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杨武林


杨武林   博士   特聘副研究员   硕士生导师

 

E-mailyangwl@ecust.edu.cn

通讯地址:上海市徐汇区梅陇路130号华东理工大学实验181121

邮编:200237

 

教育背景

1. 2012.09–2017.09华东理工大学,药学专业博士,导师:邓卫平 教授

2. 2016.09–2017.08美国罗格斯大学国家公派联合培养博士研究生导师Daniel Seidel 教授

3. 2008.09–2012.07华东理工大学药物制剂专业学士

 

工作经历

1. 2019.12–至今,华东理工大学药学院特聘副研究员

2. 2017.10–2019.12华东理工大学药学院师资博士后合作导师李忠 教授

 

研究方向

1. 新型杂环骨架导向的手性技术开发

2. 基于新型手性杂环骨架的创新药物研发

3. 手性药物绿色合成工艺创新研究

 

承担科研项目情况

1. 国家自然科学基金青年基金 (21901072)基于新型吲哚类1,3-偶极体的稠环吲哚不对称合成及生物活性研究202001-202212项目负责人

2. 上海市青年科技英才扬帆计划 (18YF1405600)基于协同催化模式的手性含氮杂环骨架构建及生物活性研究201805-202104项目负责人

3. 中国博士后科学基金特别资助 (2019T120310)基于新型吲哚类1,3-偶极体的催化不对称环加成反应研究201906-201912项目负责人

4. 中国博士后科学基金面上资助 (2018M632037)手性稠环吲哚化合物的不对称合成及生物活性研究201806-201912项目负责人

5. 上海市博士后日常工作经费

 


代表性论文

26. Ye Chao,# Yang Wu‐Lin#, Zhai Yufei, Deng Hua, Luo Xiaoyan*, Kai Guoyin*, Deng Wei-Ping. Copper(I)-Catalyzed Asymmetric [3 + 3] Annulation Involving Aziridines to Construct Tetrahydro-β-carbolines. Org. Chem. Front., 2020, DOI: 10.1039/D0QO00742K. (#equal contribution)


25. Tian Fei#, Yang Wu‐Lin#*, Ni Tao, Zhang Jian, Deng Wei‐Ping*. Catalytic Asymmetric Dipolar Cycloadditions of Indolyl Delocalized Metal-allyl Species for the Enantioselective Synthesis of Cyclopenta[b]indoles and Pyrrolo[1,2-a]indoles. Sci. China Chem., 2020, DOI: 10.1007/s11426-020-9854-3. (#equal contribution)


24. Yang Wu‐Lin#, Huang Zesheng#, Liu Yang‐Zi, Yu Xingxin*, Deng Wei‐Ping*. Highly Regio‐, Diastereo‐, and Enantioselective Assembly of Azepino[2,3‐b]indoles via Palladium‐Catalyzed [4 + 3] Cycloaddition. Chin. J. Chem., 2020, DOI: 10.1002/cjoc.202000264. (#equal contribution)

 

23. Tian Fei#, Zhang Jian#, Yang Wu-Lin*, Deng Wei-Ping*. Progress in Iridium-Catalyzed Asymmetric Allylic Substitution Reactions via Synergetic Catalysis. Chin. J. Org. Chem., 2020, DOI: 10.6023/cjoc202005008. (#equal contribution)

 

22. Zhang Jian, Ni Tao, Yang Wu-Lin*, Deng Wei-Ping*. Catalytic Asymmetric [3 + 2] Annulation via Indolyl Copper-Allenylidene Intermediates: Diastereo- and Enantioselective Assembly of Pyrrolo[1,2-a]indoles. Org. Lett., 2020, 22(11), 4547-4552.

 

21. Yang Wu-Lin*, Li Wen, Yang Zhong-Tao, Deng Wei-Ping*. Organocatalytic Regiodivergent Ring Expansion of Cyclobutanones for the Enantioselective Synthesis of Azepino[1,2‑a]indoles and Cyclohepta[b]indoles. Org. Lett., 2020, 22(10), 4026-4032.

