Contact Information

• Office:Room 1507, Researching Building 18

• Email: wpzhu@ecust.edu.cn

• Office Phone: +86 21 6425 3822

• Office Fax: +86 21 6425 2603

Education

• 2004.06 Ph.D.Chemical Engineering, East China University of Science &Technology, Shanghai, P. R. China

• 1992.06 M.Sc.Fine Chemicals, East China University of Science &Technology, Shanghai, P. R. China

• 1989.06 Eng.Applied Chemistry, National University of Defense &Technology, Changsha, P. R. China

Professional Experience

• 2010-now Professor, School of Pharmacy, East China Universityof Science and Technology

• 2005-2009  AssociateProfessor, School of Pharmacy, East China University of Science and Technology

Research Interests

• Construction of stimuli-responsive drug delivery systems

• Design of activable fluorescent probes for the diagnosis of diseases

Publications

1. Mingyang Hei, Huijing Wu, Yun Fu, Yufang Xu, Weiping Zhu*. Phenylboronic acid functionalized silica nanoparticles with enlarged ordered mesopores for efficient insulin loading and controlled release. Journal of Drug Delivery Science and Technology, 2019, 51(3), 320-326

2. Yao Tang, Hongyuan Shi, Di Cheng, Jing Zhang, Yuncheng Lin, Yufang Xu, Xuhong Qian, WeipingZhu*. pH-Activatable tumor-targeting gold nanoprobe for near-infrared fluorescence/CT dual-modal imaging in vivo. Colloids and Surfaces B: Biointerfaces, 2019, 179(7), 56-65

3. Houna Duan, Yu Ding, Chusen Huang,* Weiping Zhu,* Rui Wang, Yufang Xu. A lysosomal targeting fluorescent probe and its zinc imaging in SH-SY5Y human neuroblastoma cells. Chinese Chemical Letters, 2019, 30(1), 55-57

4. Yuezheng Ti, Ling Yu, Yao Tang, Tongxia Jin, Ming Yang, Rui Wang*, Yufang Xu, Weiping Zhu*. A hypoxia-activated near infrared fluorescent probe for cyclooxygenase-2 and in vivo imaging for tumor and inflammation, Sensors and Actuators B: Chemical, 2018, 265, 582-590

5. Huijing Wu, Junhua Jia, Yufang Xu, Xuhong Qian, and Weiping Zhu*. A reusable bifunctional fluorescent sensor for the detection and removal of silver ions in aqueous solutions, Sensors and Actuators B: Chemical, 2018, 265, 59-66

6. Mingyang Hei, Jun Wang, Kelly Wang, Weiping Zhu* and Peter X Ma*. Dually responsive mesoporous silica nanoparticles regulated by upper critical solution temperature polymers for intracellular drug delivery, J. Mater. Chem. B, 2017, 5, 9497-9501

7. Feng Yu, Huijing Wu, Yao Tang, Yufang Xu, Xuhong Qian, and Weiping Zhu*. Temperature-sensitive copolymer-coated fluorescent mesoporous silica nanoparticles as a reactive oxygen species activated drug delivery system, International Journal of Pharmaceutics, 2018, 536, 11-20

8. Dandan Li, Yuqiong Xu, Nannan Zhou, Jianxu Liu, Rui Wang, Tao Cheng, Yun Tang, Weiping Zhu, Yufang Xu,* Xuhong Qian*. A novel ‘‘donor-two-acceptor’’ type fluorophore-based probe for fast detection and intracellular imaging of nitroreductase, Dyes and Pigments, 2017, 136, 627-632

9. Xiaotong Jia, Qiangqiang Chen, Yingfang Yang, Yao Tang, Rui Wang, Yufang Xu, Weiping Zhu, Xuhong Qian*. A FRET-based Mito-Specific Fluorescent Probe for Ratiometric Detection and Imaging of Endogenous Peroxynitrite: Dyad of Cy3 and Cy5, Journal of American Chemistry Society, 2016, 138 (34), 10778–10781

10. Jingwen Zhang, Chao Wang, Lei Zhang, Huijing Wu, Yi Xiao,* Yufang Xu, Xuhong Qian and Weiping Zhu*. Novel nonplanar and rigid fluorophores with intensive emission in water and the application in two-photon imaging of live cells, RSC Advances, 2016, 6, 71624-72627

