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朱丽丽


  

  

朱丽丽,博士,华东理工大学副教授,硕士生导师。


研究方向:

主要研究领域为与疾病有关蛋白质的化学生物学和结构生物学研究。包括基于靶标蛋白的抑制剂筛选、以X射线蛋白质晶体学为手段研究与疾病有关靶标蛋白的晶体结构、药物作用机制及基于结构生物学的创新药物设计。2012年入选上海市高校青年教师培养资助计划。作为课题负责人承担科研项目5项(1项国家科技重大专项子课题任务;2项中央高校基本科研业务费;1项国家自然科学基金青年项目;1项上海市自然科学基金),作为重要成员参加科研项目3项(1项重点研发计划;1项国家自然科学基金面上项目;1863计划)。申请专利8项,已授权1项。

简历:

20087月毕业于中科院福建物质结构研究所获博士学位,专业为生物化学与分子生物学。

20088月至20117月在德国吕贝克大学生物化学系做博士后研究。

20118月至今在华东理工大学药学院任副教授。

联系方式:

电话021-64253379.  emailzhulfl@ecust.edu.cn

科研成果:

1)        Wanqi Wang1, Yanyan Diao1, Wenjie Li1, Yating Luo, Tingyuan Yang, Yuyu Zhao, TianTian Qi, Fangling Xu, Xiangyu Ma, Huan Ge, Yingfan Liang, Zhenjiang Zhao, Xin Liang, Rui Wang, Lili Zhu, Honglin Li, Yufang Xu. Design, synthesis and structure-activity relationship study of aminopyridine derivatives as novel inhibitors of Janus kinase 2. Bioorg Med Chem Lett. 2019;29(12):1507-1513.

2)        Shiliang Li, Chun Qin, Shichao Cui, Hongling Xu, Fangshu Wu, Jiawei Wang, Mingbo Su, Xiaoyu Fang, Dan Li, Qian Jiao, Ming Zhang, Chunmei Xia, Lili Zhu, Rui Wang, Jia Li, Hualiang Jiang, Zhenjiang Zhao*, Jingya Li*, Honglin Li*. Discovery of a Natural-Product-Derived Preclinical Candidate for Once-Weekly Treatment of Type 2 Diabetes. J Med Chem. 2019;62(5):2348-2361.

3)        Yi Tong1, Qian Jiao1, Yuanru Liu, Jiankun Lv, Rui Wang*, Lili Zhu*. Maprotiline Prevents Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats. Front Pharmacol. 2018;9:1032.

4)        Yongjia Hao, Jiankun Lyu, Rong Qu, Yi Tong, Deheng Sun, Fang Feng, Linjiang Tong, Tingyuan Yang, Zhenjiang Zhao, Lili Zhu, Jian Ding, Yufang Xu*, Hua Xie*, Honglin Li*. Design, Synthesis, and Biological Evaluation of Pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation. J Med Chem. 2018;61(13):5609-5622.

5)        Le Xu, Wenjie Li, Yanyan Diao, Hongxia Sun, Honglin Li, Lili Zhu*, Hongchang Zhou*, Zhenjiang Zhao*.Synthesis, Design, and Structure–Activity Relationship of the Pyrimidone Derivatives as Novel Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase. Molecules. 2018, 23(6), 1254.

6)        Fang Bai1, Kangdong Liu1, Huiliang Li1, Jiawei Wang, Junsheng Zhu, Pei Hao, Lili Zhu, Shoude Zhang, Lei Shan, Weiya Ma, Ann M. Bode, Weidong Zhang*, Honglin Li* and Zigang Dong*. Veratramine modulates AP-1-dependent gene transcription by directly binding to programmable DNA. Nucleic Acids Res. 2018; 46(2): 546–557.

7)        Fanxun Zeng, Tiantian Qi, Chunyan Li, Tingfang Li, Honglin Li, Shiliang Li,* Lili Zhu*, Xiaoyong Xu. Synthesis, structure–activity relationship and binding mode analysis of 4-thiazolidinone derivatives as novel inhibitors of human dihydroorotate dehydrogenase. Med. Chem. Commun.,2017, 8, 1297.

