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陶黎明



陶黎明   教授  博士生导师

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电话:  021-64253756


E-mail: taolm@ecust.edu.cn


地址:华东理工大学 徐汇校区实验十八楼1335室


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个人简介

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陶黎明,男,1958年生于上海,博士、教授、博士生导师,中国化工学会农药专业委员会委员、《农药学学报》编委、享受国务院政府特殊津贴、上海市优秀学科带头人等。1982年毕业于华东化工学院(现华东理工大学)生物化学专业,1987年获中国农科院昆虫生化专业硕士学位,2005年获中国科学院上海生命科学院理学博士学位。分别在1991~1992年赴日本理化学研究所、1996~1997年赴德国巴斯夫公司开展农用生物活性物质研究。先后工作于中科院武汉水生生物研究所、上海市农药研究所,2010年调入华东理工大学药学院药物化工研究所工作至今。近30年来,一直从事天然产物类农药的筛选与研发,“八五” 至“十二五”期间主持和参与多项关于农药研究的国家科技攻关和科技支撑项目;参与完成“973计划”中“绿色化学农药”项目子课题研究;承担完成海洋”863计划”课题一项;承担完成上海市优秀学科带头人计划一项,获授权国内外发明专利30多项。

  

研究方向

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方向一: 生物农药的研发

开展以天然产物类农用抗生素的发现、研究与创制等方面为主的工作。

方向二: 农药毒理学

系统研究农药的作用方式、作用机理及代谢机制,重点开展杀虫剂的潜在作用靶标及对非靶标生物与环境生态的影响研究。


2010年调入我校以来的主要论著

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29Ping Zhang, Yang Zhang, Kuikui Liu, Bin Liu, Wenping Xu, Jufang Gao, Lei Ding, Liming Tao*. Ivermectin induces cell cycle arrest and apoptosis of HeLa cells via mitochondrial pathway.Cell Proliferation, (2018) https://doi,org/10.1111/cpr.12543

28Yun Yang, Wenjing Liu, Jian Wang, Yang Zhang, Wenping Xu,Liming Tao*.The different effects of natural pyrethrins and beta-cypermethrin on human hepatocyte QSG7701 cells by ROS-mediated oxidative damage. Environmental Science and Pollution Research, 2018, 25(24): 24230-24240.

27Yun Yang, Jufang Gao, Yang Zhang, Wenping Xu, Youwu Hao, Zhiping Xu, Liming Tao*. Natural pyrethrins induce autophagy of HepG2 cells through the activation of AMPK/mTOR pathway.Environmental Pollution,2018,241: 1091-1097.

26Wenping Xu, Mingjun Yang, Jufang Gao, Yang Zhang, Liming Tao*.Oxidative stress and DNA damage induced by spinosad exposure in Spodoptera frugiperda Sf9 cells.Food and Agricultural Immunology, 2018,29:171-181..

25Yang Zhang, Yuansen Chang, Haijing Cao, Wenping Xu, Zhong Li, Liming Tao*.Potential threat of Chlorpyrifos to human liver cells via the caspase-dependent mitochondrial pathways.Food and Agricultural Immunology,2018, 29, 294-305.

24Haijing Cao, Wenjing Liu, Yuansen Chang, Hui Chen, Yang Zhang, Wenping Xu, Liming Tao*. 5′-Epi-SPA-6952A, a new insecticidal 24-membered macrolide produced by Streptomyces diastatochromogenes SSPRC-11339Nature product research,http://dx.doi.org/10.1080/14786419.2017.1405401.

23Wenping Xu, Songlin Liu, Yang Zhang, Jufang Gao, Mingjun Yang, XiaoLiu, Liming Tao*., Cypermethrin resistance conferred byincreased target insensitivity and metabolic detoxification in Culex pipienspallens Coq. Pesticide Biochemistry and Physiology, 2017,142:77-82.

22Yang Zhang, Jigang Wu, Wenping Xu, Jufang Gao, Haijing Cao, MingjunYang, Bo Wang, Youwu Hao, Liming Tao*., Cytotoxic effects ofAvermectin on human HepG2 cells in vitro bioassays. EnvironmentalPollution, 2017,220(Pt B):1127-1137.

21Yun Yang, Mimi Zong, Wenping Xu, YangZhang, Bo Wang, Mingjun Yang,Liming Tao*., Natural pyrethrins induces apoptosis in humanhepatocyte cells via Bax- and Bcl-2-mediated mitochondrial pathway,Chemico-Biological Interactions, 2017,262:38-45.

20Wenping Xu, Bo Wang, Mingjun Yang, Yang Zhang, Zhiping Xu, Yun Yang,Haijing Cao, Liming Tao*.,Tebufenozide induces G1/S cell cyclearrest and apoptosis in human cells. Environmental Toxicology and Pharmacology, 2017,49:89 - 96.

19Youwu Hao, Gaohui Zhou, Wei Wu, Yang Zhang, LimingTao, Jianhua Yao,Wenping Xu*., Synthesis and antiviral evaluation of novel N-6 substituted adenosine analogues. Tetrahedron Letters, 2017, 58(3):190-193.

18Mingjun Yang, Bo Wang, Jufang Gao, Yang Zhang, Wenping Xu, Liming Tao*. Spinosad induces programmed cell death involves mitochondrial dysfunction and cytochrome c release in spodoptera frugiperda Sf9 cells. Chemosphere, 2017,169:155-161.

