杨泱泱，副研究员

博士生导师

Tel：021-64252419,；E-mail：triyang@ecust.edu.cn

招生方向:

  (1)博士:植物保护

  (2)硕士:药学(学硕,专硕),制药工程(学硕)

主要研究方向：

(一) 核酸药物的设计,构建与应用

   利用核酸折纸技术,设计与构建功能化核酸折纸纳米材料,实现其在疾病诊断与治疗中的应用

(二) RNA生物农药(核酸农药)递送系统的设计,开发及应用

   针对RNA生物农药的创制瓶颈,开发RNA生物农药设计,筛选及递送的新底盘技术,实现RNA生物农药的高效递送与应用

(三) 纳米农药连续制备工艺与装备系统开发

   针对纳米农药传统制备时面临的粒径不均一,分散性差,不稳定,难以放大生产等问题,利用微纳流控技术,开展纳米农药连续制备的配方筛选,工艺开发以及放大

代表性论文:

1. Yue Liao; Chunyu Fan; Jiaxin Zheng; Caixia Liu; Weiping Zhu; Yufang Xu; Xuhong Qian; Yangyang Yang*, Enhanced liquid–liquid phase separation of stress granules in a reconstructed model and their cytoplasmic targeting using a DNA nanodevice, Journal of Materials Chemistry B, 2025, DOI: 10.1039/D4TB02161D

2. Jianmian Fu; Bin Wang; Weiping Zhu; Yufang Xu; Xuhong Qian; Yangyang Yang*, Feedback-induced phase separation of hollow condensates to create biomimetic membraneless compartments, Journal of Materials Chemistry B, 2025 DOI: 10.1039/D4TB01670J

3. Jinshan Xie; Jiaxin Zhang; Jingyi Yang; Shuqin Wu; Xuanming Teng; Hongyu Han; Yufang Xu; Xuhong Qian; Weiping Zhu*; Yangyang Yang*, Microfluidic-Based dsRNA Delivery Nanoplatform for Efficient Spodoptera exigua Control, Journal of Agricultural and Food Chemistry, 2024, DOI: 10.1021/acs.jafc.4c03307

4. Jingyi Yang; Jiahao Qu; Xuanming Teng; Weiping Zhu; Yufang Xu; Yangyang Yang*; Xuhong Qian, Tumor Microenvironment‐Responsive Hydrogel for Direct Extracellular ATP Imaging‐Guided Surgical Resection with Clear Boundaries, Advanced Healthcare Materials, 2023, DOI: 10.1002/adhm.202301084

5. Caixia Liu; Jingyi Yang; Jiaxin Zheng; Jianmian Fu; Weisi Wang; Liping Duan; Xuhong Qian; Yangyang Yang*, Phase Separation in cGAS‐STING Signaling: Cytosolic DNA Sensing and Regulatory Functions, ChemBioChem, 2023, DOI: 10.1002/cbic.202300147

6. Caixia X. Liu; Bin Wang; Weiping P. Zhu; Yufang F. Xu; Yangyang Y. Yang*; Xuhong H. Qian*, An Endoplasmic Reticulum (ER)‐Targeting DNA Nanodevice for Autophagy‐Dependent Degradation of Proteins in Membrane‐Bound Organelles, Angewandte Chemie International Edition, 2022, DOI: 10.1002/anie.202205509

7. Bin Wang; Honglong Fang; Weiping Zhu; Yufang Xu; Yangyang Yang*; Xuhong Qian*, Dynamic Compartmentalization of Peptide–Oligonucleotide Conjugates with Reversible Nanovesicle–Microdroplet Phase Transition Behaviors, ACS Applied Materials & Interfaces, 2022, DOI: 10.1021/acsami.2c05268

8. Shengtao Yao; Yongyun Chang; Zanjing Zhai; Hiroshi Sugiyama; Masayuki Endo; Weiping Zhu; Yufang Xu*; Yangyang Yang*; Xuhong Qian, DNA-Based Daisy Chain Rotaxane Nanocomposite Hydrogels as Dual-Programmable Dynamic Scaffolds for Stem Cell Adhesion, ACS Applied Materials & Interfaces, 2022, DOI: 10.1021/acsami.2c03265