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陈显军



陈显军 博士 特聘副研究员

  

联系方式

电话/传真:021-64251287

E-mail: xianjunchen@ecust.edu.cn

通讯地址:上海市徐汇区梅陇路130号实验18733室;邮编:200237

  

个人简介

20096月本科毕业于华东理工大学生物工程学院生物技术专业,获理学学士学位。20156月博士毕业于华东理工大学药学院化学生物技术与工程专业,获工学博士学位20157月开始从事华东理工大学药学博士后研究。20186月受聘于华东理工大学药学院特聘副研究员。迄今已在Nature MethodsCell ResearchNucleic Acid Research等国际权威期刊发表SCI论文11篇,编写英文著作Curr Protoc Chem Biol 1个章节。已申请6项中国发明专利(授权2项)和2项国际PCT专利(授权1项美国发明专利)。

  

研究方向

1、新型光遗传学技术的开发与应用

2、生物大分子荧光标记技术开发与应用

  

研究生招生

本实验室研究对象涉及基因、蛋白质、细菌、哺乳动物细胞、线虫、斑马鱼、果蝇和小鼠,研究领域涉及细胞生物学、生物化学与分子生物学、合成生物学、光遗传学、化学遗传学、化学生物学等。我们热忱欢迎有志于从事光遗传学、合成生物学、生物大分子标记研究的同学加盟本实验室。


发表论文

1Chen, X., Liu, R., Ma, Z., Xu, X., Zhang, H., Xu, J., Ouyang, Q., Yang, Y. An extraordinary stringent and sensitive light-switchable gene expression system for bacterial cells. Cell research(2016), 26: 854-857.

2Chen, X., Li, T#., Wang, X., Du, Z., Liu, R. and Yang, Y. (2015) Synthetic dual-input mammalian genetic circuits enable tunable and stringent transcription control by chemical and light. Nucleic acids research (2016), 44: 2677-2690.

3 Chen, X., L, T., Wang, X. and Yang, Y. A light-switchable bidirectional expression module allowing simultaneous regulation of multiple genes. Biochemical and biophysical research communications (2015), 465: 769-776.

4Sun, W., Zhang, W., Zhang, C., Mao, M., Zhao, Y., Chen, X*., Yang, Y*. Light-induced protein degradation in human-derived cells. Biochemical and biophysical research communications (2017), 487, 241-246.

5X. Wang, X. Chen, Y. Yang, Spatiotemporal control of gene expression by a light-switchable transgene system, Nat Methods (2012), 9 :266-269.

6Y. Chu, C. Yang, X. Chen, W. Zheng, Y. Yang, Y. Tang, Structure-function analysis of human protein Ero1-Lalpha, Biochem Biophys Res Commun (2009), 389: 645-650.

7Y. Chu, X. Chen, Y. Yang, Y. Tang, Identification of small molecular inhibitors for Ero1p by structure-based virtual screening, Bioorg Med Chem Lett (2011), 21: 1118-1121.

8Z. Ma, Z. Du, X. Chen, X. Wang, Y. Yang, Fine tuning the LightOn light-switchable transgene expression system, Biochem Biophys Res Commun (2013), 440 : 419-423.

9Y. Zhao, Q. Hu, F. Cheng, N. Su, A. Wang, Y. Zou, H. Hu, X. Chen, H.M. Zhou, X. Huang, K. Yang, Q. Zhu, X. Wang, J. Yi, L. Zhu, X. Qian, L. Chen, Y. Tang, J. Loscalzo, Y. Yang, SoNar, a Highly Responsive NAD(+)/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents, Cell Metab (2015) , 21:777-789.

10Hu, H., Gu, Y., Xu, L., Zou, Y., Wang, A., Tao, R., Chen, X., Zhao, Y. and Yang, Y. A genetically encoded toolkit for tracking live-cell histidine dynamics in space and time. Scientific reports (2017), 7, 43479.

11Tao, R., Zhao, Y., Chu, H., Wang, A., Zhu, J., Chen, X., Zou, Y., Shi, M., Liu, R., Su, N. et al. (2017) Genetically encoded fluorescent sensors reveal dynamic regulation of NADPH metabolism.            Nature methods.




网页发布时间: 2018-07-11