郑军  教授  博士生导师

招生专业：制药工程 （博士/学硕）生物与医药（专硕）E-mail: jz@ecust.edu.cn

课题组网站：郑军课题组 (x-mol.com)

通讯地址：上海市徐汇区梅陇路130号实验18楼927室；邮编：200237

个人简介：

       2011年本科毕业于苏州大学材料与化学化工学部，并于2016年在上海有机化学研究所取得博士学位，师从游书力院士。随后加入德国弗莱堡大学Bernhard Breit教授课题组开展博士后研究。2022年7月加入华东理工大学药学院任特聘研究员，2024年1月升任教授。曾获国家(2022)和上海市(2021)高层次人才引进计划，德国洪堡奖学金 (2017)，中国科学院优秀博士论文(2017)，SABIC-CAS SCHOLARSHIP (2016) 和中国科学院院长优秀奖 (2016)。

研究方向：

课题组主要研究兴趣有不对称催化，自由基化学，合成方法学，天然产物合成以及新药研发。

科研项目：

上海市海外高层次人才项目(2021)，主持

国家海外高层次青年人才项目(2022)，主持

上海市自然科学基金面上项目(2023)，主持

国家自然科学基金青年基金项目(2024)，主持

成果及论文：

Independent Work:

 7. Zwitterionic π-Allyl-Pd Species Enabled [2σ+2π] Cycloaddition Reactions of Vinylbicyclo[1.1.0]butanes (VBCBs) with Alkenes, Carbonyls, and Imines

Tianxiang Li, Yao Wang, Yang Xu, Haosong Ren, Zhongren Lin, Zhenyue Li, Jun Zheng,* ACS Catal. 2024, 14,  18799–18809.

6. Synthesis of Azabicyclo[3.1.1]heptenes Enabled by Catalyst-Controlled Annulations of Bicyclo[1.1.0]butanes with Vinyl Azides

Zhongren Lin, Haosong Ren, Xinbo Lin, Xinhong Yu, and Jun Zheng* J. Am. Chem. Soc. 2024, https://pubs.acs.org/doi/10.1021/jacs.4c04485.

5. Metal-free β,γ-C(sp3)–H difunctionalization of propanols: DMP-initiated asymmetric spirocyclopropanation

Zheyao Li, Huiwen Zhang, Lin Zhao, Yueyue Ma,* Qiufang Wu, Haosong Ren, Zhongren Lin, Jun Zheng,* Xinhong    Yu,* Chem. Commun., 2024, https://doi.org/10.1039/D4CC00116H.

4. Ti-Catalyzed Formal [2π + 2σ] Cycloadditions of Bicyclo[1.1.0]butanes with 2-Azadienes  to Access  Amino-bicyclo[2.1.1]hexanes

Haosong Ren, Tianxiang Li, Jinping Xing, Zhenyue Li, Yanxia Zhang, Xinhong Yu,* Jun Zheng,* Org. Lett. 2024, 26, 1745–1750. https://doi.org/10.1021/acs.orglett.4c00421.

3. Visible-Light Induced Cross-Electrophile Coupling of Imines and Anhydrides to Synthesize α Amino Ketones

Ren-Xu Cao, Yu Liu, Xiao-Xin Shi,* Jun Zheng,* Chem. Commun. 2023, DOI: 10.1039/D3CC03028H.

2. Rhodium(III)-Catalyzed Atroposelective C-H Indolylization of 1‑Aryl Isoquinolines with 3-Indolylphenyliodonium Salts

Dong-Song Zheng, Jun Zheng, Qiang Wang, Qing Gu, Shu-Li You,* Chin. J. Chem. 2023, DOI: 10.1002/cjoc.202300289.

1. Visible-light induced metal-free intramolecular reductive cyclisations of ketones with alkynes and allenes

Nana Tang,‡ Raphael J. Zachmann,‡ Hui Xie, Jun Zheng *, Bernhard Breit*, Chem. Commun. 2023, 59, 2122–2125.  (‡N.-N. T. and R.-J. Zachmann. contributed equally to this work.)

