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张阳

张阳 博士


电话:  021-64253756

E-mail: zhangyang@ecust.edu.cn

地址:华东理工大学 徐汇校区实验十八楼1335

男,汉族,1987年2月生,山东 泰安人,中共党员


教育经历

1. 2011.9–2017.5华东理工大学,农药学专业(导师:陶黎明 教授),农学博士

2. 2006.9–2010.6山东农业大学,生物工程专业,工学学士


工作经历

1. 2017.6-至今,华东理工大学,药学院,药物化工研究所,博士后(合作导师:李忠 教授)

2. 2011.2-2011.8,山东农业大学,生命科学学院,思想政治辅导员

3. 2010.7-2011.1,山东农业大学,生命科学学院,行政秘书

  

研究方向

主要开展农药毒理学方向的研究工作:

1.  农药残留及暴露对人体组织的细胞毒性研究及遗传毒性诱导风险评价

2.  农用杀虫剂的生物活性筛选、药效分析及杀虫作用方式研究

  

主要研究经历及承担的课题

研究生就读期间,先后参与了导师(陶黎明 教授、徐文平 副教授)承担的“十二五”科技支撑计划课题“以天然产物为母体的绿色农药研究”“973计划课题分子靶标导向的绿色化学农药创新研究”的子课题研究。目前,主持中国博士后基金一项(2017~2018)、教育部探索基金一项(2018~2019)、“十三五”国家重点研发计划子课题一项(2017~2020)。

  

发表的论文

18Yang Zhang, Yuansen Chang, Haijing Cao, Wenping Xu, Zhong Li, Liming Tao*.Potential threat of Chlorpyrifos to human liver cells via the caspase-dependent mitochondrial pathways.Food and Agricultural Immunology,2018, 29: 294-305.

17Yang Zhang, Jigang Wu, Wenping Xu, Jufang Gao, Haijing Cao, Mingjun Yang, Bo Wang, Youwu Hao, Liming Tao*. Cytotoxic effects of Avermectin on human HepG2 cells in vitro bioassays. Environmental Pollution2017, 220 (Pt B): 1127-1137.

16Yang Zhang, Mingming Luo, Wenping Xu, Mingjun Yang, Bo Wang, Jufang Gao, Yaxiao Li, and Liming Tao*. Avermectin Confers Its Cytotoxic Effects by Inducing DNA Damage and Mitochondria-Associated Apoptosis. Journal of Agricultural and Food Chemistry, 2016, 64 (36): 6895-6902.

15Yang Zhang, Songlin Liu, Xing Yang, Mingjun Yang, Wenping Xu, Yaxiao Li, Liming Tao*. Staurosporine shows insecticidal activity against Mythimna separate Walker (Lepidoptera: Noctuidae) potentially via induction of apoptosis. Pesticide Biochemistry and Physiology2016, 128: 37-44.

14Xiaoqin Yu1, Yang Zhang1, Mingjun Yang, Junfu Guo, Wenping Xu, Jufang Gao, Yaxiao Li, Liming Tao*. Cytotoxic effects of tebufenozide in vitro bioassays. Ecotoxicology and Environmental Safety2016, 129: 180-188.

13. Ping Zhang, Yang Zhang, Kuikui Liu, Bin Liu, Wenping Xu, Jufang Gao, Lei Ding, Liming Tao*. Ivermectin induces cell cycle arrest and apoptosis of HeLa cells via mitochondrial pathway.Cell Proliferation, (2018) https://doi,org/10.1111/cpr.12543

12. Yun Yang, Wenjing Liu, Jian Wang, Yang Zhang, Wenping Xu, Liming Tao*.The different effects of natural pyrethrins and beta-cypermethrin on human hepatocyte QSG7701 cells by ROS-mediated oxidative damage.Environmental Science and Pollution Research, 2018, 25(24): 24230-24240.

