邵旭升，教授，博士生导师

 电话: 021-64253967 
 传真: 021-64252603 
 E-mail: shaoxusheng@ecust.edu.cn

个人简介 

邵旭升：博士，教授，博士生导师。2009年7月毕业于华东理工大学应用化学专业，导师李忠教授。2012年至2013年在美国加州大学伯克利分校John E. Casida教授课题组进行农药的毒理、代谢和作用机制研究。主要研究方向为绿色农药创制与应用、光药理学、杀虫剂作用的生物学机制。在PNAS、J. Agric. Food Chem.、Insect Biochem. Mol. Biol.等杂志发表SCI论文100多篇，其中第一或通讯作者论文60多篇；申请国内外专利50多项，获中国专利授权6项，国外专利授权21项；是新烟碱杀虫剂哌虫啶和环氧虫啶的主要发明人；国内外重大学术会议邀请报告20多次；获中国专利优秀奖、中国农药工业协会农药创新贡献奖-技术创新奖一等奖和二等奖各一项，获上海市优秀博士论文以及上海市科创杯一等奖2次。作为项目负责人承担国家重点研发计划子课题、国家自然科学基金、上海市科技创新行动计划，澳大利亚DC研究基金等多项科研项目。

研究方向 

1.   绿色农药创制

2.   光药理学

3.   农药毒理学

4.   合成方法学

发表论文

1)         Zhi Qiao, Yunfan Ji, Yongchao Zhang, Zhong Li, Zhiping Xu, Xusheng Shao*. Azobenzene-Isoxazoline as photopharmacological ligand for optical control of insect GABA receptor and behavior. Pest Manag. Sci. 2022, 78, 467-474.

2)         Zhi, Qiao, Wen Fu, Yongchao Zhang, Ruijia Chen, Zhiping Xu, Zhong Li, Xusheng Shao*. Azobenzene-Semicarbazone Enables Optical Control of Insect Sodium Channel and Behavior，J. Agric. Food Chem. 2021, 51, 15554-155561.

3)         Shaoqing Du, Qinglong Yuan, Xueping Hu, Wen Fu, Qi Xu, Ziyi Wei, Jiazheng Xu, Xusheng Shao*, Xuhong Qian*. Synthesis and Biological Activity of Novel Antifungal Leads: 3,5-Dichlorobenzyl Ester Derivatives. J. Agric. Food Chem. 2021, 69, 15521-15529.

4)         Yaoyao Du, Zhongli Shao, Qi Xu, Zhong Li, Xusheng Shao*.Azobenzene-Avermectin B1a Derivatives for Optical Modulation of Insect Behaviors. J. Agric. Food Chem. 2021, 69, 15530-15537.

5)         Wen Fu, Qinglong Yuan, Xinyue Hu, Xujuan Sun, Zhiping Xu, Yang Zhang, Jiagao Cheng, Yonghao Ye, Zhong Li, Xusheng Shao*. Azo-incorporating Increases Inhibitory Activity of Succinate Dehydrogenase. J. Agric. Food Chem. 2021, 69, 13448-13459.

6)         Qi Xu, Hao Feng, Xusheng Shao*. Light-induced Activities of Novel Naphtho[1,8-ef]isoindole-7,8,10(9H)-trione and Oxoisoaporphine Derivatives towards Mosquito Larvae. Bioorg. Med. Chem. Lett. 2021, 48, 128225-128231.

7)         Qi Xu, Yunfan Ji, Meijun Chen, Xusheng Shao*. 4-Hydroxyl-oxoisoaporphine, one small molecule as theranostic agent for simultaneous fluorescence imaging and photodynamic therapy as type II photosensitizer. Photochem. Photobio. Sci. 2021, 20, 501-512.

8)         Xusheng Shao. Photoresponsive pesticidal agents. (Chapter 18), P297-310. Recent highlights in the discovery and optimization of crop protection products. ISBN 9780128210352, 2021.03.26, Elsevier, London.ISBN: 978-0-12-821035-2.

9)         Xusheng Shao, Zhong Li, Xuhong Qian. Research and development of green pesticide in China (Chapter 5), P39-64. Recent highlights in the discovery and optimization of crop protection products. ISBN 9780128210352, 2021.03.26, Elsevier, London.

10)      Long, Wang, Meijun, Chen, Shanshan Xia, Zhiping Xu, Yuxin Li, Xusheng Shao*. Azobenzene-diamides as Photopharmacological ligands for Insect Ryanodine Receptor. J. Agric. Food Chem. 2020, 68, 49, 14409-14416.

11)      Cuncun Zhou, Liping Ren, Yunfan, Ji, Xusheng Shao*. Photochromic Meta-diamides for Optical Modulation of Ligand Activity and Neuron Function.Photochem. Photobio. Sci., 2020, 19, 854-857.

12)      Qi Xu, Yujun Shen, Yongchao Zhang; Xusheng Shao*. PEGylated Cyanine Dye Nanoparticles as Photothermal Agents for Mosquito and Cancer Cell Control. Bioorg. Med. Chem. Lett. 2019, 29, 2398-2404.