Prior to ECUST:

13. Regio- and Diastereoselective Decarboxylative Allylation of N-Aryl α-Amino Acids by Dual Photoredox/Nickel Catalysis.  

J. Zheng,‡ C. Nopper,‡ R. Bibi, A. Nikbakht, F. Bauer, B. Breit,* ACS Catal. 2022, 12, 5949−5960. (‡J.Z. and C.N. contributed equally to this work.)

12. Regio-, Diastereo-, and Enantioselective Decarboxylative Hydroaminoalkylation of Dienol Ethers Enabled by Dual Palladum/Photoredox Catalysis. 

J. Zheng,* N. Tang, H. Xie, B. Breit,* Angew. Chem. Int. Ed. 2022, DOI: 10.1002/anie.202200105.

11. Dual Palladium/Photoredox-Catalyzed Enantioselective and Regioselective Decarboxylative Hydroaminoalkylation of Allenes. 

J. Zheng, Ali Nikbakht, and Bernhard Breit,* ACS Catal. 2021, 11, 3343−3350.

10. Regiodivergent Hydroaminoalkylation of Alkynes and Allenes by a Combined Rhodium and Photoredox Catalytic System. 

J. Zheng, B. Breit,* Angew. Chem. Int. Ed. 2019, 58, 3392-3397.

9.  Asymmetric Synthesis of Spiropyrazolones by Rhodium-Catalyzed C(sp2)–H Functionalization/Annulation Reactions. 

J. Zheng, S.-B. Wang, C. Zheng, S.-L. You,* Angew. Chem. Int. Ed. 2017, 56, 4540-4544. (Highlighted by Synfacts 2017, 13(6), 0609).

8.  Synthesis and Application of Chiral Spiro Cp Ligands in RhodiumCatalyzed Asymmetric Oxidative Coupling of Biaryl Compounds with Alkenes. 

J. Zheng, W.-J. Cui, C. Zheng, S.-L. You,* J. Am. Chem. Soc. 2016, 138, 5242-5245.

7.  A DFT Study on Rh-Catalyzed Asymmetric Dearomatization of 2-Naphthols Initiated with C–H Activation: A Refined Reaction Mechanism and Origins of Multiple Selectivity. 

C. Zheng, *  J. Zheng, S.-L. You,* ACS Catal. 2016, 6 (1), 262-271.

6.  Asymmetric Dearomatization of Naphthols via a Rh-Catalyzed C(sp2)–H Functionalization/Annulation Reaction. 

J. Zheng, S.-B. Wang, C. Zheng, S.-L. You,* J. Am. Chem. Soc. 2015, 137, 4880-4883. (Highlighted by Synfacts 2015, 11(7),0721)

5.  Construction of Axial Chirality by Rhodium-Catalyzed Asymmetric Dehydrogenative Heck Coupling of Biaryl Compounds with Alkenes. J. Zheng, S.-L. You,* Angew. Chem. Int. Ed. 2014, 53, 13244-13247.

4.  Palladium-Catalyzed Trisallylation of Azoles with Alkyne via sequential C(sp2)-H and C(sp3)-H Functionalization. 

J. Zheng, F. Hosseini-Eshbala, Y.-X. Dong, B. Breit,* Chem. Commun. 2019, 55, 624-627.

3.  Palladium-Catalyzed Direct C-H Allylation of Electron-Deficient Polyfluoroarenes with Alkynes. 

J. Zheng, B. Breit,* Org. Lett. 2018, 20, 1866-1870.

2.  Rhodium-catalyzed direct coupling of biaryl pyridine derivatives with internal alkynes. 

J. Zheng, S.-L. You,* Chem. Commun. 2014, 50, 8204-8207.

1.  Rhodium-Catalyzed Chemo-, Regio-, and Enantioselective Allylation of 2-Aminothiazoles with Terminal Allenes. 

J. Zheng, B. Worl, B. Breit,* Eur. J. Org. Chem. 2019, 21, 5180-5182.

专利：

1.  You, S.-L.; Zheng, J.; Cui, W.-J. Based on the spiro skeleton of cyclopentadiene compounds and their rhodium complex, preparation and application, Chinese Patent, 201610120414.7.