个人简介
发布人: 邵旭升 发布时间: 2016-09-09 作者: 访问次数: 6949

 

 

 

邵旭升,博士,副教授,博士生导师

 电话: 021-64253967 
 传真: 021-64252603 
 E-mail:
shaoxusheng@ecust.edu.cn

  

个人简介 

邵旭升:博士,副教授,博士生导师。2009年7月毕业于华东理工大学应用化学专业,导师李忠教授。2012年至2013年在美国加州大学伯克利分校John E. Casida教授课题组从事农药的毒理、代谢和作用机制研究。主要研究方向为植物化学保护、杀虫剂作用的生物学机制、杀虫剂作用靶酶的智能调控、杀虫剂的创制和应用。在PNASJ. Agric. Food Chem.Insect Biochem. Mol. Biol.Scientific ReportJ. Org. Chem.等杂志发表SCI论文70多篇,其中第一或通讯作者论文36篇;申请国内外专利39项,获中国专利授权6项,国外专利授权21项;是新烟碱杀虫剂哌虫啶和环氧虫啶的主要发明人;国内外重大学术会议邀请报告10多次;获中国农药工业协会农药创新贡献奖-技术创新奖一等奖和二等奖各一项,入选上海市浦江人才计划和校青年英才计划,获获上海市优秀博士论文和上海市科创杯一等奖2次。作为项目负责人承担国家自然科学基金,上海市科技创新行动计划,澳大利亚DC研究基金等多项科研项目,作为项目主要研究人员参与国家863项目和十二五国家科技支撑计划。


研究方向 

1.   植物害虫化学防治,绿色及新概念农药创制

2.   光调控的农药化学生物学,光致异构、光控释放、光敏化、光热及其在植物保护中的应用

3.   农药毒理、作用机制、代谢及生物学行为

4.   靶标导向的多样性衍生,有机合成方法学及杂环构建

 

发表论文

 

