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Professor You Yang
发布时间：2019-05-20   访问次数:826   作者:


Contact Information

  • Office: Room 1035A, Researching Building 18

  • Email: yangyou@ecust.edu.cn

  • Office Phone: +86 21 6425 3851

Education

  • 2010.06  Ph.D.  Organic Chemistry, University of Science and Technology of China (USTC), Hefei, P. R. China

  • 2004.06  B.S.  Chemistry, University of Science and Technology of China (USTC), Hefei, P. R. China

Professional Experience

  • 2015.09-now  Professor, East China University of Science and Technology (ECUST), Shanghai, China

  • 2014.09-2018.08  Associate Professor, East China University of Science and Technology (ECUST), Shanghai, China

  • 2010.08-2014.06  Postdoctoral Fellow, Max Planck Institute of Colloids and Interfaces, Berlin, Germany

Research Interests

  • Synthetic Methodology, Total Synthesis, and Chemical Biology of Biologically Significant Carbohydrates and Glycoconjugates

  • Development of Carbohydrate-based Drugs and Vaccines

  • Interactions of Carbohydrates and Proteins for the Application in New Diagnostic Tools

Publication

33. Wang, X.;† Chen, Y.;† Wang, J.; Yang, Y.* Total Synthesis of the Trisaccharide Antigen of the Campylobacter jejuni RM1221 Capsular Polysaccharide via de Novo Synthesis of the 6-Deoxy-d-manno-heptose Building Blocks. J. Org. Chem. 2019, 84, 2393−2403. (†: co-first author)

  • Cover

32. Zhuang, L.; Chen, Y.; Lou, Q.; Yang, Y.* Synthesis of the -Linked GalNAc-Kdo Disaccharide Antigen of the Capsular Polysaccharide of Kingella kingae KK01. Org. Biomol. Chem.2019, 17, 1694–1697.

  • Outside front cover

31. Geissner, A.; Reinhardt, A.; Rademacher, C.; Johannssen, T.; Monteiro, J.; Lepenies, B.; Thepaut, M.; Fieschi, F.; Mrazkova, J.; Wimmerova, M.; Schuhmacher, F.; Götze, S.; Grünstein, D.; Guo, X.; Hahm, H. S.; Kandasamy, J.; Leonori, D.; Martin, C. E.; Parameswarappa, S. G.; Pasari, S.; Schlegel, M. K.; Tanaka, H.; Xiao, G.; Yang, Y.; Pereira, C. L.; Anish, C.; Seeberger, P. H.* Microbe-focused Glycan Array Screening Platform. Proc. Natl. Acad. Sci. USA.2019, 116, 1958–1967.

30. Fan, W.; Chen, Y.; Lou, Q.; Zhuang, L.; Yang, Y.* Synthesis of 3-C-Branched Kdo Analogues via Sonogashira Coupling of 3-Iodo Kdo Glycal with Terminal Alkynes. J. Org. Chem. 2018, 83, 6171–6177.

  • Highlighted by ChemBeanGo (May 28, 2018).

29. Hu, X.; Wang, D.; Tong, Y.; Tong, L.; Wang, X.; Zhu, L.; Xie, H.; Li, S.; Yang, Y.*, Xu, Y.* Design, Synthesis and Evaluation of Ribose-modified Anilinopyrimidine Derivatives as EGFR Tyrosine Kinase Inhibitors. Front. Chem.2017, 5, 101.

28. Yang, Y.*, Yu, B.* Recent Advances in the Chemical Synthesis of C-Glycosides. Chem. Rev. 2017, 117, 12281–12356.

  • Most Read Articles in October, 2017.

  • ESI “Highly Cited Paper”

27. Mi, X.; Lou, Q.; Fan, W.; Zhuang, L.; Yang, Y.* Gold(I)-catalyzed Synthesis of -Kdo Glycosides Using Kdo ortho-Hexynylbenzoate as Donor. Carbohydr. Res.2017, 448, 161–165.

