姣涙枑锛屽崥澹紝鍓暀鎺�

鍦板潃锛氭闄囪矾130鍙峰疄楠�18妤�431瀹�

Email锛�maofei@ecust.edu.cn

涓汉绠€浠�

2014骞�6鏈堟瘯涓氫簬涓北澶у鑽闄㈣嵂鐗╁寲瀛︿笓涓氾紝鑾峰崥澹浣嶏紝鍚庤繘鍏ュ崕涓滅悊宸ュぇ瀛﹁嵂瀛﹂櫌浠庝簨鍗氬＋鍚庣爺绌讹紝鍚堜綔瀵煎笀涓烘潕鍓戞暀鎺堛€�2016骞�10鏈堝嚭绔欏悗鐣欐牎宸ヤ綔锛屼粠浜嬭嵂鐗╁寲瀛︽暀瀛﹀拰绉戠爺宸ヤ綔锛�2018骞�9鏈堟檵鍗囧壇鏁欐巿銆�

浣滀负椤圭洰璐熻矗浜猴紝鍏堝悗涓绘寔鍥藉鑷劧绉戝鍩洪噾闈掑勾鍩洪噾1椤广€侀潰涓婇」鐩�1椤广€佷笂娴峰競鑷劧绉戝鍩洪噾闈笂椤圭洰1椤广€佸崥澹悗绉戝鍩洪噾锛堥潰涓婁竴绛夎祫鍔╋級1椤广€佹暀鑲查儴楂樻牎鍩烘湰绉戠爺涓氬姟璐�1椤�锛�2017骞村叆閫変笂娴峰競鈥�闈掑勾绉戞妧鑻辨墠鎵竼璁″垝鈥�锛�2018骞村叆閫夊崕涓滅悊宸ュぇ瀛�鈥�闈掑勾鑻辨墠鍩硅偛璁″垝鈥滱绫伙紱浣滀负鐮旂┒楠ㄥ共鍙備笌鍥藉鏂拌嵂鍒涘埗閲嶅ぇ涓撻」1椤癸紝鍥藉閲嶇偣鐮斿彂璁″垝璇鹃1椤广€�

杩勪粖宸插湪鍥藉唴澶栭噸瑕佸垔鐗╁Adv. Sci., J. Med. Chem., Eur. J. Med. Chem., Cell Death Dis., ACS Chem. Neurosci.绛変笂鍙戣〃SCI璁烘枃60浣欑瘒锛涚敵璇峰彂鏄庝笓鍒�32椤癸紝鎺堟潈19椤癸紙鍖呮嫭鍥藉涓撳埄5椤癸級锛�鍙傜紪銆婅嵂鐗╃粨鏋勪紭鍖�鈥�璁捐绛栫暐鍜岀粡楠岃鍒�銆嬭钁楀拰鍥藉涓€娴佹湰绉戣绋嬫暀鏉�銆婅嵂鐗╁寲瀛︺€�銆�

鏁欒偛缁忓巻

2009.9 鈥� 2014.6锛屼腑灞卞ぇ瀛︼紝鑽闄紝鑽墿鍖栧锛屽崥澹紱

2005.8 鈥� 2009.6锛屾矆闃宠嵂绉戝ぇ瀛︼紝鍒惰嵂宸ョ▼瀛﹂櫌锛屽簲鐢ㄥ寲瀛︼紝瀛﹀＋銆�

宸ヤ綔缁忓巻

2018.9 鈥� 鑷充粖锛屽崕涓滅悊宸ュぇ瀛︼紝鑽闄紝鍓暀鎺堬紱

2016.11 鈥� 2018.8锛屽崕涓滅悊宸ュぇ瀛︼紝鑽闄紝璁插笀锛�

2014.7 鈥� 2016.10锛屽崕涓滅悊宸ュぇ瀛︼紝鑽闄紝甯堣祫鍗氬＋鍚庛€�

涓昏鐮旂┒鏂瑰悜

1. 鎶楄偪鐦ゅ垱鏂拌嵂鐗╁紑鍙戠爺绌�

2. 鎶楄€愯嵂鑿屽垱鏂拌嵂鐗╁紑鍙戠爺绌�

3. 鑰佽嵂浜屾寮€鍙戠爺绌�  

浠ｈ〃鎬ц鏂� (^#鍏卞悓绗竴浣滆€咃紝*涓洪€氳浣滆€�)

1. Xianwu Ling^#, Jiahui Zhang^#, Lingyi Song^#, Huiwen Wu^#, Qi Wang, Xiaohu Liu, Wei Ni, Jian Li*, Yudong Wang*, Fei Mao*. Discovery of novel azaphenothiazine derivatives to suppress endometrial cancer by targeting GRP75 to impair its interaction with IP3R and mitochondrial Ca²⁺ homeostasis. J. Med. Chem. 2024, 67, 13829鈭�13851.

