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陈彦佐


陈彦佐   副教授   硕士生导师

 电话:021-64252449

E-mail:  chenyz@ecust.edu.cn

 地址:上海市徐汇区梅陇路130号  实验18329

 邮编:200237


个人简介:

2013年毕业于复旦大学药学院药剂学专业,获理学博士学位。同年9月加入华东理工大学药学院,从事新型纳米递药系统方向的博士后研究。2017年至2018年间在美国北卡罗来纳大学教堂山分校Leaf Huang教授课题组进行肿瘤微环境和免疫机制方面研究。20189月晋升副教授,从事药剂学相关的教学和科研工作。作为项目负责人,先后主持中国博士后基金,上海市博士后基金,国家自然科学基金青年基金,教育部基本科研业务费探索研究基金等科研项目6项,发表SCI科研论文30余篇,申请中国发明专利3项,参与出版教材3册。



研究方向:


1. 新型药物传递系统的构建与评价

2. 肿瘤联合治疗策略研究

3. 药物新剂型与新制剂的研究开发



代表性论文:

1. Yanzuo Chen, Wantong Song*, Limei Shen, Nasha Qiu, Mengying Hu, Yun Liu, Qi Liu, Leaf Huang*. Vasodilator hydralazine promotes nanoparticle penetration in advanced desmoplastic tumor. ACS Nano. 2019; DOI: 10.1021/acsnano.8b078302.

2. Junru Wu, Shu Feng, Wenchao Liu, Feng Gao*Yanzuo Chen*. Targeting integrin-rich tumors with temoporfin-loaded vitamin-E-succinate-grafted chitosan oligosaccharide/d-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles to enhance photodynamic therapy efficiency. Int. J. Pharm. 2017; 528(1-2): 287-298.

3. Yanzuo Chen, Shu Feng, Wenchao Liu, Zeting Yuan, Peihao Yin, Feng Gao*. Vitamin E succinate-grafted-chitosan oligosaccharide/RGD-conjugated TPGS mixed micelles loaded with paclitaxel for U87MG tumor therapy. Mol. Pharm. 2017; 14(4):1190-1203.

4. Yukun Huang, Wenchao Liu, Feng Gao, Xiaoling Fang, Yanzuo Chen*. c(RGDyK)-decorated Pluronic micelles for enhanced doxorubicin and paclitaxel delivery to brain glioma. Int. J. Nanomedicine. 2016; 11: 1629-1641.

5. Yanzuo Chen*, Wei Zhang, Yukun Huang, Feng Gao, Xiaoling Fang*. In vivo biodistribution and anti-tumor efficacy evaluation of doxorubicin and paclitaxel-loaded Pluronic micelles decorated with c(RGDyK) peptide. PLoS One. 2016; 11(3): e0149952.

6. Yanzuo Chen, Yukun Huang, Dongdong Qin, Wenchao Liu, Chao Song, Kaiyan Lou*, Wei Wang, Feng Gao*. β-cyclodextrin based inclusion complexation bridged biodegradable self-assembly macromolecular micelle for the delivery of paclitaxel. PLoS One. 2016; 11(3): e0150877.

7. Yanzuo Chen*Wei Zhang, Yukun Huang, Feng Gao, Xianyi Sha, Xiaoling Fang*. Pluronic-based functional polymeric mixed micelles for co-delivery of doxorubicin and paclitaxel to multidrug resistant tumor. Int. J. Pharm. 2015; 488(1-2): 44-58.

8. Yanzuo Chen*Wei Zhang, Yukun Huang, Feng Gao, Xianyi Sha, Kaiyan Lou, Xiaoling Fang*. The therapeutic effect of methotrexate-conjugated Pluronic-based polymeric micelles on the folate receptor-rich tumors treatment. Int. J. Nanomedicine. 2015; 10: 4043-4057.

9. Yanzuo Chen*Wei Zhang, YukunHuang, Feng Gao, Xiaoling Fang*. Dual-functional c(RGDyK)-decorated Pluronic micelles designed for antiangiogenesis and the treatment of drug-resistant tumor. Int. J. Nanomedicine. 2015; 10: 4863-4881.

10. Yanzuo ChenYukun Huang, Yuan Chen, Yajing Ye, Kaiyan Lou, Feng Gao*. Novel nanoparticles composed of chitosan and β-cyclodextrin derivatives as potential insoluble drug carrier. Chin. Chem. Lett. 2015; 26: 909-913.

11. Yanzuo Chen, Wuli Yang, Baisong Chang, Hangting Hu, Xiaoling Fang, Xianyi Sha*. In vivo distribution and antitumor activity of doxorubicin-loaded N-isopropylacrylamide-co-methacrylic acid coated mesoporous silica nanoparticles and safety evaluation. Eur. J. Pharm. Biopharm. 2013; 85: 406-412.



网页发布时间: 2018-10-22