谢贺新

谢贺新

教授，博士生导师

电话：021-64252269

课题组网页：https://www.x-mol.com/groups/xiehexin

址：上海市徐汇区梅陇路130号实验14楼西501室

个人简介

1998年毕业于上海复旦大学化学系，获理学学士学位。后到中国科学院上海有机化学研究所金属有机国家重点实验室工作。2008年毕业于美国新墨西哥大学化学与化学生物学系，获理学博士学位。2009年1月至2012年12月间，在美国斯坦福大学医学院分子影像中心（MIPS）从事博士后研究。2013年1月加入华东理工大学药学院药物科学系。

研究成果

谢贺新的主要研究兴趣包括有机化学，药物化学及化学生物学,分子影像等交叉学科领域。迄今为止，共在SCI收录的国际期刊杂志发表论文60余篇，其中包括Nature Chem.，Nature Commun.，J. Am. Chem. Soc.，Angew. Chem. Int. Ed.等知名期刊。多篇论文被Nature,C&E News(美国化学化工新闻)，ChemistryViews，ChemCatChem，Scientific American等期刊、网站等作专文评论、介绍。

研究方向

1.化学生物学

以有机合成为基础，发展以生物体系中重要的酶蛋白为靶标的分子探针，应用于疾病的快速诊断、药物活性筛选模型的建立及细胞荧光成像中。

2.药物化学

针对致病细菌抗生素耐药日益严峻的情况，发展针对耐药菌的新型抗生素及酶抑制剂。

代表性论文

1. Mao, W.; Xia, L.; Xie, H.* “Detection of Carbapenemase-Producing Organisms With A Carbapenem-Based Fluorogenic Probe” Angew. Chem. Int. Ed. 2017, 56, 4468. (Hot paper). (IF = 11.709)

2. Huang, H.; Yu, C.; Li, X.; Zhang, Y.; Zhang, Y.; Chen, X.; Mariano, P. S.*; Xie, H.*; Wang, W.* “Synthesis of Aldehydes by Organocatalytic Formylation Reactions of Boronic Acids with Glyoxylic Acid” Angew. Chem. Int. Ed.2017, 56, 8201 (IF = 11.709)

3. .Mao, W.; Xia, L.; Wang, Y.; Xie, H.* “A self-immobilizing and fluorogenic probe for β-lactamases detection”Chem. Asian J. 2016, 11, 3493 (IF = 4.592)

4. Zhou, D.; Huang, Z.; Yu, X.; Wang, Y.; Li, J.; Wang, W*; Xie, H.* “A Quinine-Squaramide Catalyzed Enantioselective Aza-Friedel-Crafts Reaction of Cyclic Trifluoromethyl Ketimines with Naphthols and Electron-Rich Phenols”Org. Lett., 2015, 17, 5554. (IF = 6.732)

5. Cheng, Y.^#; Xie, H.^#; Sule, P.; Hassounah, H.; Graviss, E. A.; Kong, Y.; Cirillo, J. D. and Rao, J.* “Fluorogenic Probes with Substitutions at the 2 and 7 Positions of Cephalosporin are Highly BlaC-Specific for Rapid Mycobacterium Tuberculosis Detection”Angew. Chem. Int. Ed.,2014,53, 9360.(Reported by “Cheap test slashes time taken to diagnose TB”,Nature doi: 10.1038/nature.2014.15503) . (IF = 11.709)

6. Xie, H.^#, Mire, J.^#, Kong, Y.^#,Chang, M.,Hassounah, H., Thornton, C.N., Sacchettini, J. C., Cirillo, J. D., Rao, J.* "Rapid point-of-care detection of the tuberculosis pathogen using a BlaC-specific fluorogenic probe",Nature. Chem.2012, 4,802.(Reported by Nature (doi:10.1038/nature.2012. 11327) and Scientific American). (IF = 27.893)

7. Xie, H.; Zhang, Y.; Zhang, S.; Chen, X.; Wang, W.* "Bifunctional Cinchona Alkaloid Thiourea Catalyzed Highly Efficient, Enantioselective Aza-Henry Reaction of Cyclic Trifluoromethyl Ketimines: Synthesis of Anti-HIV Drug DPC 083"Angew. Chem. Int. Ed.,2011, 50, 11773. (IF = 11.709)

8. Zhang, S.-L.^#,Xie, H.^#; Zhu, J.; Li, H.; Zhang, X.-S.; Li, J.*; Wang, W.*, “Organocatalytic enantioselective β-functionalization of aldehydes by oxidation of enamines and their application in cascade reactions”Nature. Commun.2011,2,211-218. (Reported by C&E News (2011,89(10), 9), ChemCatChem(2012,4, 612) and Synfacts (2011, 5, 0560)) (IF = 11.329)

9. Xie, H.; Zu, L.; Li, H.; Wang, J.; Wang, W.* “Organocatalytic Enantioselective Cascade Michael-Alkylation Reactions: Synthesis of Chiral Cyclopropanes and Investigation of Unexpected Organocatalyzed Stereoselective Ring Opening of Cyclopropanes”,J. Am. Chem. Soc.,2007,129, 10886. (IF = 13.038)

^#co-first author, * correspondence author