徐玉芳 教授
Tel: 021-64251399; Fax: 021-64252603
E-mail: yfxu@ecust.edu.cn
个人简介
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徐玉芳，博士，教授，博士生导师。上海市优秀学科带头人。1994年博士毕业于华东理工大学精细化工专业；1999-2001日本东京医科齿科大学博士后；2004.9至今华东理工大学教授。2006年日本京都大学日本学术振兴会(JSPS)访问学者。近年来主要从事化学生物技术方面的研究，主要包括荧光传感技术及细胞激活与调控技术。主持完成了国家自然科学基金、国家重大新药创制项目、国家科技支撑计划、上海市光科技重点项目、上海市科委基础研究重点项目，共同主持完成了国家973子课题。目前承担着上海市优秀学科带头人计划、共同承担着863专项。迄今为止，申请中国发明专利41项，授权13项，国际PCT 4项，获美国、欧盟授权。已在J. Am. Chem. Soc.、Angew. Chem. Int.、Chem. Comm.、J. Med. Chem.、Org. Lett.等国际SCI期刊发表论文100余篇，SCI 他引1100余次，单篇最高他引100余次(J. Am. Chem. Soc.,2008)。《Journal of Pharmaceutics 》国际编委、《Chinese Chemical Letters》、《现代药物与临床》编委。
研究方向
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A:荧光传感技术
A-1 纯水体系高选择性高灵敏重金属离子荧光探针及其活体细胞应用：针对环境和生物组织中的重要重金属及过渡金属离子,设计、创制纯水体系、高选择性、高灵敏金属离子荧光探针，并实现活体细胞应用。
A-2 生物体内重要靶酶诊疗荧光探针：针对疾病生物标志物，设计创制一系列特异性响应荧光探针，对疾病进行早期诊断与治疗。
B:细胞激活与调控技术
B-1 新型植物激活剂：设计创制各类植物抗病激活剂及能明显增加植物次生代谢物的高效细胞激活剂。
B-2 新作用机制抗肿瘤药物先导：基于不同母体结构，设计创制新作用机制抗肿瘤药物先导。
B-3 乏氧特异性前药: 利用乏氧特异性响应基团，设计创制乏氧选择性抗肿瘤试剂。
获奖成果
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2008年国家科技进步二等奖（九）；
2008年上海市自然科学一等奖（四）;
2007年上海市优秀学科带头人。
代表性论著
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1) Qingshan Du, Weiping Zhu, Zhenjiang Zhao*, Xuhong Qian, Yufang Xu* Novel Benzo-1, 2,3-thiadiazole-7-carboxylate derivatives as plant activators and the development of their agriculturalapplications, Journal of Agricultural Food Chemistry, 2012, 60, 346-353
2) Shenyi Zhang, Chunmei Yang, Weiping Zhu, Bubing Zeng, Youjun Yang, Yufang Xu*, Xuhong Qian*,Highly selective, naked-eye and fluorescent “off-on” probe for detection of histidine/histidine-rich protein and its application in living cell imaging, Org. Biomol. Chem.,2012,10,1653-1658
3) Tanyu Cheng, Tao Wang, Weiping Zhu, Xinlei Chen, Youjun Yang, Yufang Xu*, Xuhong Qian*,Red-emission fluorescent probe sensing cadmium andpyrophosphate selectively in aqueous solution,Org. Lett., 2011, 13, 3656-3659.
4) Shenyi Zhang, Chunmei Yang, Weiqiang Lu, Jin Huang, Weiping Zhu, Honglin Li, Yufang Xu*, Xuhong Qian*, A Highly Selective Space-folded Photo-induced Electron Transfer Fluorescent Probe for Carbonic Anhydrase Isozymes IX and Its Applications for Biological Imaging, Chem. Commun., 2011, 47,8301-8303
5) Kishore Baathulaa, Yufang Xu, Xuhong Qian, Short and Scalable Synthesis of an Anhydride Precursor of the Environment-sensitive Fluorophore 6-DMN, Nature Protocols, 2011, 6,1990-1997.
