黄瑾      教授/博导

联系方式：

电话: 021-64253681

办公室：华东理工大学实验18楼625

E-mail: huangjin@ecust.edu.cn

招生专业：药学一级学科（博士/学硕/专硕）, 生物与医药（专博/专硕）

欢迎有志于药理学、化学生物学、新药开发研究的优秀学生加入！！

本课题组长期招收博士研究生及博士后

个人简介：

本科毕业于四川大学，于南京大学获博士学位，现为华东理工大学药学院教授，博士生导师。作为项目负责人，承担了国家自然科学基金面上项目、上海市科委生物医药专项等多项研究计划。上海市药学会药理学专业委员会委员，中国中医药信息学会中医临床药学分会常务理事，担任Pharmacological Research、中国癌症防治杂志 期刊编委。

上海市一流本科课程《药物化学生物学》负责人，获中国石油教育学会石油高等教育教学成果奖一等奖、上海市高校优秀教学成果二等奖等奖项。

主要研究方向：

1) 抗肿瘤药物靶标发现；

2) 抗肿瘤药物药理；

3) 高效药物筛选平台构建。

入选人才计划：

1) 上海市东方英才拔尖计划，2024年
2)  上海市浦江人才，2007年

学生培养：

本课题组以分子药理学为基础，开展高效药物筛选平台构建，抗肿瘤药物作用靶标确证及药物发现相关研究，具体工作涵盖药理学、药物筛选、药物化学生物学等方面的研究，研究对象从蛋白质、基因、细菌、酵母、动物细胞直到活体动物都可能涉及，欢迎追求卓越的同学加盟本实验室。

经过三年或五年的培养，学生在分子克隆构建、信号通路分析、蛋白表达纯化、蛋白结晶及三维结构解析、紫外可见吸收光谱、稳态与瞬态荧光光谱、共聚焦显微成像、超分辨成像、荧光生物标记等方面有较好的培训。

研究成果发表在Nature Communications、Haematologica、Oncogene、Journal of Medicinal Chemistry等领域高影响期刊。课题组培养的多个研究生曾获国家奖学金、上海市优秀毕业生、中国药理学会青年药理学家奖等荣誉称号。

代表性论文：

1. Fei Pan, Zhaomin Xu, Zehui Liu, Caiyue Chen, Jingwei Yu, Zengrui Wu, Ze Wang, Long Chen, Chengyuan Yue, Weihua Li, Guixia Liu, Jin Huang*, Yun Tang*. ComplexDnet: A Network-Based Strategy to Discover Critical Targets and Screen Active Compounds for Complex Diseases. Journal of Medicinal Chemistry. 2025, 68(18): 19463-19481.

2. Ning Tian, Haoyu Ju, Qian Hu, Qifeng Hou, Yiping Lu, Yu Liu, Jinmei Huang, Zhonghong Zhu, Bin Zhang, Jin Huang*, Minghua Zeng*. Solvothermal domino synthesis of an ER-targeted iron(II) complex for inducing immunogenic cell death. Chinese Chemical Letters. 2025, 10.1016/j.cclet.2025.111038.

3. Weiqiang Lu*, Jiayan Cui, Wanyan Wang, Qian Hu, Yun Xue, Xi Liu, Ting Gong, Yiping Lu, Hui Ma, Xinyu Yang, Bo Feng, Qi Wang, Naixia Zhang, Yechun Xu, Mingyao Liu, Ruth Nussinov, Feixiong Cheng, Hongbin Ji, Jin Huang*. PPIA dictates NRF2 stability to e lung cancer progression. Nature Communications. 2024, 15: 4703.   

4. Hui Ma, Jiayan Cui, Zehui Liu, Wenqing Fang, Sisi Lu, Shuying Cao, Yuanyuan Zhang, Ji-An Chen, Lixue Lu, Qiong Xie, Yonghui Wang, Ying Huang, Kongfei Li, Hongyan Tong, Jin Huang*, Weiqiang Lu*. Blockade of de novo pyrimidine biosynthesis triggers autophagic degradation of oncoprotein FLT3-ITD in acute myeloid leukemia. Oncogene. 2023, 42(45): 3331-3343.

