张阳 博士 副教授 博士生导师
中共党员，山东 肥城人
电话: 021-64253756
E-mail: zhangyang@ecust.edu.cn
地址：华东理工大学徐汇校区实验十八楼1335室
学术兼职
中国化学会农业化学专业委员会青年委员
皮肤健康产业中国科技联盟（筹）创新工程专业委员会委员
上海市毒理学会理事、青年委员会委员
上海市预防医学会病媒生物预防与控制专业委员会委员
《农药学学报》首届青年编委会副主任、常务青年编委
中国化学会农业化学奖评审委员会秘书（长）
上海市化学化工学会农用化学专委会秘书（长）
教育背景
1. 2011.09–2017.05，华东理工大学，药学院，植物保护，博士，导师：陶黎明 教授
2. 2006.09–2010.06，山东农业大学，生命科学学院，生物工程，工学学士
工作经历
1. 2022.10-至今，华东理工大学，副教授，博士生导师
2. 2021.08-2022.09，华东理工大学，副教授，硕士生导师
3. 2019.09-2021.07，华东理工大学，特聘副研究员，硕士生导师
4. 2017.06-2019.09，华东理工大学，药物化工研究所，博士后，导师：李忠 教授
5. 2011.02-2011.08，山东农业大学，团委，思政辅导员
6. 2010.07-2011.01，山东农业大学，生命科学学院，综合行政
研究方向
1. 农药与环境健康研究：农药的健康效应及其分子机制研究
2. 化妆品功效原料开发：①基于皮肤健康的功效评价策略研究 ②天然产物类功效原料的发现、开发与产业化
科研经历
主持国家重点研发计划子课题2项，其他省部级以上课题6项，企业合作课题多项；先后参与“973计划”项目、“863计划”课题、“十二五”国家科技支撑计划课题、“十三五”国家重点研发计划项目以及上海市科技支撑重点项目的研究工作。2017年至今，在国内外期刊发表研究论文58篇，申请中国发明专利18件，获授权5件，入选上海市青年科技英才，荣获2019年度“全国农药行业优秀通讯员”荣誉称号（全国共19人）等。
招生专业
1. 博士招生
学术型：植物保护（090400）
2. 硕士招生
学硕：植物保护（090400）（农药与环境健康）
专硕：生物与医药（086000）（化妆品功效原料）
发表论文(近三年)
[1]Jian Lu, Weiguo Wang, Cheng Zhang, Wenping Xu, Weidong Chen, Liming Tao, Zhong Li, Jiagao Cheng*, Yang Zhang*. Characterization of glyphosate-induced cardiovascular toxicity and apoptosis in zebrafish embryos. Sci. Total Environ.2022, 851, 158308.
[2]Weiguo Wang, Minkang Feng, Xiaomeng Li, Feiyu Chen, Zhihao Zhang, Wenlong Yang, Chen Shao, Liming Tao, Yang Zhang*. Antibacterial Activity of Aureonuclemycin Produced by Streptomyces aureus Strain SPRI-371. Molecules.2022, 27(15), 5041.
[3]Ruirui Li#, Bin Liu#, Wenping Xu, Lvnan Yu, Cheng Zhang, Jiagao Cheng, Liming Tao, Zhong Li, Yang Zhang*.DNA damage and cell apoptosis induced by fungicide difenoconazole in mouse mononuclear macrophage RAW264.7. Environ Toxicol.2022, 37(3), 650-659.
[4]Ping Zhang, Yandi Li, Wenping Xu, Jiagao Cheng, Cheng Zhang, Jufang Gao, Zhong Li, Liming Tao, Yang Zhang*. Immunotoxicity induced by Ivermectin is associated with NF-κB signaling pathway on macrophages. Chemosphere. 2022,288, 133087
[5]Jian Lu, Weiguo Wang, Wenping Xu, Chenggong Zhang, Cheng Zhang, Liming Tao, Zhong Li, Yang Zhang*. Induction of developmental toxicity and cardiotoxicity in zebrafish embryos by Emamectin benzoate through oxidative stress. Sci. Total Environ. 2022, 825, 154040.
[6]Jian Lu, Yun Yang, Lianhua Zhu, Meng Li, Wenping Xu, Cheng Zhang, Jiagao Cheng, Liming Tao, Zhong Li, Yang Zhang*.Exposure to environmental concentrations of natural pyrethrins induces hepatotoxicity: Assessment in HepG2 cell lines and zebrafish models.Chemosphere. 2022, 288(part 2), 132565.