2. Qi Wang^#, Lijuan Li^#, Xiaoyan Gao^#, Chunxue Zhang, Chen Xu, Lingyi Song, Jian Li, Xiao Sun*, Fei Mao*, Yudong Wang*. Targeting GRP75 with a Chlorpromazine Derivative Inhibits Endometrial Cancer Progression Through GRP75鈥揑P3R-Ca²⁺-AMPK Axis. Adv. Sci. 2024, 11, 2304203.

3. Chunxue Zhang^#, Xiaojing Lu^#, Ting Ni , Qi Wang, Xiaoyan Gao, Xiao Sun, Jian Li, Fei Mao*, Jin Hou*, Yudong Wang*. Developing patient-derived organoids to identify JX24120 inhibit SAMe synthesis in endometrial cancer by targeting MAT2B. Pharmacol. Res. 2024, 209, 107420.

   
   

4. Lijuan Li^#, Xiaohu Liu^#, Yunxia Cui, Yang Chen, Huiwen Wu, Jing Wang, Xiaodi Gong, Xiaoyan Gao, Linlin Yang, Jian Li, Xiao Sun*, Fei Mao*, Yudong Wang*. Novel chlorpromazine derivatives as anti-endometrial carcinoma agents with reduced extrapyramidal side effects. Bioorg. Chem. 2022, 127, 106008.

5. Keting Bao^#, Yongyun Li^#, Jinlian Wei^#, Ruoxi Li, Jie Yang, Jiahao Shi, Baoli Li, Jin Zhu, Fei Mao*, Renbing Jia*, Jian Li*. Fangchinoline suppresses conjunctival melanoma by directly binding FUBP2 and inhibiting the homologous recombination pathway. Cell Death Dis. 2021, 12, 380.

6. Yunxia Cui, Huiwen Wu, Linlin Yang, Ting Huang, Jian Li, Xiaodi Gong, Lijuan Li, Xiao Sun*, Fei Mao*, Yudong Wang*. Chlorpromazine sensitizes progestin-resistant endometrial cancer cells to MPA by upregulating PRB. Front. Oncol. 2021, 11, 665832.

7. Linghao Hu^#, Hongxuan Feng^#,Hongguang Zhang, Songda Yu, Qinyuan Zhao, Wei Wang, Fengxia Bao, Xun Ding, Jiajing Hu, Manjiong Wang, Yixiang Xu, Zengrui Wu, Xiaokang Li, Yun Tang, Fei Mao*, Xiaoyan Chen, Haiyan Zhang*, Jian Li*. Development of Novel N-hydroxypyridone Derivatives as Potential Anti-Ischemic Stroke Agents. J. Med. Chem. 2020, 63, 1051-1067.

8.  Yang Chen^#, Yunxia Cui^#, Xiao Sun^#, Huiwen Wu, Manjiao Ou, Yunzhe Tang, Shuaishuai Ni, Xiaokang Li, Jin Zhu, Fei Mao*, Yudong Wang* and Jian Li*. Repurposing of antipsychotics perphenazine for the treatment of endometrial cancer. Bioorg. Med. Chem Lett. 2020, 30, 127239.

9. Wenwen Liu^#, Huan Wang^#, Xiaokang Li^#, Yixiang Xu, Jian Zhang, Wei Wang, Qi Gong, Xiaoxia Qiu, Jin Zhu, Fei Mao*, Haiyan Zhang*, Jian Li*. Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment. Bioorg. Med. Chem. 2018, 26, 3117鈥�3125.

10. Wei Ni^#, Huan Wang^#, Xiaokang Li^#, Xinyu Zheng^#, Manjiong Wang, Jian Zhang, Qi Gong, Dazheng Ling, Fei Mao*, Haiyan Zhang*, Jian Li*. Novel tadalafil derivatives ameliorates scopolamine-induced cognitive impairment in mice via inhibition of acetylcholinesterase (AChE) and phosphodiesterase 5 (PDE5). ACS Chem. Neurosci. 2018, 9, 1625鈥�1636.

11. Baoli Li^#, Shuaishuai Ni^#, Fei Mao^#, Feifei Chen, Yifu Liu, Hanwen Wei, Wenhua Chen, Jin Zhu, Lefu Lan*, Jian Li*. Novel terminal bipheny-based diapophytoene desaturases (CrtN) inhibitors as anti-MRSA/VISR/LRSA agents with reduced hERG activity. J. Med. Chem. 2018, 61, 224鈥�250.

