马磊
发布人: 发布时间: 2016-09-18 作者: 访问次数: 9192

 

 马磊 副教授 硕导

电话: 021-64253691
传真: 021-64253691
E-mail:
malei@ecust.edu.cn
通讯地址:上海市梅陇路130号华东理工大学318信箱
邮编:200237

  

一.简历

马磊,男,1979年生,河南辉县人,中共党员,上海市“浦江人才”,药学实验教学中心主任,教育部学位中心评审专家,上海市药学会会员,执业药师。20076月毕业于中国药科大学药物化学专业,获理学博士学位,期间在中科院上海药物研究所联合培养。20078月,应聘为华东理工大学药学院讲师,20109月晋升为副教授,硕士研究生导师。20125-20135月在美国西北大学化学系Silverman教授和Mirkin教授课题组从事神经系统类疾病的药物合成和DNA纳米载药系统的研发工作。20158-20168月在苏州吴中东太湖科技金融城管理局任副局长(挂职),负责人才引进和产学研对接工作。目前在Journal of Medicinal ChemistryBioorganic & Medicinal Chemistry (Letters)PhytochemistryPlanta Medica等杂志发表论文50余篇,申请国家专利5项。科研基金方面,目前作为负责人承担国家自然科学青年及面上基金,上海市支撑计划,上海市浦江人才计划,上海市联盟计划以及中央高校基本科研业务费等国家和上海市项目多项。本课题组致力于基于天然产物的新药开发工作,近年来成果显著,一个新药项目以上千万的价值实现转让、数个药物候选物正在与研发型的制药企业商讨开发事宜,发现多个有苗头的化合物并正在开展进一步的新药开发工作。

【研究兴趣】

²  天然产物基于活性和ADME-Tox的结构优化和全合成及新药开发工作

²  中药作用的物质基础及其作用机制阐明

²  纳米载药系统在药物研发中的应用

²  有机合成方法学及药物合成工艺研究

【研究疾病领域】

²  神经退行性疾病

²  多药耐药癌症

²  抗病原微生物

【课程】

²  本科生:天然药物化学、生药学、药物合成实验、制药工艺实验。

²  研究生:药物波谱解析、药学导论、中药学研究进展。

【荣誉及社会兼职】

²  上海市浦江人才(2015

²  上海市药学会中药专业委员会委员(2015

²  教育部学位中心评审专家(2014

²  苏州国际精英创业周评审专家(2016

²  114产学研专家(2016

²  华东理工大学优秀班导师(2010

²  华东理工大学研究生课程优秀任课教师二等奖(2016

²  BMCBMCLTTL、化学教育等国内外杂志通讯评议人

 

本课题组热忱欢迎有志于药物化学、天然药物化学以及新药开发领域研究的学生加入!!

 

二.论文专利及项目情况

【专利】

1.        专利名称:知母皂苷元结构修饰的衍生物、其药物组合物及其应用;发明人:马磊,王蕊,周南南,徐婷,赵建宏,张骥、张忠国,徐刘昕,杨雅琴,熊加伟,尹欢欢,潘辉;申请时间:2015.01.28;申请号:201510042229.6;范围:国内。

2.        专利名称:β-芳香基硫醚取代的α,β-环烯酮衍生物及其制备方法和应用;发明人:郑剑斌、李佳、周宇波、马磊、彭延敏、曹现超;申请时间:2014.10.10;申请号:201410531378.4;范围:国内。

3.        专利名称:一种分离富集并同时检测饮用水源水中12种抗生素的方法; 发明人:崔长征,张东,程文欢,卢宁,马磊,姜蕾,林匡飞,孙晓燕,石杰,薛佳怡,金磊,李志杰,黄玲;申请时间:2014.12.08;申请号:201410735911.9;范围:国内。

4.        专利名称:含Withanolide型化合物的免疫抑制剂;发明人:马磊、刘建文、胡立宏、孙丽娟、于有军;申请时间:2007.11.2;申 号:200710047733.0;范围:国内。CN101422467

5.        专利名称:线型呋喃香豆素衍生物、其制备方法和用途以及包含该衍生物的药物组合物;发明人:胡立宏、沈旭、蒋华良、张余、马磊;申请时间:2007.05.16;申 号:200710040733.8;范围:国内。CN101307056

Natural Medicinal Chemistry

6.        Peng Liu, Xing Xu, Lili Chen, Lei Ma, Xu Shen, Lihong Hu*, Discovery and SAR study of hydroxyacetophenone derivatives as potent, non-steroidal farnesoid X receptor (FXR) antagonists. Bioorganic & Medicinal Chemistry, 2014, 22, 1596-1607.

