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梁欣

梁欣 博士


副教授,硕士生导师

邮箱:xin.liang@ecust.edu.cn

地址:上海市徐汇区梅陇路130号实验十八楼633室;

邮编:200237

 

个人简历:

20039-20076华东理工大学生物工程专业工学学士

20079-20123华东理工大学生物化工专业工学博士

20127-20155美国埃默里大学Emory UniversityRenhao Li’s Lab 博士后

20157-20168月 华东理工大学药学院,讲师

20169月至今           华东理工大学药学院,副教授

主持上海市自然科学基金一项,国家自然科学基金青年基金一,教育部基本科研业务费探索研究基金一


研究方向:

主要研究领域为以及微环境的相互作用研究。包括血小板参与肿瘤转移微环境形成的机制研究,miRNA以及微环境中的相互作用研究小分子化合物或抗体药物的抗肿瘤机制研究。


代表性论文:

1.     Xu K*, Zhan Y, Yuan Z, Qiu Y, Wang H, Fan G, Wang J, Li W, Cao Y, Shen X, Zhang J, Liang X*, Yin P*. Hypoxia Induces Drug Resistance in Colorectal Cancer through the HIF-1α/miR-338-5p/IL-6 Feedback Loop.Molecular Therapy. 2019 Jun 4. IF:8.402

2.    Qi Y, Chen W, Liang X, Xu K*, Gu X, Wu F, Fan X, Ren S, Liu J, Zhang J, Li R, Liu J*, Liang X*. Novel antibodies against GPIbα inhibit pulmonary metastasis by affecting vWF-GPIbα interaction. Journal of Hematology & Oncology. 2018, 11(1):117. IF:8.731

3.    Liang X, Chen W, Shi H, Gu X, Li Y, Qi Y, Xu K*, Zhao A*, Liu J*. PTBP3 contributes to the metastasis of gastric cancer by mediating CAV1 alternative splicing. Cell Death & Disease. 2018, 9:569. IF:5.959

4.    Liang X, Shi H, Yang L, Qiu C, Lin S, Qi Y, Li J*, Zhao A*, Liu J*. Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells. Br J Cancer. 2017 Mar 28;116(7):903-911. IF: 5.416.

5.    Liang X, Wang J, Chen W, Ma X, Wang Y, Nagao N, Weng W*, Huang J*, Liu J*. Inhibition of airway remodeling and inflammation by isoforskolin in PDGF-induced rat ASMCs and OVA-induced rat asthma model. Biomed Pharmacother. 2017 Aug 26;95:275-286. IF: 3.743

6.     Xu K, Chen G, Li X, Wu X, Chang Z, Xu J, Zhu Y, Yin P, Liang X*, Dong L*. MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling. Sci Rep. 2017, 7:41718. IF: 4.011      

7.     Lin S, Yang L, Shi H, Du W, Qi Y, Qiu C, Liang X*, Shi W*, Liu J*. Endoplasmic reticulum-targeting photosensitizer Hypericin confers chemo-sensitization towards oxaliplatin through inducing pro-death autophagy. Int J Biochem Cell Biol. 2017 Jun;87: 54-68. IF: 3.144

8.    Chen W, Ma X, Zhang P, Li Q, Liang X*, Liu J*. MiR-212-3p inhibits LPS-induced inflammatory response through targeting HMGB1 in murine macrophages. Exp Cell Res. 2017, 350(2):318-26. IF: 3.329

9.    Chen W1, Liang X1, Syed AK, Jessup P, Church WR, Ware J, Josephson CD, Li R*. Inhibiting GPIbα shedding preserves post-transfusion recovery and hemostatic function of platelets after prolonged storage. Arterioscler Thromb Vasc Biol. 2016, 36(9):1821-8. IF: 6.618

10.  Liang X, Syed AK, Russell SR, Ware J, Li R*. Dimerization of glycoprotein Ib is not sufficient to induce platelet clearance. J Thromb Haemost. 2016,14: 381-6. IF: 4.662

11.  Li Q1, Liang X1, Wang Y, Meng X, Xu Y, Cai S, Wang Z*, Liu J*, Cai G*. miR-139-5p Inhibits the Epithelial- Mesenchymal Transition and Enhances the Chemotherapeutic Sensitivity of Colorectal Cancer Cells by Downregulating BCL2. Sci Rep. 2016, 6: 27157. IF: 4.011

12.  Zou F, Mao R, Yang L, Lin S, Lei K, Zheng Y, Ding Y, Zhang P, Cai G*, Liang X*, Liu J*. Targeted deletion of miR-139-5p activates MAPK, NF-kB and STAT3 signaling and promotes intestinal inflammation and colorectal cancer. FEBS J. 2016, 283(8): 1438-52. IF: 4.739

13.  Lei K, Du W, Lin S, Yang L, Xu Y, Gao Y, Xu B, Tan S, Xu Y, Qian X, Liang X*, Liu J*3B, a novel photosensitizer, inhibits glycolysis and inflammation via miR-155-5p and breaks the JAK/STAT3/SOCS1 feedback loop in human breast cancer cells. Biomed Pharmacother. 2016, 82: 141-50. IF:3.743

14.  Zheng Y, Yin G, Le V, Zhang A, Chen S, Liang X*, Liu J*. Photodynamic-therapy Activates Immune Response by disrupting Immunity Homeostasis of Tumor Cells, which Generates Vaccine for Cancer Therapy. Int J Biol Sci. 2016, 12(1): 120-32. IF: 4.067

15.  Lin S, Lei K, Du W, Yang L, Shi H, Gao Y, Yin P*, Liang X*, Liu J*. Enhancement of oxaliplatin sensitivity in human colorectal cancer by hypericin mediated photodynamic therapy via ROS-related mechanism. Int J Biochem Cell Biol. 2016, 71:24-34. IF: 3.144

16.  Mao R, Zou F, Yang L, Lin S, Li Y, Ma M, Yin P*, Liang X*, Liu J*. The loss of MiR-139-5p promotes colitis-associated tumorigenesis by mediating PI3K/AKT/Wnt signaling. Int J Biochem Cell Biol. 2015, 69: 153-61. IF: 3.144

17.  Liang X, Russell SR, Estelle S, Jones LH, Cho S, Kahn ML, Berndt MC, Bunting ST, Ware J, Li R*. Specific inhibition of ectodomain shedding of glycoprotein Ibα by targeting its juxtamembrane shedding cleavage site. J Thromb Haemost. 2013, 11(12): 2155-62 IF: 4.662

注:1共同第一作者, 通讯作者


网页发布时间: 2017-06-29