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朱丽丽


  

  

朱丽丽,博士,华东理工大学副教授,硕士生导师。

研究方向:

主要研究领域为与疾病有关蛋白质的化学生物学和结构生物学研究。包括基于靶标蛋白的抑制剂筛选、以X射线蛋白质晶体学为手段研究与疾病有关靶标蛋白的晶体结构、药物作用机制及基于结构生物学的创新药物设计。2012年入选上海市高校青年教师培养资助计划。主持完成的项目有上海市自然科学基金1项,中央高校基本科研业务费专项资金1项,国家基金委自然基金青年基金1项,作为主要成员参与“863计划”1项及基金委重点项目等多项研究项目。

简历:

20087月毕业于中科院福建物质结构研究所获博士学位,专业为生物化学与分子生物学。

20088月至2011年7月在德国吕贝克大学生物化学系做博士后研究。

20118月至今在华东理工大学药学院任副教授。

联系方式:

电话021-64253379.  email:zhulfl@ecust.edu.cn

科研成果:

1)Guozhen  Wu1, Lili  Zhu1, Xing Yuan, Hao Chen, Rui Xiong, Shoude Zhang,  Hao Cheng, Yunheng Shen, Huazhang An, Tiejun Li, Honglin Li, Weidong zhang,  Britanin ameliorates cerebral ischemia-reperfusion injury by inducing the Nrf2 protective pathway,  Antioxidants & Redox Signaling,2017DOI:10.1089/ars.2016.6885.

2)Qiao Li,  Lina QuanJiankun LyuZenghui HeXia  WangJiajia MengZhenjiang ZhaoLili  Zhu*Xiaofeng Liu *Honglin Li *. Discovery of peptide  inhibitors targeting human programmed death 1(PD-1) receptor.  Oncotarget2016.8.127(40)64967~64976.

3)Wenlin  SongShiliang LiYi  TongJiawei WangLina  QuanZhuo ChenZhenjiang ZhaoYufang XuLili  Zhu*Xuhong Qian *Honglin Li*. Structure-based design of  potent human dihydroorotatedehydrogenase inhibitors as anticancer agents.  Medchemcomm2016.01.017(7)1441~1448.  

4)Jiawei  Wang, Yanyan Diao, Junsheng Zhu, Shiliang Li, Zhenjiang Zhao, Honglin Li *,  Lili Zhu *.  Biological evaluation of quinoline derivatives as inhibitors of human  dihydroorotate dehydrogenase.  MedChemComm,   2016, 7(5):853-858.

5)Yongjia  Hao,Xia Wang,Tao Zhang,Deheng Sun,Yi Tong,Yuqiong  Xu,Haiyang Chen,Linjiang Tong,Lili  Zhu,Zhenjiang Zhao,Zhuo  Chen,Jian Ding,Hua Xie,Yufang  Xu,Honglin Li, Discovery and Structural Optimization of  N5-Substituted 6,7-Dioxo- 6,7-dihydropteridines as Potent and Selective  Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M  Resistance Mutation. J. Med.  Chem.2016,  11;59(15):7111-24.

6)Shiliang  Li,Hongling Xu,Shichao Cui,Fangshu Wu,Youli  Zhang,Mingbo Su,Yinghui Gong,Shaobing  Qiu,Qian Jiao,Chun Qin,Jiwei  Shan,Ming Zhang,Jiawei Wang,Qiao  Yin,Minghao Xu,Xiaofeng Liu,Rui  Wang,Lili  Zhu,Jia Li,Yufang  Xu,Hualiang Jiang,Zhenjiang Zhao,Jingya  Li,and Honglin Li.  DiscoveryandRationalDesignofNatural-Product-Derived  2-Phenyl-3,4-dihydro-2H-benzo[f]chromen-3-amine Analogs as Novel and Potent  Dipeptidyl Peptidase 4 (DPP-4)Inhibitorsfor theTreatmentofType 2 Diabetes. J. Med. Chem. 2016, 28;59(14):6772-90.

7)Shiliang  Li(#)Guoqin Luan(#)Xiaoli Ren(#)Wenlin SongLiuxin XuMinghao XuJunsheng ZhuDong  DongYanyan DiaoXiaofeng LiuLili  ZhuRui WangZhenjiang ZhaoYufang XuHonglin Li(*)Rational Design of  Benzylidenehydrazinyl-Substituted Thiazole Derivatives as Potent Inhibitors of  Human Dihydroorotate Dehydrogenase with in Vivo Anti-arthritic  ActivityScientific Reports2015.10.751):14836.