11. Yujie Li, Mingyang Hei, Yufang Xu, Xuhong Qian, Weiping Zhu*. Ammonium salt modified mesoporous silica nanoparticles for dual intracellular-responsive gene delivery, International Journal of Pharmaceutics, 2016, 511, 689-702

12. Qi Cai, Gaosheng Liang, Yufang Xu, Xuhong Qian*, and Weiping Zhu*. A Reusable Heterogeneous Catalyst without Palladium Leaking for High-efficient Suzuki-Miyaura Reaction in Pure Water under Air, RSC Advances, 2016, 6, 60996-61000

13. Yao Tang, Yu Liu, Yiqiao Qin, Yufang Xu, Xuhong Qian, and Weiping Zhu*. A reusable thioether-rich crown-based fluorescent sensor for the detection and removal of mercuric ions, Journal of Colloid and Interface Science, 2016, 479, 7-14

14. Junhua Jia, Luling Wu, Yu Ding, Chusen Huang, Weiping Zhu*, Yufang Xu and Xuhong Qian. A DPA-based highly selective and sensitive fluorescent probe for mercuric ions and its imaging in living cells, Dalton Transactions, 2016, 45, 9402-9406

15. Mengfang Tang, Luling Wu, Dan Wu, Chusen Huang, Weiping Zhu*, Yufang Xu and Xuhong Qian. An “Off-On” Fluorescent Probe for the Detection of Cysteine /Homocysteine and Its Imaging in Living Cells, RSC Advances, 2016, 6(41), 34996-35000

16. Qi Cai, Tao Yu, Weiping Zhu*, Yufang Xu, and Xuhong Qian. A turn-on fluorescent probe for tumor hypoxia imaging in living cells, Chemical Communications, 2015, 51(79), 14739-14741

17. Chunsheng He, Long Ren, Weiping Zhu*, Yufang Xu, and Xuhong Qian*. Removal of mercury from aqueous solution using mesoporous silica nanoparticles modified with polyamide receptor, Journal of Colloid and Interface Science, 2015, 458(1), 229-234.

18. Yu Ding, Weiping Zhu*, Yufang Xu, and Xuhong Qian. A small molecular fluorescent sensor functionalized silica microsphere for detection and removal of mercury, cadmium, and lead ions in aqueous solutions, Sensors and Actuators B: Chemical, 2015, 220(1), 762-771.

19. Shenyi Zhang, Mei Zhao, Weiping Zhu, Yufang Xu* and Xuhong Qian*. A highly sensitive, selective ratiometric fluorescent probe for cobalt(II) and its applications for biological imaging, Dalton Transactions.2015, 44, 9740-9743.

20. Gaosheng Liang, Qi Cai, Weiping Zhu*, Yufang Xu, and Xuhong Qian. A highly selective heterogeneous fluorescent sensor for palladium ions, Analytical Methods, 2015, 7(12), 4877-4880.

21. Yuanyuan Luo, Dan Tang, Weiping Zhu, Yufang Xu and Xuhong Qian*. Reactive fluorescent dye functionalized cotton fabric as a "Magic Cloth'' for selective sensing and reversible separation of Cd²⁺ in water, Journal of Materials Chemistry C, 2015, 3, 8485-8489.

22. Yi Xiao*, Fengyu Liu, Zhuo Chen, Weipin Zhu, Yufang Xu and Xuhong Qian*. Discovery of a novel family of polycyclic aromatic molecules with unique reactivity and members valuable for fluorescent sensing and medicinal chemistry. Chemical Communications, 2015, 51, 6480-6488.

