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余星昕

       

余星昕  博士

副教授、硕士生导师

 


联系方式

邮箱:xxyu@ecust.edu.cn

传真:021-64252431

通讯地址:上海市徐汇区梅陇路130318信箱

邮编:200237

 

个人简介

20126月获复旦大学有机化学博士学位,上海市优秀毕业生。毕业后赴美国明尼苏达大学(University of Minnesota)药学院从事小分子肺癌抑制剂研发的博士后研究。20138月加入华东理工大学药学院,开展药物小分子设计合成及其作用机制研究。20159月晋升副教授,同年被聘为硕士生导师。

作为项目负责人,主持国家自然科学基金(青年基金),主持教育部基本科研业务费探索研究基金(2项);2014年入选上海市浦江人才计划和上海市首批青年科技英才扬帆计划2015年被评为华东理工大学青年英才引进与培育计划骨干药学院优秀青年教师

已在Org. Lett.; J. Org. Chem.; Chem. Commun.; Chem. Eur. J.; Chem. Soc. Rev.等国际核心期刊上发表SCI论文40余篇,论文被引用1000余次,H指数22。获得中国发明专利授权1项。

       

主要研究方向

基于新技术、新方法和新反应的新型杂环化合物的设计合成,构建具有生物活性的类天然小分子化合物用于创新药物研究。

 

近期发表论文

1. Renmeng Jia, Jiang Meng, Jiaying Leng, Xingxin Yu*, Wei-Ping Deng*. Chem. Asian. J., 2018, 13, 2360-2364.

Rhodium(II)-Catalyzed Reaction of 1-Tosyl-1,2,3-triazoles with Morita-Baylis-Hillman Adducts: Synthesis of 3,4-Fused Pyrroles.

2. Jiang Meng, Renmeng Jia, Jiaying Leng, Min Wen, Xingxin Yu*, Wei-Ping Deng*. Org. Lett., 2017, 19, 4520-4523.

Carbon-Carbon Bond Formation by Reaction of Rhodium Azavinylcarbenes with Secondary Amides: Access to Indigo Analogues from Isatins.

3. Jiang Meng, Min Wen, Shiwei Zhang, Peiwen Pan, Xingxin Yu*, Wei-Ping Deng*. J. Org. Chem., 2017, 82, 1676-1687. (Highlighted by Synfacts, 2017, 13, 354.)

Unexpected O-H Insertion of Rhodium-Azavinylcarbenes with N-Acylhydrazones: Divergent Synthesis of 3,6-Disubstituted- and 3,5,6-Trisubstituted-1,2,4-Triazines.

4. Jiang Meng, Xiangfeng Ding, Xingxin Yu*, Wei-Ping Deng. Tetrahedron, 2016, 72, 176-183.

Synthesis of 2,5-epoxy-1,4-benzoxazepines via rhodium(II)-catalyzed reaction of 1-tosyl-1,2,3-triazoles and salicylaldehydes.

5. Bo Zhou[+], Xingxin Yu[+], Chunlin Zhuang*, Peter Villalta, Yong Lin, Junxuan Lu, Chengguo Xing*. ChemMedChem, 2016, 11, 1436-1445. ([+] equal contribution)

Unambiguous Identification of β-Tubulin as the Direct Cellular Target Responsible for the Cytotoxicity of Chalcone by Photoaffinity Labeling.

6. Linwei Huang, Jinbin Zhu, Guangjun Jiao, Zheng Wang, Xingxin Yu, Wei-Ping Deng*, Wenjun Tang*. Angew. Chem. Int. Ed., 2016, 55, 4527-4531. (Highlighted by Synfacts, 2016, 12, 557.)

Highly Enantioselective Rhodium-Catalyzed Addition of Arylboroxines to Simple Aryl Ketones: Efficient Synthesis of Escitalopram.

7. Fu-Sheng He, Jing-Hai Jin, Zhong-Tao Yang, Xingxin Yu, John S. Fossey, Wei-Ping Deng*. ACS Catal., 2016, 6, 652-656. (Highlighted by Synfacts, 2016, 12, 390.)

Direct Asymmetric Synthesis of β-Bis-Aryl-α-Amino Acid Esters via Enantioselective Copper-Catalyzed Addition of p-Quinone Methides.

8. Wu-Lin Yang, Chun-Yan Li, Wen-Jing Qin, Fei-Fei Tang, Xingxin Yu, Wei-Ping Deng*. ACS Catal., 2016, 6, 5685-5690. (Highlighted by Synfacts, 2016, 12, 1058.)