8)        宫荥恢, , 齐甜甜, 李洪林, 朱丽丽*, 赵振江*.二氢乳清酸脱氢酶抑制剂的设计、合成和构效关系研究. 药学学报 Acta Pharmaceutica Sinica 2017, 52 (2): 264 −270.

9)        Xiuqin Hu, Disha Wang, Yi Tong, Linjiang Tong, Xia Wang,Lili Zhu, Hua Xie, Shiliang Li , You Yang, Yufang Xu. Design, Synthesis, and Evaluation of Ribose-Modified Anilinopyrimidine Derivatives as EGFR Tyrosine Kinase Inhibitors. Front Chem. 2017, 15;5:101.

10)     Fangshu Wu,Junsheng Zhu,Honglin Li*, Lili Zhu*. Structural analysis of recombinant human ubiquitin-conjugating enzyme UbcH5c. Acta Pharm Sin B. 2017;7(3):390-394.

11)     Guozhen Wu1, Lili Zhu1, Xing Yuan, Hao Chen, Rui Xiong, Shoude Zhang, Hao Cheng, Yunheng Shen, Huazhang An, Tiejun Li, Honglin Li, Weidong zhang, Britanin ameliorates cerebral ischemia-reperfusion injury by inducing the Nrf2 protective pathway. Antioxid Redox Signal. 2017;27(11):754-768.

12)     Qiao Li, Lina QuanJiankun LyuZenghui HeXia WangJiajia MengZhenjiang ZhaoLili Zhu*Xiaofeng Liu *Honglin Li *. Discovery of peptide inhibitors targeting human programmed death 1(PD-1) receptor. Oncotarget2016;7(40)64967~64976.

13)     Wenlin SongShiliang LiYi TongJiawei WangLina QuanZhuo ChenZhenjiang ZhaoYufang XuLili Zhu*Xuhong Qian *Honglin Li*. Structure-based design of potent human dihydroorotate  dehydrogenase inhibitors as anticancer agents. Medchemcom2016.01.017(7)1441~1448.

14)     Jiawei Wang, Yanyan Diao, Junsheng Zhu, Shiliang Li, Zhenjiang Zhao, Honglin Li *, Lili Zhu *. Biological evaluation of quinoline derivatives as inhibitors of human dihydroorotate dehydrogenase. MedChemComm,  2016, 7(5):853-858.

15)     Yongjia Hao, Xia Wang, Tao Zhang, Deheng Sun,Yi Tong,Yuqiong Xu,Haiyang Chen,Linjiang Tong,Lili Zhu,Zhenjiang Zhao,Zhuo Chen,Jian Ding,Hua Xie,Yufang Xu,Honglin Li, Discovery and Structural Optimization of N5-Substituted 6,7-Dioxo- 6,7-dihydropteridines as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation. J. Med. Chem.2016, 11;59(15):7111-24.

16)     Shiliang Li, Hongling Xu, Shichao Cui,Fangshu Wu, Youli Zhang,Mingbo Su,Yinghui Gong,Shaobing Qiu,Qian Jiao,Chun Qin,Jiwei Shan,Ming Zhang,Jiawei Wang,Qiao Yin, Minghao Xu,Xiaofeng Liu,Rui Wang,Lili Zhu,Jia Li,Yufang Xu,Hualiang Jiang, Zhenjiang Zhao,Jingya Li,and Honglin Li. Discovery and Rational Design of Natural-Product-Derived 2-Phenyl-3,4-dihydro-2H-benzo[f]chromen-3-amine Analogs as Novel and Potent Dipeptidyl Peptidase 4 (DPP-4) Inhibitors for the Treatment of Type 2 Diabetes.J. Med. Chem. 2016, 28;59(14):6772-90.

17)     Shiliang Li1Guoqin Luan1Xiaoli Ren1Wenlin SongLiuxin XuMinghao XuJunsheng ZhuDong DongYanyan DiaoXiaofeng LiuLili ZhuRui WangZhenjiang ZhaoYufang XuHonglin Li(*)Rational Design of Benzylidenehydrazinyl-Substituted Thiazole Derivatives as Potent Inhibitors of Human Dihydroorotate Dehydrogenase with in Vivo Anti-arthritic Activity. Sci Rep. 2015; 5:14836.

