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张永强

张永强 副教授、硕士生导师

联系方式:

通讯地址:华东理工大学实验十四楼西侧402,邮编200237

电话:021-64253299

电邮:yongqiangzhang@ecust.edu.cn

个人简介:

2013年毕业于第二军医大学(现海军军医大学)药学院药物化学专业,获医学博士学位,导师张万年教授和盛春泉教授。后赴美国犹他大学化学系生物有机专业从事博士后研究,合作导师季海涛助理教授。20161月回国受聘于华东理工大学药学院,从事药物化学教学和科研工作,先后主持国家自然科学基金青年基金1教育部高校基本科研业务费1项,参编论著一部(Targeting Protein-Protein Interactions by Small Molecules);已在国际核心刊物如J. Am. Chem. Soc.; Angew. Chem. Int. Ed.; Chem. Sci.; Chem. Commun.; J. Med. Chem. 等上发表10余篇SCI论文。

主要研究方向:

1新型自由基化学的开发及其在药物化学中的应用

  • 基于自由基的碳硅键构建方法研究与多样性含硅药物骨架的合成

  • 基于自由基偶联反应的芳基碳糖苷合成研究

  • 基于自由基化学的天然产物精准修饰新策略开发与应用

2、多样性导向合成与抗肿瘤,抗感染药物先导物的发现

3天然产物结构改造与抗肿瘤活性研究

代表性论文:

回国后研究工作(2016-至今)

1. Shihui Liu, Aoxia Liu, Yongqiang Zhang*(通讯作者), Wei Wang*. Direct Cα-Heteroarylation of Structurally Diverse Ethers via a Mild N-Hydroxysuccinimide Mediated Cross-Dehydrogenative Coupling Reaction. Chem. Sci. 2017, 8, 4044-4450.

2. Yongqiang Zhang(第一作者), Kevin B. Teuscher, Haitao Ji*. Direct α-Heteroarylation of Amides (α to Nitrogen) and Ethers through a Benzaldehyde -Mediated Photoredox Reaction. Chem. Sci.2016, 7, 2111–2118.

3. Wenbin Cai, Huaqiang Fan, Dazhong Ding, Yongqiang Zhang*(通讯作者), Wei Wang*. Synthesis of Z-alkenes via Visible Light Promoted Photocatalytic E - Z Isomerization under Metal-Free Conditions. Chem. Commun.2017, 53, 12918-12921.

4.He Huang, Chenguang Yu, Yueteng Zhang, Yongqiang Zhang, Patrick S. Mariano*, and Wei Wang*. Chemo- and Regioselective Organo-Photoredox Catalyzed Hydroformylation of Styrenes via a Radical Pathway. J. Am. Chem. Soc. 2017, 139, 9799−9802.

博士后期间(2013-2016)

1. Logan R. Hoggard,† Yongqiang Zhang(并列第一作者),Min Zhang, Vanja Panic, John A. Wisniewski, and Haitao Ji*. Rational Design of Selective Small-Molecule Inhibitors for β‑Catenin/B-Cell Lymphoma 9 Protein−Protein Interactions. J. Am. Chem. Soc. 2015, 137, 12249−12260.

2. J. Leon Catrow,† Yongqiang Zhang(并列第一作者),† Min Zhang, and Haitao Ji*. Discovery of Selective Small-Molecule Inhibitors for the β‑Catenin/TCell Factor Protein−Protein Interaction through the Optimization of the Acyl Hydrazone Moiety. J. Med. Chem. 2015, 58, 4678−4692.

3.Yongqiang Zhang, Shanchao Wu, Shengzheng Wang, Kun Fang, Guoqiang Dong, Na Liu, Zhenyuan Miao, Jianzhong Yao, Jian Li, Wannian Zhang,* Chunquan Sheng,* and Wei Wang*. Divergent Cascade Construction of Skeletally Diverse “Privileged” Pyrazole-Derived Molecular Architectures. Eur. J. Org. Chem.2015, 2030–2037.

4. Shanchao Wu, † Yongqiang Zhang(并列第一作者),† Xiaomeng He,† Xiaoying Che, Shengzheng Wang, Yang Liu, Yan Jiang, Na Liu, Guoqiang Dong, Jianzhong Yao, Zhenyuan Miao, Yan Wang, Wannian Zhang,* and Chunquan Sheng*. From Antidiabetic to Antifungal: Discovery of Highly Potent Triazole-Thiazolidinedione Hybrids as Novel Antifungal Agents. ChemMedChem 2014, 9, 2639 – 2646.


网页发布时间: 2018-03-02