王熳炯，特聘副研究员，硕士生导师
地址：海思路999号实验5楼309
Email：wangmj@ecust.edu.cn
个人简介
2022年6月毕业于华东理工大学药学院药物化学专业，获博士学位，后进入华东理工大学药学院从事博士后研究，合作导师为李剑教授。2025年7月出站后留校工作，从事药学教学和科研工作。
主要从事基于老药新用及二次研发策略的药物新靶标发现与候选新药研发工作，聚焦抗心衰研究领域。迄今已在Acta Pharm. Sin. B、J. Med. Chem. 等国内外重要刊物上发表论文20余篇；申请发明专利18项，授权5项。作为项目负责人主持国家自然科学基金青C基金项目1项，2024年入选上海市启明星计划扬帆专项，2022年获上海市超级博士后资助。
主要研究方向
1、抗心衰靶标发现与机制研究
2、源于中药的抗心衰药物设计合成与候选新药研发
3、老药新用与二次研发
教育经历
2017.9 – 2022.6，华东理工大学，药学院，药物化学，博士；
2013.8 – 2017.7，华东理工大学，药学院，药物制剂，学士。
工作经历
2025.7 – 至今，华东理工大学，药学院，特聘副研究员；
2022.7 – 2025.6，华东理工大学，药学院，博士后。
招生专业
药学一级学科（学硕）
欢迎有志于药物化学、药理学及新药研发领域研究的优秀学生加入！
代表性论文(#共同第一作者，*为通讯作者)
Manjiong Wang#, Xiaobo Guo#, Hanfang Liu, Xiao Li, Yue Yao, Qing Fu, Yu Jin, Shuaishuai Ni, Xiaokang Li, Chaojiang Xiao, Bei Jiang, Conglong Xia*, Jian Li*, Yixiang Xu*. Veronica anagallis-aquatica L. iridoid glycosides alleviate heart failure via metabolites homoveratrumic acid and 2-hydroxy-3,4-dimethoxybenzoic acid mediated by the gut microbiota. Acta Pharm. Sin. B 2025, 15, 3338−3342.
Hanfang Liu#, Xiaobo Guo#, Jin Yang, Conglong Xia, Yue Yao, Xiao Li, Xiaoyang Liu, Junqi Yang, Xiaokang Li, Yixiang Xu*, Jian Li*, Manjiong Wang*. Structure optimization of natural product catalpol to obtain novel and potent analogs against heart failure. J. Med. Chem. 2025, 68, 4540−4560.
Manjiong Wang#, Tongke Tang#, Ruoxi Li, Zhenghui Huang, Dazheng Ling, Lulu Zheng, Yan Ding, Taiping Liu, Wenyue Xu, Feng Zhu, Hui Min, Rachasak Boonhok, Fei Mao, Jin Zhu, Xiaokang Li*, Lubin Jiang*, Jian Li*. Drug repurposing of quisinostat to discover novel plasmodium falciparum HDAC1 inhibitors with enhanced triple-stage antimalarial activity and improved safety. J. Med. Chem. 2022, 65, 4156–4181.
Manjiong Wang#, Tongke Tang#, Zhenghui Huang, Ruoxi Li, Dazheng Ling, Jin Zhu, Lubin Jiang*, Jian Li*, Xiaokang Li*. Design and synthesis of novel hydroxamic acid derivatives based on quisinostat as promising antimalarial agents with improved safety. Acta Mater. Med. 2022, 1, 212–223.
Xiao Li#, Manjiong Wang#, Yunpeng Guo#, Luoyifan Zhou, Yue Yao, Xiaobo Guo, Conglong Xia, HanFang Liu, Zihan Wang, Tiankuo Zhang, Chao Zhang, Yi Ge, Xiaokang Li *, Jian Li*, Yixiang Xu*. Discovery of novel Psoralen derivatives as potent anti-heart failure agents through drug repurposing and secondary development. Chinese Chem. Lett. 2025, 112287.
Taotao Lu#, Manjiong Wang#, Yunyuan Huang#, Donglei Shi, Xiao Li, Jiaqi Liu, Jian Li, Bei Jiang*, Baoli Li*, Yixiang Xu*. Euphorbia neriifolia L. extract attenuates heart failure by modulating the Nrf2/ROS/HIF-1α signaling pathway. Acta Mater. Med. 2025. 4, 698-710
Yayuan Peng#, Manjiong Wang#, Yixiang Xu#, Zengrui Wu, Jiye Wang, Chao Zhang, Guixia Liu, Weihua Li, Jian Li*, Yun Tang*. Drug repositioning by prediction of drug’s anatomical therapeutic chemical code via network-based inference approaches. Brief. Bioinform. 2021, 22, 2058–2072.