11. Yun Yang, Jufang Gao, Yang Zhang, Wenping Xu, Youwu Hao, Zhiping Xu, Liming Tao*. Natural pyrethrins induce autophagy of HepG2 cells through the activation of AMPK/mTOR pathway. Environmental Pollution,2018, 241: 1091-1097.

10. Wenping Xu, Mingjun Yang, Jufang Gao, Yang Zhang,Liming Tao*. Oxidative stress and DNA damage induced by spinosad exposure in Spodoptera frugiperda Sf9 cells.Food and Agricultural Immunology, 2018,29:171-181.

9Mingjun Yang, Bo Wang, Jufang Gao, Yang Zhang, Wenping Xu, Liming Tao*. Spinosad induces programmed cell death involves mitochondrial dysfunction and cytochrome c release in spodoptera frugiperda Sf9 cells.Chemosphere,2017, 169: 155-161.

8Yun Yang, Mimi Zong, Wenping Xu, Yang Zhang, Bo Wang, Mingjun Yang, Liming Tao*. Natural pyrethrins induces apoptosis in human hepatocyte cells via Bax- and Bcl-2-mediated mitochondrial pathway.Chemico-Biological Interactions,2017, 262: 38-45.

7Wenping Xu, Bo Wang, Mingjun Yang, Yang Zhang, Zhiping Xu, Yun Yang, Haijing Cao, Liming Tao*. Tebufenozide induces G1/S cell cycle arrest and apoptosis in human cells.Environmental Toxicology and Pharmacology2017, 49: 89 - 96.

6Youwu Hao, Gaohui Zhou, Wei Wu, Yang Zhang, Liming Tao, Jianhua Yao, Wenping Xu*. Synthesis and antiviral evaluation of novel N-6 substituted adenosine analogues. Tetrahedron Letters, 2017, 58 (3): 190-193.

5Mingjun Yang, Youwu Hao, Jufang Gao, Yang Zhang, Wenping Xu, Liming Tao*. Spinosad induces autophagy of Spodoptera frugiperda Sf9 cells and the activation of AMPK/mTOR signaling pathway.Comparative Biochemistry and Physiology, Part C, 2017, 195: 52-59.

4Wenping Xu, Songlin Liu, Yang Zhang, Jufang Gao, Mingjun Yang, Xiao Liu, Liming Tao*. Cypermethrin resistance conferred by increased target insensitivity and metabolic detoxification inCulex pipiens pallens Coq.Pesticide Biochemistry and Physiology, 2017, 142C: 77-82.

3.Zhiping Xu, Miaoqing Lu, Mingjun Yang, Wenping Xu, Jufang Gao, Yang Zhang, Yun Yang, Liming Tao*. Pyrethrum-extract induced autophagy in Insect cells: A new target? Pesticide Biochemistry and Physiology,2017,137: 21-26.

2.Haijing Cao, Wenjing Liu, Yuansen Chang, Hui Chen, Yang Zhang, Wenping Xu, Liming Tao* 5′-Epi-SPA-6952A, a new insecticidal 24-membered macrolide produced by Streptomyces diastatochromogenes SSPRC-11339Nature product research,2017http://dx.doi.org/10.1080/14786419.2017.1405401.

1Mingjun Yang, Guanggang Xiang, Diqiu Li, Yang Zhang, Wenping Xu, Liming Tao*. The insecticide spinosad induces DNA damage and apoptosis in HEK293 and HepG2 cells.Mutation Research/Genetic Toxicology and Environmental Mutagenesis2016, 812: 12-19.

  

获授权的专利

1.  腺苷衍生物及其应用. 中国发明专利,授权号:ZL 2015 1 0022902.X 

2.  阿维菌素B1a 荧光标记物及其应用. 中国发明专利,授权号:ZL 2014 10025107.1 

3.  用于制备昆虫神经元细胞的生理缓冲液、消解液及方法. 中国发明专利,授权号:ZL 2014 10025109.0 


网页发布时间: 2018-11-07