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Associate Professor Xingxin Yu
发布时间：2019-05-20   访问次数:509   作者:



Contact Information

  • Email: xxyu@ecust.edu.cn

  • Office Fax: +86 21 6425 2431

  • Address:130 Meilong Road, Shanghai 200237, China

Professional Experience

Xingxin Yu received her PhD in organic chemistry from Fudan University and an Excellent Graduate of Shanghai Municipality in June 2012. Then she carried out her post-doctoral research on small molecule lung cancer inhibitors at University of Minnesota. In August 2013, she joined the School of Pharmacy, ECUST, where her research interests focus on construction of diverse natural product-like small molecule compounds for drug candidates study. She was promoted to associate professor and appointed as a master's supervisor in 2015.

As the project leader, she presided over the National Natural Science Foundation (Youth Foundation) and the Fundamental Research Funds for the Central Universities (2 funds). She was selected into the Shanghai Pujiang Talents Program and the first batch of Shanghai Yangfan Program in 2014. And she was awarded the backbone of "young talents introduction and cultivation program at ECUST" and "outstanding young teacher at school of pharmacy" in 2015.

She has co-authored over 40 peer-reviewed SCI papers, with more than 1000 citations and an H index of 22. And she is co-inventor of an authorized Chinese patent.

Research Interests

Design and synthesis of novel heterocyclic compounds based on new technologies, new methods and new reactions, to construct bioactive natural product-like small molecule compounds for innovative drug research.

Selected Publications

  1. Renmeng Jia, Jiang Meng, Jiaying Leng, Xingxin Yu*, Wei-Ping Deng*. Chem. Asian. J., 2018,DOI:10.1002/asia.201800057.

  2. Rhodium(II)-Catalyzed Reaction of 1-Tosyl-1,2,3-triazoles with Morita-Baylis-Hillman Adducts: Synthesis of 3,4-Fused Pyrroles.

  3. Jiang Meng, Renmeng Jia, Jiaying Leng, Min Wen, Xingxin Yu*, Wei-Ping Deng*. Org. Lett., 2017, 19, 4520-4523.

  4. Carbon-Carbon Bond Formation by Reaction of Rhodium Azavinylcarbenes with Secondary Amides: Access to Indigo Analogues from Isatins.

  5. Jiang Meng, Min Wen, Shiwei Zhang, Peiwen Pan, Xingxin Yu*, Wei-Ping Deng*. J. Org. Chem., 2017,82, 1676-1687. (Highlighted by Synfacts, 2017, 13, 354.)

  6. Unexpected O-H Insertion of Rhodium-Azavinylcarbenes with N-Acylhydrazones: Divergent Synthesis of 3,6-Disubstituted- and 3,5,6-Trisubstituted-1,2,4-Triazines.

  7. Jiang Meng, Xiangfeng Ding, Xingxin Yu*, Wei-Ping Deng. Tetrahedron, 2016, 72, 176-183.

  8. Synthesis of 2,5-epoxy-1,4-benzoxazepines via rhodium(II)-catalyzed reaction of 1-tosyl-1,2,3-triazoles and salicylaldehydes.

  9. Bo Zhou[+], Xingxin Yu[+], Chunlin Zhuang*, Peter Villalta, Yong Lin, Junxuan Lu, Chengguo Xing*. ChemMedChem, 2016, 11, 1436-1445. ([+] equal contribution)

  10. Unambiguous Identification of β-Tubulin as the Direct Cellular Target Responsible for the Cytotoxicity of Chalcone by Photoaffinity Labeling.

  11. Linwei Huang, Jinbin Zhu, Guangjun Jiao, Zheng Wang, Xingxin Yu, Wei-Ping Deng*, Wenjun Tang*. Angew. Chem. Int. Ed., 2016, 55, 4527-4531.

  12. Highly Enantioselective Rhodium-Catalyzed Addition of Arylboroxines to Simple Aryl Ketones: Efficient Synthesis of Escitalopram.

  13. Fu-Sheng He, Jing-Hai Jin, Zhong-Tao Yang, Xingxin Yu, John S. Fossey, Wei-Ping Deng*. ACS Catal., 2016, 6, 652-656.

  14. Direct Asymmetric Synthesis of β-Bis-Aryl-α-Amino Acid Esters via Enantioselective Copper-Catalyzed Addition of p-Quinone Methides.

  15. Wu-Lin Yang, Chun-Yan Li, Wen-Jing Qin, Fei-Fei Tang, Xingxin Yu, Wei-Ping Deng*. ACS Catal., 2016, 6, 5685-5690.

  16. Cu(I)-Catalyzed Chemoselective and Stereoselective [3+3] Cycloaddition of Azomethine Ylides with 2-Indolylnitroethylenes: Facile Access to Highly Substituted Tetrahydro-γ-Carbolines.

