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| 发布时间：2019-05-20 访问次数:670 作者: |
Vice Dean Contact Information Office: Room 316, Researching Building 18 Email: rgb@ecust.edu.cn Office Phone: +86 21 6425 3406 Office Fax: +86 21 6425 3406
Education 7/2005-6/2007 Postdoctoral Research Associate. Pharmaceutical crystal engineering Tianjin University 9/2002-7/2005 Ph.D., Pharmaceutical crystal engineering Tianjin University 9/1999-7/2002 M.S., Pharmaceutical crystal engineering Zhengzhou University 9/1993-7/1997 B.S., Chemical Engineering and Technology Zhengzhou University
Professional Experience 20 years’ research experiences in the field of pharmaceutical crystal engineering. Wide investigations in pharmaceutical crystallization, mainly including pharmaceutical crystallization process optimization, pharmaceutical solid-state characterization (XRPD, DSC, TGA, HSM, IR, Raman, DVS, PSA, ssNMR), high throughput polymorph, salt and co-crystal screening, pharmaceutical preformulation study: 7/2013-now Professor, Vice Dean of School of Pharmacy, East China University of Science and Technology (ECUST) 6/2010-7/2013 Professor, head of pharmaceutical crystal engineering research group, center for analysis and testing (CAT), Shanghai Institute of Pharmaceutical Industry (SIPI) 6/2008-6/2010 Member of experts committee, Principal scientist, Chemical & Pharmaceutical Profiling, China Novartis Institutes for BioMedical Research Co., Ltd, Shanghai, China 6/2007-6/2008 Principal scientist, salt lab head, Suzhou Novartis Pharma Technology Co., ltd, Suzhou, China 6/2007-12/2007 Principal scientist, salt and polymorphism lab, Novartis, Basel, Switzerland Research Interests Awards: 2017 Grade 2 Award of Shanghai Science And Technology Progress Award, East University of Science and Technology 20174087-2-R01 2017 Chinese Innovation Award For Industry-University-Research Cooperation, East University of Science and Technology 20173082 2011 Chinese Patent Award Of Excellence, Tianjin University ZL 200410093967.5 2009 SPOT AWARD of CNIBR, China Novartis Institutes for BioMedical Research Co., Ltd 2009 TOP POPULAR AWARD, China Novartis Institutes for BioMedical Research Co., Ltd 2007 Grade 1 Award for Technological Invention of Tianjin, Tianjin University 2007FM-1-001 2006 Grade 1 Award of Education Ministry Award, Tianjin University 2006-152 Publication Bin Zhu, Xiaoxue Fang, Qi Zhang, Xuefeng Mei, Guobin Ren, Study of Crystal Structures, Properties, and Form Transformations among a Polymorph, Hydrates, and Solvates of Apatinib, Cryst. Growth Des., 2019, 19(5): 3060-3069 Dan Du, Zhi-Ping Shi, Guo-Bin Ren, Ming-Hui Qi, Zhong Li, Xiao-Yong Xu, Preparation and characterization of several azoxystrobin channel solvates, J. Mol. Struct., 2019, 1189: 40-50 Hao Wu, Zhaizhu Deng, Bijian Zhou, Minghui Qi, Minghuang Hong*, Guobin Ren, Improved transdermal permeability of ibuprofen by ionic liquid technology: Correlation between counterion structure and thephysicochemical and biological properties, J. Mol. Liq., 2019, 283: 399-409 Dan Du, Guo-Bin Ren, Ming-Hui Qi, Zhong Li, Xiao-Yong Xu, Solvent-Mediated Polymorphic Transformation of Famoxadone from Form II to Form I in Several Mixed Solvent Systems, Crystals, 2019, 9: 161 Ming-Hui Qi, Qiao-Dan Zhang, Yang Liu, Fu-Zheng Ren, Guo-Bin Ren, Four solid forms of filgotinib hydrochloride: Insight into the crystal structures, properties, stability, and solid-state transitions, J. Mol. Struct., 2019, 1178: 242-250 Dan Du, Peng-Jian Liu, Zhi-Ping Shi, Guo-Bin Ren, Ming-Hui Qi, Zhong Li, Xiao-Yong Xu, Three solid forms of chlorantraniliprole: Structure, characterization, and phase transformation, J. Mol. Struct., 2018, 1171: 323-332 Minghuang Hong, Sai Guo, Kai Wang, Lei Ma, Guobin Ren, Influence Factor Investigation on the Solution‐Mediated Polymorphic Transformation of Baricitinib Phosphate, Z. Anorg. Allg. Chem., 2018, 644(15): 849-855 Bin Zhu, Jian-Rong Wang, Qi Zhang, Meiqi Li, Chunyang Guo, Guobin Ren, Xuefeng Mei, Stable Cocrystals and Salts of the Antineoplastic Drug Apatinib with Improved Solubility in Aqueous Solution, Cryst. Growth Des., 2018, 18(8): 4701-4714 Fuzheng Ren, Hanjing Sun, Lin Cui, Yike