止，已申请国内发明专利10项，已获授权三项；世界专利一项。已在J. Am. Chem. Soc.、Chem. Comm.、Chem. J. Eur.等国际SCI期刊发表论文50余篇。 

 

研究方向
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 A:荧光传感技术

A-1 纯水体系高选择性高灵敏重金属离子荧光探针及其活体细胞应用：针对环境和生物组织中的重要重金属及过渡金属离子,设计、创制纯水体系、高选择性、高灵敏金属离子荧光探针，并实现活体细胞应用。
A-2 诊疗用乏氧细胞探针及实现活体示踪：利用硝基的生物还原性及恶性肿瘤乏氧特性，设计、创制系列乏氧用荧光检测探针，并已实现活体示踪。
A-3 生物体内重要靶酶荧光探针：针对恶性肿瘤导致的异常表达的一些靶酶，设计创制一些列特异性响应的酶荧光探针，通过检测体内异常表达的酶，可以专一性的识别、定位以及早期诊断与各种异常酶相关的疾病。
 

B:细胞激活与调控技术

B-1 新型植物激活剂：以噻二唑及噻唑五元杂环作为活性子，设计创制各类植物抗病激活剂及能明显增加植物次生代谢物的高效细胞激活剂。
B-2 基于凋亡机制的萘酰亚胺抗肿瘤药物先导：基于萘酰亚胺母体结构，设计创制直接诱导凋亡的新型抗肿瘤药物先导。
B-3 乏氧特异性前药: 利用乏氧特异性响应基团，设计创制萘酰亚胺乏氧选择性抗肿瘤试剂，提高先导的水溶性及靶向性。

 

获奖成果
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2008年国家科技进步二等奖（九）；2008年上海市自然科学一等奖（四）; 2007年上海市优秀学科带头人。

 

代表性论著
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  1. Zhuo Chen, Xin Liang, Huanying Zhang, Hua Xie, Jianwen Liu, Yufang Xu*, Weiping Zhu, Yi Wang, Xin Wang, Shaoying Tan, Dong Kuang, Xuhong Qian,*A New Class of Naphthalimide-based Antitumor Agents that Inhibit Topoisomerase II (Topo II) and Induce Lysosomal Membrane Permeabilization (LMP) and Apoptosis，J. Med. Chem. 2010, 53, 2589–2600
 
  1. Junhong Qian, Yufang Xu, Xuhong Qian*,Shenyi Zhang , Molecular Logic Gates with Different Functions, Journal of Photochemistry and Photobiology A: Chemistry, 2009, 207,181-189.
 
  1. Xu Yufang, Lu Feng, Xu ZhaoChao, Cheng Tanyu & Qian Xuhong, Highly sensitive and selective ratiometric fluorescent copper sensors: Different binding affinities modulated by three separate side chains of naphthalimide, Science in China Series B: Chemistry, 2009,52,771-779
 
  1. Lijuan Xie,Yufang Xu, Fang Wang, JianwenLiu,Xuhong Qian*, Jingnan Cui*, Synthesis of new amonafide analogues via coupling reaction and their cytotoxic evaluation and DNA-binding studies, Bioorg. Med. Chem., 2009, 17, 804-810
 
  1. Junhai Huang, Yufang Xu, Xuhong Qian*, A Rhodamine-based Sensor for Real-time Determination of Hg2+ with High Selectivity and Sensitivity in Aqueous Solution: The Integration of Cyclic Conversion and NS2-contained Receptor, J. Org. Chem., 2009, 74, 2167-2170.
 
  1. Junhai Huang, Yufang Xu, Xuhong Qian*, A Red-shift Colorimetric and Fluorescent Sensor for Cu2+ in Aqueous Solution: Unsymmetrical 4,5-Diaminonaphthalimide with N-H Deprotonation Induced by Metal Ion, Org. Biomol. Chem., 2009,7,1299-1303
 
  1. Ingo Ott, Xuhong Qian, Yufang Xu, N. N. Univ. Leiden, Dominik Kubat, Joanna Will, Patrick Jesse, Aram Prokop, Christoph Bagowski, William S. Sheldrick, A luminescent gold (I) phosphine complex containing a naphthalimide ligand as TrxR inhibiting antiproliferative agent and angiogenesis inhibitor. J. Med. Chem.2009, 52,763-770
 
  1. Junhai Huang, Yufang Xu, Xuhong Qian*, A Colorimetric Sensor for Cu2+ in Aqueous Solution Based on The Metal Ion-induced Deprotonation: Deprotonation/Protonation Mediated by Cu2+-ligand Interactions Dalton Transactions，2009, 1761–1766.
 
