Contact Information

• Office: Room 403, Researching Building 14 West

• Email: xuhuan@ecust.edu.cn

• Office Phone: +86 21 6425 3739

• Office Fax: +86 21 6425 3739

Education

• 2017.04  Ph.D.  Biomedical Sciences, University of New Mexico, Albuquerque, New Mexico, USA.

• 2013.05  M.S.  Biomedical Sciences, Long Island University, Post Campus, Nassau County, New York, USA.

• 2011.06  B.S.  Clinical Laboratory Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.

Professional Experience

• 2017.12-now  East China University of Science and Technology, School of Pharmacy, Associate Professor

• 2017.05-2017.10  University of New Mexico, College of Pharmacy, Post-doctoral researcher

Research Interests

• Immunotoxicity induced by drugs and environmental contaminants

• Molecular mechanisms of chemical-induced immunosuppressive effects

• Development and optimization of immunotoxicology and immunology assays

Selected Publications

1. Xu H, Zhou X, Wen X, Lauer FT, Liu KJ, Hudson LG, Aleksunes LM, Burchiel SW. Environmentally-Relevant Concentrations of Arsenite Induce Dose-Dependent Differential Genotoxicity Through Poly(ADP-ribose) Polymerase (PARP) Inhibition and Oxidative Stress in Mouse Thymus Cells. Toxicol. Sci. 2016, 149(1), 31-41.

2. Xu H, Lauer FT, Liu KJ, Hudson LG, Burchiel SW. Environmentally relevant concentrations of arsenite and monomethylarsonous acid inhibit IL-7/STAT5 cytokine signaling pathways in mouse CD3+CD4-CD8- double negative thymus cells. Toxicol. Lett. 2016, 247, 62-68.

3. Xu H, McClain S, Medina S, Lauer FT, Liu KJ, Hudson LG, Stýblo M, Burchiel SW. Differential Sensitivities of Bone Marrow, Spleen and Thymus to Genotoxicity Induced By Environmentally Relevant Concentrations of Arsenite. Toxicol. Lett. 2016, 262, 55-61.

4. Xu H, Lauer FT, Liu KJ, Hudson LG, Burchiel SW. Interactive Genotoxicity Induced by Environmentally Relevant Concentrations of Benzo(a)pyrene Metabolites and Arsenite in Mouse Thymus Cells. Toxicol. Sci. 2016, 154(1), 153-161.

5. Xu H, Medina S, Lauer FT, Douillet C, Liu KJ, Hudson LG, Stýblob M, Aleksunes LM, and Burchiel SW. Efflux Transporters Regulate Arsenite Induced Genotoxicity in Double Negative and Double Positive T Cells. Toxicol. Sci. 2017, 158(1), 127-139.

6. Xu H, Medina S, Lauer FT, Douillet C, Liu KJ, Hudson LG, Stýblob M, and Burchiel SW. Genotoxicity induced by monomethylarsonous acid (MMA+3) in developing mouse thymic T cells. Toxicol. Lett. 2017, 279, 60-66.

7. Xu H, Wan X, Wang W. Monomethylarsonous acid: induction of DNA damage and oxidative stress in mouse natural killer cells at environmentally-relevant concentrations. Mut. Res.-Gen. Tox. En. 2018, 832-833, 1-6.

8. Xu H, Wang X, Burchiel SW.Toxicity of environmentally-relevant concentrations of arsenic on developing T lymphocyte.62,107-113.