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徐缓

             徐缓 副教授、硕导  

通讯地址:

华东理工大学实验十四楼西侧403,邮编200237

电话:021-64253739  电邮:xuhuan@ecust.edu.cn

学习简历:

2007.9-2011.7,上海交通大学医学院,医学检验,学士

2011.9-2013.5,美国长岛大学Post校区,血液学检验,硕士

2013.9-2017.4,美国新墨西哥大学医学院,生物医学,博士

工作简历:

2017.5-2017.10 美国新墨西哥大学药学院,免疫毒理学,博士后

2017.12-2018.4 华东理工大学药学院,讲师、特聘副研究员

2018.5- 华东理工大学药学院,副教授


研究方向:

1.   低浓度砷对免疫系统的毒性作用与机制。

2.   甲醛的生物学效应及其对免疫细胞的毒性。

3.   毒物间的协同作用机制。

近期论文:

2019

1.       Xu H, Ma S, Liu Q, Huang L, Wu P, Liu X, Huang Y, Wang X, Xu H*(共通讯), Lou K*, Wang W*. A naphthalimide-aminal-based pH-sensitive fluorescent donor for lysosome-targeted formaldehyde release and fluorescence turn-on readout. Chem. Commun. 2019, 55, 7053-7056.

2018

1.        Xu H, Wang X, Wang W. Functional suppression of macrophages derived from THP-1 cells by environmentally-relevant concentrations of arsenite. Comp Biochem Physiol C Toxicol Pharmacol. 2018, 214,36-42.

2.        Xu H, Xu H, Ma S, Chen X, Huang L, Chen J, Gao F, Wang R, Lou K, Wang W. Analyte Regeneration Fluorescent Probes for Formaldehyde Enabled by Regiospecific Formaldehyde-Induced Intramolecularity. J. Am. Chem. Soc. 2018, 140, 16408-16412.

3.        Bolt AM, Medina S, Lauer FT, Xu H, Ali AM, Liu KJ, Burchiel SW. Minimal uranium accumulation in lymphoid tissues following an oral 60-day uranyl acetate exposure in male and female C57BL/6J mice. PLoS One. 2018, 13(10), e0205211.

4.        Xu H, Wang X, Burchiel SW. Toxicity of environmentally-relevant concentrations of arsenic on developing T lymphocyte. Environ Toxicol Pharmacol.62,107-113.

5.        Xu H, Wang X, Wang W. Monomethylarsonous acid: induction of DNA damage and oxidative stress in mouse natural killer cells at environmentally-relevant concentrations. Mut. Res.-Gen. Tox. En. 2018, 832-833, 1-6.

2017

1.      Xu H, Medina S, Lauer FT, Douillet C, Liu KJ, Hudson LG, Stýblob M, and Burchiel SW. Genotoxicity induced by monomethylarsonous acid (MMA+3) in developing mouse thymic T cells. Toxicol. Lett. 2017, 279, 60-66.

2.      Medina S, Xu H, Wang SC, Lauer FT, Liu KJ, Burchiel SW. Low Level Arsenite Exposures Suppress the Development of Bone Marrow Erythroid Progenitors and Result in Anemia in Adult Male Mice. Toxicol. Lett.2017, 273, 106-111.

3.      Xu H, Medina S, Lauer FT, Douillet C, Liu KJ, Hudson LG, Stýblob M, Aleksunes LM, and Burchiel SW. Efflux Transporters Regulate Arsenite Induced Genotoxicity in Double Negative and Double Positive T Cells. Toxicol. Sci. 2017, 158(1), 127-139.

2016

1.      Zhou X, Cooper KL, Huestis J, Xu H, Burchiel SW, Hudson LG, Liu KJ. S-nitrosation on zinc finger motif of PARP-1 as a mechanism of DNA repair inhibition by arsenite. Oncotarget. 2016, 7(49), 80482–80492.

2.      Xu H, Lauer FT, Liu KJ, Hudson LG, Burchiel SW. Interactive Genotoxicity Induced by Environmentally Relevant Concentrations of Benzo(a)pyrene Metabolites and Arsenite in Mouse Thymus Cells. Toxicol. Sci. 2016, 154(1), 153-161.

3.      Xu H, McClain S, Medina S, Lauer FT, Liu KJ, Hudson LG, Stýblo M, Burchiel SW. Differential Sensitivities of Bone Marrow, Spleen and Thymus to Genotoxicity Induced By Environmentally Relevant Concentrations of Arsenite. Toxicol. Lett. 2016, 262, 55-61.

4.      Xu H, Lauer FT, Liu KJ, Hudson LG, Burchiel SW. Environmentally relevant concentrations of arsenite and monomethylarsonous acid inhibit IL-7/STAT5 cytokine signaling pathways in mouse CD3+CD4-CD8- double negative thymus cells. Toxicol. Lett. 2016, 247, 62-68.

5.      Ezeh PC, Xu H, Wang SC, Medina S, and Burchiel SW. Evaluation of toxicity in mouse bone marrow progenitor cells. Curr. Protoc. Toxicol. 2016, 67, 18.9.1-18.9.12.

6.      Ezeh PC, Xu H, Lauer FT, Liu KJ, Hudson LG, Burchiel SW. Monomethylarsonous acid (MMA+3) Inhibits IL-7 Signaling in Mouse Pre-B Cells. Toxicol. Sci. 2016, 149(2), 289-99.

7.   Xu H, Zhou X, Wen X, Lauer FT, Liu KJ, Hudson LG, Aleksunes LM, Burchiel SW. Environmentally-Relevant Concentrations of Arsenite Induce Dose-Dependent Differential Genotoxicity Through Poly(ADP-ribose) Polymerase (PARP) Inhibition and Oxidative Stress in Mouse Thymus Cells. Toxicol. Sci. 2016, 149(1), 31-41.




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