 

20. Zou Xue-Jie, Yang Wu-Lin*, Zhu Jing-Yan, Deng Wei-Ping*. Catalytic Enantioselective Formal Synthesis of MDM2 Antagonist RG7388 and Its Analogue. Chin. J. Chem., 2020, 38(5), 435-438.

 

19. Zheng Xing, Sun Hao, Yang Wu-Lin*, Deng Wei-Ping*. Elaboration of phosphoramidite ligands enabling palladium-catalyzed diastereo- and enantioselective all carbon [4 + 3] cycloaddition. Sci. China Chem., 2020, 63(7), 911-916.

 

18. Zou Xuejie, Liu Yangzi, Shang Shaojing, Yang Wulin*, Deng Weiping*. Diastereoselective Synthesis of Functionalized Tetrahydro-γ-Carbolines via a [3 + 3] Cycloaddition of 2,2'-Diester Aziridines with β-(Indol-2-yl)-α,β-unsaturated Ketones. Chin. Chem. Lett., 2020, 31(5), 1293-1296.

 

17. Yang Wulin, Wang Hao, Pan Zirong, Li Zhong*, Deng Weiping. Asymmetric synthesis of pyrrolo[1,2-a]indoles via organocatalytic [3 + 2] annulation of substituted 2-vinylindoles with azlactones. Chin. Chem. Lett., 2020, 31(3), 721-724.

 

16. Liu Yang-Zi, Wang Zhongao, Huang Zesheng, Zheng Xing, Yang Wu-Lin*, Deng Wei-Ping*. Palladium-Catalyzed Asymmetric [4 + 3] Cyclization of Trimethylenemethane: Regio-, Diastereo-, and Enantioselective Construction of Benzofuro[3,2-b]azepine Skeletons. Angew. Chem. Int. Ed., 2020, 59(3), 1238-1242.

 

15. Chen Long#, Yang Wu-Lin#*, Shen Jia-Huan, Deng Wei-Ping*. Nickel(II)-Catalyzed Diastereo- and Enantioselective Michael/Hemiacetalization Cascade Reaction of α-Ketoesters with 2-(2-Nitrovinyl)phenols. Adv. Synth. Catal., 2019, 361(19), 4611-4622. (#equal contribution)

 

14. Yang Wu-Lin, Sun Zhong-Tao, Sun Hao, Deng Wei-Ping*. Nickel(II)-Catalyzed Diastereo- and Enantioselective [3 + 2] Cycloaddition of α-Ketoesters with 2-Nitrovinylindoles and 2-Nitrovinylpyrroles. Chin. J. Chem., 2019, 37(3), 216-220.

 

13. Yang Wu-Lin, Sun Zhong-Tao, Zhang Jian, Li Zhong*, Deng Wei-Ping. Enantioselective synthesis of 3-amino-hydrobenzofuran-2,5-diones via Cu(I)-catalyzed intramolecular conjugate addition of imino esters. Org. Chem. Front., 2019, 6(5), 579-583.

 

12. Gu Bo-Qi, Yang Wu-Lin*, Wu Shu-Xiao, Wang Yan-Bing, Deng Wei-Ping*. Organocatalytic asymmetric synthesis oftetrahydrocarbazoles via an inverse-electron demand Diels-Alder reaction of 2,3-indole-dienes with enals. Org. Chem. Front., 2018, 5(23), 3430-3434.

 

11. Ding Xiang-Feng, Su Ruo-Heng, Yang Wu-Lin*, Deng Wei-Ping*. Organocatalytic Asymmetric Formal Aza-[3 + 3] Cycloadditions of 3-Aminobenzofuran with α,β-Unsaturated Aldehydes. Adv. Synth. Catal., 2018, 360(21), 4168-4177.

 

10. Deng Hua, Yang Wu-Lin*, Tian Fei, Tang Wenjun, Deng Wei-Ping*. Asymmetric Construction of 3-Azabicyclo[3.1.0]hexane Skeleton with Five Contiguous Stereogenic Centers by Cu-Catalyzed 1,3-Dipolar Cycloaddition of Trisubstituted Cyclopropenes. Org. Lett., 2018, 20(13), 4121-4125. (Highlighted by Synfacts 2018, 14(9), 935.)

