个人简介：

2014年博士毕业于中国科学院大学；在中国科学院生命科学研究院营养科学研究所从事博士后工作；2017年人才引进到天津医科大学，基础医学院药理系副教授、硕士生导师；2021年12月至今，华东理工大学药学院药物科学系，特聘研究员/副教授，博士生导师。

        作为项目负责人主持国家自然科学基金面上项目2项、国家自然科学基金青年项目、京津冀基础研究合作专项、天津市自然科学基金等，作为项目骨干参与国家重点研发计划等。曾获2021年度华夏医学科技奖二等奖；中国中医科学院科学技术二等奖；2018年天津市青年人才托举工程；2018年天津市创新人才推进计划青年科技优秀人才；2017年天津市131创新型人才培养工程等。主要学术兼职包括世界中医药学会联合会气血专业委员会理事、中国心胸血管麻醉学会精准医疗分会委员、中国药理学会心血管药理专业委员会青年学者、中国医药教育协会中医药慢病防治与教育工作委员会委员、中国青年科技工作者协会第六届生物医药专委会会员、上海市衰老与退行性疾病学会青年委员、天津院士专家工作发展促进会理事、《血管生物学》编委、Frontiers in Pharmacology期刊副主编等。

研究方向：

       心血管疾病及相关代谢综合征的机制研究和新靶标的发现。

近五年代表性论文：

1. Xiang Peng, Bin Sun, Chaohui Tang, Chengyu Shi, Xianwei Xie, Xueyu Wang, Dingsheng Jiang, Shuo Li, Ying Jia, Yani Wang, Huifang Tang, Shan Zhong, Minghui Piao, Xiuru Cui, Shenghao Zhang, Fan Wang, Yan Wang, Ruisi Na, Renping Huang, Yanan Jiang, Weihua Zhang, Juan Xu, Kaiyang Lin, Junli Guo, Zhenwei Pan, Kun Wang, Qiang Zhao, Huibin Liu, Yong Ji, Bo Yu, Jian Zhang*, Shuijie Li*, Jinwei Tian*. LDHB is essential for HMOX1-dependent ferroptosis through regulating mitochondrial function of foamy macrophages in advanced atherosclerosis. Developmental Cell. Accepted.

2. Fangdi Zou, Yong Li, Shijie Zhang, Jian Zhang*. DP1 Activation Protects Against Vascular Remodeling and VSMC Transition to Myofibroblasts in Angiotensin II-induced Hypertension in Mice. Hypertension. 2021 Jan 31^th Accepted.（心血管国际顶级期刊）

3. Daile Jia, Peiyuan Bai, Naifu Wan, Jiao Liu, Qian Zhu, Yuhu He, Guilin Chen, Jing Wang, Han Chen, Chen Wang, Ankang Lyu, Michael Lazarus, Yunchao Su, Yoshihiro Urade, Ying Yu*, Jian Zhang*, Yujun Shen*. Niacin Attenuates Pulmonary Hypertension Through H-PGDS in Macrophages.Circulation Research. 2020;127:1323–1336. （心血管国际顶级期刊）

4.Xiangjun Yin, Min Li, Yongzhi Wang, Guifang Zhao, Tao Yang, Yuqing Zhang, Jianbo Guo, Tiantian Meng, Ruolin Du, Honglin Li*, Zhe Wang*, Jian Zhang*, Qingyong He*. Herbal medicine formula Huazhuo Tiaozhi granule ameliorates dyslipidaemia via regulating histone lactylation and miR-155-5p biogenesis. Clinical Epigenetics. 2023;15(1):175. 

5. Shumin Guo, Rui Zhang, Qian Liu,Qiangyou Wan, Yuanyang Wang, Yu Yu, Guizhu Liu, Yujun Shen, Lijian Hui, Ying Yu, Jian Zhang*. 2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes injury-induced vascular neointima formation in mice through c-Jun activation. FASEB J. 2019;33(9):10207-10217. 

6. Guizhu Liu, Qian Liu, Yujun Shen, Deping Kong, Yanjun Gong, Bo Tao, Guilin Chen, Shumin Guo, Juanjuan Li, Shengkai Zuo, Yu Yu, Huiyong Yin, Li Zhang, Bin Zhou, Colin D Funk, Jian Zhang*, Ying Yu*. Early treatment with Resolvin E1 facilitates myocardial recovery from ischaemia in mice. Brit J Pharmacol. 2018; 175:1205–1216. （药理学顶级期刊）

7. Guizhu Liu, Yanjun Gong, Rui Zhang, Lingjuan Piao, Xinzhi Li, Qian Liu, Shuai Yan, Yujun Shen, Shumin Guo, Mingjiang Zhu, Huiyong Yin, Colin D. Funk, Jian Zhang*, Ying Yu*. Resolvin E1 attenuates injury-induced vascular neointimal formation by inhibition of inflammatory responses and vascular smooth muscle cell migration.FASEB J. 2018; 32(10):5413-5425.

8. Mulin Jun Li^#, Jian Zhang^#, Jiexing Wu, Peng Jiang, Wei Li, Yun Zhu, Daniel Fernandez, Russell J. H. Ryan, Yiwen Chen , Junwen Wang , Jun S. Liu, X. Shirley Liu. Exploring genetic associations with ceRNA regulation in the human genome. Nucleic Acids Research. 2017 Jun 2;45(10):5653-5665.（生物学TOP期刊）

9. Qian Jiao, Fangdi Zou, Shiliang Li, Jiawen Wang, Yunping Xiao, Zhihua Guan, Liang Dong,Jinwei Tian, Shengqing Li, Rui Wang*, Jian Zhang*, Honglin Li*. Dexlansoprazole prevents pulmonary artery hypertension by inhibiting pulmonary artery smooth muscle cell to fibroblast transition. Am J Transl Res 2022;14(8):5466-5479.IF,3.9

10. Jian Zhang, Fangfang Zou, Juan Tang, Qianqian Zhang, Yanjun Gong, Qingsong Wang, YujunShen, Lixia Xiong, Richard M. Breyer, Michael Lazarus, Colin D. Funk, Ying Yu. Cyclooxygenase-2–derived prostaglandin E2 promotes injury-induced vascular neointimal hyperplasia through the E-prostanoid 3 receptor. Circulation Research. 2013;113(2):104-114. （心血管领域国际顶级期刊）

11. Jian Zhang, Yanjun Gong, Ying Yu. PGF_2alpha receptor: a promising therapeutic target for cardiovascular disease.Frontiers in Pharmacology. 2010; 1(116):1-7. 

12. Yong Li, Jian Zhang*. The role of arachidonic acid and its derivatives in the development of pulmonary arterial hypertension. Chinese Journal of Nature. 2022, 44(5): 357-368.

13. 倪文君，王雪羽，钟珊，赵鹏，张健*，田进伟*，肠道菌群和心血管疾病的免疫调节.中国动脉粥样硬化.2023,31(7):625-631.

14. 血管生物学(第2版)，第三十章前列腺素与血管炎症，余鹰，张健，北京大学医学出版社，2014.

15. 花生四烯酸衍生物在腹主动脉瘤发生发展中的作用，焦志昂，昌悦悦，孟硕，马思静，王哲，张健*，中国动脉硬化杂志. 2024,32(05):75-81.