中文 | English
 
黄青春

 黄青春  博士,教授    

 

 个人简介 
  ********************
******       

        黄青春博士,教授。2001年毕业于南京农业大学植保学院获博士学位,同年进入华东理工大学工作至今。2003年-2007年国家南方农药创制中心(上海)药效部主管,2011-2012美国Purdue大学访问学者。现为中国生物化学与分子生物学会会员,上海市毒理学会理事,上海市昆虫学会会员

    主要从事农药毒理及新药研究,包括农业昆虫和植物病原生物学、有害生物的化学防治等方面的研究。承担和参与了国家自然科学基金项目、国家重点基础研发项目、国家科技支撑计划项目、上海市科技攻关重点和重大项目等研究。目前在J Agric Food ChemPest Manag SciPestic Biochem PhysiolJ Insect SciChemosphereEcotoxic Environ Saf、昆虫学报、农药学学报等国内外期刊发表学术论文70余篇,获得授权或公开的发明专利近20项曾获得教育部自然科学一等奖1项,华东理工大学先进工作者称号。

 

研究方向 
**************************        

方向一:农药毒理病虫害化学防治开展生物农药或化学农药的高效筛选和作用机制及其在病原菌和害虫体内的代谢与转化行为等研究,主要探明天然源生物农药的病虫害防治与应用技术。


方向二:新药研究。开展新型小分子活性药物的制备及衍生,通过化合物结构修饰与构效关系研究,及其对细胞发育与凋亡调控等研究,探明活性药物在农药或医药方面的潜在应用。 

 

发表的部分研究论文
************************** 

[1] Zhang L, Rao W, Muhayimana S, Zhang X, Xu J, Xiao C, Huang Q*. Purification and biochemical characterization of a novel transglutaminase from Mythimna separata larvae (Noctuidae, Lepidoptera). J. Biotech. 2018, 265: 1-7.

[2] Xiao C, Luan S, Xu Z, Lang J, Rao W, Huang Q*. Tolerance potential of Chilo suppressalis larvae to fipronil exposure via the modulation of detoxification and GABA responses. J. Asia Pac. Entomol. 2017, 20: 1287-1293.

[3] Yun X, Huang Q*, Rao W, Xiao C, Zang T, Mao Z, Wan Z. A comparative assessment of cytotoxicity of commonly used agricultural insecticides to human and insect cells. Ecotox. Environ. Safe. 2017, 137: 179-185.

[4] Luan S,Rao W, Yun X, Xiao C, Xu Z,Lang J, Huang Q*. Emamectin benzoate induces ROS-mediated DNA damage and apoptosis in Trichoplusia Tn5B1-4 cells. Chem. Biol. Interact. 2017, 273: 90-98.

[5] Huang Q*,Yun X, Rao W, Xiao C. Antioxidative cellular response of lepidopteranovariancells to photoactivated alpha-terthienyl. Pestic. Biochem. Physiol. 2017, 137: 1-7.

[6] Yun X, Rao W, Xiao C, Huang Q*. Apoptosis of leukemia K562 and Molt-4 cells induced by emamectin benzoate involving mitochondrial membrane potential loss and intracellular Ca2+ modulation. Environ. Toxicol. Pharm. 2017, 52: 280-287.

[6] Huang Q*, Zhang L, Yang C, Yun X, He Y. The competence of hemocyte immunity in the armyworm Mythimna separata larvae to sublethal hexaflumuron exposure. Pestic. Biochem.Physiol. 2016, 130: 31-38.

[7]  Wu X, Zhang L, Yang C, Zong M, HuangQ*, et al. Detection on emamectin benzoate-induced apoptosis and DNA damage in Spodoptera frugiperda Sf9 cell line. Pestic Biochem  Physiol 2016, 126: 6-12. 

[8] Liu P, Shu C, Liu L, Huang Q, Peng Y. Design and synthesis of thiourea derivatives with sulfur-containing heterocyclic scaffolds as potential tyrosinase inhibitors. Bioorg Med Chem 2016, 24: 1866-1871.

[9] Huang Q*,  Wu X, Yu X, et al. Suppression of carbendazim-susceptible and -resistant Sclerotinia sclerotiorum with Macleya alkaloids. Arch Phytopathol Plant Prot 2015, 48(6): 485-494.

[10] Li D, Huang Q*,  Lu M, Zhang L, et al. The organophosphate insecticide chlorpyrifos confers its genotoxic effects by inducing DNA damage and cell apoptosis. Chemosphere 2015, 135: 387-393. 

[11] Li D, Wu X, Yu X, Huang Q*, et al. Synergistic effect of nonionic surfactants Tween 80 and PEG6000 on cytotoxicity of insecticides. Environ Toxicol Pharmacol 2015, 39: 677–682. 

[12] Huang Q*, Wu X, Yu X, Zhang L, et al. Comparison of the cytotoxic impact of chlorfluazuron on selected insect and human cell lines. Environ Toxicol Chem 2015, 34: 1675-1682. 