7.        Guoping Hu, Xi Li, Xuan Zhang, Yaozong Li, Lei Ma, Liumeng Yang, Guixia Liu, Weihua Li, Jin Huang, Xu Shen, Lihong Hu, Yongtang Zheng, Yun Tang* Discovery of Inhibitors To Block Iteractions of HIV-1 Integrase with Human LEDGF/p75 via Structure-Based Virtual Screening and Bioassays, Journal of Medicinal Chemistry, 2012, 55, 10108-10117.

8.        Weibin Song, Lingjun Hu, Yuhui Meng, Lei Ma, Dean Guo, Xuan Liu, Lihong Hu* The effect of vindoline C-16 substituents on the biomimetic coupling reaction: Synthesis and cytotoxicity evaluation of the corresponding vinorelbine analogues, Bioorganic & Medicinal Chemistry Letters, 2012, 22, 3485–3487.

9.        Lixia Pei, Yuanwu Bao, Lei Ma, Qiqi Wang, Yiyi Ye, Xianghui Han, Sheng Liu*, Xiuping Chen*, A Sensitive Method for Determination of Platycodin D in Rat Plasma Using Liquid Chromatography/Tandem Mass Spectrometry and its Application to a Pharmacokinetic Study, Planta Medica, 2012, 78, 244-251.

10.    Xubing Chen, Jingjing Zhuang, Junhua Liu, Min Lei, Lei Ma, Jing Chen, Xu Shen, Lihong Hu*, Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle. Bioorganic & Medicinal Chemistry 2011, 19 5776–5781

11.    Lei Ma, Zhengyi Yang, Chenjing Li, Zhiyuan Zhu, Xu Shen, Lihong Hu* Design, synthesis and SAR study of hydroxychalcone inhibitors of human b-secretase (BACE1). Journal of Enzyme Inhibition and Medicinal Chemistry 2011, 26 643-648.

12.    Lijuan Sun, Jianwen Liu*, Ping Liu*, Youjun Yu, Lei Ma, Lihong Hu Immunosuppression effect of Withangulatin A from Physalis angulata via heme oxygenase 1-dependent pathways. Process Biochemistry 2011, 46, 482-488.

13.    Lijuan Sun, Jianwen Liu,* Daling Cui, Jiyu Li,* Youjun Yu, Lei Ma, Lihong Hu. Anti-Inflammatory Function of Withangulatin A by Targeted Inhibiting COX-2 Expression via MAPK and NF-kB Pathways. Journal of Cellular Biochemistry 2010, 109, 532–541.

14.    Youjun Yu, Lijuan Sun, Lei Ma, Jiyu Li, Lihong Hu, Jianwen Liu*. Investigation of the immunosuppressive activity of Physalin H on T lymphocytes. International immunopharmacology, 2010, 10, 290-297.

Phytochemistry

15.    Wenhuan Cheng, Lei Jiang, Ning Lu, Lei Ma, Xiaoyan Sun, Yi Luo, Kuangfei Lin Changzheng Cui* Development of a method for trace level determination of antibiotics in drinking water sources by high performance liquid chromatography-tandem mass spectrometry. Analytical Methods, 2015, 7, 1777-1787.

16.    Pham Van Khang, Ting Xu, Liuxin Xu, Nannan Zhou, Lihong Hu, Rui Wang*, Lei Ma* Steroidal glycosides from Marsdenia tenacissima. Phytochemistry Letters, 2015, 12, 54-58.

17.    Yongmei Zhou, Xianming Shi, Lei Ma, Sifang Zhang*, Isolation and identification of Withaphysalins from Physalis minima. Journal of China Pharmaceutical University, 2015, 46, 62-65.

18.    Khangvan Pham, Zhongguo Zhang, Yuhui Meng, Dean Guo, Xuan Liu, Lihong Hu*, Lei Ma*. Cardenolides from the bark of Calotropis gigantea. Natural Product Research, 2014, 28, 1191-1196.

19.    Changzheng Cui, Lei Ma, Jie Shi, kuangfei Lin, Qishi Luo, Yongdi Liu*, Metabolic pathway for degradation of anthracene by halophilicMartelella sp. AD-3. International Biodeterioration & Biodegradation, 2014, 89, 67-73.

20.    Wenjuan Xiang, Qiqi Wang, Lei Ma*, Lihong Hu* β-Orcinol-type depsides from the lichen Thamnolia vermicularis, Natural Product Research, 2013, 27, 804-808.

