蒋晓雪 讲师  硕士生导师

E-mail: xxjiang@ecust.edu.cn

通讯地址：上海市徐汇区梅陇路130号；邮编：200237

个人简介：

蒋晓雪，博士，华东理工大学药学院讲师、硕士生导师。2020年毕业于中国科学院上海营养与健康研究所获博士学位。之后在复旦大学从事博士后研究。2025年加入华东理工大学药学院，从事教学科研工作。主要聚焦于衰老、糖尿病、肥胖等慢性代谢疾病的调控机制研究，尤其在中枢神经系统对外周代谢的研究中开展了系统性的工作。

至今，以第一作者或通讯作者身份在 Signal Transduction and Targeted Therapy、Nature Communications、Cell Report等国际著名学术期刊上发表多篇学术论文。作为项目负责人主持国家自然科学基金青C基金项目，中国博士后科学基金第74批面上资助，中国博士后科学基金第17批特别资助，以及国家资助博士后研究人员计划等基金项目资助。先后入选上海市超级博士后以及前沿中心珠峰青年学者计划等人才项目。

研究方向：

1、中枢神经系统调控外周代谢的机制研究

2、亚细胞器稳态与代谢调控

3、高通量代谢调控网络以及药物筛选

代表性论文：

[1] Jiang X#, Liu K#, Luo P, Li Z, Xiao F, Jiang H, Wu S, Tang M, Yuan F, Li X, Shu Y, Peng B, Chen S, Ni S, Guo F*. Hypothalamic SLC7A14 accounts for aging-reduced lipolysis in white adipose tissue of male mice. Nat Commun. 2024 Sep 11;15(1):7948.

[2] Jiang X#, Liu K, Jiang H, Yin H, Wang ED, Cheng H, Yuan F, Xiao F, Wang F, Lu W, Peng B, Shu Y, Li X, Chen S, Guo F.* SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2. Cell Rep. 2023 Jan 31;42(1):111984.

[3] Jiang X#, Xiao F, Guo F*. Oocyte TET3: an epigenetic modifier responsible for maternal inheritance of glucose intolerance. Signal Transduct Target Ther. 2022 Oct 8;7(1):357.

[4] Jiang X#, Guo F*. The role and mechanism of amino acids in regulating hepatic glucose and lipid metabolism. Acta physiologica Sinica. 2021 Oct 25;73(5):723-733.

[5] Jiang H, Ni S, Li Z, Chen S, Li X, Zhang H, Shen WL, Jiang X, Luo P, Shu Y, Yuan F, Tong K, Xiao F, Guo F. Leucine catabolic enzyme AUH regulates BAT thermogenesis via PPARγ HMGylation and RNA-binding function in male mice. Nat Commun. 2026 Apr 10.

[6] Luo P, Tong K, Gan Y, Tang M, Niu Y, Liu K, Ni S, Wu S, Jiang X, Jiang H, Xiao F, Chen S, Lv W, Li X, Yuan F, Guo F. Amino Acid-Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis. Adv Sci (Weinh). 2025 Jul;12(27):e2502421.

[7] Xiao F, Jiang H, Li Z, Jiang X, Chen S, Niu Y, Yin H, Shu Y, Peng B, Lu W, Li X, Li Z, Lan S, Xu X, Guo F. Reduced hepatic bradykinin degradation accounts for cold-induced BAT thermogenesis and WAT browning in male mice. Nat Commun. 2023 May 2;14(1):2523.

[8] Yuan F, Zhou Z, Wu S, Jiao F, Chen L, Fang L, Yin H, Hu X, Jiang X, Liu K, Xiao F, Jiang H, Chen S, Liu Z, Shu Y, Guo F. Intestinal activating transcription factor 4 regulates stress-related behavioral alterations via paraventricular thalamus in male mice. Proc Natl Acad Sci U S A. 2023 May 9;120(19):e2215590120.

[9] Yuan F, Jiang H, Yin H, Jiang X, Jiao F, Chen S et al. Activation of GCN2/ATF4 signals in amygdalar PKC-δ neurons es WAT browning under leucine deprivation. Nat Commun. 2020 Jun 5;11(1):2847.

[10] Deng J, Guo Y, Yuan F, Chen S, Yin H, Jiang X, Jiao F, Wang F, Ji H, Hu G, Ying H, Chen Y, Zhai Q, Xiao F, Guo F. Autophagy inhibition prevents glucocorticoid-increased adiposity via suppressing BAT whitening. Autophagy. 2020 Mar;16(3):451-465.