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Professor Ya-Fei Ji
发布时间：2019-05-20   访问次数:1012   作者:


Contact Information

  • Office: Room 1035B, Researching Building 18

  • Email: jyf@ecust.edu.cn

  • Office Phone: +86 21 6425 3314

  • Office Fax: +86 21 6425 3314

Education

  • 2001.06  Ph.D.  Applied Chemistry, China University of Mining Technology, Beijing, P. R. China

  • 1992.06  M.Eng.  Fine Chemical Engineering, East China University ofScience&Technology, Shanghai, P. R. China

  • 1984.06  B.S.  Chemical Education, Anhui Normal University, Wuhu, P. R. China

Professional Experience

  • 2007.9-Now  Professor, Department of Pharmaceutical Engineering, School of Pharmacy, ECUST

  • 2009.03-2010.03  Visiting Scholar, Department of chemistry and chemical biology, University of New Mexico

  • 2003.12-2007.8  Associate Professor, Department of Pharmaceutical Engineering, ECUST

  • 2001.12-2003.11  Postdoc Fellow, Institute of Materia Medica, Peking Union Medical College, Chinese Academy of Medical Sciences

  • 1996.11-2001.10  Associate Professor, School of Chemical Engineering, China University of Mining Technology, Xuzhou, P. R. China

  • 1992.8-1996.10  Assistant Research Fellow, Anhui Institute of Materia Medica, Hefei, P. R. China

Research Interests

  • Organic Chemistry - developing new synthetic methods, practical catalysts and efficient strategies for the synthesis of valuable fine chemicals and pharmaceuticals.

  • Green Chemistry - designing new synthetic pathways for sustainable synthesis and production.

Publication

  1. Hu YH, Shao LY, Ji YF.* Palladium-catalyzed arylation of aromatic amides directed by 2-amino-5-cholophenyl-1H-pyrazole auxiliary. Synlett 2018-6-15, accepted.   

  2. Shao LY, Xing LH,Guo Y, Yu KK, Wang W, Liu HW, Liao DH, Ji YF.* Catalytic cascade access to biaryl-2-methyl acetates from pyruvate O-arylmethyl ketoximes via the palladium-catalyzed C(sp2)–H bond arylation and C–O bond solvolysis. Adv. Synth. Catal. 2018, DOI 10.1002/adsc.201800216, published online.

  3. Qiao WL, Shao LY, Hu YH, Xing LH, Deng KZ, Liao DH, Dao-Hua Liao, Ji YF.* Palladium-catalyzed Csp3–H bond mono-aroyloxylation of O-alkyl substituted 2,4,6-tri- methoxybenzaldoxime ethers. Synlett2018, 29, 1249–1255.

  4. Guo Y, Shao LY, Yu KK, Hu YH, Liu HW,* Liao DH, Ji YF*. Palladium-catalyzed site-selective direct olefination of 6-electron-withdrawing group substitued 3-arylbenzo[d]isoxazoles. Org. Chem. Front.2017, 4, 1962–1966.

  5. Guo Y, Yu KK, Xing LH, Liu HW, Wang W,* Ji YF*. Palladium-catalyzed divergent regioselective homocoupling and hydroxylation of 3-arylbenzo[d]isoxazoles. Adv. Synth. Catal. 2017, 359(3), 410–418.

  6. Shao LY, Li C,Guo Y, Yu KK,Zhao FY,Qiao WL, Liu HW, Liao DH,* Ji YF*. Pd-catalyzed direct oxidative mono-aroyloxylation of O-aralkyl substituted acetoxime ethers. RSC Advances, 2016, 6, 78875–78880.

  7. Yu, KK, Guo Y, Hu YH, Xu Z, Liu HW, Liao DH,* Ji YF*. Pd-Catalyzed diverse mono-acyloxylation of 5-alkyl-4-aryl-thiazole-2-carboxylates. Asian J. Org. Chem. 2016, 5, 1219–1224.

  8. Ding J, Guo Y, Shao LY, Zhao FY, Liao DH, Liu HW*, Ji YF*. Palladium-catalyzed multi-acetoxylation of 1,3-disubstituted 1H-pyrazole-5-carboxylates via direct C(sp2)−H or C(sp3)−H bond activation. Chin. Chem. Lett.2016, 27, 1617–1621.

  9. Fan XM,Guo Y, Li YD,Yu KK, Liu HW, Liao DH, Ji YF*.Pd-catalyzed late-stage mono-acetoxylation and mono-iodination of 4-alkyl-1,5-diaryl-1H-pyrazole-3-carboxylates via direct Csp2-H bond activation. Asian J. Org. Chem. 2016, 5, 499–505.

  10. Zhang ZN, Huang JG, Zhai JJ, Guo Y, Ji YF*. Copper(II)-catalyzed oxidative esterification of substituted p-cresols under ligand- and additive-free conditions. Synlett2015, 26, 2145–2150.

  11. Guo Y, Li YD, Chen C, Zhao JH, Liu HW, Liao DH, Ji YF*. A practical ligand-free copper(I) bromide-catalyzed fluoroalkoxylation of unactivated aryl bromides. Res. Chem. Intermediat. 2016, 42, 2525–2537.

  12. Huang JG, Guo Y, Li YD, Liu HW,* Liao DH, Ji YF*. Undecorated Cu(OAc)2-catalyzed C(sp3)–C(sp3) bond formation through a para-hydroxyl group-triggered remote benzylic C(sp3)–H bond functionalization. Eur. J. Org. Chem.2015, 5334–5338.

