朱维平
发布人: 发布时间: 2014-08-29 作者: 访问次数: 3279

 

 

朱维平 教授  博士生导师
电话:  021-64253822
传真:  021-64252603
地址: 上海市梅陇路130号华东理工大学实验18楼1507室
 
个人简介

朱维平,男,1967年生于江苏扬中。1989.7毕业于国防科技大学应用化学专业,获工学学士学位,1992.7毕业于华东化工学院(现华东理工大学)精细化工专业,获工学硕士学位,2004.6毕业于华东理工大学化学工程专业,获工学博士学位。1992.7-1999.9扬子石化研究院工程师、副所长;1999.10-2005.1扬子石化研究院高级工程师、副所长、所长;2005.2-2010.8,华东理工大学药学院副教授, 2010.9至今,华东理工大学教授,博士生导师。2009-2010,美国加州大学洛杉矶分校访问学者。作为负责人先后承担国家自然科学基金项目、国家“863”计划项目、国家科技支撑计划课题、上海市浦江人才计划项目、上海市科委重点攻关项目、上海市科委基础研究重点项目等。 2007年至今,已在Angew. Chem. Int. Ed., Chem. Commun., J. Mater. Chem.等国际著名学术刊物上发表 SCI 论文40余篇,申请中国发明专利18项,授权5项。

 

 研究方向
Ø       新型药物控制释放系统的构建。针对生物大分子药物(如胰岛素、抗体药物、siRNA等)、难溶性药物的体内输送,以介孔氧化硅纳米粒子、聚合物纳米凝胶等为载体,设计各类微环境和/或刺激响应型控制释放系统,实现药物分子的可控、靶向给药。

Ø       荧光探针及其在生物分析、医学诊断及环境监测中的应用。针对环境及生物体系中各种离子、小分子、生物大分子(酶、蛋白质等),开展高选择性、高灵敏性荧光分子探针的设计、合成及应用研究。 

 

代表性论文
1.       Zhenlin Tian, Weiping Zhu*, Yufang Xu*, and Xuhong Qian. Unnatural Amino Acid Based Fluorescent Probe for Phenylalanine Ammonia Lyase, Org. Biomol. Chem., 2014, 12, 5818-5821
2.       殷丽艳,陈甜甜,朱维平. 基于萘酰亚胺的Turn-On型Fe(III)荧光探针,影像科学与光化学,2014, 32(1): 84-90
3.       Mengjie Chen, Chusen Huang, Chunsheng He, Weiping Zhu*, and Yufang Xu. A Novel Controlled-Release System Based on Horseradish Peroxidase-Gated Mesoporous Silica Nanocontainers. J. Control. Release, 2013, 172(1), e73–e74
4.       Liyan Wang, Chunmei Yang, Weiqiang Lu, Li Liu, Rui Gao, Sha Liao, Zhenjiang Zhao, Lili Zhu, Yufang Xu, Honglin Li*, Jin Huang*, Weiping Zhu*, Discovery of new potent inhibitors for carbonic anhydrase IX by structure-based virtual screening, Bioorg. Med. Chem. Lett., 2013, 23, 3496–3499
5.       Qin Yin, Chusen Huang, Chao Zhang, Weiping Zhu,* Yufang Xu,*Xuhong Qian and Yi Yang*, In situ visualization and detection of protein sulfenylation responses in living cells through a dimedone-based fluorescent probe, Org. Biomol. Chem., 2013,11(43), 7566-7573
6.       Chusen Huang, Qin Yin,Jiangjiang Meng, Weiping Zhu*,Yi Yang,Xuhong Qian and Yufang Xu*. Versatile Probes for Selective Detection of Vicinal-Dithiol-Containing Proteins (VDPs): Design, Synthesis and Application in living cells. Chem. Eur. J., 2013, 19(24), 7739-7747
7.       Mengjie Chen, Chusen Huang, Chunsheng He, Weiping Zhu*, Yufang Xu, and Yunfeng Lu, Glucose-Responsive Controlled Release System Using Glucose Oxidase-Gated Mesoporous Silica Nanocontainers,  Chem. Commun., 2012, 48(76), 9522-9524.
9.       黄楚森,朱维平*, 徐玉芳*, 钱旭红, 蛋白质巯基及其氧化性修饰的化学检测方法, 药学学报, 2012, 47(3): 280−290
10.   Chusen Huang, Qin Yin, Weiping Zhu*, Yi Yang*, Yufang Xu*, Xin Wang, and Xuhong Qian. Highly selective fluorescent probe for vicinal dithiol-containing proteins and in-situ imaging in living cells. Angew. Chem. Int. Ed., 2011, 50, 7551-7556
11.   Chunsheng He, Xuhong Qian*, Yufang Xu, Chunmei Yang, Liyan Yin, Weiping Zhu*. A Ratiometric Fluorescent Probe for Oxalate Based on Alkyne-conjugated Carboxamido- quinolines in Aqueous Solution and Imaging in Living Cells. Dalton Trans., 2011, 40, 1034-1037
12.   Chunsheng He, Weiping Zhu*, Yufang Xu, Ye Zhong, Juan Zhou and Xuhong Qian*. Ratiometric and Reusable Fluorescent Nanoparticles for Zn2+ and H2PO4- Detection in Aqueous Solution and Living Cell, J. Mater. Chem., 2010, 20, 10755-10764
13.   Tao Chen, Weiping Zhu*, Yufang Xu, Shenyi Zhang, Xiaojun Zhang, Xuhong Qian. A Thioether-Rich Crown-Based Highly Selective Fluorescent Sensor for Hg2+ and Ag+ in Aqueous Solution, Dalton Trans., 2010, 39, 1316-1320.
14.   Chunsheng He, Weiping Zhu*, Yufang Xu, Xuhong Qian*, Tao Chen. Trace Mercury (II) Detection and Separation in Serum and Water Samples Using a Reusable Bifunctional Fluorescent Sensor, Anal. Chim. Acta, 2009, 651, 227-233
15.   Weiping Zhu, Min Dai, Yufang Xu*, Xuhong Qian*. Novel Nitroheterocyclic Hypoxic Markers for Solid Tumor: Synthesis and Biological Evaluation, Bioorg. Med. Chem., 2008, 16, 3255-3260
16.   朱维平,徐玉芳,钱旭红*. 具有重要生物学意义的重金属及过渡金属荧光分子传感器,化学进展, 2007, 19, 1229-1238