[13] Xu W, Huang Q*, Wu X, Yu X, et al. Property of midgut a-amylase from Mythimna separata (Lepidoptera: Noctuidae) larvae and its responses to potential inhibitors in vitro. J Insect Sci 2014, 14(282). 

[14] Xiao C, Huang Q*. Inhibitory effects of two 1,3,4-oxadiazoles on larval growth and α-amylase in the midguts of Mythimna separata larvae. J Asia-Pacific Entomol 2014, 17: 251-256. 

[15] Guo P, Huang J, Huang Q, Qian X. Synthesis of novel 1,3-oxazole derivatives with insect growth-inhibiting activities. Chin Chem Let 2013, 24: 957-961. 

[16] Qian Q, Zhu Y, Zhang M, Lu D, Cao W, Song L, Huang Q*. Efficient synthesis and insecticidal activity of novel pyridin-3-yl-[1,2,4]triazolo [3,4-b][1,3,4]thiadiazoles. Monatshefte für Chemie 2013, 144: 231-236.

[17] Wu M, Zhao W, Jin G, Huang Q, Cao S. Synthesis and insecticidal activities of novel analogues of flubendiamide containing a hexafluoroisopropanol moiety. Chin J Chem 2012, 30: 1310-1314. 

[18] Zhu Q, He Y, Yao J, Liu Y, Tao L, Huang Q*. Effects of sublethal concentrations of the chitin synthesis inhibitor, hexaflumuron, on the development and hemolymph physiology of the cutworm, Spodoptera litura. J Insect Sci 2012, 12 (27).

[19] Huang Q*, Y Liu, T Zhan, Y Deng, Y He. Comparable Susceptibility of Human 293 Cells and  Insect Tn-5B1-4 Cells to Photoactivated α-Terthienyl. J. Agric. Food Chem.2010, 58(5): 2637-2642.

[20] Li B, H Yuan, J Fang, L Tao, Huang Q*, X Qian*, Z Fan. Recent progress of highly efficient in vivo  biological  screening for novel agrochemicals in China. Pest Manag. Sci.2010, 66: 107-112.

[21] Huang Q*,  Deng Y,  Zhan T,  He Y. Differential synergism of fipronil by piperonyl butoxide in the susceptible and resistant Chilo suppressalis. Journal of Insect Science 2010, 10/162. 

[22] Deng Y, He Y, Zhan T, Huang Q*. Novel 2′-hydroxylfurylchalcones: Synthesis and biological activity. Carbohydrate Research 2010, 5: 1844-1855.

[23] Cai M, Z Li, F Fan, Q Huang, X Shao, G Song. Design and synthesis of novel insecticides based on serotonergic ligand PAPP. J. Agric. Food Chem. 2010, 58, 2624-2629.

 

授权和申请发明专利
*******************
******* 

喹唑啉基羧酸酯类化合物及其用途.   201710809500.3

亚氨基噻唑烷类化合物的新用途.    201710140803.0

分离纯化昆虫谷氨酰胺转氨酶的方法.  201610458931.5

一种新型昆虫细胞免疫抑制剂的用途201610301431.0

用于制备昆虫神经元细胞的生理缓冲液、消解液及方法    201410025109.0

阿维菌素B1a荧光标记物及其应用    201410025107.1

用于检测油菜菌核病菌的方法和培养基    201310564218.5

含七氟异丙基苯甲酰脲类化合物及其用途    101538227B

2’-羟基六氟异丙基的邻苯二甲酰胺类化合物及其用途    102320998

新型3-硒代吲哚的合成对植物生长促进和富硒作用    101117329B 

含二氟(亚)甲基邻甲酰胺基苯甲酰胺类化合物    102617551A

具有杀虫活性的含氮杂环化合物、其制备及用途    PCT/CN2008/071115

一类具有高杀虫活性化合物的制备方法及用途    PCT/CN 2006/000360

硝基亚甲基衍生物及其用途    PCT/CN2005/000617,WO05745204.7,US11/751,836,EP1826209A1,JP2007-541642

含硒三唑酰胺类化合物及其制备和应用    200310108478.8

一类新型3-硒代吲哚的合成对植物生长促进和富硒作用    200610029737. 1

一种噁唑哒嗪及其衍生物的剂型与应用    200410017164.1

哌嗪衍生物及其用途    200710045661.6

腺苷衍生物及其用途    201510022902.X

美国专利 Nitrogenous heterocyclic compounds with insecticidal activity, and the preparation and use thereof.    US 12/864,410

PCT专利 Benzoylurea compounds bearing heptafluoroisopropyl and uses thereof. WO/2009/115040 A1

 

联系方式
*******************
*******

地址: 上海市徐汇区梅陇路130号 华东理工大学 药学院

电话:  021-64253724  

E-mail:  qchuang@ecust.edu.cn

网页发布时间: 2014-03-26