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朱维平

 

 

朱维平 教授  博士生导师
电话:  021-64253822
传真:  021-64252603
地址: 上海市梅陇路130号华东理工大学实验18楼1507室
E-mail: wpzhu@ecust.edu.cn  
 
个人简介

朱维平,男,1967年生于江苏扬中。1989.7毕业于国防科技大学应用化学专业,获工学学士学位,1992.7毕业于华东化工学院(现华东理工大学)精细化工专业,获工学硕士学位,2004.6毕业于华东理工大学化学工程专业,获工学博士学位。1992.7-1999.9扬子石化研究院工程师、副所长;1999.10-2005.1扬子石化研究院高级工程师、副所长、所长;2005.2-2010.8,华东理工大学药学院副教授, 2010.9至今,华东理工大学教授,博士生导师。2009-2010,美国加州大学洛杉矶分校访问学者;2016.2-2016.8,美国斯坦福大学医学院访问学者。作为负责人先后承担国家自然科学基金项目、国家“863”计划项目、国家科技支撑计划课题、上海市浦江人才计划项目、上海市科委重点攻关项目、上海市科委基础研究重点项目等。 2007年至今,已在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Chem. Commun., J. Mater. Chem., Int. J. Pharmaceut.等国际著名学术刊物上发表 SCI 论文60余篇,申请中国发明专利20余项,授权8项。

 

研究方向
Ø      新型药物控制释放系统的构建。针对生物大分子药物(如胰岛素、抗体药物、siRNA等)、难溶性药物的体内输送,以介孔氧化硅纳米粒子、聚合物纳米凝胶等为载体,设计各类微环境和/或刺激响应型控制释放系统,实现药物分子的可控、靶向给药。

Ø       荧光探针及其在生物分析、医学诊断及环境监测中的应用。针对环境及生物体系中各种离子、小分子、生物大分子(酶、蛋白质等),开展高选择性、高灵敏性荧光分子探针的设计、合成及应用研究。 

 

代表性论文

1. Yuezheng Ti, Ling Yu b, Yao Tang, Tongxia Jin, Ming Yang, Rui Wang*, Yufang Xu, Weiping Zhu*. A hypoxia-activated near infrared fluorescent probe for cyclooxygenase-2 and in vivo imaging for tumor and inflammation, Sensors and Actuators B: Chemical, 2018, DOI: 10.1016/j.snb.2018.02.122

2. Huijing Wu, Junhua Jia, Yufang Xu, Xuhong Qian, and Weiping Zhu*. A reusable bifunctional fluorescent sensor for the detection and removal of silver ions in aqueous solutions, Sensors and Actuators B: Chemical, 2018, DOI: 10.1016/j.snb.2018.01.241

3. Feng Yu, Huijing Wu, Yao Tang, Yufang Xu, Xuhong Qian, and Weiping Zhu*. Temperature-sensitive copolymer-coated fluorescent mesoporous silica nanoparticles as a reactive oxygen species activated drug delivery system, International Journal of Pharmaceutics, 2018, 536, 11-20

4. Mingyang Hei, Jun Wang, Kelly Wang, Weiping Zhu* and Peter X Ma*. Dually responsive mesoporous silica nanoparticles regulated by upper critical solution temperature polymers for intracellular drug delivery, J. Mater. Chem. B, 2017, 5, 9497-9501

5. Jingwen Zhang, Chao Wang, Lei Zhang, Huijing Wu, Yi Xiao,* Yufang Xu, Xuhong Qian and Weiping Zhu*. Novel nonplanar and rigid fluorophores with intensive emission in water and the application in two-photon imaging of live cells, RSC Advances, 2016, 6, 71624-72627

6. Yujie Li, Mingyang Hei, Yufang Xu, Xuhong Qian, Weiping Zhu*. Ammonium salt modified mesoporous silica nanoparticles for dual intracellular-responsive gene delivery, International Journal of Pharmaceutics, 2016, 511, 689-702