5. Xiangli He, Jiayan Cui, Hui Ma, Naijipu Abuduaini, Ying Huang, Lu Tang, Wanyan Wang, Yuanyuan Zhang, Yang Wang, Weiqiang Lu*, Bo Feng*, Jin Huang*. Berberrubine is a novel and selective IMPDH2 inhibitor that impairs the growth of colorectal cancer.  Biochemical Pharmacology. 2023, 218: 115868.

6.  Ji-An Chen, Hui Ma, Zehui Liu, Jinlong Tian, Sisi Lu, Wenqing Fang, Shuyin Ze, Weiqiang Lu, Qiong Xie*, Jin Huang*, Yonghui Wang*. Discovery of Orally Available Retinoic Acid Receptor-Related Orphan Receptor γ-t/Dihydroorotate Dehydrogenase Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease. Journal of Medicinal Chemistry. 2022, 65(1): 592-615.

7.  Zengrui Wu, Hui Ma, Zehui Liu, Lulu Zheng, Zhuohang Yu, Shuying Cao, Wenqing Fang, Lili Wu, Weihua Li, Guixia Liu, Jin Huang*, Yun Tang*. wSDTNBI: a novel network-based inference method for virtual screening. Chemical Science. 2022, 13(4): 1060-1079.

8. Xi Liu, Qian Hu, Wanyan Wang, Hui Ma, Jiaqian Pu, Jiayan Cui, Ting Gong, Yu Wu, Weiqiang Lu*, Jin Huang*. A protein-fragment complementation assay reveals that celastrol and gambogic acid suppress ERα mutants in breast cancer. Biochemical Pharmacology. 2021, 188: 114583.

9. Wanyan Wang, Jiayan Cui, Hui Ma, Weiqiang Lu, Jin Huang*. Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine. Frontiers In Oncology. 2021, 11: 684961.

10. Wanyan Wang, Yu Wu, Si Chen, Xi Liu, Jiacheng He, Shuyi Wang, Weiqiang Lu*, Yong Tang*, Jin Huang*. Shikonin is a novel and selective IMPDH2 inhibitor that target triple-negative breast cancer. Phytotherapy Research. 2021, 5(1): 63-476.

11. Zehui Liu, Qian Hu, Wanyan Wang, Sisi Lu, Dang Wu, Shuyin Ze, Jiacheng He, Ying Huang, Wuyan Chen, Yechun Xu, Weiqiang Lu*, Jin Huang*. Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase. Biochemical Pharmacology. 2020, 177: 114000.

12. Zhonghong Zhu, Qian Hu, Huiling Pan, Yuexing Zhang, Haibing Xu, Mohamedally Kurmoo, Jin Huang*, Minghua Zeng*. Tracking the multiple step formation of an iron(III) complex and its application in photodynamic therapy for breast cancer. Science China-Chemistry. 2019, 62(6): 719-726.

13. Xueyuan Wu, Mingbo Wang, Yaqian Wang; Mengyin Li, Yilun Ying, Jin Huang*, Yitao Long*. Precise Construction and Tuning of an Aerolysin Single-Biomolecule Interface for Single Molecule Sensing. CCS Chemistry, 2019, 1: 304-312.

14. Dang Wu, Wanyan Wang, Wuyan Chen, Fulin Lian, Li Lang, Ying Huang, Yechun Xu, Naixia Zhang, Yinbin Chen, Mingyao Liu, Ruth Nussinov, Feixiong Cheng*, Weiqiang Lu*, Jin Huang*. Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells. Haematologica. 2018, 103(9): 1472-1483.

15. Weiqiang Lu, Feixiong Cheng, Wenzhong Yan, Xi Li, Xue Yao, Wenqiang Song, Mingyao Liu, Xu Shen, Hualiang Jiang, Jing Chen, Jian Li*, Jin Huang*. Selective targeting p53WT lung cancer cells harboring homozygous p53 Arg72 by an inhibitor of CypA. Oncogene. 2017, 36(33): 4719-4731.

16. Weiqiang Lu, Xue Yao, Ping Ouyang, Ningning Dong, Dang Wu, Xingwu Jiang, Zengrui Wu, Chen Zhang, Zhongyu Xu, Yun Tang, Shien Zou, Mingyao Liu, Jian Li, Minghua Zeng, Ping Lin, Feixiong Cheng*, Jin Huang*. Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis. Journal of Medicinal Chemistry. 2017, 60(5): 1817-1828.