26. Wang, J.; Liu, R.; Yang, Y.* Rapid and Efficient Conversion of Sialyl Thioglycosides to Sialyl Esters via NIS/BF3OEt2-Promoted Glycosylation. Tetrahedron Lett. 2017, 58, 2370–2373.

25. Chen, Y.; Wang, X.; Wang, J.; Yang, Y.* Synthesis of d-manno-Heptulose via a Cascade Aldol/hemiketalization Reaction. Beilstein J. Org. Chem.2017, 13, 795–799.

24. Wang, J.; Mi, X.; Wang, J.; Yang, Y.* An Efficient Approach to Chloro(organophosphine) Gold(I) Complexes for the Synthesis of Auranofin. Green Chem.2017, 19, 634–637.

23. Reinhardt, A.; Wehle, M.; Geissner, A.; Crouch, E. C.; Kang, Y.; Yang, Y.; Anish, C.; Santer, M.;* Seeberger, P. H.* Structure Binding Relationship of Human Surfactant Protein D and Various Lipopolysaccharide Inner Core Structures. J. Struct. Biol. 2016, 195, 387–395.

22. Chen, X.; Shen, D.; Wang, Q.; Yang, Y.; Yu, B.* ortho-(Methyltosylaminoethynyl)benzyl Glycosides as New Glycosyl Donors for Latent-active Glycosylation. Chem. Commun. 2015, 51, 13957–13960.

21. Yang, Y.;* Zhang, X.; Yu, B.* O-Glycosylation Methods in the Total Synthesis of Complex Natural Glycosides. Nat. Prod. Rep. 2015, 32, 1331–1355.

  • ESI “Highly Cited Paper”

  • Abstracted by ChemInform 2015, 43-237

20. Yang, Y.;* Lian, G.; Yu, B.* Naturally Occurring Polyphenolic Glucosidase Inhibitors. Isr. J. Chem. 2015, 55, 268–284. (Chi-Huey Wong – Wolf Prize Special Issue)

  • Abstracted by ChemInform 2015, 24-287

19. Reinhardt, A.;†Yang, Y.;† Claus, H.; Pereira, C. L.; Cox, A. D.; Vogel, U.; Anish, C.;* Seeberger, P. H.* Antigenic Potential of a Highly Conserved Neisseria meningitidis Lipopolysaccharide Inner Core Structure Defined by Synthetic Approach. Chem. Biol.2015, 22, 38–49. (†: co-first author)

18. Yang, Y.;* Laval, S.; Yu, B.* Chemical Synthesis of Saponins. In Adv. Carbohydr. Chem. Biochem. Academic press, 2014, 71, 137–226.

17. Xu, P.; Xu, W.; Dai, Y.; Yang, Y.; Yu, B.* Efficient Synthesis of a Library of Heparin Tri- and Tetrasaccharides Relevant to the Substrate of Heparanase. Org.Chem. Front.2014, 1, 405–414.

16. Broecker, F.; Aretz, J.; Yang, Y.; Hanske, J.; Guo, X.; Reinhardt, A.; Wahlbrink, A.; Rademacher, C.; Anish, C.;* Seeberger, P. H.* Epitope Recognition of Antibodies against a Yersinia pestis Lipopolysaccharide Trisaccharide Component. ACS Chem. Biol.2014, 9, 867–873.

15. Yang, Y.;* Yu, B.* Recent Advances in the Synthesis of Chitooligosaccharides and Congeners. Tetrahedron2014, 70, 1023–1046.

  • Abstracted by ChemInform 2014, 17-257

14. Yang, Y.; Oishi, S.; Martin, C. E.; Seeberger, P. H.* Diversity-oriented Synthesis of Inner Core Oligosaccharides of the Lipopolysaccharide of Pathogenic Gram-negative Bacteria. J. Am. Chem. Soc.2013, 135, 6262–6271.

13. Yang, Y.; Martin, C. E.; Seeberger, P. H.* Total Synthesis of the Core Tetrasaccharide of Neisseria meningitidis Lipopolysaccharide, a Potential Vaccine Candidate for Meningococcal Diseases. Chem. Sci.2012, 3, 896–899.