6) Weiqiang Lu, Xiaofeng Liu, Xianwen Cao, Mengzhu Xue, Kangdong Liu, Zhenjiang Zhao, Xu Shen,Hualiang Jiang, Yufang Xu, Jin Huang*, and Honglin Li*，SHAFTS: A Hybrid Approach for 3D Molecular Similarity Calculation. 2. Prospective Case Study in the Discovery of Diverse p90 Ribosomal S6 Protein Kinase 2 Inhibitors to Suppress Cell Migration, J. Med. Chem. 2011, 54 (10), 3564–3574
7) Zhuo Chen, Xin Wang, Weiping Zhu, Xianwen Cao, Linjiang Tong, Honglin Li, Hua Xie,* Yufang Xu,* Shaoying Tan, Dong Kuan, Jian Ding, Xuhong Qian,* Acenaphtho[1,2-b]pyrrole-BasedSelective Fibroblast Growth Factor Receptors 1 (FGFR1) Inhibitors : Design, Synthesis and Biological Activity, J. Med. Chem. 2011, 54 (11), 3732–3745
8) Chusen Huang, Qin Yin, Weiping Zhu*, Yi Yang*, Xin Wang, Xuhong Qian, Yufang Xu*, Highly Selective Fluorescent Probe for Vicinal Dithiol-Containing Proteins and In-Situ Imaging in Living Cells, Angew. Chem. Int., 2011, 50(33), 7551-6.
9) Hong Yin, Weiping Zhu, Yufang Xu*, Min Dai, Xuhong Qian*, Yuanli Li, Jianwen Liu, Novel aliphatic N-oxide of naphthalimides as fluorescent markers for hypoxic cells in solid tumor, European Journal of Medicinal Chemistry, 2011, 46 ,3030-3037
10) Tanyu Cheng, Tao Wang, Weiping Zhu, Yangyang Yang, Bubing Zeng, Yufang Xu* and Xuhong Qian*, Modulating the selectivity of Near Infrared Fluorescent Probes Toward Various Metal Ions by Judicious Choice of Aqueous Buffer Solutions, Chem. Commun., 2011, 47, 3915-3917.
11) Lei Cui, Ye Zhong, Weiping Zhu, Yufang Xu*, Qingshan Du, Xin Wang, Xuhong Qian*, and Yi Xiao, A Novel Prodrug-Derived Ratiometric Fluorescent Probe for Hypoxia: High Selectivity of Nitroreductase and Imaging in Tumor Cell, Org. Lett., 2011, 13, 928-931.
12) Yangyang Yang, Tanyu Cheng, Weiping Zhu, Yufang Xu,* Xuhong Qian*, Highly Selective and Sensitive Near-infrared Fluorescent Sensors for Cadmium in Aqueous Solution, Org. Lett., 2011, 13, 264-267.
13) Lei Cui, Ye Zhong, Weiping Zhu, Yufang Xu*, Xuhong Qian*, Selective and Sensitive Detection and Quantification of Arylamine N-Acetyltransferase 2 by a Ratiometric Fluorescence Probe, Chem. Commun., 2010, 46, 7121 - 7123 (Highlights in Chemical Biology, Predicting drug response, Harriet Brewerton,27 August 2010）
14) Zhuo Chen, Xin Liang, Huanying Zhang, Hua Xie, Jianwen Liu, Yufang Xu*, Weiping Zhu, Yi Wang, Xin Wang, Shaoying Tan, Dong Kuang, Xuhong Qian,*A New Class of Naphthalimide-based Antitumor Agents that Inhibit Topoisomerase II (Topo II) and Induce Lysosomal Membrane Permeabilization (LMP) and Apoptosis，J. Med. Chem. 2010, 53, 2589–2600
15) Tanyu Cheng, Yufang Xu,* Shenyi Zhang, Weiping Zhu, Xuhong Qian,* Liping Duan A highly sensitive and selective OFF-ON fluorescent sensor for cadmium in aqueous solution and living cell, J. Am. Chem. Soc., 2008, 130 (48), 16160–16161