7. Qi Cai, Gaosheng Liang, Yufang Xu, Xuhong Qian*, and Weiping Zhu*. A Reusable Heterogeneous Catalyst without Palladium Leaking for High-efficient Suzuki-Miyaura Reaction in Pure Water under Air, RSC Advances, 2016, 6, 60996-61000

8. Yao Tang, Yu Liu, Yiqiao Qin, Yufang Xu, Xuhong Qian, and Weiping Zhu*. A reusable thioether-rich crown-based fluorescent sensor for the detection and removal of mercuric ions, Journal of Colloid and Interface Science, 2016, 479, 7-14

9. Junhua Jia, Luling Wu, Yu Ding, Chusen Huang, Weiping Zhu*, Yufang Xu and Xuhong Qian. A DPA-based highly selective and sensitive fluorescent probe for mercuric ions and its imaging in living cells, Dalton Transactions, 2016, 45, 9402-9406

10. Mengfang Tang, Luling Wu, Dan Wu, Chusen Huang, Weiping Zhu*, Yufang Xu and Xuhong Qian. An “Off-On” Fluorescent Probe for the Detection of Cysteine /Homocysteine and Its Imaging in Living Cells, RSC Advances, 2016, 6(41), 34996-35000

11. Qi Cai, Juan Zhou, Weiping Zhu*, Yufang Xu, Xuhong Qian. Fluorescent and MRI bimodal imaging agent for tumor hypoxia, Nanomedicine: Nanotechnology, Biology, and Medicine, 2016, 12, 506

12. 杨润洁,唐尧,朱维平*. 用于检测细胞内谷胱甘肽的比率型荧光探针,高等学校化学学报2016374):643-647

13. Qi Cai, Tao Yu, Weiping Zhu*, Yufang Xu, and Xuhong Qian. A turn-on fluorescent probe for tumor hypoxia imaging in living cells, Chemical Communications, 2015, 51(79), 14739-14741

14. Chunsheng He, Long Ren, Weiping Zhu*, Yufang Xu, and Xuhong Qian*. Removal of mercury from aqueous solution using mesoporous silica nanoparticles modified with polyamide receptor, Journal of Colloid and Interface Science, 2015, 458(1), 229-234.

15. Yu Ding, Weiping Zhu*, Yufang Xu, and Xuhong Qian. A small molecular fluorescent sensor functionalized silica microsphere for detection and removal of mercury, cadmium, and lead ions in aqueous solutions, Sensors and Actuators B: Chemical, 2015, 220(1), 762-771.

16. Gaosheng Liang, Qi Cai, Weiping Zhu*, Yufang Xu, and Xuhong Qian. A highly selective heterogeneous fluorescent sensor for palladium ions, Analytical Methods, 2015, 7(12), 4877-4880.

17. Mingyang Hei, Weiping Zhu*, Yujie Li, Yufang Xu, Xuhong Qian. A novel biomacromolecule controlled-release system based on mesoporous silica nanoparticles with large pore size and small particle size, Journal of Controlled Release, 2015, 213, e114.

18. Tiantian Chen, Liyan Yin, Chusen Huang*, Yiqiao Qin, Weiping Zhu*, Yufang Xu, and Xuhong Qian, Highly selective “off-on” fluorescent probe for histidine and its imaging in living cells,Biosensors and Bioelectronics, 2015, 66(1), 259-265

19. Chusen Huang, Ti Jia, Mengfang Tang, Qin Yin, Weiping Zhu*, Chao Zhang, Yi Yang,Nengqin Jia*, Yufang Xu*, Xuhong Qian. Selective and Ratiometric Fluorescent Trapping and Quantification of Protein Vicinal Dithiols and In Situ Dynamic Tracing in Living Cells, Journal of American Chemistry Society, 2014,  136 (40), 14237–14244

20. Zhenlin Tian, Weiping Zhu*, Yufang Xu*, and Xuhong Qian. Unnatural Amino Acid Based Fluorescent Probe for Phenylalanine Ammonia Lyase, Organic and Biomolecular Chemistry, 2014, 12(31), 5818-5821

