李 忠
发布人: 发布时间: 2008-12-04 作者: 访问次数: 18163

 

李忠   教授

 

Tel: 021-64253540; Fax: 021-64252603; E-mail: lizhong@ecust.edu.cn

 

 

 

 

个人简介   


 

  李忠:博士,教授,博士生导师,教育部新世纪优秀人才,上海市优秀学科带头人。19687月出生。1990年获华东理工大学应用化学专业工学学士学位,1993年获华东理工大学物理化学专业理学硕士学位,1996年获华东理工大学精细化工专业工学博士学位。1995年在华东理工大学留校工作,1998年被聘为副教授,2003年被聘为教授,2004年被聘为博士生导师。期间于19992001年,获得日本国立AISTITIT博士后基金资助,在日本工业技术研究院从事博士后研究。现任华东理工大学药物化工研究所所长,国家863”现代农业领域重大项目总体专家,中国农药学会理事,上海市农药学会秘书长,宝钢化工集团科技咨询专家。2004年获得教育部科技进步一等奖(第五完成人),2005年获得上海市曙光学者人才2006年获得上海市科教党委青年科技创新人才奖,2007年获得教育部新世纪优秀人才2009年获上海市优秀学科带头人。

在国际重要学术刊物(如J. Am. Chem. Soc.; J. Org. Chem.; Org. Lett.; J. Agri. Food Chem.; Tetrahedron Lett.; Bioorg. Med. Chem.; Bioorg. Med. Chem. Lett.; SYNLETT; J. Fluorine Chem.; New J. of Chem.等)发表学术论文三十余篇。作为课题负责人,先后主持国家“863”高科技攻关项目两项,国家自然科学基金两项;作为课题副组长承担国家“973”计划项目一项;此外,还主持了多个上海市科委重大攻关及重点攻关项目。

近年来,主要从事绿色化学农药分子设计及合成的研究,并在顺式硝基烯类新烟碱杀虫剂创制研究方面取得突破性进展,发现了三类具有全新结构的超高活性化合物,活性显著超越目前最著名的杀虫剂品种吡虫啉,并对抗性品系超高效。申请国际PCT发明专利3项,中国发明专利7项(2项已获授权),相关专利化合物的国内实施许可权已经以2000万人民币的价格转让给江苏克胜集团。

 

   

 

 研究方向


 

1)昆虫行为调控剂的分子设计、合成及作用机制研究

主要包含:昆虫生长调节剂、昆虫飞行调控剂、新烟碱杀虫剂等绿色农药的创制研究;

2)含硒化合物的设计合成及生物性能研究

主要包含:含硒除草剂、含硒植物生长调节剂的创制及生物性能研究

 

 

 获奖情况


 

2009:上海市优秀学科带头人

2007(1)教育部新世纪优秀人才;(2)科创杯上海高校学生创造发明奖一等奖(第一指导老师)

2006(1)上海市教委曙光学者人才;(2) 第一届上海市科教党委系统青年科技创新人才奖

2005年:第四届徐汇区徐光启奖银奖

 

 

2007年-今代表性论著 


 

 

1.        Feng Fan, Jiagao Cheng, Zhong Li*, Xiaoyong Xu, Xuhong Qian*. “Novel dimer based descriptors with solvational computation for QSAR study of oxadiazoylbenzoyl-ureas as novel isect-growth regulators”. Journal of Computational Chemistry. 2009, published online, DOI: 10.1002/jcc.2135

2.        Feng Fan, Zhiqi You, Zhong Li*, Jiagao Cheng, Yun Tang, Zhenhua Tang. “A Butterfly Effect: Highly Insecticidal Resistance Caused by Only a Conservative Residue Mutated of Drosophila Melanogaster Acetylcholinesterase”. Journal of Molecular Modeling, 2009, 15, 1229-1236

3.        Xusheng Shao, Zhong Li*, Xuhong Qian, Xiaoyong Xu*. “Design, Synthesis, and Insecticidal Activities of Novel Analogues of Neonicotinoids: Replacement of Nitromethylene with Nitroconjugated System”. J. Agric. Food Chem. 2009, 57, 951–957

4.        Xusheng Shao, Wenwen Zhang, Yanqing Peng, Zhong Li*, Zhongzhen Tian, Xuhong Qian *, “cis-Nitromethylene neonicotinoids as new nicotinic family: Synthesis, structural diversity, and insecticidal evaluation of hexahydroimidazo[1,2-a]pyridine”, Bioorg. Med. Chem. Lett., 2008, 18, 6513-6516.