17Mingjun Yang, Guanggang Xiang, Diqiu Li, Yang Zhang, Wenping Xu,Liming Tao*., The insecticide spinosad induces DNA damage and apoptosis in HEK293 and HepG2 cells. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2016,812:12-19.

16Yang Zhang, Mingming Luo, Wenping Xu, Mingjun Yang, Bo Wang, JufangGao, Yaxiao Li, and Liming Tao*., Avermectin Confers Its Cytotoxic Effects by Inducing DNA Damage and Mitochondria-Associated ApoptosisJournal of Agricultural and Food Chemistry, 2016, 64(36): 6895-6902.

15Zhiping Xu, Miaoqing Lu, Mingjun Yang, Wenping Xu, Jufang Gao, YangZhang, Yun Yang, Liming Tao*., Pyrethrum-extract induced autophagy in Insect cells: A new target? Pesticide Biochemistry and Physiology, 2017,137:21-26.

14Xiaoqin Yu, Yang Zhang, Mingjun Yang, Junfu Guo, Wenping Xu, JufangGao, Yaxiao Li, Liming Tao*., Cytotoxic effects of tebufenozidein vitro bioassaysEcotoxicology and Environmental Safety, 2016,129: 180-188.

13Yang Zhang, Songlin Liu, Xing Yang, Mingjun Yang, Wenping Xu, YaxiaoLi, Liming Tao*., Staurosporine shows insecticidal activityagainst Mythimna separataPesticide Biochemistry and Physiology, 2016,128: 37-44.

12Xiwei Wu, Lei Zhang, Chao Yang, Mimi Zong, Qingchun Huang*, Liming Tao.Detection on emamectin benzoate induced apoptosis and DNA damage inSpodoptera rugiperda Sf9 cell line.Pesticide Biochemistry and Physiology, 2016, 126: 6–12.

11Diqiu Li, Qingchun Huang* Miaoqing Lu, Lei Zhang, Zhichuan Yang, Mimi Zong, LimingTao*.The organophosphate insecticide chlorpyrifos confers its genotoxic effects by inducing DNA damage and cell apoptosis.Chemosphere2015, 135: 387–393.

10Diqiu Li, Xiwei Wu, Xiaoqin Yu, Qingchun Huang, LimingTao*.Synergistic effect of nonionic surfactants Tween 80 andPEG6000 oncytotoxicity of insecticides. Environmental Toxicology and Pharmacology, 2015, 39: 677–682.

9 Qingchun Huang*, Xiwei Wu, Xiaoqin Yu, Lei Zhang, Miaoqing Lu, Liming Tao*., Comparison of the cytotoxic impact of chlorfluazuron on selected insect and human cell lines.Environmental Toxicology Chemical.2015, 34(7): 1675-1682.

8Wenping Xu, Qingchun Huang*, Xiwei Wu, Xiaoqin Yu, Xuexiao  Wang, Liming Tao. Property of midgut a-amylase from Mythimna  separate Lepidoptera: Noctuidae) larvae and its responses to potential  inhibitors in vitro. Journal of Insect Science, 2014,  14(282); DOI:10.1093/jisesa/ieu144.

7Xiuyuan Zhuang, Daojing Zhang, Wen Qin, Jia Deng, Hui Shan,  Liming Tao* and Yuanguang Li*., A comparison on the preparation  of hot water extracts from Chlorella pyrenoidosa (CPEs) and radical scavenging  and macrophage activation effects of CPEs. Food & Function,  2014, 5(12):3252-3260.

6Xiang Guanggang, Li Diqiu, Yuan Jianzhong, Guan Jingmin, Zhai  Huifeng, Shi Mingan*, Tao Liming* Carbamate insecticide  methomyl confers cytotoxicity through DNA damage induction.  Food  and Chemical Toxicology,2013, 53,352-358.

5Wenping Xu, Daojing Zhang, Congcong Si, Liming  Tao*., ANTIFUNGAL MACROLIDES FROM Streptomyces cavourensis  YY01-17.Chemistry of Natural Compounds ,2013, 49(5),  988-989.

4Baoju Li, Huizhu Yuan, Jichao Fang, Liming  Tao, Qingchun Huang*, Xuhong Qian*, Zhijin Fan. Recent progress of highly efficient in vivo biological screening for novel agrochemicals in China  .Pest Management Science,2010, 66 (3): 229 –  344

3Daojing Zhang, Gang Wei, Ying Wang, Congcong Si, Li Tian,  Liming Tao* and Yuan-guang Li. Bafilomycin K, a new antifungal macrolide from Streptomyces flavotricini Y12-26. The Journal of Antibiotics,2011, 64, 391–393.

2DaoJing Zhang, Rong-Feng Liu, Yuan-Guang Li*, LiMing  Tao, Li Tian. Two New Antifungal Cyclic Lipopeptides from Bacillus  marinus B-9987. Chemical & Pharmaceutical  Bulletin,2010, 58(12):1630-1634

1Rong-Feng Liu, Dao-Jing Zhang, Yuan-Guang Li*, Li-Ming  Tao, Li Tian*. A New Antifungal Cyclic Lipopeptides from Bacillus  marinus B-9987. Helvetica Chimica Acta,2010,  93(12):2419-2425.

网页发布时间: 2014-09-09