 

9. Tian Fei, He Fu-Sheng, Deng Hua, Yang Wu-Lin*, Deng Wei-Ping*. β-Silyl Acrylates in Asymmetric [3 + 2] Cycloadditions Affording Pyrrolidine Azasugar Derivatives. Org. Lett., 2018, 20(13), 3838-3842. (Highlighted by Synfacts 2018, 14(9), 936.)

 

8. Zheng Xing, Yang Wu-Lin*, Liu Yang-Zi, Wu Shu-Xiao, Deng Wei-Ping*. Enantioselective Synthesis of Tropanes via [3 + 3] Annulation of Cyclic Azomethine Ylides with Substituted 2-Vinylindoles and 2-Vinylpyrroles. Adv. Synth. Catal., 2018, 360(15), 2843-2853. (VIP) (Highlighted by Synfacts 2018, 14(8), 0846.)

 

7. Liu Yang-Zi, Shang Shao-Jing, Zhu Jing-Yan, Yang Wu-Lin*, Deng Wei-Ping*. Regioselective and Stereoselective [3 + 3] Annulation of Ketones Derived Azomethine Ylides with 2-Indolylethylenes: Direct Access to Highly Substituted Tetrahydro-γ-Carbolines. Adv. Synth. Catal., 2018, 360(11), 2191-2203.

 

6. Zhu Jing-Yan, Yang Wu-Lin*, Liu Yang-Zi, Shang Shao-Jing, Deng Wei-Ping*. Copper(I)-catalyzed Asymmetric Mannich Reaction of Glycine Schiff Bases with Isatin-derived Ketimines: Enantioselective Synthesis of 3-Substituted 3-Aminooxindoles. Org. Chem. Front., 2018, 5(1), 70-74.

 

5. Yang Zhong-Tao, Yang Wu-Lin*, Chen Long, Sun Hao, Deng Wei-Ping*. Organocatalytic Enantioselectiveaza-Friedel-Crafts Reactions ofPyrazolinone Ketimineswith Hydroxyindoles and Electron-Rich Phenols. Adv. Synth. Catal., 2018, 360(10), 2049-2054.

 

4. Yang Wu-Lin, Li Chun-Yan, Qin Wen-Jing, Tang Fei-Fei, Yu Xingxin, Deng Wei-Ping*. Cu(I)-Catalyzed Chemoselective and Stereoselective [3 + 3] Cycloaddition of Azomethine Ylides with 2-Indolylnitroethylenes: Facile Access to Highly Substituted Tetrahydro-γ-Carbolines. ACS Catal., 2016, 6(9), 5685-5690. (Highlighted by Synfacts 2016, 12(10), 1058.)

 

3. Yang Wu-Lin, Tang Fei-Fei, He Fu-Sheng, Li Chun-Yan, Yu Xingxin*, Deng Wei-Ping*. Asymmetric construction of spirocyclic pyrrolidine- thia(oxa)zolidinediones via N,O-ligand/Cu(I) catalyzed 1,3-dipolar cycloaddition of azomethine ylides with 5-alkylidene thia(oxa)zolidine-2,4-diones. Org. Lett., 2015, 17(19), 4822-4825. (Highlighted by Synfacts 2015, 11(12), 1285.)

 

2. Yang Wu-Lin, Liu Yang-Zhi, Luo Shuai, Yu Xingxin*, Fossey John S., Deng Wei-Ping*. Copper-catalyzed asymmetric construction of dispiropyrrolidine skeleton via 1,3-dipolarcycloaddition of azomethine ylides with α-alkylidene. Chem. Commun., 2015, 51(44), 9212-9215. (Highlighted by Synfacts 2015, 11(12), 738.)

 

1. Li Chun-Yan#, Yang Wu-Lin#, Luo Xiaoyan*, Deng Wei-Ping*. Diastereodivergent asymmetric Michael addition of cyclic azomethine ylides to nitroalkenes: direct approach for the synthesis of 1,7-diazaspiro[4.4]nonane diastereoisomers. Chem. Eur. J., 2015, 21(52), 19048-19057. (#equal contribution) (Highlighted by Synfacts 2016, 12(2), 167.)




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