程家高  教授、博导

山东沂南人

电  话：021-64252751

Email：jgcheng@ecust.edu.cn

地  址：华东理工大学徐汇校区实验十八楼531室   

个人简介

程家高：博士、教授、博导。2000年获曲阜师范大学学士学位，2005年获中国科学院上海药物研究所博士学位，2007年华东理工大学博士后出站留校工作至今，入选国家级高层次人才（2026）、上海市首批东方英才计划拔尖人才（2023），荣获宝钢优秀教师奖（2023）、上海市高等教育（本科）教学成果奖一等奖（2022, 7/10）、中国化学会“中华扬农农业化学创新奖”（2024）。

主要围绕绿色农药创制国家重大需求，聚焦农药面临的抗性问题、生态风险，开展药物分子设计、绿色农药创制以及传统农药绿色化改进研究。共在CEJ、JAFC、PMS、PBP等学术期刊发表学术论文150余篇；申请中国发明专利23项（授权7项）、PCT专利3项。共主持国家重点研发计划课题1项、子课题2项，主持国家自然科学基金5项，主持上海市自然科学基金等省部级课题5项；作为骨干承担国家973、863、科技支撑、基金委重点课题/项目5项。

主要学术兼职

1. 中国农药工业协会创新工作委员会委员

2. 上海市化学化工学会理事

3. 《Chinese Chemistry Letter》青年编委

4. 《Advanced Arogchem》青年编委

主要招生专业

1.  博士招生专业

      工程型博士：生物与医药

      学术型博士：植物保护

                              药学

2.  硕士招生专业

      专硕：生物与医药

      学硕：植物保护

                  药学     

2023年以来部分研究论文

[1]     Chen Qin, Yue Gao, Bo Zhang, Cong Zhou, Li Sun, Aihua Zou*, Jiagao Cheng*. Water-based DNF@PLA microcapsules with excellent interface properties enhancing insecticidal activity against Nilaparvata lugens. Pest Manag. Sci., 2026,  in press

[2]     Cong Zhou, Zihang Gao, Zhong Li, Xuhong Qian, Peter Maienfisch*, Jiagao Cheng*. Recent Advances and Prospects of Succinate Dehydrogenase Inhibitor Acaricides. J. Agric. Food Chem., 2026, DOI: 10.1021/acs.jafc.6c06747

[3]     Yanjuan Zhu, Hao Fang, Wenping Xu, Xuhong Qian, Yang Zhang*, Jiagao Cheng*. Enantioselective neurotoxicity of pydiflumetofen in zebrafish embryos: R-enantiomer disrupts neurodevelopment via suppression of Wnt/β-catenin signaling. J. Agric. Food Chem., 2026, DOI: 10.1021/acs.jafc.6c05092

[4]     Li Sun, Demei Xing, Zhen Li, Yanyan Gao, Yue Peng, Jiale Zhang, Yue Gao, Ruihan Gong, Cong Zhou*, Jiagao Cheng*. Facile construction of a dual pH/redox-responsive nanopesticide for precise control of Fusarium graminearum with enhanced biosafety. Chemical Engineering Journal, 2026, 540, 177474.

[5]     Cong Zhou, Jingwen Ge, Zhong Li, Xuhong Qian, Peter Maienfisch*,Jiagao Cheng*. Rational Design of β-Ketonitrile Acaricides through Binding-Mode-Guided Isosteric Ring Replacement. J. Agric. Food Chem. 2026, 74, 478−485.

[6]     Wei-Guo Wang^#, Yi-Min Duan^#, Da-Wei Yan, Lan Xu, Wen-Ping Xu, Li-Ming Tao, Yang Zhang*, Jia-Gao Cheng*. Cyflumetofen induces hepatic steatosis and disrupts lipid metabolism in zebrafish larvae. Chemico-Biological Interactions, 2026, 429, 111957.

[7]     Wei-Guo Wang^#, Yi-Min Duan^#, Wen-Ping Xu, Li-Ming Tao, Yang Zhang*, Jia-Gao Cheng*. Cyflumetofen disrupts the blood-brain barrier and induces neurotoxicity in zebrafish larvae. Chemico-Biological Interactions, 2026, 426, 111911.

[8]     Fei Fang^#, Bo Peng^#, Yanjuan Zhu, Wenping Xu, Yang Zhang*, Jiagao Cheng*. Bixafen-Induced Immunotoxicity in Zebrafish: TLR4/NF-κB Activation and DNA Replication Disruption as Critical Pathways. Ecotoxicol. Environ. Saf., 2025, 307, 119400.

[9]     Liangliang Cheng, Sihui Wang, Cong Zhou, Na Zhai, Biao Wu, Zhong Li, Jiagao Cheng*. Discovery of Novel Flexible β-ketonitrile Derivatives Bearing a Biphenyl Moiety as Potential Succinate Dehydrogenase Inhibitors. J. Agric. Food Chem., 2025, 73, 25908−25915.

