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何薇薇，博士

副教授,博导

电话：021-64252293

E-mail:  heweiwei@ecust.edu.cn

地址：上海市徐汇区梅陇路130号实验十八楼1219室；邮编：200237

  

个人简历：

2007年6月毕业于中国科学技术大学，获硕士学位，从事生物化学及结构生物学研究；随后赴美，2013年2月毕业于美国Scripps研究所，获博士学位，从事神经肌肉萎缩症的分子生物学机制研究。2014年7月加入华东理工大学药学院，任副教授。2015年入选上海市浦江人才计划。作为项目负责人，主持了国家自然科学基金（青年，面上），并参与科技部“973计划”（青年项目）,国家自然科学基金国际(地区)合作与交流项目,NSFC-云南联合基金重点支持项目。

  

研究方向：

致力于活性小分子特别是天然产物靶点识别与机制研究。


利用表观活性良好的天然产物作为工具，

（1）研究与癌症等疾病密切相关的细胞周期、自噬、代谢、蛋白相分离等生命过程；
（2）阐释分子机制，揭示疾病发生发展机制，发现生物学事件及其关联的契机；
（3）发展具有潜在治疗意义的小分子调控剂。



  

代表性论文：

  

1.      Yan Peng,# Yumeng Zhang,# Ruan Fang,# Hao Jiang,# Gongcai Lan, Zhou Xu, Yajie Liu, Zhaoyang Nie, Lu Ren, Fengcan Wang, Shou-De Zhang, Yuyong Ma, Peng Yang, Hong-Hua Ge, Wei-Dong Zhang,* Cheng Luo,* Ang Li,* and Weiwei He* Target Identification and Mechanistic Characterization of Indole Terpenoid Mimics: Proper Spindle Microtubule Assembly Is Essential for Cdh1-Mediated Proteolysis of CENP-A. Advanced Science 2024, e2305593.

2.       Shaonan Wang,# Min Sun,# Yajuan Su, Zhou Xu, Ang Li,* and Weiwei He* Deucravacitinib induces proteasomal degradation of YAP1 in human glioblastoma cells. Synlett 2024, DOI: 10.1055/a-2331-6463.

3.       Shaonan Wang,# Yali Wu,# Mengyu Ba, Zhou Xu, Guoxing Gu, William G. Whittingham, Cong Liu, Ang Li,* and Weiwei He* Discovery of the lysosome-inhibiting function of acremolactone B. Synlett 2024, DOI: 10.1055/a-2325-3938.

4.       Weiwei He,# Hongbo Zhang,# Xudong Lin, Lili Zhu, Tingting Zheng, Hao Pei, Yang Tian, Min Zhang, Guoyue Shi, Lei Wu, Jianlong Zhao, Gulinuer Wumaier, Shengqing Li, Yufang Xu, Honglin Li,* and Xuhong Qian* Advancements in life-on-a-chip: The impact of “Beyond Limits Manufacturing” technology. Chinese Chemical Letters 2023, 109091.

5.       Fan Yang, Jie Zhang, Jiacheng Li, Wenbo Ye, Ang Li,* and Weiwei He* Synthesis of a glucose conjugate of pristimerin and evaluation of its anticancer activity. Chinese Chemical Letters 2022, 34, 107438.

6.       Gongcai Lan, Jie Zhang, Wenbo Ye, Fan Yang, Ang Li,* Weiwei He,* and Wei-Dong Zhang* Celastrol as a tool for the study of the biological events of metabolic diseases. Science China Chemistry 2019, 62, 409–416.

7.      Jinpeng Pei, Shupeng Zhou, Fan Yang, Yu Sun, Ang Li,* Wei-Dong Zhang,* and Weiwei He* Identification and mechanistic studies of a cell cycle regulator JP18 from a library of synthetic indole terpenoid mimics. Chem. Asian J. 2016, 11, 2715–2718.

8.     Zhongyin Zhang, Fan Yang, Jian-Jun Fu, Yun-Heng Shen,* Weiwei He,* and Wei-Dong Zhang* Delavatine A, a structurally unusual cyclopenta[de] isoquinoline alkaloid from Incarvillea delavayi. RSC advances 2016, 6, 65885–65888.

9.      Weiwei He,# Ge Bai,# Huihao Zhou, Na Wei, Nicholas M. White, Janelle Lauer, Huaqing Liu, Yi Shi, Calin Dan Dumitru, Karen Lettieri, Veronica Shubayev, Albena Jordanova, Velina Guergueltcheva, Patrick Griffin, Robert W. Burgess, Samuel L. Pfaff,* and Xiang-Lei Yang* CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase. Nature 2015, 526, 710–714.

10.   Weiwei He,# Hui-Min Zhang,# Yeeting E. Chong, Min Guo, Alan G. Marshall, and Xiang-Lei Yang* Dispersed disease-causing neomorphic mutations on a single protein promote the same localized conformational opening. Proc. Natl. Acad. Sci. USA 2011, 108, 12307–12312.

11.  Weiwei He,# Yi Wang,# Wei Liu, and Cong-Zhao Zhou,* Crystal structure of Saccharomyces cerevisiae 6-phosphogluconate dehydrogenase Gnd1. BMC Structural Biology 2007, 7, 38–46.