余星昕
发布人: 余星昕 发布时间: 2017-07-07 作者: 访问次数: 57

  

余星昕 博士

副教授、硕士生导师

   

联系方式

邮箱:xxyu@ecust.edu.cn

传真:021-64252431

通讯地址:上海市徐汇区梅陇路130318信箱

邮编:200237


个人简介

        20126月获复旦大学有机化学博士学位,上海市优秀毕业生。毕业后赴美国明尼苏达大学(University of Minnesota)药学院从事小分子肺癌抑制剂研发的博士后研究。20138月加入华东理工大学药学院,开展药物小分子设计合成及其作用机制研究。20159月晋升副教授,同年12月被聘为硕士生导师。

    作为项目负责人,主持国家自然科学基金(青年基金),主持教育部基本科研业务费探索研究基金(2项);2014年入选上海市浦江人才计划和上海市首批青年科技英才扬帆计划2015年被评为华东理工大学青年英才引进与培育计划骨干2015药学院优秀青年教师

    已在Org. Lett.; J. Org. Chem.; Chem. Commun.; Chem. Eur. J.; Catal. Sci. Technol.; Chem. Soc. Rev.等国际核心期刊上发表第一作者和通讯作者SCI论文30余篇,论文被引用600余次,获得中国发明专利授权1项。


主要研究方向

基于新技术、新方法和新反应的新型杂环化合物的设计合成,构建具有生物活性的类天然小分子化合物用于创新药物研究。


近期发表论文

1. Jiang Meng, Min Wen, Shiwei Zhang, Peiwen Pan, Xingxin Yu*, Wei-Ping Deng*. J. Org. Chem., 2017, 82, 1676-1687. (Highlighted by Synfacts, 2017, 13, 354.)

Unexpected O-H Insertion of Rhodium-Azavinylcarbenes with N-Acylhydrazones: Divergent Synthesis of 3,6-Disubstituted- and 3,5,6-Trisubstituted-1,2,4-Triazines.

2. Jiang Meng, Xiangfeng Ding, Xingxin Yu*, Wei-Ping Deng. Tetrahedron, 2016, 72, 176-183.

Synthesis of 2,5-epoxy-1,4-benzoxazepines via rhodium(II)-catalyzed reaction of 1-tosyl-1,2,3-triazoles and salicylaldehydes.

3. Bo Zhou[+], Xingxin Yu[+], Chunlin Zhuang*, Peter Villalta, Yong Lin, Junxuan Lu, Chengguo Xing*. ChemMedChem, 2016, 11, 1436-1445. ([+] equal contribution)

Unambiguous Identification of β-Tubulin as the Direct Cellular Target Responsible for the Cytotoxicity of Chalcone by Photoaffinity Labeling.

4. Linwei Huang, Jinbin Zhu, Guangjun Jiao, Zheng Wang, Xingxin Yu, Wei-Ping Deng*, Wenjun Tang*. Angew. Chem. Int. Ed., 2016, 55, 4527-4531.

Highly Enantioselective Rhodium-Catalyzed Addition of Arylboroxines to Simple Aryl Ketones: Efficient Synthesis of Escitalopram.

5. Fu-Sheng He, Jing-Hai Jin, Zhong-Tao Yang, Xingxin Yu, John S. Fossey, Wei-Ping Deng*. ACS Catal., 2016, 6, 652-656.

Direct Asymmetric Synthesis of β-Bis-Aryl-α-Amino Acid Esters via Enantioselective Copper-Catalyzed Addition of p-Quinone Methides.

6. Wu-Lin Yang, Chun-Yan Li, Wen-Jing Qin, Fei-Fei Tang, Xingxin Yu, Wei-Ping Deng*. ACS Catal., 2016, 6, 5685-5690.

Cu(I)-Catalyzed Chemoselective and Stereoselective [3+3] Cycloaddition of Azomethine Ylides with 2-Indolylnitroethylenes: Facile Access to Highly Substituted Tetrahydro-γ-Carbolines.

7. Wu-Lin Yang, Fei-Fei Tang, Fu-Sheng He, Chun-Yan Li, Xingxin Yu*, Wei-Ping Deng*. Org. Lett., 2015, 17, 4822-4825. (Highlighted by Synfacts, 2015, 11, 1285.)