  13. Guo Y, Fan XM, Nie M, Liu HW, Liao DH, Pan XD,* Ji YF*. Practical ligand-free Cu-catalyzed short-chain alkoxylation of unactivated aryl bromides. Eur. J. Org. Chem.2015, 4744–4755.

  14. Guo Y, Chen C, Liu HW,* Zhao JH, Zheng, YL, Ji YF*. A ligand-free, powerful and practical method for methoxylation of unactivated aryl bromides by use of CuCl/HCOOMe/MeONa/MeOH system. Res. Chem. Intermediat.2015, 41, 8651–8664.

  15. Zhai JJ, Gu CH, Guo Y, Liao DH, Zhu DR, Ji YF*. One-pot synthesis of highly substituted 1H-pyrazole-5-carboxylates from 4-aryl-2,4-diketoesters and arylhydrazines. J. Heterocyclic Chem.2016, 53, 840–848.

  16. Huang JG, Guo Y, Jiang JA, Liu HW, Ji YF*. An eco-friendly Co(OAc)2-catalyzed aerobic oxidation of 4-benzylphenols into 4-hydroxybenzophenones. Res. Chem. Intermediat.2015, 41, 7115–7124.

  17. Jiang JA, Chen C, Guo Y, Liao DH, Pan XD, Ji YF*. A highly efficient approach to vanillin starting from 4-cresol. Green Chem.2014, 16, 2807–2814.

  18. GuCH, Zhai JJ, Jiang JA, Liu HW, Wang L, Zhu DR, Ji YF*. An efficient one-pot synthesis of aryl-substituted 1-(thiazol-2-yl)-1H-pyrazole-3-carboxylates via a Hantzsch synthesis-Knorr reaction sequence. Chin. J. Chem.2014, 32, 179–190.

  19. Jiang JA, Chen C, Huang JG, Liu HW, Cao S, Ji YF*. Cu(OAc)2-catalyzedremote benzylic C(sp3)–Hoxyfunctionalization for C=O formation directed by the hindered para-hydroxyl group with ambient air as terminal oxidant under ligand- and additive-free conditions. Green Chem.2014, 16, 1248–1254.

  20. Jiang JA, Du JL, Liao DH, Wang ZG, Ji YF*. Efficient Co(OAc)2-catalyzed aerobic oxidation of EWG-substituted 4-cresols to access 4-hydroxybenzaldehydes. Tetrahedron Lett. 2014, 55, 1406– 1411.

  21. Jiang JA, Du JL, Zhang ZN, Zhai JJ, Ji YF*. An environmentally friendly and highly efficient Co(OAc)2-catalyzed aerobic oxidation to access 2,6-di-electron-donating group substituted 4-hydroxybenzaldehydes. Syn. Commun. 2014, 44, 1430–1440.

  22. Zhai JJ, Gu CH, Jiang JA, Zhang SL, Liao DH, Wang L,Zhu DR, Ji YF*. A one- pot approach to ethyl 1,4,5-triaryl-1H-pyrazole-3-carboxylates via an improved Claisen condensation-Knorr reaction sequence. Chin. J. Chem.2013, 31, 1526–1538.

  23. Zhai JJ, Jiang JA, Zhang SL, Chen C, Liu HW, Liao DW, Ji YF*. Stereoselective or exclusive synthesis of ethyl Z-2-(2-substituted-thiazol-4-yl)pent-2-enoates from ethyl E/Z-2-(2-bromoacetyl) pent-2-enoate. Synlett 2013, 24, 1399–1404.

  24. Huang WB, Guo Y, Jiang JA, Pan XD, Liao DH, Ji YF*. An efficient strategy for protecting dihydroxyl groups of catechols. Synlett 2013, 24, 741–746.

  25. Jiang JA, Huang WB, Zhai JJ, Liu HW, Cai Q, Xu LX, Wang W, Ji YF*. “One-pot” synthesis of 4-substituted 1,5-diaryl-1H-pyrazole-3-carboxylates via lithium tert-butoxide-mediated sterically hindered Claisen condensation and Knorr reaction. Tetrahedron 2013, 69, 627–635.

  26. Jiang JA, Ji YF*.  Alternative synthesis of apixaban (BMS-562247), an inhibitor of blood coagulation factor Xa. Syn. Commun. 2013, 43, 72–79.

  27. Huang WB, Du CY, Jiang JA, Ji YF*. Concurrent synthesis of vanillin and isovanillin. Res. Chem. Intermediat.2013, 39(6), 2849–2856.

  28. Ji YF*, Jiang JA, Liu HW, Liao DH, Wei XY. Practical preparation of trimethoprim: a classical antibacterial agent.Syn. Commun. 2013, 43, 1517–1522.

  29. Jiang JA, Du CY, Gu CH, Ji YF*. “One-pot” synthesis of 4-substituted 1,5-diaryl-1H-pyrazole-3- carboxylic acids via a MeONa/LiCl-mediated sterically hindered Claisen condensation-Knorr reaction-hydrolysis sequence. Synlett 2012,23, 2965–2968.   

  30. Jiang JA, Zhai JJ, Yu XH, Teng X, Ji YF*. A practical synthesis of cefcapene pivoxil. Synthesis2012, 44, 207–214.