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李写 特聘副研究员 硕士生导师

E-mail: xieli@ecust.edu.cn

通讯地址：上海市徐汇区梅陇路130号，第六教学楼辅楼316室；邮编：200237


【个人简介】

李写，博士，华东理工大学特聘副研究员，上海市细胞代谢光遗传学技术前沿科学研究基地和光遗传学与合成生物学交叉学科研究中心成员。2018年9月毕业于华东理工大学药学院，获理学博士学位。随后加入光遗传学与合成生物学交叉学科研究中心团队。迄今以第一作者（含共一）发表于Cell Metabolism、PNAS、Nucleic Acids Research、Trends in Cell Biology和Cell Reports，以共同作者在Nature Communications和The Journal of Clinical Investigation发表论文4篇，授权4项中国发明专利，申请11项国际PCT发明专利和17项中国发明专利。主持国自然青年科学基金项目、上海市自然科学基金面上项目等项目，获得第十七届细胞生物学青年论坛技术创新奖。


【研究方向】

  1. 遗传编码荧光探针的开发与应用

  2. 光遗传学技术的开发与应用


【发表论文】

1. Xie Li#, Yinan Zhang#, Lingyan Xu#, Aoxue Wang#, Yejun Zou#, Ting Li#, Li Huang#, Weicai Chen#, Shuning Liu, Kun Jiang, Xiuze Zhang, Dongmei Wang, Lijuan Zhang, Zhuo Zhang, Zeyi Zhang, Xianjun Chen, Wei Jia, Aihua Zhao, Xinfeng Yan, Haimeng Zhou, Linyong Zhu, Xinran Ma, Zhenyu Ju, Weiping Jia, Congrong Wang*, Joseph Loscalzo, Yi Yang* and Yuzheng Zhao*. Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease. Cell Metabolism, 2023, 35(1), 200-211.

2. Xie Li, Changcheng Zhang, Xiaopei Xu, Jun Miao, Jing Yao, Renmei Liu, Yuzheng Zhao, Xianjun Chen* and Yi Yang*. A single-component light sensor system allows highly tunable and direct activation of gene expression in bacterial cells. Nucleic Acids Research, 2020, 48(6), e33.

3. Dan huang#, Changcheng Zhang#, Ming Xiao#, Xie Li#, Weicai Chen#, Yu Jiang, Yamin Yuan, Yaping Zhang, Yejun Zou, Lei Deng, Yang Wang, Yuying Sun, Wenping Dong, Zhuo Zhang, Li Xie, Zhuo Yu, Chiqi Chen, Ligen Liu, Jing Wang, Yi Yang*, Jie Yang*, Yuzheng Zhao* and Junke Zheng*. Redox metabolism maintains the leukemogenic capacity and drug resistance of AML cells. PNAS, 2023, 120 (13), e2210796120.

4. Zhuo Zhang#, Chiqi Chen#, Xie Li#, Junke Zheng*, Yuzheng Zhao*. Regulation of leukemogenesis via redox metabolism. Trends in Cell Biology, 2023, online, doi.org/10.1016/j.tcb.2023.10.001.

5. Xiaoye Liu#, Feifei Zhang#, Yaping Zhang#, Xie Li#, Chiqi Chen#, Meiyi Zhou, Zhuo Yu, Yunxia Liu, Yuzheng Zhao, Xiaoxin Hao, Yabin Tang, Liang Zhu, Ligen Liu, Li Xie, Hao Gu, Hongfang Shao, Fangzhen Xia, Chunrong Yin, Minfang Tao, Jingjing Xie, Cheng Cheng Zhang, Yi Yang, Haipeng Sun*, Guo-Qiang Chen*and Junke Zheng*. PPM1K regulates hematopoiesis and leukemogenesis through CDC20-mediated ubiquitination of MEIS1 and p21. Cell Reports, 2018, 23(5), 1461-1475.

6. Mengshu Jia#, XiaoYue#, Weixia Sun#, Qianjun Zhou#, ChengChang#, Weihua Gong, Jian Feng, Xie Li, Ruonan Zhan, Kemin Mo, Lijuan Zhang, Yajie Qian, Yuying Sun, Aoxue Wang, YejunZou, Weicai Chen, Yan Li, Li Huang, Yi Yang*, Yuzheng Zhao*, Xiawei Cheng*. ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation. Science Advances, 2023, 9, eadg499.

7. Ting Li#, Xianjun Chen#, Yajie Qian, Jiawei Shao, Xie Li, Shuning Liu, Linyong Zhu, Yuzheng Zhao, Haifeng Ye* and Yi Yang*. A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice. Nature Communications, 2021, 12, 615.

8. Xiaoxiao He#, Jiangbo Wan#, Xiaona Yang, Xiuze Zhang, Dan Huang, Xie Li, Yejun Zou, Chiqi Chen, Zhuo Yu, Li Xie, Yaping Zhang, Ligen Liu, Shangang Li, Yuzheng Zhao, Hongfang Shao*, Ye Yu* and Junke Zheng*. Bone marrow niche ATP levels determine leukemia-initiating cell activity via P2X7 in leukemic models. The Journal of Clinical Investigation, 2021, 131(4): e140242.

9. Kai Yang, Ming Wang, Yuzheng Zhao, Xuxu Sun, Yi Yang, Xie Li, Aiwu Zhou, Huilin Chu, Hu Zhou, Jianrong Xu, Mian Wu, Jie Yang* and Jing Yi*. A redox mechanism underlying nucleolar stress sensing by nucleophosmin. Nature Communications, 2016, 7, 13599.