Si, Ning Chen, Guobin Ren, Qiufang Jing, Antisolvent Recrystallization Strategy to Screen Appropriate Carriers to Stabilize Filgotinib Amorphous Solid Dispersions, J. Pharm. Sci., 2018, 107(6): 1624-1632 Jinping Fu, Lin Cui, Congbin Yang, Hui Xiong, Guobin Ren, Xingyuan Ma, Qiufang Jing, Fuzheng Ren, Screen for Inhibitors of Crystal Growth to Identify Desirable Carriers for Amorphous Solid Dispersions Containing Felodipine, AAPS PharmSciTech, 2018, 19(3): 1231-1242 Fuzheng Ren, Jinping Fu, Hui Xiong, Lin Cui, Guobin Ren, Haiying Guan, Qiufang Jing, Complexes of Felodipine Nanoparticles With Zein Prepared Using a Dual Shift Technique, J. Pharm. Sci., 2018, 107(1): 239-249. Congbin Yang, Peiwen Di, Jingping Fu, Hui Xiong, Qiufang Jing, Guobin Ren, Yun Tang, Wenyun Zheng, Guixia Liu, Fuzheng Ren, Improving the physicochemical properties of bicalutamide by complex formation with bovine serum albumin, Eur. J. Pharm. Sci., 2017, 106: 381-392 Bin Zhu, Qi Zhang, Guobin Ren, Xuefeng Mei, Solid-State Characterization and Insight into Transformations and Stability of Apatinib Mesylate Solvates, Cryst. Growth Des., 2017, 17(11): 5994-6005 Hui Xiong, Jinping Fu, Hanjing Sun, Enfu Wang, Yunhui Ding, Guobin Ren, Qiufang Jing Fuzheng Ren, The Physicochemical Investigation of 17β-Estradiol Crystalline Prepared by In Situ pH-Dependent Solubility Technique with Polyvinylpyrrolidone, AAPS PharmSciTech, 2017, 18(8): 2889-2897 Wenhua Chen, Ne Guo, Minghui Qi, Haiying Dai, Minghuang Hong, Longfei Guan, Xiajuan Huan, Shanshan Song, Jinxue He, Yingqing Wang, Yong Xi, Xinying Yang, Yanyan Shen, Yi Su, Yiming Sun, Yinglei Gao, Yi Chen, Jian Ding, Yun Tang, Guobin Ren, Zehong Miao, Jian Li, Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy, Eur. J. Med. Chem., 2017, 138: 514-531 Wen-hua CHEN, Shan-shan SONG, Ming-hui QI, Xia-juan HUAN, Ying-qing WANG, Hualiang JIANG, Jian DING, Guo-bin REN, Ze-hong MIAO, Jian LI, Discovery of potent 2,4-difluoro-linker poly(ADPribose) polymerase 1 inhibitors with enhanced water solubility and in vivo anticancer efficacy, Acta Pharmacol. Sin., 2017, 38(11): 1521-1532 Minghuang Hong, Jingyan Chen, Hui Zhou, Hao Xu, Guobin Ren, Investigation of a solution-mediated phase transformation of pranlukast DMF solvate to hemihydrate, Cryst. Res. Technol., 2017, 52(6): 1700045 Ming-Hui Qi, Wan-Shang Chen, Hui Zhou, Jing-Yan Chen, Guo-Bin Ren, Solution-mediated polymorphic transformation of amorphous form to Form I of olmesartan medoxomil in methanol-water mixture solvents, Cryst. Res. Technol., 2017, 52(4): 1700038 Fuzheng Ren, Yaru Zhou, Yan liu, Jinping Fu, Qiufang Jing, Guobin Ren, A mixed solvent system for preparation of spherically agglomerated crystals of ascorbic acid, Pharm. Dev. Technol., 2017, 22(6): 818-826 Fuzheng Ren, Jianping Su, Hui Xiong, Ying Tian, Guobin Ren, Qiufang Jing, Characterization of ibuprofen microparticle and improvement of the dissolution, Pharm. Dev. Technol., 2017, 22(1): 63-68 Bin Zhu, Jian-Rong Wang, Guobin Ren, Xuefeng Mei, Polymorphs and hydrates of apatinib mesylate: insight into the crystal structures, properties, and phase transformations, Cryst. Growth Des., 2016, 16(11): 6537-6546 Yan Liu, Huiru Gao, Hao Xu, Fuzheng Ren, Guobin Ren, Influence of temperature, solvents, and excipients on crystal transformation of agomelatine, Org. Process Res. Dev., 2016, 20(9): 1559-1565 Minghuang Hong, Shiwang Wu, Minghui Qi, Guobin Ren, Solubility correlation and thermodynamic analysis of two forms of metaxalone in different pure solvents, Fluid Phase Equilib., 2016, 409: 1-6 Yan Liu, Huiru Gao, Fuzheng Ren, Guobin Ren, Solubility of agomelatine crystal form I and form II in pure solvents and (isopropanol + water) mixtures, J. Chem. Eng. Data, 2015, 60(11): 3347-3352 Ming-Hui Qi, Ming-Huang Hong, Yan Liu, En-Fu Wang, Fu-Zheng Ren, Guo-Bin Ren, Estimating thermodynamic stability relationship of polymorphs of sofosbuvir, Cryst. Growth Des., 2015, 15(10): 5062-5067 Yan Liu, Zhi-Peng Zhao, Jingbin Cui, Guobin Ren, Solubility of amorphous clopidogrel hydrogen sulfate in different pure solvents, J. Chem. Eng. Data, 2015, 60(8): 2442-2446
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