23. Tiantian Chen, Liyan Yin, Chusen Huang*, Yiqiao Qin, Weiping Zhu*, Yufang Xu, and Xuhong Qian, Highly selective “off-on” fluorescent probe for histidine and its imaging in living cells,Biosensors and Bioelectronics, 2015, 66(1), 259-265

24. Chusen Huang, Ti Jia, Mengfang Tang, Qin Yin, Weiping Zhu*, Chao Zhang, Yi Yang,Nengqin Jia*, Yufang Xu*, Xuhong Qian. Selective and Ratiometric Fluorescent Trapping and Quantification of Protein Vicinal Dithiols and In Situ Dynamic Tracing in Living Cells, Journal of American Chemistry Society, 2014,  136 (40), 14237–14244

25. Zhenlin Tian, Weiping Zhu*, Yufang Xu*, and Xuhong Qian. Unnatural Amino Acid Based Fluorescent Probe for Phenylalanine Ammonia Lyase, Organic and Biomolecular Chemistry, 2014, 12(31), 5818-5821

26. Qin Yin, Chusen Huang, Chao Zhang, Weiping Zhu*, Yufang Xu,*Xuhong Qian and Yi Yang*. In situ visualization and detection of protein sulfenylation responses in living cells through a dimedone-based fluorescent probe, Organic and Biomolecular Chemistry, 2013, 11(43), 7566-7573

27. Ting Guo, Lei Cui, Jiaoning Shen, Weiping Zhu, Yufang Xu* and Xuhong Qian*. Highly Sensitive Long-wavelength Fluorescence Probe for Nitroreductase and Hypoxia: Selective Detection and Quantification, Chemical Communications, 2013, 49, 10820-10822

28. Lei Cui, Weiping Zhu, Yufang Xu*, Xuhong Qian. A novel ratiometric sensor for the fast detection of palladium species with large red-shift and high resolution both in aqueous solution and solid state, Analytica Chimica Acta, 2013, 786, 139–145

29. Liyan Wang, Chunmei Yang, Weiqiang Lu, Li Liu, Rui Gao, Sha Liao, Zhenjiang Zhao, Lili Zhu, Yufang Xu, Honglin Li*, Jin Huang*, Weiping Zhu*. Discovery of new potent inhibitors for carbonic anhydrase IX by structure-based virtual screening, Bioorganic Medicinal Chemistry Letters, 2013, 23, 3496–3499

30. Chusen Huang, Qin Yin,Jiangjiang Meng, Weiping Zhu*,Yi Yang,Xuhong Qian and Yufang Xu*. Versatile Probes for Selective Detection of Vicinal-Dithiol-Containing Proteins (VDPs): Design, Synthesis and Application in living cells. Chemistry: A European Journal, 2013, 19(24), 7739-7747

31. Xin Wang, Lei Cui, Nannan Zhou, Weiping Zhu, Rui Wang*, Xuhong Qian and Yufang Xu*. A highly selective and sensitive near-infrared fluorescence probe for arylamine N-acetyltransferase 2 in vitro and in vivo, Chemical Science, 2013,4, 2936-2940

32. Ting Guo, Lei Cui, Jiaoning Shen, Rui Wang, Weiping Zhu, Yufang Xu* and Xuhong Qian*. A dual-emission and large Stokes shift fluorescence probe for real-time discrimination of ROS/RNS and imaging in live cells, Chemical Communications, 2013, 49, 1862-1864

33. Mengjie Chen, Chusen Huang, Chunsheng He, Weiping Zhu*, Yufang Xu, and Yunfeng Lu. Glucose-Responsive Controlled Release System Using Glucose Oxidase-Gated Mesoporous Silica Nanocontainers, Chemical Communications, 2012, 48, 9522-9524.

34. Lin Xu, Yufang Xu, Weiping Zhu, Bubing Zeng, Chunmei Yang, Bin Wu and Xuhong Qian*. Versatile trifunctional chemosensor of rhodamine derivative for Zn²⁺, Cu²⁺, and His/Cys in aqueous solution and living cells, Organic and Biomolecular Chemistry, 2011, 9, 8284-8287

35. Shenyi Zhang, Chunmei Yang, Weiping Zhu, Bubing Zeng, Youjun Yang, Yufang Xu* and Xuhong Qian*. Highly selective, naked-eye and fluorescent “off-on” probe for detection of histidine/histidine-rich proteins and its application in living cell imaging, Organic and Biomolecular Chemistry, 2012, 10, 1653-1658

36. Qingshan Du, Weiping Zhu, Zhenjiang Zhao*, Xuhong Qian, and Yufang Xu*. Novel Benzo-1,2,3-thiadiazole-7-carboxylate Derivatives As Plant Activators and the Development of Their Agricultural Applications, Journal of Agricultural and Food Chemistry, 2012, 60, 346−353