  1. Yian Feng, Minming Zou, Runjiang Song, Xusheng Shao*, Zhong Li, Xuhong Qian. Formation of 1,4,2-Dithiazolidines or 1,3-Thiazetidines from 1,1-Dichloro-2-nitroethene and Phenylthiourea Derivatives. J. Org. Chem. 2016, 81, 10321-10327.
  2. Shen Li, Runjiang Song, Donghui Wang, Xue Tian, Xusheng Shao*, Zhong Li. Azopyridine-imidacloprid derivatives as photoresponsive neonicotinoids. Chin. Chem. Lett. 2016, 27, 635-639.
  3. Feilong Sun, Xusheng Shao*, Zhong Li. Access of Indenofurans and Indenopyridines via Annulation of Heterocyclic Ketene Aminals, o-Phthalaldehyde and cyclic 1.3-diketones. RSC Advance 2016, 6, 15382-15389.
  4. Fengjuan Zhu, Runjiang Song, Shen Li, Xusheng Shao*. In-water Synthesis of Quinazolinones from 1,1-Dichloro-2-nitroethene and Anthranilamides. Synlett 2016, 27, 2167-2170.
  5. Ye Liu, Chao Lei, Xiaoyong Xu, Xusheng Shao*, Zhong Li*. Design, synthesis and insecticidal activity of biphenyl-diamide derivatives, Chin. Chem. Lett. 2016, 27, 321-324.
  6. Jiling Li, Dang Wu, Xiaoyong Xu, Jin Huang, Xusheng Shao* and Zhong Li*. Design, synthesis and inhibitory activity against human dihydroorotate dehydrogenase (hDHODH) of 1, 3-benzoazole derivatives bearing amide units. Bioorg. Med. Chem. Lett. 2016, 26, 3064-3066.
  7. Fengjuan Zhu, Xue Tian, Xusheng Shao*, Zhong Li. Direct Amidation of Aniline Derivatives with 1,1-Dichloro-2-nitroethene in Water. Tetrahedron Lett. 2015, 56, 5945-5949.
  8. Zhiping Xu, Lina Shi, Danping Jiang, Jiagao Cheng, Xusheng Shao*, Zhong Li. Azobenzene Modified Imidacloprid Derivatives as Photoswitchable Insecticides: Steering Molecular Activity in a Controllable Manner. Scientific Reports 2015, 5, 13962.
  9. Fengjuan Zhu, Minming Zou, Xusheng Shao*, Zhong Li. On-water, Catalyst-Free and Room-temperature Construction of 2-Aryl-1,3,4-oxadiazole Derivatives from 1,1-Dichloro-2-nitroethene and Hydrazides. RSC Advance 2015, 5, 61752-61758.
  10. Feilong Sun, Fengjuan Zhu, Xusheng Shao*, Zhong Li. One-pot and Three-components Synthesis of 1,8-Naphthyridine Derivatives from Heterocyclic Ketene Aminals, Malononitrile Dimer and Aryl Aldehydes. Synlett 2015, 26, 2306-2312.
  11. Nanyang Chen, Xiaoqing Meng, Fengjuan Zhu, Jiagao Cheng, Xusheng Shao*, Zhong Li. Tetrahydroindeno[1’,2’:4,5]pyrrolo[1,2-a]imidazol-5(1H)-ones as Novel Neonicotinoid Insecticides: Reaction Selectivity and Substituent Effects on the Activity Level. J. Agric. Food Chem. 2015, 63, 1365-1369.
  12. Jiling Li, Zhicheng Zhang, Xiaoyong Xu, Xusheng Shao*, Zhong Li*. Nematicidal Activities of Diamides with Diphenylacetylene Scaffold against Meloidogyne Incognita. Aust. J. Chem. 2015, 68, 1543-1549.
  13. Jiling Li, Xiaoyong Xu, Xusheng Shao*, Zhong Li*. A Novel Colorimetric Fluoride Sensor Based on a Semi-rigid Chromophore Controlled by Hydrogen Bonding, Luminescence, 2015, 30, 1285-1289.
  14. Minming Zou, Xue Tian, Nanyang Chen, Xusheng Shao*. Nematicidal Activity of Sprio and Bridged Heterocyclic Neonicotinoid Analogues against Meloidogyne incognita. Lett. Drug Des. Discov. 2015, 12, 439-445.
  15. Yefeng Fan, Song Liu, Nanyang Chen, Xusheng Shao*, Xiaoyong Xu, Zhong Li*. Oxidation strategy for the synthesis of regioisomeric spiroisobenzofuranopyrroles: facile entries to spiro[isobenzofuran-1,2’-pyrrole] and spiro[isobenzofuran-1,3’-pyrrole] derivatives. Synlett 2015, 26, 393-403.
  16. Nanyang Chen, Shanshan Xia, Minming Zou, Xusheng Shao*. Bridged heterocyclic neonicotinoid analogues: design, synthesis, and insecticidal activity. Res. Chem. Intermed. 2015, 41, 5293-5300.
  17. Minming Zou, Nanyang Chen, Liping Ren, Xusheng Shao*, Zhong Li. A novel and facile synthesis of 2-oxo-1,2-dihydropyridine-fused 1,3-diazaheterocycles via heterocyclic ketene aminals and Knoevenagel adducts formed by phthalic anhydride and ethyl cyanacetate. Chin. Chem. Lett. 2014, 25, 1515-1519.