21.    Junhua Liu, Abdul Latif, Mumtaz Ali, Guiping Zhang, Wenjuan Xiang, Lei Ma, Mohammad Arfan*, Lihong Hu*, Diterpenoids from Euphorbia neriifolia, Phytochemistry, 2012, 75, 153-158.

22.    Lei Ma, Wenjuan Xiang, Pham Van Khang, Yang Liang, Yaping Xiao*, Lihong Hu*, New dammarane-type glycosides from the roots of Gynostemma pentaphyllum, Planta Medica, 2012, 78, 597-605.

23.    Wenjuan Xiang, Lei Ma*, Lihong Hu*. Neolignans and flavonoids from the root bark of Illicium henryi. Fitoterapia, 2010, 81, 1228-1231.

24.    Wenjuan Xiang, Chunyu Guo, Lei Ma*, Lihong Hu*. Dammarane-type Glycosides and Long chain Sesquiterpene Glycosides from Gynostemma yixingense. Fitoterapia, 2010, 81, 248-252.

25.    Wenjuan Xiang, Lei Ma*, Lihong Hu*. C21 Steroidal Glycosides from Cynanchum wilfordii. Helvetica Chimica Acta. 2009, 92, 2659-2674. 

26.    Haigang Liu, Xiong Huang, Guanghui Xie, Lei Ma*, Lihong Hu*. One New C21 Steroidal Glycoside from the Roots of Cynanchum auriculatum. Journal of China Pharmaceutical University, 2009, 40, 34-36.

27.    Chaofeng Huang, Lei Ma (co-first author), Lijuan Sun, Mumtaz Ali, Mohammad Arfan, Jianwen Liu*, Lihong Hu*. Immunosuppressive Withanolides from Withania coagulans, Chemistry & Biodiversity, 2009, 6, 1415-1426.

28.    Xianwen Gan, Lei Ma, Qigang Chen, Qiuqun Chen, Qiang Yu, Lihong Hu*. Terpenoids from Roots of Chloranthus henryi. Planta Medica, 2009, 75, 1344–1348.

29.    Hao Gan, Wenjuan Xiang, Lei Ma*, Lihong Hu*. Six New C21 Steroidal Glycosides from Cynanchum bungei Decne, Helvetica Chimica Acta, 2008, 91, 2222-2234.

30.    Yinhua Yin, Lei Ma (co-first author), Lihong Hu*. Cassane-Type Diterpenoids from the Seeds of Caesalpinia magnifoliolata, Helvetica Chimica Acta, 2008, 91, 972-977.

31.    Chaofeng Huang, Xianwen Gan, Haiyun Bai, Lei Ma, Lihong Hu*. Schoepfin A, B, C: three new chalcone C-glycosides from Schoepfia chinensis. Natural Product Research, 2008, 22, 623-627

32.    Lili Wang, Jianping Zuo, Lei Ma, Xiachang Wang and Lihong Hu*. Two New Xanthone Glycosides from Ventilago leiocarpa Benth. Natural Product Communications, 2008, 3, 795-798.

33.    Lei Ma, Xianwen Gan, Qingping He, Haiyun Bai, Mohammad Arfan, Fengchang Lou, Lihong Hu*. Cytotoxic withaphysalin from Physalis minima. Helvetica Chimica Acta, 2007, 90, 1406-1419.

34.    Lei Ma, Mumtaz Ali, Mohammad Arfan, Li-Guang Lou, and Li-Hong Hu*. Withaphysanolide A, a novel C-27 norwithanolide skeleton, and other cytotoxic compounds from Physalis divericata. Tetrahedron Letters 2007, 48, 449-452.

35.    Guanghui xie, Lei Ma, Zongping Zheng, Lihong Hu*. Lignana from Gardneria multiflora. Chin. J. Nat. Med., 2007, 5, 255-258.

36.    Qingping He, Lei Ma, Jieying Luo, Fuyuan He, Liguang Lou, Lihong Hu*. Cytotoxic Withanolides from Physalis angulata L. Chemistry & Biodiversity, 2007, 4, 443-449.

37.    Lei Ma, Fengchang Lou*. The Anticancer Activity in vitro of Constituents from Fruits of Sophora japonica. Chin. J. Nat. Med., 2006, 4, 151-153.

38.    Lei Ma, Chuanming Xie, Jia Li, Feng-Chang Lou, Lihong Hu*. Daturametelins H, I and J: Three New Withanolide Glycosides from Datura metel L. Chemistry & Biodiversity, 2006, 3, 180-186.