13)      Yifei Jing, Qi Xu, Meijun Chen, Xusheng Shao*. Pyridone-containing Phenalenone-based Photosensitizer Working Both under Light and in the Dark for Photodynamic Therapy. Bioorg. Med. Chem. 2019, 27, 2201-2208.

14)      Zhiping Xu, Zhenhong Gao, Xusheng Shao*. Light-triggered release of insecticidally active spirotetramat-enol. Chin. Chem. Lett. 2018.29, 1648-1650.

15)      Qingqing Hou, Yifei Jing, Xusheng Shao*. Synthesis and insecticidal activities of 1,8-naphthyridine derivatives.Chin. Chem. Lett. 2017, 28, 1723-1726.

16)      Zhenhong Gao, Yifei Jing, Donghui Wang, Zhiping Xu, Zhong Li, Xusheng Shao*. Photo-controlled Release of Fipronil from a Coumarin Triggered Precursor. Bioorg. Med. Chem. Lett. 2017, 27, 2528-2535.

17)      Yanan Zhang, Yian Feng, Zhong Li, Xusheng Shao*. Synthesis and Insecticidal Evaluation of Phytoalexin Phenalenones Derivatives. Chin. Chem. Lett. 2017, 28, 1228-1231.

18)      Xue Tian, Chao Zhang, Qi Xu, Zhong Li and Xusheng Shao*. Azobenzene-Benzoylphenylureas as Photoswitchable Chitin Synthesis Inhibitors. Org. Biomol. Chem. 2017, 15, 3320-3323.

19)      Runjiang Song, Yian Feng, Donghui Wang, Zhiping Xu, Zhong Li, Xusheng Shao*. Phytoalexin Phenalenone Derivatives Inactivate Mosquito Larvae and Root-knot Nematode as Type-Ⅱ Photosensitizer. Sci. Rep. 2017, 7, 42058.

20)      Yian Feng, Minming Zou, Runjiang Song, Xusheng Shao*, Zhong Li, Xuhong Qian. Formation of 1,4,2-Dithiazolidines or 1,3-Thiazetidines from 1,1-Dichloro-2-nitroethene and Phenylthiourea Derivatives. J. Org. Chem. 2016, 81, 10321-10327.

21)      Shen Li, Runjiang Song, Donghui Wang, Xue Tian, Xusheng Shao*, Zhong Li. Azopyridine-imidacloprid derivatives as photoresponsive neonicotinoids. Chin. Chem. Lett. 2016, 27, 635-639.

22)      Zhiping Xu, Lina Shi, Danping Jiang, Jiagao Cheng, Xusheng Shao*, Zhong Li. Azobenzene Modified Imidacloprid Derivatives as Photoswitchable Insecticides: Steering Molecular Activity in a Controllable Manner. Sci. Rep. 2015, 5, 13962.

23)      Nanyang Chen, Xiaoqing Meng, Fengjuan Zhu, Jiagao Cheng, Xusheng Shao*, Zhong Li*. Tetrahydroindeno[1’,2’:4,5]pyrrolo[1,2-a]imidazol-5(1H)-ones as Novel Neonicotinoid Insecticides: Reaction Selectivity and Substituent Effects on the Activity Level. J. Agric. Food Chem. 2015, 63, 1365-1369.

24)      Minming Zou, Nanyang Chen, Liping Ren, Xusheng Shao*, Zhong Li. A novel and facile synthesis of 2-oxo-1,2-dihydropyridine-fused 1,3-diazaheterocycles via heterocyclic ketene aminals and Knoevenagel adducts formed by phthalic anhydride and ethyl cyanacetate. Chin. Chem. Lett. 2014, 25, 1515-1519.

25)      Nanyang Chen, Minming Zou, Xue Tian, Fengjuan Zhu, Danping Jiang, Xusheng Shao*, Zhong Li* Isomerization of Ninhydrin-Heterocyclic Ketene Aminals Adducts: Kinetic versus Thermodynamic Control, Solvents Dependency and Mechanism.Eur. J. Org. Chem. 2014, 28, 6210-6218.

26)      Nanyang Chen, Liping Ren, Zhiping Xu, Minming Zou, Xusheng Shao*, Xiaoyong Xu, Zhong Li*. Design, Synthesis and Insecticidal Activity of Spiro Heterocycle Containing Neonicotinoid Analogues. Chin. Chem. Lett. 2014, 25, 197-200.

27)      Xusheng Shao*, Shanshan Xia, Kathleen A. Durkin, John E. Casida*. Insect Nicotinic Receptor Interactions in Vivo with Neonicotinoid, Organophosphorus and Methylcarbamate Insecticides and a Synergist. Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 17273–17277.

28)      Xusheng Shao, Tami L. Swenson, John E. Casida*. Cycloxaprid Insecticide: Nicotinic Acetylcholine Receptor Binding Site and Metabolism. J. Agric. Food Chem. 2013, 61, 7883–7888.