21. 殷丽艳,陈甜甜,朱维平*,基于萘酰亚胺的“Turn-On”型Fe3+荧光探针,影像科学与光化学, 2014, 32(1): 84-90

22. Mengjie Chen, Chusen Huang, Chunsheng He, Weiping Zhu*, and Yufang Xu. A Novel Controlled-Release System Based on Horseradish Peroxidase-Gated Mesoporous Silica Nanocontainers. Journal of Controlled Release, 2013, 172(1), e73–e74

23. Qin Yin, Chusen Huang, Chao Zhang, Weiping Zhu*, Yufang Xu,*Xuhong Qian and Yi Yang*. In situ visualization and detection of protein sulfenylation responses in living cells through a dimedone-based fluorescent probe, Organic and Biomolecular Chemistry, 2013, 11(43),7566-7573

24. Chusen Huang, Qin Yin,Jiangjiang Meng, Weiping Zhu*,Yi Yang,Xuhong Qian and Yufang Xu*. Versatile Probes for Selective Detection of Vicinal-Dithiol-Containing Proteins (VDPs): Design, Synthesis and Application in living cells. Chemistry: A European Journal, 2013, 19(24), 7739-7747

25. Mengjie Chen, Chusen Huang, Chunsheng He, Weiping Zhu*, Yufang Xu, and Yunfeng Lu. Glucose-Responsive Controlled Release System Using Glucose Oxidase-Gated Mesoporous Silica Nanocontainers, Chemical Communications, 2012, 48, 9522-9524.

26. 黄楚森,朱维平*,徐玉芳*,钱旭红,蛋白质巯基及其氧化性修饰的化学检测方法,药学学报2012, 47 (3): 280−290

27. Liyan Yin, Chunsheng He, Chusen Huang, Weiping Zhu*, Xin Wang, Yufang Xu* and Xuhong Qian*. A pH and Temperature Dual Responsive Polymeric Fluorescent Sensor and Its Imaging in Living Cells, Chemical Communications, 2012, 48, 4486-4488

28. Chusen Huang, Qin Yin, Weiping Zhu*, Yi Yang*, Yufang Xu*, Xin Wang, and Xuhong Qian. Highly selective fluorescent probe for vicinal dithiol-containing proteins and in-situ imaging in living cells. Angewandte Chemie International Edition, 2011, 50, 7551-7556

29. Chunsheng He, Xuhong Qian*, Yufang Xu, Chunmei Yang, Liyan Yin, Weiping Zhu*. A Ratiometric Fluorescent Probe for Oxalate Based on Alkyne-conjugated Carboxamido- quinolines in Aqueous Solution and Imaging in Living Cells. Dalton Transactions, 2011, 40, 1034-1037

30. Chunsheng He, Weiping Zhu*, Yufang Xu, Ye Zhong, Juan Zhou and Xuhong Qian*. Ratiometric and Reusable Fluorescent Nanoparticles for Zn2+ and H2PO4- Detection in Aqueous Solution and Living Cell, Journal of Materials Chemistry, 2010, 20, 10755-10764

31. Tao Chen, Weiping Zhu*, Yufang Xu, Shenyi Zhang, Xiaojun Zhang, Xuhong Qian. A Thioether-Rich Crown-Based Highly Selective Fluorescent Sensor for Hg2+ and Ag+ in Aqueous Solution, Dalton Transactions, 2010, 39, 1316-1320.

32. Chunsheng He, Weiping Zhu*, Yufang Xu, Xuhong Qian*, Tao Chen. Trace Mercury (II) Detection and Separation in Serum and Water Samples Using a Reusable Bifunctional Fluorescent Sensor, Analytica Chimica Acta, 2009, 651, 227-233

33. Weiping Zhu, Min Dai, Yufang Xu*, Xuhong Qian*. Novel Nitroheterocyclic Hypoxic Markers for Solid Tumor: Synthesis and Biological Evaluation, Bioorganic and Medicinal Chemistry, 2008, 16, 3255-3260

34. 朱维平,徐玉芳,钱旭红*,具有重要生物学意义的重金属及过渡金属离子荧光分子探针,化学进展,2007, 19, 1229-1238

网页发布时间: 2014-08-29