Yongqiang Zhang                       

Ph.D., Associate Professor

Tel：+86-021-64253299

E-mail：yongqiangzhang@ecust.edu.cn

Office: Room 402, West Researching Building 14

Address: 130 Mei-long Road, Shanghai 200237, P. R. China

Institution: School of Pharmacy, East China University of Science and Technology

Professional experience

2006.06-2008.07     Organic chemist, Basilea Pharm (China)

2013.09-2015.09     Post-doctor, The University of Utah (USA)

Education background

2009.09-2013.07     Ph.D., Second Military Medical University (China)

2008.09-2009.07     Shanghai Jiao Tong University (China)

2003.09-2006.06     M.S., Soochow University (China)

1999.09-2003.07     B.S., Datong University (China)

Researching Interests

1) The development of novel radical based synthetic methodology for the construction of unique medicinally valuable structures.

2) The development of natural product based anti-cancer/anti-infective drugs.

Representative publications

1) Logan R. Hoggard^†, Yongqiang Zhang^† (co-first author), Min Zhang, Vanja Panic, John A. Wisniewski, and Haitao Ji*; Rational Design of selective small-molecule inhibitors for β-catenin/B-cell lymphoma 9 protein–protein interactions; J. Am. Chem. Soc.2015, 137, 12249–12260.

2) J. Leon Catrow^†, Yongqiang Zhang^† (co-first author), Min Zhang, and Haitao Ji*; Discovery of selective small-molecule inhibitors for the β-catenin/T-cell factor protein–protein interaction through the optimization of the acyl hydrazone moiety; J. Med. Chem.2015, 58, 4678–4692.

3) Yongqiang Zhang, Kevin B. Teuscher, Haitao Ji; Direct α-heteroarylation of amides (α to nitrogen) and ethers through a benzaldehyde-mediated photoredox reaction; Chem. Sci.2016, 7, 2111–2118.

4) Shihui Liu, Aoxia Liu, Yongqiang Zhang* (corresponding author) and Wei Wang*; Direct Ca-heteroarylation of structurally diverse ethers via a mild N-hydroxysuccinimide mediated cross-dehydrogenative coupling reaction; Chem. Sci.2017, 8, 4044-4050.

5) Wenbin Cai, Huaqiang Fan, Dazhong Ding, Yongqiang Zhang*(corresponding author) and Wei Wang* ; Synthesis of Z-alkenes via visible light promoted photocatalytic E - Z isomerization under metal-free conditions; Chem. Commun., 2017, 53, 12918-12921.

6) Huaqiang Fan, Peng Pan, Yongqiang Zhang* and Wei Wang*. Synthesis of 2‑Quinolinones via a Hypervalent Iodine(III)-Mediated Intramolecular Decarboxylative Heck-Type Reaction at Room Temperature. Org. Lett.2018, 20, 7929−7932.

7) Shihui Liu, Peng Pan, Huaqiang Fan, Hao Li, Wei Wang* and Yongqiang Zhang*. Photocatalytic C–H Silylation of Heteroarenes by Using Trialkylhydrosilanes. Chem. Sci. 2019, 10, 3817-3825.

8) Yingying Ma, Shihui Liu, Yifan Xi, Hongrui Li, Kai Yang, Zhihao Cheng, Wei Wang* and Yongqiang Zhang*. Highly Stereoselective Synthesis of Aryl/Heteroaryl-C-Nucleosides via the Merger of Photoredox and Nickel catalysis. Chem. Commun. 2019, doi: 10.1039/C9CC07184A.