5.        Xiaobao Yang, Hongbin Zhai,* Zhong Li*, “Enantiocontrolled Synthesis of (-)-9-epi- Pentazocine and (-)-Aphanorphine”. Org. Lett., 2008, 10 , 2457–2460.

6.        Xiaobao Yang, Li Zhu,Yuedong Zhou, Zhong Li*, Hongbin Zhai*, “Efficient Synthesis of Monosubstituted 3-Alkynylfurans via Suzuki Coupling”, Synthesis, 2008, (No.11), 1729–1732.

7.        Xiaobao Yang, Bin Cheng, Zhong Li*, Hongbin Zhai*, “Formal Asymmetric Synthesis of (–)-Aphanorphine via Ring- Closing Metathesis Reaction”, SYNLETT, 2008, (No.18), 2821-2822.

8.        Shaoyong Ke, Zhong Li, Xuhong Qian*, “1,3,4-Oxadiazole-3(2H)- carboxamide derivatives as potential novel class of monoamine oxidase (MAO) inhibitors: Synthesis, evaluation, and role of urea moiety”. Bioorg. Med. Chem., 2008, 16, 7565–7572.

9.        Chuanxiang Liu, Xuhong Qian,* Guangqiang Sun, Liwei Zhao and Zhong Li*, Chromogenic and fluorescent chemodosimeter for fluoride ion based on novel anion-catalyzed intramolecular hydrogen transfer, New J. Chem., 2008, 32, 472-476.

10.    Chuanxiang Liu, Xuhong Qian*, Jiaobing Wang, Zhong Li*, Anion recognition by a novel Fipronil-based receptor: efficient deprotonation or stable intermolecular hydrogen bonding, Tetrahedron Lett., 2008, 49, 1087-1090.

11.    Ming-Yi Cai, Zhong Li*, Qingchun Huang, and Gonghua Song* “{[1-(Arylmethyl) piperidin-4-yl]oxy} -(trifluoromethyl)- pyridines: Ketanserin Analogues with Insect Growth Regulating Activity” Chem. Biodivers, 2008, 1844-1855.

12.    Yanli Wang, Jiagao Cheng, Xuhong Qian*, Zhong Li*. “Actions between neonicotinoids and key residues of insect nAChR based on an ab initio quantum chemistry study: Hydrogen bonding and cooperative ππ interaction”. Bioorgan. Med.Chem. 2007, 15, 2624-2630.

13.    Feng Fan, Zhong Li*, Xiaoyong Xu, Xuhong Qian*. “Quantitative Aggregation- Activity Relationship (QAAR): Supermolecular view, dimer as the simplest aggregation state and monomolecule.” QSAR & Combinatorial Science, 2007, 26, 737-743.

14.    Zhongzhen Tian, Zhaoxing Jiang, Zhong Li*, Gonghua Song*, Qingchun. Huang. “Syntheses and Biological Activities of octahydro-1H-cyclopenta[d] pyrimidine derivatives”. J. Agric. Food Chem., 2007, 55, 143-147.

15.    ZhongzhenTian, Xusheng Shao, Zhong Li*, Xuhong Qian*, Qingchun Huang, “Synthesis, Insecticidal Activity, and QSAR of Novel Nitromethylene Neonicotinoids with Tetrahydropyridine Fixed cis Configuration and Exo-Ring Ether Modification”, J. Agric. Food Chem., 2007, 55,  2288-2292.