Asymmetric Construction of Spirocyclic Pyrrolidine-thia(oxa)zolidinediones via N,O-Ligand/Cu(I) Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides with 5-Alkylidene Thia(oxa)zolidine-2,4-diones.

8. Fu-Sheng He, Han Zhu, Zheng Wang, Ming Gao, Xingxin Yu*, Wei-Ping Deng*. Org. Lett., 2015, 17, 4988-4991. (Highlighted by Synfacts, 2015, 11, 1284.)

Asymmetric Construction of 3,4-Diamino Pyrrolidines via Chiral N,O-Ligand/Cu(I) Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides with β-Phthalimidonitroethene.

9. Zheng Wang[+], Xingxin Yu*[+], Bo-Xue Tian, Daniel T. Payne, Wu-Lin Yang, Yang-Zi Liu, John S. Fossey, Wei-Ping Deng*. Chem. Eur. J., 2015, 21, 10457-10465. ([+] equal contribution)

Chiral N,O-Ligand/Cu(OAc)2 Catalyzed Asymmetric Construction of 4-Aminopyrrolidine Derivativesvia 1,3-Dipolar Cycloaddition of Azomethine Ylides with α-phthalimidoacrylates.

10. Wu-Lin Yang, Yang-Zi Liu, Shuai Luo, Xingxin Yu*, John S. Fossey, Wei-Ping Deng*. Chem. Commun., 2015, 51, 9212-9215. (Highlighted by Synfacts, 2015, 11, 738.)

The copper-catalyzed asymmetric construction of a dispiropyrrolidine skeleton via 1,3-dipolar cycloaddition of azomethine ylides to α-alkylidene succinimides.

11. Fei-Fei Tang, Wu-Lin Yang, Xingxin Yu*, Wei-Ping Deng*. Catal. Sci. Technol., 2015, 5, 3568-3575.

Cu(OAc)2/FOXAP complex catalyzed construction of 2,5-dihydropyrrole derivatives via asymmetric 1,3-dipolar cycloaddition of azomethine ylides with ethynyl ketones.

12. Shan-Shan Jiang, Qin-Chang Xu, Ming-Yu Zhu, Xingxin Yu*, Wei-Ping Deng*. J. Org. Chem., 2015, 80, 3159-3169.

Kinetic Resolution of α-Methylene-β-hydroxy Esters Catalyzed by Acyl Transfer Catalyst An-PIQ.

13. Shan-Shan Jiang, Bo-Qi Gu, Ming-Yu Zhu, Xingxin Yu*, Wei-Ping Deng*. Tetrahedron, 2015, 71, 1187-1191.

Nonenzymatic kinetic resolution of α-aryl substituted allylic alcohols catalyzed by acyl transfer catalyst Np-PIQ.

14. Wen-Jing Qin, Yi Li, Xingxin Yu*, Wei-Ping Deng*. Tetrahedron, 2015, 71, 1182-1186.

TBAI/TBHP catalyzed direct N-acylation of sulfoximines with aldehydes.

15. Jiang Meng, Di Wu, Ying Shi, Xingxin Yu*, Wei-Ping Deng. Tetrahedron, 2015, 71, 1074-1079.

Construction of 1H-pyrrol-2-ylphosphonates via [3+2] cycloaddition of phosphate azomethine ylides with ynones.

16. Xianbo Wang, Xingxin Yu*. J. Org. Chem., 2014, 79, 7854-7860.

Silver(I) and Copper(I) Co-catalyzed Tandem Reaction of 2-Alkynylbenzaldoximes with Aldehydes or Alcohols: Approach to 4-Carboxylated Isoquinolines.

17. Shanshan Jiang, Bin Hu, Xingxin Yu*, Weiping Deng*. Chin. J. Chem.,2014, 32, 694-698.

Fc-PIP Catalyzed Asymmetric Synthesis of cis-2,3-Dihydrobenzofurans.

18. Yong Luo, Xiaolin Pan, Xingxin Yu*, Jie Wu*. Chem. Soc. Rev.,2014, 43, 834-846.

Double Carbometallation of Alkynes: An Efficient Strategy for the Construction of Polycycles.