  1. Tanyu Cheng, Yufang Xu,* Shenyi Zhang, Weiping Zhu, Xuhong Qian,* Liping Duan A highly sensitive and selective OFF-ON fluorescent sensor for cadmium in aqueous solution and living cell,  J. Am. Chem. Soc., 2008, 130 (48). 16160–16161
 
  1. Liping Duan, Yufang Xu, Xuhong Qian, Highly Sensitive and Selective Pd2+ Sensor of Naphthalimide Derivative Based on Complexation with Alkynes and Thio-heterocycle，Chem. Commun. 2008,6339-6341
 
  1. Liping Duan, Yufang Xu, Xuhong Qian,Yexiang Zhang, Yang Liu, Novel naphthalimide derivatives with near-infrared emission: Synthesis via photochemical cycloaromatization, fluorescence in solvents and living cell , Tetrahedron Lett.,2009, 50, 22–25
 
  1. Liping Duan,Yufang Xu, Xuhong Qian, Fang Wang, Jianwen Liu, Tanyu Cheng, Highly Selective Fluorescent Chemosensor with Red Shift for Cysteine in Buffer Solution and Its Bioimage: Symmetrical Naphthalimide Aldehyde, Tetrahedron Lett., 2008, 49,6624-6627
 
  1. Junhong Qian, Yufang Xu, Xuhong Qian, Shenyi Zhang. Molecular Logic Operations Based on Surfactant Nano-aggregates: Premicelle, Micelle and Its Formation Induced by Inorganic Salt. ChemPhyChem, 2008, 9, 1891-1898
 
  1. Junhong Qian, Yufang Xu, Xuhong Qian, Jiaobing Wang, Shenyi Zhang. Effects of Anionic Surfactant SDS on the Photophysical Properties of Two Fluorescent Molecular Sensors. J. Photochem. Photobiol. A , Chemistry, 200 (2008) 402–409
 
  1. Ingo Ott, Yufang Xu, Jianwen Liu, Malte Kokoschka, Melanie Harlos, William S. Sheldrick, Xuhong Qian ,Sulfur Substitued Naphthalimides as Photoactivatable Anticancer Agents: DNA Interaction, Fluorescence Imaging and Phototoxic Effects in Cultured Tumor Cells, Bioorg. Med. Chem., 2008, 16, 7107-7116
 
  1. Weiping Zhu, Zhenjiang Zhao, Yufang Xu,* Derivatives of Benzothiadiazole-7- Carboxylates: Synthesis and Biological Activity，Monatshefte fur Chemie，2008，39，1067-1071
 
  1. Min Dai Weiping ZhuYufang Xu* Xuhong Qian* Yan Liu Yi XiaoYin You，Versatile Nitro-Fluorophore as Highly-effective Sensor for Hypoxic Tumor Cells: Design, Imaging and Evaluation，Journal of Fluorescence, 18, 591-597, 2008.
 
  1. Weiping Zhu, Min Dai, Yufang Xu*, Xuhong Qian* , Novel Nitroheterocyclic Hypoxic Markers for Solid Tumor: Synthesis and Biological Evaluation, Bioorganic and medicinal chemistry, 16,3255-3260,2008.
 
  1. Weiping Zhu, Yufang Xu, Xuhong Qian, Fluorescent molecular sensors for heavy and transition metallic cations with biological interests  Progress in Chemistry 19, 1229-1238 , 2007
 
  1. Yufang Xu, Yan Liu, Xuhong Qian Novel Cyanine Dyes as Fluorescent pH Sensors: PET, ICT Mechanism or Resonance Effect? Journal of Photochemistry and Photobiology A: Chemistry, 190,1–8 ,2007
 
  1. Hong Yin, Yufang Xu,* Xuhong Qian,* Yuanli Li, Jianwen Liu Novel N-oxide of Naphthalimides as Prodrug Leads against Hypoxic Solid Tumor: Synthesis and Biological Evaluation, Bioorganic and medicinal chemistry Letter, 17 ,2166–2170,2007
 
  1. Hong Yin, Yufang, Xu, Xuhong Qian* Novel antitumor agent family of 1-H benzo [c,d]indol-2-one with flexible side chains: Synthesis and biological evaluation, Bioorganic and medicinal chemistry 15(3), 1356-1362, 2007
 
  1. Yufang Xu, Zhenjiang Zhao, Xuhong Qian, Zhigang Qian, Wenhong Tian, Jian-Jiang Zhong, Novel Unnatural Benzo-1,2,3-thiadiazole-7-carboxylate Elicitors of Taxoid Biosynthesis  Journal of Agricultural Food Chemistry54 (23): 8793-8798 2006,
 
  1. Yan Liu, Yufang Xu*, Xuhong Qian*, Yi Xiao, Jianwen Liu, Liyun Shen, Junhui Li and Yuan xing Zhang Synthesis and evaluation of Novel 8-oxo-8H-acenaphtho[1,2-b] pyrrole-9- carbonitrile as Long-wavelength Fluorescent Markers for Hypoxic cells in Solid Tumor Bioorganic and medicinal chemistry Letter 16,1562-1566,2006
 
  1. Yan Liu, Yufang Xu*, Xuhong Qian*, Jianwen Liu, Liyun Shen, Junhui Li and Yuanxing Zhang Novel Fluorescent Markers for Hypoxic Cells of Naphthalimides with Two Heterocyclic Side Chains for Bioreductive Binding Bioorganic and medicinal chemistry 14,2935-2941,2006