程侠卫 特聘研究员 博士生导师

电话：021-64251287

Email: chengxw@ecust.edu.cn

通讯地址：上海市徐汇区梅陇路130号华东理工大学第六教学楼辅楼305室

[个人简介]

程侠卫，博士，华东理工大学特聘研究员，生物反应器工程国家重点实验室、上海市前沿科学研究基地和光遗传学和合成生物学交叉学科研究中心成员。2014年毕业于南京大学生命科学学院，获得博士学位，同年进入浙江大学医学院从事博士后研究工作。2019年加入华东理工大学光遗传学和合成生物学交叉学科研究中心，从事细胞自噬和细胞代谢的研究工作。主要研究成果发表在Molecular Cell、Science Advances、Science、Autophagy、Theranostics等国际权威期刊，授权2项中国发明专利。主持国家自然科学基金青年项目和面上项目各1项，国家重点研发计划子项目2项，并主持参与多项省部级项目。现担任Frontiers in Pharmacology杂志客座编辑,《医学分子生物学杂志》青年编委等学术职位。

[主要研究方向]

1.细胞代谢物调控自噬的分子机理

2.赖氨酸酰化修饰调控细胞代谢和自噬的分子机制

3.细胞自噬在细菌感染和衰老中的作用

[代表性论文]

1. Jia Mengshu, Yue Xiao, Sun Weixia, Zhou Qianjun, Chang Cheng, Gong Weihua, Feng Jian,  Li Xie, Wang Aoxue, Zou Yejun, Zhang Lijuan, Chen Weicai, Yan Li, Qian Yajie, Dong Wenping, Huang Li, Zhan Ruonan, Yang Yi, Zhao Yuzheng, Cheng Xiawei*. ULK1-mediated metabolic reprogramming Regulates Vps34 Lipid Kinase Activity by its lactylation, Science Advances, 2023, 9(22): eadg4993.

2. Sun Weixia, Jia Mengshu, Feng Yingyan, Cheng Xiawei*. Lactate is a bridge linking glycolysis and autophagy through lactylation,Autophagy, 2023, 19(12):3240-3241.

3. Cheng Xiawei, Ma Xiuling, Zhu Qi, Song Dandan, Ding Xianming, Li Lin, Jiang Xiao, Wang Xinyi, Tian Rui, Su Hua, Shen Zhirong, Chen She, Liu Ting, Gong Weihua, Liu Wei, Sun Qiming. Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism, Molecular Cell, 2019, 73(4): 788-802.

4. Cheng Xiawei, Ma Xiuling, Ding Xingming, Li Lin, Jiang Xiao, Chen She, Shen Zhirong, Liu Wei, Gong Weihua, Sun Qiming. Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17, Molecular Cell, 2017, 65(6): 1029-1043.

5. Cheng Xiawei, Sun Qiming. RUBCNL/Pacer and RUBCN/Rubicon in regulation of autolysosome formation and lipid metabolism, Autophagy, 2019, 15(6): 1120-1121.

6. Liu Chen#, Cheng Xiawei#, Chen Juntao, Wang Yao, Wu Xiaoying, Tian Rui, Liu Baoqing, Ding Xianfeng, Sun Qiming, Gong Weihua. Suppression of YAP/TAZ-Notch1-NICD axis by bromodomain and extraterminal protein inhibition impairs liver regeneration, Theranostics, 2019, 9(13):3840-3852

7. Cheng Xiawei, Zhang Xiaoxin, Cheng Wei, Chen Jianxiang, Ma Cailie, Yang Bingya, Hua Zichun. Tumor-specific delivery of histidine-rich glycoprotein suppresses tumor growth and metastasis by anti-angiogenesis and vessel normalization, Curr Gene Ther, 2014;14(2):75-85.

8. Cheng Xiawei, Zhang Xiaoxin, Zhou Yuqiang, Zhang Chunmei, Hua Zichun. A Salmonella Typhimurium mutant strain capable of RNAi delivery: higher tumor-targeting and lower toxicity, Cancer Biol Ther, 2014,15(8):1068-76. 

9. Lu Yan, Zheng Yuping, Coyaud Etienne,Zhang Chao, Selvabaskaran, Apiraam, Yu  Yuyun, Xu Zizhen, Weng Xialian, Chen JiShun, Meng Ying, Warner Neil, Cheng Xiawei, Liu Yangyang, Yao Bingpeng, Hu Hu, Xia Zonping, Muise Aleixo M, Klip Amira, Brumell, John H, Girardin Stephen E, Ying Songmin, Fairn Gregory D, Raught Brian, Sun Qiming, Neculai Dante. Palmitoylation of NOD1 and NOD2 is required for bacterial sensing, Science, 2019, 366(6464): 460-467.

10. Zhang Zhuo, Cheng Xiawei, Zhao Yuzheng, Yang Yi. Lighting Up Live-Cell and In Vivo Central Carbon Metabolism with Genetically Encoded Fluorescent Sensors, Annu Rev Anal Chem, 2020,13(1):293-314.