张阳  博士  副教授   博士生导师

汉族，出生于山东 肥城，籍贯淄博 淄川

电话:  021-64253756

E-mail: zhangyang@ecust.edu.cn

地址：华东理工大学徐汇校区实验十八楼1335室

学术兼职

《农药学学报》（首届）青年编委会副主任、常务编委

皮肤健康产业中国科技联盟（筹）创新工程专业委员会委员

中国化学会农业化学专业委员会青年委员

上海市毒理学会首届理事、青委会委员

上海市预防医学会病媒生物预防与控制专业委员会委员

中国化学会农业化学奖评审委员会秘书（长）

上海市化学化工学会农用化学专委会秘书（长）

教育背景

1. 2011.09–2017.05，华东理工大学，药学院，植物保护，博士，导师：陶黎明 教授

2. 2006.09–2010.06，山东农业大学，生命科学学院，生物工程，工学学士

工作经历

1. 2022.10-至今，华东理工大学，副教授，博士生导师

2. 2021.08-2022.09，华东理工大学，副教授，硕士生导师

3. 2019.09-2021.07，华东理工大学，特聘副研究员，硕士生导师

4. 2017.06-2019.09，华东理工大学，药物化工研究所，博士后，导师：李忠 教授

5. 2011.02-2011.08，山东农业大学，团委，思政辅导员

6. 2010.07-2011.01，山东农业大学，生命科学学院，综合行政

研究方向

    1. 农药毒理与健康

    2. 化妆品功效原料开发：①基于皮肤健康的功效评价策略研究  ②天然产物类功效原料的发现、开发与产业化

科研经历

先后主持国家重点研发计划子课题2项，其他省部级以上课题8项，企业合作课题多项；参与国家“973计划”项目、“863计划”课题、“十二五”国家科技支撑计划课题、“十三五”、“十四五”国家重点研发计划项目以及上海市科技创新项目等的组织和研究工作。

2017年至今，在国内外期刊发表研究论文77篇，申请国家发明专利27件、国际专利1件，入选上海市青年科技英才扬帆计划（2019年）、华东理工大学青年英才培育计划（2022年）、上海市首届东方英才青年人才（乡村振兴领域，共20人，2023年）等，荣获2019年度“全国农药行业优秀通讯员”荣誉称号（全国共19人）、中国化学会2022年度“中化扬农”农业化学青年新秀奖（共5人）、华东理工大学研究生优秀指导教师（2022年）、大学生社会实践优秀指导教师（2023年）、五四青年奖章（个人，2024年）等。

招生专业

1.  博士招生专业

      学术型博士：植物保护（代码：090400，农药毒理与健康效应方向）

      工程博士：生物与医药（代码：086000，化妆品功效原料开发方向）

2.  硕士招生专业

      学硕：植物保护（代码：090400，农药毒理与健康效应方向）

                  制药工程与技术（代码：0817Z3，化妆品功效原料开发）

      专硕：生物与医药（代码：086000，化妆品功效评价与原料开发）

近三年发表论文(2022-至今)

      [1]Weiguo Wang, Xufeng Jiang, Cheng Zhang, Xiuping Zhan, Jiagao Cheng, Liming Tao, Wenping Xu, Zhong Li, Yang Zhang*. Avermectin induced vascular damage in zebrafish larvae: association with mitochondria-mediated apoptosis and VEGF/Notch signaling pathway. J. Hazard Mater. 2024, 477, 135376.

      [2]Ruirui Li, Ning Zhou, Cheng Zhang, Mengqi Wu, Wenping Xu, Jiagao Cheng, Liming Tao, Zhong Li, Yang Zhang*. Cardiotoxicity risk induced by sanitary insecticide Dimefluthrin. Chemosphere. 2024, 364, 142910.

       [3]Ruirui Li, Cheng Zhang, Wenping Xu, Liming Tao, Jiagao Cheng, Zhong Li, Yang Zhang*. Natural pyrethrins induced developmental toxicity of zebrafish swim bladder in vivo and genotoxicity of lung cells in vitro. Toxicol in Vitro. 2024, 100, 105896.  

      [4] Weiguo Wang, Shoulin Li, Bin Liu, Ning Tang, Cheng Zhang, Xufeng Jiang, Cheng, Liming Tao, Wenping Xu, Yang Zhang*. Natural pyrethrins induce cytotoxicity in SH-SY5Y cells and neurotoxicity in zebrafish embryos (Danio rerio).  Environ. Res. 2024, 257, 119267.