[10]Cong Zhou, Ziye Cao, Li Sun, Na Zhai, Liangliang Cheng, Zheyi Feng, Zhong Li, Xuhong Qian*, Jiagao Cheng*. Structure-based molecular design of fungicidal β-ketonitrile derivatives with biphenyl moiety as novel succinate dehydrogenase inhibitors. Pestic. Biochem. Physiol.,2025, 215, 106703.

[11]Na Zhai, Cong Zhou, Liangliang Cheng, Xiaoyong Xu, Zhong Li, Jiagao Cheng*. Binding differences of fluxapyroxad with succinate dehydrogenase across species: Insights from in-silico simulations. Pest Manag. Sci., 2025, 81, 8038–8049.

[12]Chen Qin, Shujing Li, Bo Zhang, Aihua Zou*, Jiagao Cheng*. Eco-friendly thifluzamide/SiO2 oil-in-water pickering emulsion with high adhesion on leaf for improving fungicidal efficacy, Pest Manag. Sci., 2025, 81(9), 5524–5532.

[13]Liangliang Cheng, Hanting Wang, Cong Zhou, Jiawei Qin, Zhong Li, Jiagao Cheng*. Discovery of Novel Pyrazole β-Ketonitrile Derivatives as Broad Spectrum SDHI Fungicide by Introducing a Flexible Motif, J. Agric. Food Chem., 2025, 73, 14831-14838.

[14]Cong Zhou, Cong Wang, Xujuan Sun, Liangliang Cheng, Xusheng Shao, Zhiping Xu,  Xiaoyong Xu, Zhong Li, Xuhong Qian, Jiagao Cheng*. Hit to lead optimization of carbothioate derivatives as novel succinate dehydrogenase inhibitors using a multistep virtual screening approach. Pest Manag. Sci., 2025, 81(8), 4373–4381.

[15]Yanjuan Zhu, Fei Fang, Bo Peng, Wenping Xu, Xuhong Qian, Yang Zhang*, Jiagao Cheng*.   Exposure to chiral pydiflumetofen induces cardiovascular toxicity in early stages of zebrafish. Environ. Pollut. 2025, 383, 126819.

[16]Cong Zhou^#, Yijin Kong^#, Huihui Zhang, Na Zhai, Zhong Li, Xuhong Qian, Zewen Liu*, Jiagao Cheng*. Computational Modelling Oriented Substructure Splicing Application in the Identification of Thiazolidine Derivatives as Potential Low Honeybee Toxic Neonicotinoids. J. Agric. Food Chem., 2024, 72(21), 11968-11979. 

[17]Yijin Kong^#, Cong Zhou^#, Du Tan, Xiaoyong Xu, Zhong Li, Jiagao Cheng*. Discovery of Potential Neonicotinoid Insecticides by AI Generative Model and Structure-Based Virtual Screening. J. Agric. Food Chem., 2024, 72, 5145-5152. 

[18]Liangliang Cheng^#, Cong Zhou^#, Qinglong Yuan, Letian Zhang, Xusheng Shao, Xiaoyong Xu, Zhong Li, Jiagao Cheng*. 3D-QSAR Model Oriented Optimization of Pyrazole β-Ketonitrile Derivatives with Diphenyl Ether Moiety as Novel Potent Succinate Dehydrogenase Inhibitors. Pest Manag. Sci., 2024, 80, 5299–5306. 

[19]Shujing Li^#, Jing Sun^#, Yue Gao, Aihua Zou*, Jiagao Cheng*. Enhanced Fungicidal Efficacy and Improved Interfacial Properties with the Co-Delivery of Prothioconazole and Tebuconazole using Polylactic acid Microspheres. Pest Manag. Sci., 2024, 80, 1831-1838.

[20]Fei Fang, Yanjuan Zhu, Wenping Xu, Yang Zhang*, Jiagao Cheng*. Insights into the Developmental and Cardiovascular Toxicity of Bixafen using Zebrafish Embryos. Environmental Research, 2024, 262, 119916.

[21]Cong Zhou, Zhong Li, Xuhong Qian, Jiagao Cheng*, Peter Maienfisch*. Novel Acaricidal Silico-Containing Pyrazolyl Acrylonitrile Derivatives Identified through Rational Carbon–Silicon Bioisosteric Replacement Strategy. J. Agric. Food Chem., 2023, 71, 18239−18249.

[22]Cong Zhou, Xujuan Sun, Wen Fu, Zhong Li, Jiagao Cheng*, Peter Maienfisch* Rational exploration of novel SDHI fungicide through amide-β-ketonitrile bioisosteric replacement strategy. J. Agric. Food Chem., 2023, 71, 14, 5483–5495.

[23]Jian Lu, Cheng Zhang, Weiguo Wang, Wenping Xu, Weidong Chen, Liming Tao, Zhong Li, Yang Zhang*, Jiagao Cheng*. Exposure to environmental concentrations of glyphosate induces cardiotoxicity through cellular senescence and reduced cell proliferation capacity. Ecotoxicol. Environ. Saf., 2023, 261, 115112.