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程侠卫


程侠卫 特聘研究员 

硕士生导师


电话:021-64251287

Email: chengxw@ecust.edu.cn

通讯地址:上海市徐汇区梅陇路130号华东理工大学实验18733室;邮编:200237

 

个人简介


程侠卫,博士,华东理工大学特聘研究员,光遗传学和合成生物学交叉学科研究中心成员。2014年毕业于南京大学生命科学学院,获得博士学位,同年进入浙江大学医学院从事博士后研究工作。2019年加入华东理工大学光遗传学和合成生物学交叉学科研究中心,从事细胞自噬和细胞代谢研究工作。目前在Molecular CellScienceAutophagyTheranostics等专业期刊上发表SCI论文多篇。主持、参与并完成多项国家自然科学基金和省部级项目。


 

主要研究方向


  1. 细胞自噬与中心碳代谢

  2. 细胞自噬信号对细胞代谢的调控机制

  3. 细胞自噬和代谢性疾病

 


代表性研究成果


  1. Cheng Xiawei; Ma Xiuling; Ding Xingming; Li Lin; Jiang Xiao; Chen She; Shen Zhirong; Liu Wei; Gong Weihua; Sun Qiming. Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17, Molecular Cell, 2017, 65(6): 1029-1043.

  2. Cheng Xiawei; Ma Xiuling; Zhu Qi; Song Dandan; Ding Xianming; Li Lin; Jiang Xiao; Wang Xinyi; Tian Rui; Su Hua; Shen Zhirong; Chen She; Liu Ting; Gong Weihua; Liu Wei; Sun Qiming. Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism, Molecular Cell, 2019, 73(4): 788-802.

  3. Cheng Xiawei; Sun Qiming. RUBCNL/Pacer and RUBCN/Rubicon in regulation of autolysosome formation and lipid metabolism, Autophagy, 2019, 15(6): 1120-1121.

  4. Liu Chen#; Cheng Xiawei#; Chen Juntao; Wang Yao; Wu Xiaoying; Tian Rui; Liu Baoqing; Ding Xianfeng; Sun Qiming*; Gong Weihua*; Suppression of YAP/TAZ-Notch1-NICD axis by bromodomain and extraterminal protein inhibition impairs liver regeneration, Theranostics, 2019, 9(13):3840-3852.

  5. Cheng Xiawei, Zhang Xiaoxin, Cheng Wei, Chen Jianxiang, Ma Cailie, Yang Bingya, Hua Zichun. Tumor-specific delivery of histidine-rich glycoprotein suppresses tumor growth and metastasis by anti-angiogenesis and vessel normalization. Curr Gene Ther. 2014;14(2):75-85.

  6. Cheng Xiawei, Zhang Xiaoxin, Zhou Yuqiang, Zhang Chunmei, Hua Zichun. A Salmonella Typhimurium mutant strain capable of RNAi delivery: higher tumor-targeting and lower toxicity. Cancer Biol Ther. 2014,15(8):1068-76. doi: 10.4161/cbt.29185.

  7. Cheng Xiawei, Lu Wuguang, Zhang Shuangquan, Cao Peng. Expression and purification of antimicrobial peptide CM4 by Npro fusion technology in E. coli. Amino Acids. 2010 ,39(5):1545-52. doi: 10.1007/s00726-010-0625-0.

  8. Lu Yan, Zheng Yuping, Coyaud Etienne,Zhang Chao, Selvabaskaran, Apiraam, Yu  Yuyun; Xu Zizhen; Weng Xialian, Chen JiShun, Meng Ying; Warner Neil; Cheng Xiawei; Liu Yangyang; Yao Bingpeng; Hu Hu; Xia Zonping; Muise Aleixo M; Klip Amira; Brumell, John H; Girardin Stephen E; Ying Songmin; Fairn Gregory D; Raught Brian; Sun Qiming; Neculai Dante; Palmitoylation of NOD1 and NOD2 is required for bacterial sensing , Science, 2019, 366(6464): 460-467.

  9. Zhang Zhuo, Cheng Xiawei, Zhao Yuzheng, Yang Yi. Lighting Up Live-Cell and In Vivo Central Carbon Metabolism with Genetically Encoded Fluorescent Sensors[J]. Annu Rev Anal Chem (Palo Alto Calif), 2020. doi: 10.1146/annurev-anchem-091619-091306.