中文 | English
 
梁欣

梁欣 博士


副教授,硕士生导师


                                  邮箱:xin.liang@ecust.edu.cn

                               地址:上海市徐汇区梅陇路130号实验十八楼633室;

                           邮编:200237

 

个人简历:

2003.9-2007.6     华东理工大学生物工程专业工学学士

2007.9-2012.3      华东理工大学生物化工专业工学博士

2012.7-2015.5      美国埃默里大学Emory UniversityRenhao Li’s Lab 博士后

2015.7-2016.8      华东理工大学药学院,讲师

2016.9至今           华东理工大学药学院,副教授

作为项目负责人主持国家自然科学基金,上海市自然科学基金,教育部基本科研业务费探索研究基金等已在Journal of Hematology & Oncology,Molecular Therapy,British Journal of Cancer,Arterioscler Thromb Vasc Biol等国际SCI期刊发表论文36篇,SCI他引500余次。


研究方向:

主要研究领域为以及微环境的相互作用研究。包括血小板参与肿瘤转移微环境形成的机制研究,miRNA以及微环境中的相互作用研究小分子化合物或抗体药物的抗肿瘤机制研究。


代表性论文:

1.    Zhao Y, Xu J, Le V, Gong Q, Li S, Gao F, Ni L*, Liu J*, Liang X*. Epcam aptamer-functionalized cationic liposome-based nanoparticles loaded with mir-139-5p for targeted therapy in colorectal cancer. Molecular Pharmaceutics. 2019, 16(11): 4696-4710.

2.    Xu K*, Zhan Y, Yuan Z, Qiu Y, Wang H, Fan G, Wang J, Li W, Cao Y, Shen X, Zhang J, Liang X*, Yin P*. Hypoxia Induces Drug Resistance in Colorectal Cancer through the HIF-1α/miR-338-5p/IL-6 Feedback Loop. Molecular Therapy. 2019, 27(10): 1810-1824. 

3.    Qi Y, Chen W, Liang X, Xu K*, Gu X, Wu F, Fan X, Ren S, Liu J, Zhang J, Li R, Liu J*, Liang X*. Novel antibodies against GPIbα inhibit pulmonary metastasis by affecting vWF-GPIbα interaction. Journal of Hematology & Oncology. 2018, 11(1):117.

4.    Liang X, Chen W, Shi H, Gu X, Li Y, Qi Y, Xu K*, Zhao A*, Liu J*. PTBP3 contributes to the metastasis of gastric cancer by mediating CAV1 alternative splicing. Cell Death & Disease. 2018, 9:569. 

5.    Liang X, Shi H, Yang L, Qiu C, Lin S, Qi Y, Li J*, Zhao A*, Liu J*. Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells. British Journal of Cancer. 2017, 116(7):903-911. 

6.    Liang X, Wang J, Chen W, Ma X, Wang Y, Nagao N, Weng W*, Huang J*, Liu J*. Inhibition of airway remodeling and inflammation by isoforskolin in PDGF-induced rat ASMCs and OVA-induced rat asthma model. Biomed Pharmacother. 2017, 95:275-286. 

7.    Xu K, Chen G, Li X, Wu X, Chang Z, Xu J, Zhu Y, Yin P, Liang X*, Dong L*. MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling. Sci Rep. 2017, 7:41718.   

8.     Lin S, Yang L, Shi H, Du W, Qi Y, Qiu C, Liang X*, Shi W*, Liu J*. Endoplasmic reticulum-targeting photosensitizer Hypericin confers chemo-sensitization towards oxaliplatin through inducing pro-death autophagy. Int J Biochem Cell Biol. 2017 Jun;87: 54-68. 

9.   Chen W1, Liang X1, Syed AK, Jessup P, Church WR, Ware J, Josephson CD, Li R*. Inhibiting GPIbα shedding preserves post-transfusion recovery and hemostatic function of platelets after prolonged storage. Arterioscler Thromb Vasc Biol. 2016, 36(9):1821-1828. 

10.  Liang X, Syed AK, Russell SR, Ware J, Li R*. Dimerization of glycoprotein Ib is not sufficient to induce platelet clearance. J Thromb Haemost. 2016,14: 381-386. 

11.  Li Q1, Liang X1, Wang Y, Meng X, Xu Y, Cai S, Wang Z*, Liu J*, Cai G*. miR-139-5p Inhibits the Epithelial- Mesenchymal Transition and Enhances the Chemotherapeutic Sensitivity of Colorectal Cancer Cells by Downregulating BCL2. Sci Rep. 2016, 6: 27157

12.  Zou F, Mao R, Yang L, Lin S, Lei K, Zheng Y, Ding Y, Zhang P, Cai G*, Liang X*, Liu J*. Targeted deletion of miR-139-5p activates MAPK, NF-kB and STAT3 signaling and promotes intestinal inflammation and colorectal cancer. FEBS J. 2016, 283(8): 1438-1452. 

13.  Zheng Y, Yin G, Le V, Zhang A, Chen S, Liang X*, Liu J*. Photodynamic-therapy Activates Immune Response by disrupting Immunity Homeostasis of Tumor Cells, which Generates Vaccine for Cancer Therapy. Int J Biol Sci. 2016, 12(1): 120-132. 

14.  Lin S, Lei K, Du W, Yang L, Shi H, Gao Y, Yin P*, Liang X*, Liu J*. Enhancement of oxaliplatin sensitivity in human colorectal cancer by hypericin mediated photodynamic therapy via ROS-related mechanism. Int J Biochem Cell Biol. 2016, 71:24-34. 

15.  Mao R, Zou F, Yang L, Lin S, Li Y, Ma M, Yin P*, Liang X*, Liu J*. The loss of MiR-139-5p promotes colitis-associated tumorigenesis by mediating PI3K/AKT/Wnt signaling. Int J Biochem Cell Biol. 2015, 69: 153-161. 

16.  Liang X, Russell SR, Estelle S, Jones LH, Cho S, Kahn ML, Berndt MC, Bunting ST, Ware J, Li R*. Specific inhibition of ectodomain shedding of glycoprotein Ibα by targeting its juxtamembrane shedding cleavage site. J Thromb Haemost. 2013, 11(12): 2155-2162. 

注:1共同第一作者, 通讯作者



网页发布时间: 2017-06-29