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李晓康 博士/副教授/博导
Email:xkli@ecust.edu.cn
邮编:200237
通讯地址1:上海市徐汇区梅陇路130号实验十八楼431办公室
通讯地址2:上海市奉贤区海思路999号实验五楼309办公室
【个人简介】
2018年6月毕业于华东理工大学药学院,获药学专业博士学位;随后进入华东理工大学药学博士后科研流动站从事博士后研究,合作导师为蒋华良院士;2020年10月出站留校工作,“长江学者”李剑教授团队核心成员。
研究方向围绕临床未满足重大疾病新药创制与精准诊断,聚焦团队老药新用与老药二次研发创新策略,形成完善的“老药先导物发现→老药新用研究→新结构二次研发→新靶标机制研究→临床前候选PCC确定”技术体系,用多学科交叉合作,聚焦肝损伤(肝脏衰老)、急慢性肾衰竭(肾脏衰老)、阿尔茨海默病(脑衰老)、耐药感染(耐药疟疾、耐药真菌)等疾病领域,形成经验丰富的临床前候选新药发现与评价体系;此外,结合荧光探针可视化技术,构建可视化药效评价新方法/新模型。
近年来,以第一/通讯作者发表SCI论文19篇,包括Acta Pharm. Sin. B(2020)、J. Med. Chem.(2016/2021/2022/2024)、Chem. Sci.(2020)、Eur. J. Med. Chem.(2022a/b)等药物化学领域一区期刊;申请发明专利20项(其中PCT专利3项),已授权专利5项。作为项目负责人主持国家基金2项,省部级基金2项;入选上海市青年科技英才扬帆计划(2019)、晨光计划(2018)和“超级博士后”激励计划(2018)。作为研究骨干参与多项国家新药创制重大专项、国家重点研发计划课题、基金委重点项目等研究项目。讲授课程包括本科专业核心课程《药物化学》、专业选修课《药物结构优化——设计策略和经验规则》,参与“十四五”规划制药工程专业《药物化学》章节编写。
【学术兼职】
1、《中国药物化学杂志》首届青年编委
2、中医药慢病防治工程委员会委员
3、华东理工大学新药研发青少年创新实验室(市级),主理人
【研究方向】
1、老药新用与老药二次研发
2、器官衰老相关疾病候选新药研发与新靶标机制解析(肝脏:ALD/NAFLD/MAFLD;肾脏:ARF/CRF;脑:AD)
3、基于中草药活性成分的新靶标机制解析与新药研发
4、基于病理标志物设计荧光探针分子并构建可视化药效评价新方法/新模型
【招生专业】
药学专业:学术型博士/学硕
【代表性论文】(#共同第一作者,*为通讯作者)
[2] Haolan You#, Yihe Song#, Yi Yang#, Xicheng Wang, Shiqi Pan, Junyang Huang, Qiqi Shao, Donglei Shi, Baoli Li*, Jian Li*, Xiaokang Li*. Rational design of a high-affinity fluorescent probe for visualizing monitoring the amyloid β clearance effect of anti-Alzheimer's disease drug candidates. Eur. J. Med. Chem.2024, 278, 116800.
[4] Chao Zhang#, Lan Wang#, Yixiang Xu#, Yunyuan Huang, Junyang Huang, Jin Zhu, Wei Wang, Wangsheng Li, Annan Sun, Xiaokang Li*, Haiyan Zhang*, Jian Li*. Discovery of novel dual RAGE/SERT inhibitors for the potential treatment of the comorbidity of Alzheimer’s disease and depression. Eur. J. Med. Chem.2022, 236, 114347.
[5] Manjiong Wang#, Tongke Tang#, Zhenghui Huang, Ruoxi Li, Dazheng Ling, Jin Zhu, Lubin Jiang*, Jian Li*, Xiaokang Li*. Design and synthesis of novel hydroxamic acid derivatives based on quisinostat as promising antimalarial agents with improved safety. Acta Materia Medica2022, 1, 212–223.
[6] Manjiong Wang#, Tongke Tang#, Ruoxi Li, Zhenghui Huang, Dazheng Ling, Lulu Zheng, Yan Ding, Taiping Liu, Wenyue Xu, Feng Zhu, Hui Min, Rachasak Boonhok, Fei Mao, Jin Zhu, Xiaokang Li*, Lubin Jiang*, and Jian Li*. Drug Repurposing of Quisinostat to Discover Novel Plasmodium falciparum HDAC1 Inhibitors with Enhanced Triple-Stage Antimalarial Activity and Improved Safety. J. Med. Chem.2022. 65, 4156−4181.
[7] Xiaokang Li#, Jinwen Li#, Yunyuan Huang#, Qi Gong, Yan Fu, Yixiang Xu, Junyang Huang, Haolan You, Dong Zhang, Dan Zhang, Fei Mao, Jin Zhu, Huan Wang*, Haiyan Zhang*, Jian Li*. The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression. Eur. J. Med. Chem.2022, 229, 114045.
