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陈晓蓓


陈晓蓓  博士


联系方式:

电话:021-64253739

地址:华东理工大学徐汇校区实验十四楼西侧403

E-mailxiaobei@ecust.edu.cn



个人简历:

2002年毕业于复旦大学药学院,获药学学士学位,随后在中科院上海药物研究所工作。2010年到美国新墨西哥大学化学系学习,于2015年毕业并获博士学位。20155月加入华东理工大学药学院,从事药学相关教学和科研工作,先后主持教育部高校基本科研业务费1项、国家自然科学基金青年基金1项,已在国际、国内核心期刊上发表SCI论文10余篇。



主要研究方向:

  1.  新颖实用的氘代反应的研究和开发及其在药物化学中的应用

 利用价廉易得的氘源,通过研究反应机理,开发新的化学活性和催化体系,来研发新颖实用的氘代反应,并将这些新型氘代方法应用于氘代药物的研究中,以期改善药物安全性及其药代动力学性质等。

  1.  肿瘤免疫疗法中小分子先导物的设计和研发

 设计和研发新型的小分子化合物以寻找和发现具有较好抗肿瘤免疫疗效的小分子候选药物。


论文发表:

  1. Qian, P; Wan, H; Jiang, J; Hu, Y; Chen, X;*Zhang S.-L.;*Discovery of a Special Intramolecular Aldol-Like Reaction in the Synthesis of Related Substance E of Tadalafil” Chin. J. Org. Chem. 2016, 36, 1878-1882.

  2. Chen, X.; Zhang, Y.; Wan, H.; Wang, W.; Zhang, S.* “Stereoselective Organocatalytic Oxidation of Alcohols to Enals: A Homologation Method to Prepare Polyenes” Chem. Commun., 2016, 3532-3535.

  3. Chen, X.*; Fan, H.; Zhang, S.; Yu, C.; Wang, W.* “Facile Installation of 2-Reverse Prenyl Functionality into Indoles by A Tandem N-Alkylation-Aza-Cope Rearrangement Reaction and Its Application in Synthesis” Chem. Eur. J., 2016, 22, 716-723.

  4. Liu, S.; Chen, X. (共同一作); Hu, Y.; Yuan, L.; Chen, S.; Wu, P.; Wang, W.; Zhang, S.;* Zhang W. “An Efficient Method for the Production of Terminal Alkynes from 1,1-Dibromo-1-alkenes and its Application in the Total Synthesis of Natural Product Dihydroxerulin” Adv. Synth. Catal., 2015, 357, 553-560.

  5. Song, A.; Zhang, X.; Song, X.; Chen, X.; Yu, C.; Huang, H.; Li, H.; Wang, W.* “Construction of Chiral Bridged Tricyclic Benzopyrans: Enantioselective Catalytic Diels–Alder Reaction and a One-Pot Reduction/Acid-Catalyzed Stereoselective Cyclization” Angew. Chem. Int. Ed. Engl., 2014, 53, 4940-4944.

  6. Song, A.; Chen, X.; Song, X.; Zhang, X.; Zhang, S.; Wang, W.* “Synthesis of Benzoxazoles via an Amine-Catalyzed [4 + 1] Annulation” Org. Lett., 2013, 15, 2510-2513.

  7. Zhang, X.; Song, X.; Li, H.; Zhang, S.; Chen, X.; Yu, X.*; Wang, W.* “An Organocatalytic Cascade Approach toward Polysubstituted Quinolines and Chiral 1,4-Dihydroquinolines–Unanticipated Effect of N-Protecting Groups” Angew. Chem. Int. Ed. Engl., 2012, 51, 7282-7286.

  8. Xie, H.; Zhang, Y.; Zhang, S.; Chen, X.; Wang, W.* “Bifunctional Cinchona Alkaloid Thiourea Catalyzed Highly Efficient, Enantioselective Aza-Henry Reaction of Cyclic Trifluoromethyl Ketimines: Synthesis of Anti-HIV Drug DPC 083” Angew. Chem. Int. Ed. Engl., 2011, 50, 11773-11776.

  9. Mei, K.; Jin, M.; Zhang, S.; Li, P.; Liu, W.; Chen, X.; Xue, F.; Duan, W.-H.;* Wang, W.* “Simple Cyclohexanediamine-Derived Primary Amine Thiourea Catalyzed Highly Enantioselective Conjugate Addition of Nitroalkanes to Enones” Org. Lett., 2009, 11, 2864-2867.

  10. Song, L.; Chen, X.; Zhang, S.;* Zhang, H.; Li, P.; Luo, G.; Liu, W.; Duan, W.;* Wang, W.* “An Organocatalytic Approach to the Construction of Chiral Oxazolidinone Rings and Application in the Synthesis of Antibiotic Linezolid and Its Analogues” Org. Lett. 2008, 10, 5489-5492.

  11. Zhang, S.; Chen, X.; Zhang, J.; Wang, W.;* Duan, W.* “An Enantioselective Formal Synthesis of (R)-(+)-alfa-Lipoic Acid by L-Proline-catalyzed Aldol Reaction” Synthesis, 2008, 383-386.



网页发布时间: 2018-10-22