37. Zheng Xu, Lin Xu, Ji Zhou, Yufang Xu, Weiping Zhu and Xuhong Qian*.A highly selective fluorescent probe for fast detection of hydrogen sulfide in aqueous solution and living cells. Chemical Communications, 2012,48, 10871-10873

38. Lin Xu, Yufang Xu, Weiping Zhu, Xiaolong Sun, Zheng Xu and Xuhong Qian*.Modulating the selectivity by switching sensing media: a bifunctional chemosensor selectivity for Cd²⁺ and Pb²⁺ in different aqueous solutions, RSC Advances, 2012,2, 6323-6328

39. Lin Xu, Yufang Xu, Weiping Zhu, Chunmei Yang, Le Han and Xuhong Qian*.A highly selective and sensitive fluorescence “turn-on” probe for Ag⁺ in aqueous solution and live cells, Dalton Transactions, 2012,41, 7212-7217

40. Lin Xu, Yufang Xu, Weiping Zhu, Zheng Xu, Mengjie Chen and Xuhong Qian*. Fluorescence sensing of iodide and bromide in aqueous solution: anion ligand exchanging and metal ion removing, New Journal of Chemistry, 2012, 36, 1435–1438

41. Xiaolong Sun, Yufang Xu, Weiping Zhu, Chunsheng He, Lin Xu, Youjun Yang and Xuhong Qian*.Copper-promoted probe for nitric oxide based on o-phenylenediamine: Large blue-shift in absorption and fluorescence enhancement, Analytical Methods, 2012,4, 919-922

42. Liyan Yin, Chunsheng He, Chusen Huang, Weiping Zhu*, Xin Wang, Yufang Xu* and Xuhong Qian*. A pH and Temperature Dual Responsive Polymeric Fluorescent Sensor and Its Imaging in Living Cells, Chemical Communications, 2012, 48, 4486-4488

43. Chusen Huang, Qin Yin, Weiping Zhu*, Yi Yang*, Yufang Xu*, Xin Wang, and Xuhong Qian. Highly selective fluorescent probe for vicinal dithiol-containing proteins and in-situ imaging in living cells. Angewandte Chemie International Edition, 2011, 50, 7551-7556

44. Chunsheng He, Xuhong Qian*, Yufang Xu, Chunmei Yang, Liyan Yin, Weiping Zhu*. A Ratiometric Fluorescent Probe for Oxalate Based on Alkyne-conjugated Carboxamido- quinolines in Aqueous Solution and Imaging in Living Cells. Dalton Transactions, 2011, 40, 1034-1037

45. Hong Yin, Weiping Zhu, Yufang Xu*, Min Dai, Xuhong Qian*, Yuanli Li, Jianwen Liu. Novel aliphatic N-oxide of naphthalimides as fluorescent markers for hypoxic cells in solid tumor, European Journal of Medicinal Chemistry, 2011, 46, 3030-3037

46. Shenyi Zhang, Chunmei Yang, Weiqiang Lu, Jin Huang, Weiping Zhu, Honglin Li, Yufang Xu* and Xuhong Qian*. A highly selective space-folded photo-induced electron transfer fluorescent probe for carbonic anhydrase isozymes IX and its applications for biological imaging, Chemical Communications,2011, 47, 8301-8303

47. Tanyu Cheng, Tao Wang, Weiping Zhu, Xinlei Chen, Youjun Yang, Yufang Xu,* and Xuhong Qian*. Red-Emission Fluorescent Probe Sensing Cadmium and Pyrophosphate Selectively in Aqueous Solution, Organic Letters, 2011, 13, 3656-3659

48. Zhuo Chen, Xin Wang, Weiping Zhu, Xianwen Cao, Linjiang Tong, Honglin Li, Hua Xie, Yufang Xu*, Shaoying Tan, Dong Kuang, Jian Ding, and Xuhong Qian*. Acenaphtho[1,2-b] pyrrole-Based Selective Fibroblast Growth Factor Receptors 1 (FGFR1) Inhibitors: Design, Synthesis, and Biological Activity, Journal of Medicinal Chemistry, 2011, 54, 3732-3745