  17. Wu-Lin Yang, Fei-Fei Tang, Fu-Sheng He, Chun-Yan Li, Xingxin Yu*, Wei-Ping Deng*. Org. Lett., 2015, 17, 4822-4825. (Highlighted by Synfacts, 2015, 11, 1285.)

  18. Asymmetric Construction of Spirocyclic Pyrrolidine-thia(oxa)zolidinediones via N,O-Ligand/Cu(I) Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides with 5-Alkylidene Thia(oxa)zolidine-2,4-diones.

  19. Fu-Sheng He, Han Zhu, Zheng Wang, Ming Gao, Xingxin Yu*, Wei-Ping Deng*. Org. Lett., 2015, 17, 4988-4991. (Highlighted by Synfacts, 2015, 11, 1284.)

  20. Asymmetric Construction of 3,4-Diamino Pyrrolidines via Chiral N,O-Ligand/Cu(I) Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides with β-Phthalimidonitroethene.

  21. Zheng Wang[+], Xingxin Yu*[+], Bo-Xue Tian, Daniel T. Payne, Wu-Lin Yang, Yang-Zi Liu, John S. Fossey, Wei-Ping Deng*. Chem. Eur. J., 2015, 21, 10457-10465. ([+] equal contribution)

  22. Chiral N,O-Ligand/Cu(OAc)2 Catalyzed Asymmetric Construction of 4-Aminopyrrolidine Derivatives via 1,3-Dipolar Cycloaddition of Azomethine Ylides with α-phthalimidoacrylates.

  23. Wu-Lin Yang, Yang-Zi Liu, Shuai Luo, Xingxin Yu*, John S. Fossey, Wei-Ping Deng*. Chem. Commun., 2015, 51, 9212-9215. (Highlighted by Synfacts, 2015, 11, 738.)

  24. The copper-catalyzed asymmetric construction of a dispiropyrrolidine skeleton via 1,3-dipolar cycloaddition of azomethine ylides to α-alkylidene succinimides.

  25. Fei-Fei Tang, Wu-Lin Yang, Xingxin Yu*, Wei-Ping Deng*. Catal. Sci. Technol., 2015, 5, 3568-3575.

  26. Cu(OAc)2/FOXAP complex catalyzed construction of 2,5-dihydropyrrole derivatives via asymmetric 1,3-dipolar cycloaddition of azomethine ylides with ethynyl ketones.

  27. Shan-Shan Jiang, Qin-Chang Xu, Ming-Yu Zhu, Xingxin Yu*, Wei-Ping Deng*. J. Org. Chem., 2015, 80, 3159-3169.

  28. Kinetic Resolution of α-Methylene-β-hydroxy Esters Catalyzed by Acyl Transfer Catalyst An-PIQ.

  29. Shan-Shan Jiang, Bo-Qi Gu, Ming-Yu Zhu, Xingxin Yu*, Wei-Ping Deng*. Tetrahedron, 2015, 71, 1187-1191.

  30. Nonenzymatic kinetic resolution of α-aryl substituted allylic alcohols catalyzed by acyl transfer catalyst Np-PIQ.

  31. Wen-Jing Qin, Yi Li, Xingxin Yu*, Wei-Ping Deng*. Tetrahedron, 2015, 71, 1182-1186.

  32. TBAI/TBHP catalyzed direct N-acylation of sulfoximines with aldehydes.

  33. Jiang Meng, Di Wu, Ying Shi, Xingxin Yu*, Wei-Ping Deng. Tetrahedron, 2015, 71, 1074-1079.

  34. Construction of 1H-pyrrol-2-ylphosphonates via [3+2] cycloaddition of phosphate azomethine ylides with ynones.

  35. Xianbo Wang, Xingxin Yu*. J. Org. Chem., 2014, 79, 7854-7860.

  36. Silver(I) and Copper(I) Co-catalyzed Tandem Reaction of 2-Alkynylbenzaldoximes with Aldehydes or Alcohols: Approach to 4-Carboxylated Isoquinolines.

  37. Shanshan Jiang, Bin Hu, Xingxin Yu*, Weiping Deng*. Chin. J. Chem.,2014, 32, 694-698.

  38. Fc-PIP Catalyzed Asymmetric Synthesis of cis-2,3-Dihydrobenzofurans.

  39. Yong Luo, Xiaolin Pan, Xingxin Yu*, Jie Wu*. Chem. Soc. Rev.,2014, 43, 834-846.

  40. Double Carbometallation of Alkynes: An Efficient Strategy for the Construction of Polycycles.