[7]Xin Wang#, Hongfei Ni#, Wenping Xu, Bing Wu, Te Xie, Cheng Zhang, Jiagao Cheng, Liming Tao, Zhong Li, Yang Zhang*.Difenoconazole induces oxidative DNA damage and mitochondria mediated apoptosis in SH-SY5Y cells.Chemosphere. 2021, 283, 131160.
[8]Meng Li#, Ping Zhang#, Wenping Xu, Jianzhong Yuan, Qingfeng Li, Liming Tao, Zhong Li, Yang Zhang*.Avermectin induces toxic effects in insect nontarget cells involves DNA damage and its associated programmed cell death.Comp. Biochem. Physiol. C: Pharmacol. Toxicol.2021, 249, 109130.
[9]Lin Diao#, Ning Tang#, Cheng Zhang, Jiagao Cheng, Zhenhai Zhang, Siyu Zhang, Can Wu, Lutong Zhang, Liming Tao, Zhong Li, Yang Zhang*.Avermectin induced DNA damage to the apoptosis and autophagy in human lung epithelial A549 cells.Ecotoxicol. Environ. Saf.2021, 215, 112129.
[10]Shuang Han#, Jian Lu#, Jufang Gao, Jiagao Cheng, Wenping Xu, Liming Tao*, Yang Zhang*.Pyraclostrobin induced AMPK/mTOR pathways mediated autophagy in RAW264.7 macrophages.J. Environ Sci. Heal, B.2021, 56(9),793-800.
[11]Nan Zhang#, Lianhua Zhu#, Ruizhi Zhang, Cheng Zhang, Jiagao Cheng, Liming Tao, Yang Zhang*, Wenping Xu*.Evaluation of toxicological effects of organophosphorus pesticide metabolites on human HepG2 cells.Environ.Toxicol. Phar.2021, 88, 103741.
[12]Jian Lu#, Ruirui Li#, Yuansen Chang,Yang Zhang, Nan Zhang, Liming Tao, Wenping Xu*. Effects of different parameters on the removal of atrazine in a water environment by Aspergillus oryzae biosorption.J. Pestic. Sci.2021, 46(2), 214-221.
[13]Wen Fu,Xinyue Hu , Qinglong Yuan, Xujuan Sun, Zhiping Xu, Yang Zhang, Jiagao Cheng, Yonghao Ye, Zhong Li, Xusheng Shao*. XinAzo-incorporating Increases Inhibitory Activity of Succinate Dehydrogenase. J. Agric. Food Chem. 2021, 69(45), 13448-13459.
[14]Zhiping Xu#, Lianhua Zhu#, Yun Yang, Yang Zhang, Miaoqing Lu, Liming Tao, Wenping Xu*.Bifenthrin induces DNA damage and autophagy in Spodoptera frugiperda (Sf9) insect cells. In Vitro &Cell Dev-An.2021, 57(3), 264-271.
[15]Susu Wang, Yang Zhang, Jufang Gao, Jingdi Zhang, Liming Tao, Wenping Xu*.The enantioselective study of the toxicity effects of chiral acetochlor in HepG2 cells.Ecotoxicol. Environ. Saf.2021, 218, 112261.
[16]张锦芳，刘焱，张阳，杨星，刘彬，徐玥，徐文平*. 敌磺钠及其代谢物在茭白中的残留分析及细胞毒性[J].农药，2021,60(2),128-130.
[17]Lei Ding#, Jian Wu#, Ning Tang, Liming Tao, Wenping Xu, Zhou Lu, Yang Zhang*. Antifungal activity of an allicin derivative against Penicillium expansum via induction of oxidative stress. J Basic Microbiol.2020, 60(11-12), 962-970.
[18]Yun Yang#, Yang Zhang#, Jufang Gao, Wenping Xu, Zhiping Xu, Zhong Li, Jiagao Cheng, Liming Tao*.Pyrethrum extract induces oxidative DNA damage and AMPK/mTOR-mediated autophagy in SH-SY5Y cells.Sci. Total Environ.2020, 740, 139925.
