张永强 副教授、博士生导师/硕士生导师
联系方式：
通讯地址：华东理工大学实验十四楼西侧402，邮编200237
电话：021-64253299
电邮：yongqiangzhang@ecust.edu.cn
个人简介：
2013年毕业于第二军医大学(现海军军医大学)药学院药物化学专业，获医学博士学位，导师张万年教授和盛春泉教授。后赴美国犹他大学化学系生物有机专业从事博士后研究，合作导师季海涛助理教授。2016年1月回国受聘于华东理工大学药学院，从事药物化学教学和科研工作。先后主持国家自然科学基金青年基金1项、面上项目2项、上海市自然科学基金面上项目1项、教育部高校基本科研业务费1项；参编英文论著一部(Targeting Protein-Protein Interactions by Small Molecules)、中文论著一部(药物合成—路线设计策略和案例解析)；已在国际核心刊物如J. Am. Chem. Soc., Angew. Chem. Int. Ed., Chem. Sci., Green Chem., Org. Lett., Chem. Commun., J. Med. Chem. 等上发表20余篇SCI论文。
研究方向：
1、基于“天然老药”二次开发策略的抗肿瘤新药创制
2、可见光催化的碳硅键构建反应研究及其在拓展含硅化学空间中的应用
研究项目：
抗肿瘤天然产物那可丁(Noscapine)的全合成与结构改造, 国家自然科学基金(青年基金), 20万
基于自由基型环醚碳氢(Cα)芳基化策略的芳基碳糖苷合成研究，国家自然科学基金面上项目，65万
可见光/硼(硅)原子转移协同催化的碳-硅键构建反应研究，国家自然科学基金面上项目，60万
可见光/有机硒协同催化硅氯键活化技术开发驱动的碳硅键构建反应研究，上海市自然科学基金面上项目，20万
基于自由基的碳氢活化技术与碳核苷合成, 教育部基本科研业务费, 16万，主持
代表性论文：
回国后研究工作(2016年-至今)：
1.Yumo Zhao, Yi Wan, Qiyang Yuan, Jinlian Wei* and Yongqiang Zhang* (通讯作者). Photocatalytic C-Si Bond Formations Using Pentacoordinate Silylsilicates as Silyl Radical Precursors: Synthetic Tricks Using Old Reagents. Org. Lett.2023, 25, 1386-1391;
2.Yi Wan, Yumo Zhao, Jiajie Zhu, Qiyang Yuan, Wei Wang* and Yongqiang Zhang* (通讯作者). Organophotocatalytic Silyl Transfer of Silylboranes Enabled by Methanol Association: A Versatile Strategy for C-Si Bond Construction. Green Chem. 2023, 25, 256-253;
3.Jianhong Zhao, Kun Qian, Mengchao Tong, Qiyang Yuan and Yongqiang Zhang* (通讯作者). Mild and Metal-Free Cross-Dehydrogenative Coupling of Nitrogen Heteroarenes with Aldehydes Enabled by Structural Hybridization of Promoting Reagents. ChemistrySelect 2022, 7, e20210417;
4.KaiLin Lu#, Yingying Ma#, Shihui Liu, Shixun Guo and Yongqiang Zhang* (通讯作者). Highly Stereoselective C-Glycosylation by Photocatalytic Decarboxylative Alkynylation on Anomeric Position: A Facile Access to Alkynyl C-Glycosides. Chin. J. Chem. 2022, 40, 681-686;
5.Yi Wan, Jiajie Zhu, Qiyang Yuan, Wei Wang* and Yongqiang Zhang* (通讯作者). Synthesis of β‑Silyl α‑Amino Acids via Visible-Light-Mediated Hydrosilylation. Org. Lett. 2021, 23, 1406-1410;
6.Xiang Li#, Chaoyang Liu#, Shixun Guo, Wei Wang* and Yongqiang Zhang* (通讯作者). PIFA-Mediated Cross-Dehydrogenative Coupling of N-Heteroarenes with Cyclic Ethers: Ethanol as an Efficient Promoter. Eur. J. Org. Chem. 2021, 411-421;
7.Jiaqi Guo, Yating Wang, Yuhang Li, Kailin Lu, Shihui Liu, Wei Wang* and Yongqiang Zhang* (通讯作者). Graphitic Carbon Nitride Polymer as a Recyclable Photoredox Catalyst for Decarboxylative Alkynylation of Carboxylic Acids. Adv. Synth. Catal. 2020, 362, 3898-3904;
8.Huaqiang Fan#, Yi Wan#, Peng Pan, Wenbin Cai, Shihui Liu, Chuanxu Liu* and Yongqiang Zhang* (通讯作者). A Cascade Approach to 3D Cyclic Carbamates via An Ionic Decarboxylative Functionalization of Olefinic Oxamic Acids. Chem. Commun. 2020, 56, 86-89;