18)     Junsheng Zhu, Le Han, Yanyan Diao, Xiaoli Ren, Minghao Xu, Liuxin Xu, Shiliang Li, Qiang Li , Dong Dong, Jin Huang, Xiaofeng Liu, Zhenjiang Zhao, Rui Wang, Lili Zhu*, Yufang Xu, Xuhong Qian *, and Honglin Li*.Design, Synthesis, X-ray Crystallographic Analysis, and Biological Evaluation of Thiazole Derivatives as Potent and Selective Inhibitors of Human Dihydroorotate Dehydrogenase. J. Med. Chem. 2015, 583, 1123-1139.

19)     Liyan Wang, Shoude Zhang, Junsheng Zhu, Lili Zhu, Xiaofeng Liu, Lei Shan, Jin Huang*, Weidong Zhang*, Honglin Li*. Identification of Diverse Natural Products as Falcipain-2 Inhibitors through Structure-based Virtual Screening. Bioorg. Med. Chem. Lett. 2014. 24(5): 1261–1264.

20)     Minghao Xu, Junsheng Zhu, Yanyan Diao, Hongchang Zhou, Xiaoli Ren, Deheng Sun, Jin Huang, Dongmei Han, Zhenjiang Zhao, Lili Zhu*, Yufang Xu*, and Honglin Li*. Novel Selective and Potent Inhibitors of Malaria Parasite Dihydroorotate Dehydrogenase: Discovery and Optimization of Dihydrothiophenone Derivatives. J. Med. Chem., 2013. 56 (20): 7911–7924

21)     Xiaojuan Yu, Xue Zhao, Lili Zhu, Chuanxin Zou, Xiaofeng Liu, Zhenjiang Zhao, Jin Huang* and Honglin Li*. Discovery of novel inhibitors for human farnesyltransferase (hFTase) via structure-based virtual screening. Med. Chem. Commun., 2013. 4: 962-971

22)     Liyan Wang, Chunmei Yang, Weiqiang Lu, Li Liu, Rui Gao, Sha Liao, Lili Zhu, Zhenjiang Zhao, Yufang Xu, Honglin Li*, Jin Huang, Weiping Zhu. Discovery of New Potent Inhibitors for Carbonic Anhydrase IX by Structure-Based Virtual Screening. Bioorg. Med. Chem. Lett.., 2013. 23 : 3496-3499

23)     Yuwei Song, Huangtao Jin, Xiaofeng Liu, Lili Zhu*, Jin Huang*, Honglin Li*. Discovery of non-peptide inhibitors of Plasmepsin II by structure-based virtual screening. Bioorg. Med. Chem. Lett., 2013. 23(7) : 2078-2082

24)     Xianwen Cao, Jing Jiang, Shoude Zhang,Lili Zhu, Juan Zou, Yanyan Diao, Weilie Xiao, Lei Shan, Handong Sun, Weidong Zhang*, Jin Huang*, Honglin Li*. Discovery of Natural Estrogen Receptor Modulators with Structure-based Virtual Screening. Bioorg. Med. Chem. Lett., 2013. 23: 3329-3333

25)     Kunqiang Cui1, Weiqiang Lu1, Lili Zhu1, Xu Shen, Jin Huang. Caffeic acid phenethyl ester (CAPE), an active component of propolis, inhibits Helicobacter pulori peptide deformylase activity. Biochem. Biophys. Res. Commun., 2013. 435(2):289-294.

26)  Lili Zhu, Shyla George, Marco  F.Schmidt, Samer I Al-Gharabli, Jorg Rademann, Rolf Hilgenfeld. Peptide aldehyde  inhibitors challenge the substrate specificity of the SARS-coronavirus main  protease. Antiviral research. 2011, 92 (2)204-216.

27)  Lili Zhu, Cai Yuan, Zhuo Chen,  Wanyu Wang, Mingdong Huang. Expression, purification and characterization of  recombinant Jerdonitin, a P-II class snake venom metalloproteinase comprising  metalloproteinase and disintegrin domains. Toxicon, 2010, 55, 375-380.

28)  Lili Zhu, Feng Yang, Liqing Chen,  Edward J.Meehan, Mingdong Huang. A new drug binding subsite on human serum  albumin and drug-drug interaction studied by X-ray crystallography. Journal of structural biology.2008, 162, 40-49.


网页发布时间: 2018-02-28