[19]Youwu Hao, Yang Zhang, Jiagao Cheng, Wenping Xu, Zhiping Xu, Jufang Gao, Liming Tao*. Adjuvant contributes Roundup's Unexpected Effects on A549 Cells. Environ. Res.2020,184, 109306.
[20]Ping Zhang, Hongfei Ni, Yang Zhang, Wenping Xu, Jufang Gao, Jiagao Cheng, Liming Tao*. Ivermectin confers its cytotoxic effects by inducing AMPK/mTOR-mediated autophagy and DNA damage. Chemosphere. 2020, 259, 127448.
[21]Yang Zhang#, Wei Guo#, Hui Chen, Jufang Gao, Zhiping Xu, Liming Tao, Zhong Li*, Wenping Xu*. Spinetoram confers its cytotoxic effects by inducing AMPK/mTOR-mediated autophagy and oxidative DNA damage. Ecotoxicol. Environ. Saf. 2019, 183, 109480.
[22]Yang Zhang#, Wei Guo#, Hui Chen, Jufang Gao, Liming Tao, Zhong Li*, Wenping Xu*. The cytotoxic effects of spinetoram on human HepG2 cells by inducing DNA damage and mitochondria-associated apoptosis. Food Agric. Immunol. 2019, 30, 1020-1032.
[23]Yang Zhang, Yangyang Fan, Jufang Gao, Wenping Xu, Zhiping Xu, Yutian Liu, Zhong Li*, Liming Tao*. A new 24-membered macrolide shows insecticidal activity against Pieris rapae potentially through induction of programmed cell death. Food Agric. Immunol. 2019, 30, 727-742.
[24]Yang Zhang, Hui Chen, Yangyang Fan, Yun Yang, Jufang Gao, Wenping Xu, Zhiping Xu, Zhong Li*, Liming Tao*.Cytotoxic effects of bio-pesticide spinosad on human lung A549 cells.Chemosphere. 2019, 230, 182-189.
[25]Yangyang Fan#, Yang Zhang#, Yutian Liu, Wenping Xu, Yun Yang, Youwu Hao, Liming Tao*.A natural product enhances apoptosis via mitochondria/caspase-mediated pathway in Hela cells.J. Cell Biochem. 2019, 120(10), 16811-16823.
[26]Youwu Hao#, Yang Zhang#, Hongfei Ni, Jufang Gao, Yun Yang, Wenping Xu, Liming Tao*.Evaluation of the cytotoxic effects of glyphosate herbicides in human liver, lung and nerve. J. Environ Sci. Heal, B. 2019, 54(9), 737-744.
[27]Youwu Hao#, Yang Zhang#, Wenping Xu, Jufang Gao, Liming Tao*. Synergistic effects of adjuvant A-134 on the herbicidal effects of glyphosate. J. Pestic. Sci.2019,44(4), 249-254.
[28]Ping Zhang, Yang Zhang, Kuikui Liu, Bin Liu, Wenping Xu, Jufang Gao, Lei Ding, Liming Tao*. Ivermectin induces cell cycle arrest and apoptosis of HeLa cells via mitochondrial pathway. Cell Proliferat. 2019, 52(2), e12543.
[29]Youwu Hao, Wenping Xu, Jufang Gao, Yang Zhang, Yun Yang, Liming Tao*. Roundup® induced AMPK/mTOR mediated autophagy in human A549 cells. J. Agric. Food Chem.2019, 67, 11364-11372.
[30]Youwu Hao, Nan Zhang, Wenping Xu, Jufang Gao, Yang Zhang, Liming Tao*. A natural adjuvant shows the ability to improve the effectiveness of glyphosate application. J. Pestic. Sci.2019,44(2), 106-111.
[31]Youwu Hao, Hui Chen, Wenping Xu, Jufang Gao, Yun Yang, Yang Zhang, Liming Tao*. Roundup® confers cytotoxicity through DNA damage and Mitochondria-Associated apoptosis induction. Environ. Pollut. 2019,252A, 917-923.
[32]Haijing Cao, Wenjing Liu, Yuansen Chang, Hui Chen, Yang Zhang, Wenping Xu, Liming Tao*. 5′-Epi-SPA-6952A, a new insecticidal 24-membered macrolide produced by Streptomyces diastatochromogenes SSPRC-11339. Nat. Prod. Res. 2019, 33(5),659-664.