12. Fei Mao^#, Huan Wang^#, Wei Ni^#, Xinyu Zheng, Manjiong Wang, Keting Bao, Dazheng Ling, Xiaokang Li, Yixiang Xu, Haiyan Zhang*, Jian Li*. Design, synthesis, and biological evaluation of orally available first-generation dual-target selective inhibitors of acetylcholinesterase (AChE) and phosphodiesterase 5 (PDE5) for the treatment of Alzheimer鈥檚 disease. ACS Chem. Neurosci. 2018, 9, 328鈥�345.

13. Hanwen Wei^#, Fei Mao^#, Shuaishuai Ni^#, Feifei Chen, Baoli Li, Xiaoxia Qiu, Linghao Hu, Manjiong Wang, Xinyu Zheng, Jin Zhu, Lefu Lan*, Jian Li*. Discovery of novel piperonyl derivatives as diapophytoene desaturase inhibitors for the treatment of methicillin-, vancomycin- and linezolid-resistant Staphylococcus aureus infections. Eur. J. Med. Chem. 2018, 145, 235鈥�251.

14. Yi-xiang Xu^#, Huan Wang^#, Xiao-kang Li, Sheng-nan Dong, Wen-wen Liu, Qi Gong, Tian-duan-yi Wang, Yun Tang, Jin Zhu, Jian Li*, Hai-yan Zhang*, Fei Mao*. Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease. Eur. J. Med. Chem. 2018, 143, 33鈥�47.

15. Xiaokang Li^#, Huan Wang^#, Yixiang Xu, Wenwen Liu, Xiaoxia Qiu, Jin Zhu, Fei Mao*, Haiyan Zhang*, Jian Li*. Novel vilazodone-tacrine hybrids as potential multitarget-directed ligands for the treatment of Alzheimer鈥檚 disease accompanied with depression: design, synthesis and biological evaluation. ACS Chem. Neurosci. 2017, 8, 2708鈥�2721.

16. Yanli Lu^#, Fei Mao^#, Xiaokang Li, Xinyu Zheng, Manjiong Wang, Qing Xu, Jin Zhu, and Jian Li*. Discovery of potent, selective stem cell factor receptor/platelet derived growth factor receptor alpha (c-KIT/PDGFR伪) dual inhibitor for the treatment of imatinib-resistant gastrointestinal stromal tumors (GISTs). J. Med. Chem. 2017, 60, 5099鈥�5119.

17. Xiaokang Li^#, Huan Wang^#, Zhengyu Lu, Xinyu Zheng, Wei Ni, Jin Zhu, Yan Fu, Fulin Lian, Naixia Zhang, Jian Li*, Haiyan Zhang*, and Fei Mao*. Development of multifunctional pyrimidinylthiourea derivatives as potential anti-Alzheimer agents. J. Med. Chem. 2016, 59, 8326鈭�8344.

18. Dengwei Wu^#, Fei Mao^#, Yan Ye, Jian Li, Chuanlian Xu*, Xiaomin Luo, Jing Chen*, Xu Shen. Policresulen as a novel inhibitor of NS2B/NS3 protease efficiently suppressed the replication of DENV2 virus. Acta Pharmacol. Sin. 2015, 36, 1126-1136.

19. Fei Mao, Jianheng Li, Hui Wei, Ling Huang*, Xingshu Li*. Tacrine-propargylamine derivatives with improved acetylcholinesterase inhibitory activity and lower hepatotoxicity as a potential lead compound for the treatment of Alzheimer鈥檚 disease. J. Enzym. Inhib. Med. Chem.2015,30, 995-1001.

20. Fei Mao, Jun Yan, Jian-heng Li, Yang sun, Xian Jia, Ling Huang*, Xing-shu Li*. New Multi-Target-Directed Small Molecules Against Alzheimer's Disease: a Combination of Resveratrol and Clioquinol. Org. Biomol. Chem. 2014, 12, 5936-5944.

21. Fei Mao, Jian-wen Chen*, Qi Zhou, Zong-hua Luo, Li Huang, Xing-shu Li*. Novel tacrine鈥揺bselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity. Bioorg. Med. Chem. Lett.2013, 23, 6737-6742.

22. Fei Mao, Ling Huang, Zong-hua Luo, Anqiu Liu, Chuan-jun Lu, Zhi-yong Xie*, Xingshu Li*. O-Hydroxyl or o-amino benzylamine-tacrine hybrids: Multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-beta aggregation. Bioorgan. Med. Chem.2012, 20, 5884-5892.