  18. Nanyang Chen, Minming Zou, Xue Tian, Fengjuan Zhu, Danping Jiang, Xusheng Shao*, Zhong Li* Isomerization of Ninhydrin-Heterocyclic Ketene Aminals Adducts: Kinetic versus Thermodynamic Control, Solvents Dependency and Mechanism.Eur. J. Org. Chem. 2014, 28, 6210-6218.
  19. Nanyang Chen, Liping Ren, Zhiping Xu, Minming Zou, Xusheng Shao*, Xiaoyong Xu, Zhong Li*. Design, Synthesis and Insecticidal Activity of Spiro Heterocycle Containing Neonicotinoid Analogues. Chin. Chem. Lett. 2014, 25, 197-200.
  20. Jingwei Zhang, Xusheng Shao*, Zhong Li, Xiaoyong Xu. Bis-phenylazoneonicotinoids as Divalent Insecticides: Design, Synthesis and Activity. Lett. Drug Des. Discov. 2014, 11,150-155.
  21. Liping Ren, Yanpeng Lou, Nanyang Chen, Shanshan Xia, Xusheng Shao*, Xiaoyong Xu, Zhong Li. Synthesis and Insecticidal Activities of Tetrahydroimidazo[1,2-a]pyridinones: Further Exploration on cis-Neonicotinoids. Synthetic Commun. 2014, 44, 858-867.
  22. Xusheng Shao*, Shanshan Xia, Kathleen A. Durkin, John E. Casida*. Insect Nicotinic Receptor Interactions in Vivo with Neonicotinoid, Organophosphorus and Methylcarbamate Insecticides and a Synergist. Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 17273–17277.
  23. Xusheng Shao, Tami L. Swenson, John E. Casida*. Cycloxaprid Insecticide: Nicotinic Acetylcholine Receptor Binding Site and Metabolism. J. Agric. Food Chem. 2013, 61, 7883–7888.
  24. Xusheng Shao, Zewen Liu, Xiaoyong Xu, Zhong Li*, Xuhong Qian. Overall Status of Neonicotinoid Insecticides in China: Production, Application and Innovation. J. Pestic. Sci. 2013, 38, 19.
  25. Xusheng Shao*, Xinglong Huang, Qian Shi, Zhong Li, Liming Tao, Gonghua Song*. Synthesis and Insecticidal Activities of Chlorothiazolyl Analogues of Nitromethylene Neonicotinoids with Tetrahydropyridine Fixed cis-Configuration. J. Heterocycl. Chem. 2012, 49, 1136–1142.
  26. Xusheng Shao, Zhenjun Ye, Haibo Bao, Zewen Liu, Xiaoyong Xu, Zhong Li*, Xuhong Qian*. Advanced research on cis-neonicotinoids. Chimia 2011, 65, 957–960.
  27. Xusheng Shao, Hanyan Liu, Haibo Bao, Xiaoyong Xu, Zewen Liu, Zhong Li*. The Mode of Action of a Nitroconjugated Neonicotinoid and the Effects of Target Site Mutation Y151S on its Potency. Insect Biochem. Mol. Biol.2011, 41, 440–445. (Insect Biochemistry and Molecular Biology),
  28. Xusheng Shao, Philip W. Lee, Xiaoyong Xu, Zewen Liu, Zhong Li*, Xuhong Qian. cis-Configuration: A New Tactic/Rationale for Neonicotinoid Molecular Design. J. Agric. Food Chem. 2011, 59, 29432949.
  29. Xusheng Shao, Hua Fu, Xiaoyong Xu, Xinglei Xu, Zhong Li*, Zewen Liu. Divalent and Oxabridged Neonicotinoids Constructed by Dialdehydes and Nitromethylene Analogues of Imidacloprid: Design, Synthesis, Crystal Structure and Insecticidal Activities. J. Agric. Food Chem. 2010, 58, 26962702.
  30. Xusheng Shao, Zhiping Xu, Xianfeng Zhao, Xiaoyong Xu, Liming Tao, Zhong Li*, Xuhong Qian*. Synthesis, crystal structure, and insecticidal activities of highly congested hexahydroimidazo[1,2-a]pyridine derivatives: effect of conformation on activities.J. Agric. Food Chem. 2010, 58, 26902695.
  31. Xusheng Shao, Xiaoyong Xu, Zhong Li *, Xuhong Qian*. Design, Synthesis and Insecticidal Activities of Novel Analogues of Neonicotinoids: Replacement of Nitromethylene with Nitro-Conjugated System.J. Agric. Food Chem. 2009, 57, 951–957.
  32. Xusheng Shao, Wenwen Zhang, Yanqing Peng, Zhong Li*. cis-Nitromethylene Neonicotinoids as new nicotinic family: Sythesis,structural diersity, and insecticidal evaluation of hexahydroimidazo[1,2-a]pyridine.Bioorg. Med. Chem. Lett. 2008, 18, 6513–6516.