9. Yingying Ma#, Shihui Liu#, Yifan Xi, Hongrui Li, Kai Yang, Zhihao Cheng, Wei Wang* and Yongqiang Zhang*(通讯作者). Highly Stereoselective Synthesis of Aryl/Heteroaryl-C-Nucleosides via the Merger of Photoredox and Nickel Catalysis. Chem. Commun. 2019, 55, 14657-14660;
10. Shihui Liu, Peng Pan, Huaqiang Fan, Hao Li, Wei Wang* and Yongqiang Zhang*(通讯作者). Photocatalytic C–H Silylation of Heteroarenes by Using Trialkylhydrosilanes. Chem. Sci. 2019, 10, 3817-3825;
11. Huaqiang Fan, Peng Pan, Yongqiang Zhang*(通讯作者) and Wei Wang*. Synthesis of 2‑Quinolinones via a Hypervalent Iodine(III)-Mediated Intramolecular Decarboxylative Heck-Type Reaction at Room Temperature. Org. Lett. 2018, 20, 7929−7932;
12. Shihui Liu, Aoxia Liu, Yongqiang Zhang*(通讯作者), Wei Wang*. Direct Cα-Heteroarylation of Structurally Diverse Ethers via a Mild N-Hydroxysuccinimide Mediated Cross-Dehydrogenative Coupling Reaction. Chem. Sci. 2017, 8, 4044-4450.
13. Yongqiang Zhang(第一作者), Kevin B. Teuscher, Haitao Ji*. Direct α-Heteroarylation of Amides (α to Nitrogen) and Ethers through a Benzaldehyde -Mediated Photoredox Reaction. Chem. Sci. 2016, 7, 2111–2118.
14. Wenbin Cai, Huaqiang Fan, Dazhong Ding, Yongqiang Zhang*(通讯作者), Wei Wang*. Synthesis of Z-alkenes via Visible Light Promoted Photocatalytic E - Z Isomerization under Metal-Free Conditions. Chem. Commun. 2017, 53, 12918-12921.
15.He Huang, Chenguang Yu, Yueteng Zhang, Yongqiang Zhang, Patrick S. Mariano*, and Wei Wang*. Chemo- and Regioselective Organo-Photoredox Catalyzed Hydroformylation of Styrenes via a Radical Pathway. J. Am. Chem. Soc. 2017, 139, 9799−9802.
博士后期间(2013年-2016年)：
1. Logan R. Hoggard,† Yongqiang Zhang(并列第一作者),†Min Zhang, Vanja Panic, John A. Wisniewski, and Haitao Ji*. Rational Design of Selective Small-Molecule Inhibitors for β‑Catenin/B-Cell Lymphoma 9 Protein−Protein Interactions. J. Am. Chem. Soc. 2015, 137, 12249−12260.
2. J. Leon Catrow,† Yongqiang Zhang(并列第一作者),† Min Zhang, and Haitao Ji*. Discovery of Selective Small-Molecule Inhibitors for the β‑Catenin/TCell Factor Protein−Protein Interaction through the Optimization of the Acyl Hydrazone Moiety. J. Med. Chem. 2015, 58, 4678−4692.
3.Yongqiang Zhang, Shanchao Wu, Shengzheng Wang, Kun Fang, Guoqiang Dong, Na Liu, Zhenyuan Miao, Jianzhong Yao, Jian Li, Wannian Zhang,* Chunquan Sheng,* and Wei Wang*. Divergent Cascade Construction of Skeletally Diverse “Privileged” Pyrazole-Derived Molecular Architectures. Eur. J. Org. Chem.2015, 2030–2037.
4. Shanchao Wu, † Yongqiang Zhang(并列第一作者),† Xiaomeng He,† Xiaoying Che, Shengzheng Wang, Yang Liu, Yan Jiang, Na Liu, Guoqiang Dong, Jianzhong Yao, Zhenyuan Miao, Yan Wang, Wannian Zhang,* and Chunquan Sheng*. From Antidiabetic to Antifungal: Discovery of Highly Potent Triazole-Thiazolidinedione Hybrids as Novel Antifungal Agents. ChemMedChem 2014, 9, 2639 – 2646.