Cu(I)-Catalyzed Chemoselective and Stereoselective [3+3] Cycloaddition of Azomethine Ylides with 2-Indolylnitroethylenes: Facile Access to Highly Substituted Tetrahydro-γ-Carbolines.

9. Wu-Lin Yang, Fei-Fei Tang, Fu-Sheng He, Chun-Yan Li, Xingxin Yu*, Wei-Ping Deng*. Org. Lett., 2015, 17, 4822-4825. (Highlighted by Synfacts, 2015, 11, 1285.)

Asymmetric Construction of Spirocyclic Pyrrolidine-thia(oxa)zolidinediones via N,O-Ligand/Cu(I) Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides with 5-Alkylidene Thia(oxa)zolidine-2,4-diones.

10. Fu-Sheng He, Han Zhu, Zheng Wang, Ming Gao, Xingxin Yu*, Wei-Ping Deng*. Org. Lett., 2015, 17, 4988-4991. (Highlighted by Synfacts, 2015, 11, 1284.)

Asymmetric Construction of 3,4-Diamino Pyrrolidines via Chiral N,O-Ligand/Cu(I) Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides with β-Phthalimidonitroethene.

11. Zheng Wang[+], Xingxin Yu*[+], Bo-Xue Tian, Daniel T. Payne, Wu-Lin Yang, Yang-Zi Liu, John S. Fossey, Wei-Ping Deng*. Chem. Eur. J., 2015, 21, 10457-10465. ([+] equal contribution)

Chiral N,O-Ligand/Cu(OAc)2 Catalyzed Asymmetric Construction of 4-Aminopyrrolidine Derivativesvia 1,3-Dipolar Cycloaddition of Azomethine Ylides with α-phthalimidoacrylates.

12. Wu-Lin Yang, Yang-Zi Liu, Shuai Luo, Xingxin Yu*, John S. Fossey, Wei-Ping Deng*. Chem. Commun., 2015, 51, 9212-9215. (Highlighted by Synfacts, 2015, 11, 738.)

The copper-catalyzed asymmetric construction of a dispiropyrrolidine skeleton via 1,3-dipolar cycloaddition of azomethine ylides to α-alkylidene succinimides.

13. Fei-Fei Tang, Wu-Lin Yang, Xingxin Yu*, Wei-Ping Deng*. Catal. Sci. Technol., 2015, 5, 3568-3575.

Cu(OAc)2/FOXAP complex catalyzed construction of 2,5-dihydropyrrole derivatives via asymmetric 1,3-dipolar cycloaddition of azomethine ylides with ethynyl ketones.

14. Shan-Shan Jiang, Qin-Chang Xu, Ming-Yu Zhu, Xingxin Yu*, Wei-Ping Deng*. J. Org. Chem., 2015, 80, 3159-3169.

Kinetic Resolution of α-Methylene-β-hydroxy Esters Catalyzed by Acyl Transfer Catalyst An-PIQ.

15. Shan-Shan Jiang, Bo-Qi Gu, Ming-Yu Zhu, Xingxin Yu*, Wei-Ping Deng*. Tetrahedron, 2015, 71, 1187-1191.

Nonenzymatic kinetic resolution of α-aryl substituted allylic alcohols catalyzed by acyl transfer catalyst Np-PIQ.

16. Wen-Jing Qin, Yi Li, Xingxin Yu*, Wei-Ping Deng*. Tetrahedron, 2015, 71, 1182-1186.

TBAI/TBHP catalyzed direct N-acylation of sulfoximines with aldehydes.

17. Jiang Meng, Di Wu, Ying Shi, Xingxin Yu*, Wei-Ping Deng. Tetrahedron, 2015, 71, 1074-1079.

Construction of 1H-pyrrol-2-ylphosphonates via [3+2] cycloaddition of phosphate azomethine ylides with ynones.

18. Xianbo Wang, Xingxin Yu*. J. Org. Chem., 2014, 79, 7854-7860.

Silver(I) and Copper(I) Co-catalyzed Tandem Reaction of 2-Alkynylbenzaldoximes with Aldehydes or Alcohols: Approach to 4-Carboxylated Isoquinolines.

19. Shanshan Jiang, Bin Hu, Xingxin Yu*, Weiping Deng*. Chin. J. Chem.,2014, 32, 694-698.

Fc-PIP Catalyzed Asymmetric Synthesis of cis-2,3-Dihydrobenzofurans.

20. Yong Luo, Xiaolin Pan, Xingxin Yu*, Jie Wu*. Chem. Soc. Rev., 2014, 43, 834-846.

Double Carbometallation of Alkynes: An Efficient Strategy for the Construction of Polycycles.

 










网页发布时间: 2018-09-10