     [5]Xin Wang, Bo Peng, Cheng Zhang, Mengqi Wu, Wenping Xu, Jiagao Cheng, Liming Tao, Zhong Li, Yang Zhang*. Hepatic effects of acetochlor chiral isomers in zebrafish and L02 cells. Sci. Total Environ. 2024, 913C, 169781.  

[6]Fan Chen^#, Jin Lu^#, Meng Li, Junwu Yang, Wenping Xu, Xufeng Jiang*, Yang Zhang*. A New Method of Preparing Aurone by Marine Actinomycetes and Its Potential Application in Agricultural Fungicides. Molecules.2024, 29(1), 253.  

[7]李瑞瑞，周宁，吴梦琪，徐文平，陶黎明，张阳*. 氯氟醚菊酯对斑马鱼胚胎及仔鱼心脏发育的毒性及氧化损伤作用[J].农药学学报, 2024, 26(1), 149-159.

     [8]Ziyi Wei, Weiguo Wang, Hao Feng, Wenping Xu, Liming Tao, Zhong Li, Yang Zhang*, Xusheng Shao*. Studies on immunotoxicity induced by emamectin benzoate in zebrafish embryos based on metabolomics. Environ Toxicol. 2024, 39(1), 97-105.  

     [9]Xin Wang, Shoulin Li, Cheng Zhang, Wenping Xu, Mengqi Wu, Jiagao Cheng, Zhong Li, Liming Tao, Yang Zhang*. Stereoselective toxicity of acetochlor chiral isomers on the nervous system of zebrafish larvae. J. Hazard Mater. 2024, 464C, 133016.

     [10]Xin Wang, Li Geng, Mengqi Wu, Wenping Xu, Jiagao Cheng, Zhong Li, Liming Tao, Yang Zhang*. Molecular mechanisms of cardiotoxicity induced by acetamide and its chiral isomers. Sci. Total Environ. 2023, 900, 166349. 

     [11] Jian Lu, Cheng Zhang, Wenping Xu, Weidong Chen, Liming Tao, Zhong Li, Jiagao Cheng, Yang Zhang*. Developmental toxicity and estrogenicity of glyphosate in zebrafish in vivo and in silico studies. Chemosphere. 2023, 343, 140275. 

     [12] Weiguo Wang, Shouqian Xiong, Jin Lu, Lianhua Zhu, Cheng Zhang, Jiagao Cheng, Zhong Li, Wenping Xu, Liming Tao, Yang Zhang*. The effects of Spinosad on zebrafish larvae and THP-1 cells: Associated with immune cell damage and NF-kappa B signaling pathway activation. Chemosphere. 2023, 343, 140237. 

     [13] Jian Lu, Cheng Zhang, Wenping Xu, Weidong Chen, Liming Tao, Zhong Li, Jiagao Cheng, Yang Zhang*. Developmental toxicity and estrogenicity of glyphosate in zebrafish in vivo and in silico studies. Chemosphere.2023, 343, 140275. 

     [14] Mengqi Wu, Jinhao Bian, Shuang Han, Cheng Zhang, Wenping Xu, Liming Tao, Zhong Li, Yang Zhang*. Characterization of hepatotoxic effects induced by pyraclostrobin in human HepG2 cells and zebrafish larvae. Chemosphere. 2023, 340, 139732. 

     [15] Jian Lu, Cheng Zhang, Weiguo Wang, Wenping Xu, Weidong Chen, Liming Tao, Zhong Li, Yang Zhang*, Jiagao Cheng*. Glyphosate Causes Vascular Toxicity through Cellular Senescence and Lipid Accumulation. Chem Res Toxicol. 2023, 36(7),1151-1161.

      [16] Mengqi Wu, Jingying Xu, Wei Li, Qifeng Han, Wei Xia, Zhong Li, Yang Zhang*, Wenqing Zhang*. Surface morphology and action mechanism of macrophage immunostimulating activity of Rosa Setate x Rosa Rugosa polysaccharide WSRP-1b. Carbohydrate Polymer Technologies and Applications. 2023, 6, 100339.  