8)Junsheng Zhu, Le Han, Yanyan Diao, Xiaoli Ren, Minghao  Xu, Liuxin Xu, Shiliang Li, Qiang Li , Dong Dong, Jin Huang, Xiaofeng  Liu, Zhenjiang Zhao, Rui Wang, Lili Zhu*, Yufang Xu, Xuhong  Qian *, and Honglin Li*.Design, Synthesis,  X-ray Crystallographic Analysis, and Biological Evaluation of Thiazole  Derivatives as Potent and Selective Inhibitors of Human Dihydroorotate  Dehydrogenase. J. Med. Chem. 2015, 583,  1123-1139.

9)Liyan Wang, Shoude Zhang, Junsheng Zhu, Lili Zhu, Xiaofeng Liu, Lei Shan, Jin Huang*,  Weidong Zhang*, Honglin Li*. Identification of Diverse Natural Products as  Falcipain-2 Inhibitors through Structure-based Virtual Screening. Bioorg. Med.  Chem. Lett. 2014. 24(5) : 1261–1264.

10)Minghao Xu, Junsheng Zhu, Yanyan Diao, Hongchang Zhou,  Xiaoli Ren, Deheng Sun, Jin Huang, Dongmei Han, Zhenjiang Zhao, Lili Zhu*, Yufang Xu*, and  Honglin Li*. Novel Selective and Potent Inhibitors of Malaria Parasite  Dihydroorotate Dehydrogenase: Discovery and Optimization of Dihydrothiophenone  Derivatives. J. Med. Chem., 2013. 56 (20) : 7911–7924  

11)Xiaojuan Yu, Xue Zhao, Lili Zhu, Chuanxin Zou,  Xiaofeng Liu, Zhenjiang Zhao, Jin Huang* and Honglin Li*. Discovery of novel  inhibitors for human farnesyltransferase (hFTase) via structure-based virtual  screening. Med. Chem. Commun., 2013. 4 : 962-971

12)Liyan Wang, Chunmei Yang, Weiqiang Lu, Li Liu, Rui Gao,  Sha Liao, Lili  Zhu, Zhenjiang Zhao, Yufang Xu, Honglin Li*, Jin Huang, Weiping  Zhu. Discovery of New Potent Inhibitors for Carbonic Anhydrase IX by  Structure-Based Virtual Screening. Bioorg. Med. Chem. Lett.., 2013. 23  : 3496-3499

13)Yuwei Song, Huangtao Jin, Xiaofeng Liu, Lili Zhu*, Jin Huang*,  Honglin Li*. Discovery of non-peptide inhibitors of Plasmepsin II by  structure-based virtual screening. Bioorg. Med. Chem. Lett., 2013.  23(7) : 2078-2082

14)Xianwen Cao, Jing Jiang, Shoude Zhang,Lili Zhu, Juan Zou,  Yanyan Diao, Weilie Xiao, Lei Shan, Handong Sun, Weidong Zhang*, Jin Huang*,  Honglin Li*. Discovery of Natural Estrogen Receptor Modulators with  Structure-based Virtual Screening. Bioorg. Med. Chem. Lett., 2013. 23 :  3329-3333

15)Kunqiang Cui1, Weiqiang Lu1,  Lili  Zhu1, Xu Shen, Jin Huang. Caffeic acid phenethyl  ester (CAPE), an active component of propolis, inhibits Helicobacter  pulori peptide deformylase activity. Biochem. Biophys. Res. Commun.,  2013. 435(2):289-294

16)Lili  Zhu, Shyla George, Marco  F.Schmidt, Samer I Al-Gharabli, Jorg Rademann, Rolf Hilgenfeld. Peptide aldehyde  inhibitors challenge the substrate specificity of the SARS-coronavirus main  protease. Antiviral research. 2011, 92 (2)204-216.

17)Lili  Zhu, Cai Yuan, Zhuo Chen,  Wanyu Wang, Mingdong Huang. Expression, purification and characterization of  recombinant Jerdonitin, a P-II class snake venom metalloproteinase comprising  metalloproteinase and disintegrin domains. Toxicon, 2010, 55,  375-380.

18)Lili  Zhu, Feng Yang, Liqing Chen,  Edward J.Meehan, Mingdong Huang. A new drug binding subsite on human serum  albumin and drug-drug interaction studied by X-ray crystallography. Journal of  structural biology.2008, 162, 40-49.


网页发布时间: 2018-02-28