39.    Xianwen Gan, Haiyun Bai, Qigang Chen, Lei Ma, Lihong Hu*. A Zwitterionic Alkaloid, Containing a Rare Cyclopentadienyl Anion Unit, from the Stem Barks of Daphniphyllum macropodum. Chemistry & Biodiversity, 2006, 3, 1255-1259.

40.    Dongmei Li, Lei Ma, Guangming Liu, Lihong Hu*. Cassane Diterpene-lactones from the Seed of Caesalpinia minax Hance. Chemistry & Biodiversity, 2006, 3, 1260-1265.

Total Synthesis of Natural Products & Synthesis Methodology

41.    Yaqin Yang, Songlan Ge, Lei Ma*. Synthesis of Tetrahydrocarbazole Derivatives Using Thiamine Hydrochloride (VB1) as Efficient Catalyst, Journal of East China University of Science and Technology, 2016, 42, 499-507.

42.    Jianhong Zhao, Ting Xu, Lei Ma*, Synthesis of Apatinib Mesylate, Chinese Journal of Pharmaceuticals, 2015, 46, 449-452

43.    Fei Ma, Lei Ma, Min Lei, Lihong Hu* Synthesis of 1,2-disubstituted 1,2-dihydropyrrolo[3,4-b]indol-3(4H)-one derivatives Monatshefte für Chemie 2014, 145, 1035-1041.

44.    Khangvan Pham, Zhongguo Zhang, Sida Shen, Lei Ma*, Lihong Hu* A one-pot synthesis of isoindolin-1-imine derivatives, Tetrahedron, 2013, 69, 10933-10939.

45.    Min Lei, Lei Ma*, Lihong Hu*. One-Pot Synthesis of 1H-Benzimidazole Derivatives Using Thiamine Hydrochloride as a Reusable Organocatalyst, Synthetic Communications, 2012, 42, 2981-2993.

46.    Weibin Song, Peng Liu, Min Lei, Hanyun You, Xubing Chen, Hu Chen, Lei Ma*, Lihong Hu*. FeCl3 and Morpholine as an Efficient Co-Catalyst for the One-Step Synthesis of Quinoxalines From α-Hydroxyketones and 1,2-Diamines. Synthetic Communications, 2012, 42, 236-245.

47.    Kun Zhao, Min Lei, Lei Ma, Lihong Hu* A facile protocol for the synthesis of 4-aryl-1,4,7,8-tetrahydro-3,5-dimethyldipyrazolo[3,4-b:4’,3’-e]pyridine derivatives by a Hantzsch-type reaction. Monatshefte für Chemie 2011, 142, 1169-1173.

48.    Min Lei, Lei Ma*, Lihong Hu*. Highly Chemoselective Condensation of β-Naphthol, Aldehyde, and Urea Catalyzed by Thiamine Hydrochloride. Synthetic Communications, 2011, 41, 3424-3432.

49.    Weibin Song, Lei Ma*, Lihong Hu*. HClO4-SiO2 as an Efficient and Recyclable Catalyst for the Synthesis of Amide Derivatives. Synthetic Communications, 2011, 41, 3186-3196.

50.    Min Lei, Lei Ma*, Lihong Hu*. Cu(ClO4)2 · 6H2O as an Efficient Catalyst for the Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Under Solvent-Free Conditions. Synthetic Communications, 2011, 41, 3071-3077.

51.    Peng Liu, Min Lei, Lei Ma,* Lihong Hu* An Efficient Procedure for the Synthesis of 2-Aminofuran-3-Carbonitriles via Cascade Stetter-Cyclization Reaction Catalyzed by N-Heterocyclic Carbene. SYNLETT 2011, 1133-1136.

52.    Min Lei, Lei Ma*, Lihong Hu*. A green, efficient, and rapid procedure for the synthesis of 2-amino-3-cyano-1,4,5,6-tetrahydropyrano[3,2-c]quinolin-5-one derivatives catalyzed by ammonium acetate Tetrahedron Letters, 2011, 52, 2597-2600.

53.    Min Lei, Lei Ma*, Lihong Hu*. Thiamine Hydrochloride-Catalyzed One-Pot Synthesis of 1,4-Dihydropyridine Derivatives Under Solvent-Free Conditions. Synthetic Communications, 2011, 41, 1969-1976.

54.    Min Lei, Lei Ma*, Lihong Hu*. VB1-Al2O3 catalyzed one-pot condensation of aromatic ketone, aromatic aldehyde and amide Tetrahedron Letters, 2010, 51, 5746-5749.

55.    Min Lei, Lei Ma*, Lihong Hu*. An efficient and environmentally friendly procedure for synthesis of pyrimidinone derivatives by use of a Biginelli-type reaction. Monatshefte für Chemie 2010, 141, 1005-1008.