    [17] Xin Wang, Fan Chen, Jian Lu, Mengqi Wu, Jiagao Cheng, Wenping Xu, Zhong Li, Yang Zhang*. Developmental and cardiovascular toxicities of acetochlor and its chiral isomers in zebrafish embryos through oxidative stress. Sci. Total Environ. 2023, 896, 165296.  

       [18] Weiguo Wang^#, Muyao Li^#, Lin Diao, Cheng Zhang, Liming Tao, Weixing Zhou, Wenping Xu, Yang Zhang*. The health risk of acetochlor metabolite CMEPA is associated with lipid accumulation induced liver injury. Environ. Pollut. 2023 , 331, 121857.

[19] Jian Lu, Cheng Zhang, Weiguo Wang, Wenping Xu, Weidong Chen, Liming Tao, Zhong Li, Yang Zhang*, Jiagao Cheng*. Exposure to environmental concentrations of glyphosate induces cardiotoxicity through cellular senescence and reduced cell proliferation.  Ecotoxicol. Environ. Saf. 2023, 261, 115112. 

     [20] Ziyi Wei, Weiguo Wang, Hao Feng, Wenping Xu, Liming Tao, Zhong Li, Yang Zhang*, Xusheng Shao*. Investigation on the immunotoxicity induced by Emamectin benzoate on THP-1 macrophages based on metabolomics analysis. Environ Toxicol. 2023, 38(5), 1053-1062. 

       [21] Xiang Wang, Jian Wang, Ping Zhang, Cheng Zhang, Weiguo Wang, Mengqi Wu, Liming Tao, Zhong Li, Yang Zhang*. Cytotoxicity and Autophagy Induced by Ivermectin via AMPK/mTOR Signaling Pathway in RAW264.7 Cells. Molecules. 2023, 28(5), 2201.

       [22] Bin Liu, XiaoMeng Li, Weiguo Wang, Xin Wang, Pahaiding Aihaiti, Tingtang Lin, Zishuo Fu, Rui Xu, Mengqi Wu, Zhong Li, Yang Zhang*. A New Method of Preparing Aurone by Marine Actinomycetes and Its Potential Application in Agricultural Fungicides. Molecules. 2022, 28(1), 17.

       [23] Jian Lu, Weiguo Wang, Cheng Zhang, Wenping Xu, Weidong Chen, Liming Tao, Zhong Li, Jiagao Cheng*, Yang Zhang*. Characterization of glyphosate-induced cardiovascular toxicity and apoptosis in zebrafish embryos. Sci. Total Environ.2022, 851, 158308.  

     [24] Weiguo Wang, Minkang Feng, Xiaomeng Li, Feiyu Chen, Zhihao Zhang, Wenlong Yang, Chen Shao, Liming Tao, Yang Zhang*. Antibacterial Activity of Aureonuclemycin Produced by Streptomyces aureus Strain SPRI-371. Molecules.2022, 27(15), 5041. 

      [25] Ruirui Li^#, Bin Liu^#, Wenping Xu, Lvnan Yu, Cheng Zhang, Jiagao Cheng, Liming Tao, Zhong Li, Yang Zhang*.DNA damage and cell apoptosis induced by fungicide difenoconazole in mouse mononuclear macrophage RAW264.7. Environ Toxicol.2022, 37(3), 650-659.

      [26] Ping Zhang, Yandi Li, Wenping Xu, Jiagao Cheng, Cheng Zhang, Jufang Gao, Zhong Li, Liming Tao, Yang Zhang*. Immunotoxicity induced by Ivermectin is associated with NF-κB signaling pathway on macrophages. Chemosphere. 2022,288, 133087

     [27] Jian Lu, Weiguo Wang, Wenping Xu, Chenggong Zhang, Cheng Zhang, Liming Tao, Zhong Li, Yang Zhang*. Induction of developmental toxicity and cardiotoxicity in zebrafish embryos by Emamectin benzoate through oxidative stress. Sci. Total Environ. 2022, 825, 154040. 

      [28] Jian Lu, Yun Yang, Lianhua Zhu, Meng Li, Wenping Xu, Cheng Zhang, Jiagao Cheng, Liming Tao, Zhong Li, Yang Zhang*. Exposure to environmental concentrations of natural pyrethrins induces hepatotoxicity: Assessment in HepG2 cell lines and zebrafish models.Chemosphere. 2022, 288(part 2), 132565.