49. Tanyu Cheng, Tao Wang, Weiping Zhu, Yangyang Yang, Bubing Zeng, Yufang Xu* and Xuhong Qian*. Modulating the selectivity of Near Infrared Fluorescent Probes Toward Various Metal Ions by Judicious Choice of Aqueous Buffer Solutions, Chemical Communications,2011,47, 3915-3917

50. Lei Cui, Ye Zhong, Weiping Zhu, Yufang Xu,* Qingshan Du, Xin Wang, Xuhong Qian,*, and Yi Xiao. A New Prodrug-Derived Ratiometric Fluorescent Probe for Hypoxia: High Selectivity of Nitroreductase and Imaging in Tumor Cell, Organic Letters, 2011, 13, 928 - 931

51. Yangyang Yang, Tanyu Cheng, Weiping Zhu, Yufang Xu*, Xuhong Qian*. Highly Selective and Sensitive Near-infrared Fluorescent Sensors for Cadmium in Aqueous Solution,Organic Letters, 2011, 13, 264 - 267

52. Chunsheng He, Weiping Zhu*, Yufang Xu, Ye Zhong, Juan Zhou and Xuhong Qian*. Ratiometric and Reusable Fluorescent Nanoparticles for Zn²⁺ and H₂PO₄^- Detection in Aqueous Solution and Living Cell, Journal of Materials Chemistry, 2010, 20, 10755-10764

53. Lei Cui, Ye Zhong, Weiping Zhu, Yufang Xu*, Xuhong Qian*. Selective and Sensitive Detection and Quantification of Arylamine N-Acetyltransferase 2 by a Ratiometric Fluorescence Probe, Chemical Communications, 2010, 46, 7121 -7123

54. Xuhong Qian*, Yi Xiao, Yufang Xu, Xiangfeng Guo, Junhong Qian, Weiping Zhu.“Alive” Dye as Fluorescent Sensor: Fluorophore, Mechanism, Receptor and Images in Living Cell, Chemical Communications, 2010, 46, 6418 – 6436

55. Zhuo Chen, Xin Liang, Huanying Zhang, Hua Xie, Jianwen Liu, Yufang Xu*, Weiping Zhu, Yi Wang, Xin Wang,Shaoying Tan, Dong Kuang, Xuhong Qian*. A New Class of Naphthalimide-based Antitumor Agents that Inhibit Topoisomerase II (Topo II) and Induce Lysosomal Membrane Permeabilization (LMP) and Apoptosis. Journal of Medicinal Chemistry, 2010, 53, 2589-2600.

56. Tao Chen, Weiping Zhu*, Yufang Xu, Shenyi Zhang, Xiaojun Zhang, Xuhong Qian. A Thioether-Rich Crown-Based Highly Selective Fluorescent Sensor for Hg²⁺ and Ag⁺ in Aqueous Solution, Dalton Transactions, 2010, 39, 1316-1320.

57. Chunsheng He, Weiping Zhu*, Yufang Xu, Xuhong Qian*, Tao Chen. Trace Mercury (II) Detection and Separation in Serum and Water Samples Using a Reusable Bifunctional Fluorescent Sensor, Analytica Chimica Acta, 2009, 651, 227-233

58. Tanyu Cheng, Yufang Xu*, Shenyi Zhang, Weiping Zhu, Xuhong Qian*, Liping Duan. A highly sensitive and selective OFF-ON fluorescent sensor for cadmium in aqueous solution and living cell,  Journal of American Chemistry Society, 2008, 130, 16160–16161

59. Weiping Zhu, Min Dai, Yufang Xu*, Xuhong Qian*. Novel Nitroheterocyclic Hypoxic Markers for Solid Tumor: Synthesis and Biological Evaluation, Bioorganic and  Medicinal Chemistry, 2008, 16, 3255-3260

60. Min Dai, Weiping Zhu, Yufang Xu*, Xuhong Qian*. Versatile Nitro-Fluorophore as Highly-effective Sensor for Hypoxic Tumor Cells: Design, Imaging and Evaluation, Journal of Fluorescence, 2008, 18, 591-597

61. Weiping Zhu, Zhenjiang Zhao, Yufang Xu*. Derivatives of benzothiadiazole-7- carboxylates: synthesis and biological activity,Monatshefte für Chemie / Chemical Monthly, 2008, 139, 1067-1071