[8] Ruoxi Li#, Dazheng Ling#, Tongke Tang#, Zhenghui Huang, Manjiong Wang, Yan Ding, Taiping Liu, Hanwen Wei, Wenyue Xu, Fei Mao, Jin Zhu, Xiaokang Li*, Lubin Jiang*, Jian Li*. Discovery of novel P. falciparum HDAC1 inhibitors with dual-stage anti-malarial potency and improved safety based on the clinical anticancer drug candidate quisinostat. J. Med. Chem. 2021, 64, 2254.
[9] Ruoxi Li#, Dazheng Ling#, Tongke Tang#, Zhenghui Huang, Manjiong Wang, Fei Mao, Jin Zhu, Lubin Jiang*, Jian Li*, Xiaokang Li*. Repurposing of antitumor drug candidate Quisinostat lead to novel spirocyclic antimalarial agents. Chin. Chem. Lett.2021, 32, 1660−1664.
[10]Xiaokang Li#, Jian Lu#, Yixiang Xu#, Jiaying Wang, Xiaoxia Qiu, Lei Fan, Baoli Li, Wenwen Liu, Fei Mao, Jin Zhu, Xu Shen*, Jian Li*. Discovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer's disease. Acta Pharm. Sin. B2020, 10, 646–666.
[11]Xiaokang Li#, Wenjing Qiu#, Jinwen Li#, Xi Chen#, Yulu Hu, Ying Gao, Donglei Shi, Xinming Li, Huiling Lin, Zelan Hu, Guoqiang Dong, Chunquan Sheng, Bei Jiang, Conglong Xia, Chu-Young Kim, Yuan Guo*, Jian Li*. First-generation species-selective chemical probes for fluorescence imaging of human senescence-associated β-galactosidase. Chem. Sci.2020, 11, 7292.(封面文章)
[12]Wenjing Qiu#, Xiaokang Li#, Donglei Shi, Xinming Li, Ying Gao, Fei Mao, Yuan Guo, Jian Li*. A rapid-response near-infrared fluorescent probe with a large Stokes shift for senescence-associated -galactosidase activity detection and imaging of senescent cells. Dyes Pigm. 2020, 182, 108657.
[13]Yixiang Xu#, Jian Zhang#, Huan Wang#, Fei Mao, Keting Bao, Wenwen Liu, Jin Zhu, Xiaokang Li*, Haiyan Zhang*, and Jian Li*. Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer's Disease Agents. ACS Chem. Neurosci. 2019, 10, 482−496.
[14]Jin Li#, Xiaokang Li#, Jianbo Jia#, Xi Chen, Yinjuan Lv, Yuan Guo*, and Jian Li*. A ratiometric near-infrared fluorescence strategy based on spiropyran in situ switching for tracking dynamic changes of live-cell lysosomal pH. Dyes Pigm.2019, 66, 433–442.
[15]Wenwen Liu#, Huan Wang#, Xiaokang Li#, Yixiang Xu, Jian Zhang, Wei Wang, Qi Gong, Xiaoxia Qiu, Jin Zhu, Fei Mao*, Haiyan Zhang*, Jian Li*. Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment. Bioorg. Med. Chem.2018, 26, 3117–3125.
[16]Wei Ni#, Huan Wang#, Xiaokang Li#, Xinyu Zheng, Manjiong Wang, Jian Zhang, Qi Gong, Dazheng Ling, Fei Mao*, Haiyan Zhang*, and Jian Li*. Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5). ACS Chem. Neurosci.2018, 9, 1625−1636.
[17]Xiaokang Li#, Yahui Huang#, Junfei Cheng#, Lingling Zhang, Fei Mao, Jin Zhu, Chunquan Sheng*, Jian Li*. Discovery of novel Syk/PDGFR-α/c-Kit inhibitors as multi-targeting drugs to treat rheumatoid arthritis. Bioorg. Med. Chem.2018, 26, 4375–4381.
[18]Xiaokang Li#, Huan Wang#, Yixiang Xu, Wenwen Liu, Qi Gong, Wei Wang, Xiaoxia Qiu, Jin Zhu, Fei Mao, Haiyan Zhang *, and Jian Li *. Novel Vilazodone–Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation. ACS Chem. Neurosci.2017, 8, 2708−2721.
[19]Xiaokang Li#, Huan Wang#, Zhengyu Lu, Xinyu Zheng, Wei Ni, Jin Zhu, Yan Fu, Fulin Lian, Naixia Zhang, Jian Li*, Haiyan Zhang*, and Fei Mao*. Development of Multifunctional Pyrimidinylthiourea Derivatives as Potential Anti-Alzheimer Agents. J. Med. Chem.2016, 59, 8326–8344.
[20]Xiaokang Li, Wei Ni, Fei Mao, Wei Wang*, Jian Li*. A Metal-free Approach to 3-Aryl-3-hydroxy-2-oxindoles by Treatment of 3-Acyloxy-2-oxindoles with Diaryliodonium Salts. Chem. Asian J.2016, 11, 226–230.
地址:上海市徐汇区梅陇路130号 邮编:200237
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