  • Broadcasted by Deutschlandfunk(30 Dec. 2011)

  • Highlighted in Chemistry World (February 2012)

12. Yang, Y.;†  Liu, T.;†  Yang, Y.; Wu, Q.;Yang, Q.;* Yu, B.* Synthesis, Evaluation, and Mechanism of N,N,N-Trimethyl-d-glucosamine-(1→4)-chitooligosaccharides as Selective Inhibitors of Glycosyl Hydrolase Family 20 -N-Acetyl-d-hexosaminidases.ChemBioChem2011, 12, 457–467. (†: co-first author)

11. Yang, Y.; Li, Y.; Yu, B.* Chemoselective Glycosylation of Carboxylic Acid with Glycosyl ortho-Hexynylbenzoates as Donors. Tetrahedron Lett.2010, 51, 1504–1507.

10. Li, Y.; Yang, X.; Liu, Y.; Zhu, C.; Yang, Y.; Yu, B.* Gold(I)-catalyzed Glycosylation with Glycosyl ortho-Alkynylbenzoates as Donors, General Scope and Application to the Synthesis of a Cyclic Triterpene Saponin. Chem. Eur. J.2010, 16, 1871–1882.

  • Abstracted by ChemInform 2010, 24-183

9. Yang, Y.; Li, Y.; Yu, B.* Total Synthesis and Structure Revision of TMG-chitotriomycin, a Specific Inhibitor of Insect and Fungal -N-Acetylglucosaminidases. J. Am. Chem. Soc.2009, 131, 12076–12077.

  • Highlighted in Chin. J. Org. Chem.2009, 29, 1867

  • Abstracted by ChemInform 2009, 51-199

8. Li, Y.; Yang, Y.; Yu, B.*An Efficient Glycosylation Protocol with Glycosyl ortho-Alkynylbenzoates as Donors under the Catalysis of PPh3AuOTf. Tetrahedron Lett.2008, 49, 3604–3608.

  • Abstracted by ChemInform 2008, 36-196

7. Yang, Y.; Yu, B.* N-Dimethylphosphoryl-Protection in the Efficient Synthesis of Glucosamine-containing Oligosaccharides with Alternate N-acyl Substitutions. Tetrahedron Lett.2007, 48, 7049–7052.

6. Yang, Y.; Yu, B.*N-Dimethylphosphoryl-Protected Glucosamine Trichloroacetimidate as an Effective Glycosylation Donor.Tetrahedron Lett.2007, 48,4557–4560.

  • Abstracted by ChemInform 2007, 41-173

5. Liu, Z.; Hu, Z.; Liang, J.; Li, S.; Yang, Y.; Peng, S.; Qian, Y.* Size-Controlled Synthesis and Growth Mechanism of Monodisperse Tellurium Nanorods by a Surfactant-Assisted Method. Langmuir2004, 20, 214–218.

4. Liu, Z.; Li, S.; Yang, Y.; Peng, S.; Hu, Z.; Qian, Y.* Complex-Surfactant-Assisted Hydrothermal Route to Ferromagnetic Nickel Nanobelts. Adv. Mater.2003, 15, 1946–1948.

3. Liu, Z.; Peng, S.; Xie, Q.; Hu, Z.; Yang, Y.; Zhang, S.; Qian, Y.* Large-scale Synthesis of Ultralong Bi2S3 Nanoribbons via a Solvothermal Process. Adv. Mater.2003, 15, 936–940.

2. Liu, Z.; Li, S.; Yang, Y.; Hu, Z.; Peng, S.; Liang, J.; Qian, Y.* Shape-controlled Synthesis and Growth Mechanism of One-dimensional Nanostructures of Trigonal Tellurium. New J. Chem.2003, 27, 1748–1752.

1. Liu, Z.; Yang, Y.; Liang, J.; Hu, Z.; Li, S.; Peng, S.; Qian, Y.*

Synthesis of Copper Nanowires via a Complex-Surfactant-Assisted Hydrothermal Reduction. J. Phys. Chem. B2003, 107, 12658–12661.

  • Abstracted by ChemInform 2004, 16-207