56.    Min Lei, Lei Ma*, Lihong Hu*. A Convenient One-pot Synthesis of Formamide Derivatives Using Thiamine Hydrochloride as a Novel Catalyst. Tetrahedron Letters, 2010, 51, 4186-4188.

57.    Min Lei, Lei Ma*, Lihong Hu*. Thiamine Hydrochloride as an Efficient Catalyst for the Synthesis of Amidoalkyl Naphthols. Tetrahedron Letters 2009, 50, 6393-6397.

58.    Yinan Zhang, Shilei Zhang, Lei Ma, Yu Zhang, Xu Shen, Wei Wang, Lihong Hu*. Total Synthesis of (+)-Rutamarin. Advanced Synthesis & Catalysis, 2008, 350, 2373-2379.

【教学论文及专著】

59.    马磊,胡立宏. 生源合成途径在天然药物化学教学中的重要性探讨. 化工高等教育2010, 3, 82-84+96.

60.    马磊,胡立宏. 天然药物化学实验,药学专业实验教程,华东理工大学出版社,201095114.

【承担项目】

v  国家自然科学基金面上项目:(81673318)“逆转癌症多药耐药天然产物的计算机辅助结构优化及构效关系研究”,执行年限:2017.1-2020.12,承担类别:项目负责人。

v  上海市科技创新行动计划生物医药支撑计划项目(15401901100):中药知母中知母皂苷元的结构优化及抗AD成药性研究。执行年限:2015.92018.8,承担类别:项目负责人。

v  上海市浦江人才计划项目(15PJD012):计算机辅助逆转癌症多药耐药天然产物的发现与新药开发。执行年限:2015.92017.8,承担类别:项目负责人。

v  上海市自然科学基金年项目(15ZR1408800):绞股蓝皂苷元的结构优化及其逆转多药耐药的构效关系研究执行年限:2015.12017.12,承担类别:项目负责人;

v  中央高校基本科研业务费专项资金项目:计算机辅助逆转癌症多药耐药先导化合物的发现及构效关系研究执行年限:2015.12016.12,承担类别:项目负责人;

v   国家自然科学基金项目:(21002027)“天然PPM1A激动剂的发现及抗肝纤维化的构效关系研究”,执行年限:2011.12013.12,承担类别:项目负责人;

v  艾滋病和病毒性肝炎等重大传染病防治科技重大专项:基于已知Aurora抑制剂结构设计的13个新改造化合物的抗肿瘤活性评价。承担类别:主要参与者。

v  上海市联盟计划难题招标专项:高纯度明月草查尔酮提取工艺研究,执行年限:2010.6-2011.5,承担类别:项目负责人;

v  中央高校基本科研业务费专项资金项目:新型非甾体FXR拮抗剂的发现及构效关系研究 执行年限:2012.12013.12,承担类别:项目负责人;

v  上海市优秀青年教师专项基金“Withanolide型化合物免疫抑制活性研究执行年限:2008.1-2009.12,承担类别:项目负责人;

v  国家科技重大专项:国家重大新药创制新长春碱类抗肿瘤药物候选物F-XA7的临床前研究执行年限:2009.1-2010.12,承担类别:主要参加者;

v  111计划:几种重要的神经退行性疾病相关蛋白酶抑制剂的发现,执行年限:2009.5-2011.12,承担类别:主要参加者;

 

本实验室毕业研究生去向:

 

谢光辉(硕) 郑州工程技术学院

  敏 (博) 中科院上海药物研究所

宋维彬(博) 中科院上海药物研究所

陈旭冰(硕) 大理大学

沈思达(博) 美国伊利诺伊大学芝加哥分校

程文欢(硕) 昆泰企业管理(上海)有限公司

向文娟(博) 芬美意香料(中国)有限公司

孙晓燕(硕) 益新国际医药科技有限公司

王琦琦(硕) 和记黄埔医药上海有限公司

  浩 (硕) 天津红日药业股份有限公司

  虎 (博) 浙江越甲药业有限公司

刘军华(博) 广东众生药业股份有限公司

  婷 (硕) 江苏豪森药业集团有限公司

刘海港(硕) 上海恒瑞医药有限公司

  鹏 (博) 上海合全药物研发有限公司

尤晗昀(博) 浙江普洛康裕制药有限公司

张忠国(硕) 瑞阳(上海)新药研发有限公司

郭春雨(硕) 北京峨兰斯科技有限公司

杨雅琴(硕) 四川科伦药业股份有限公司

陆瑶琦(硕) 药明康德新药开发有限公司